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Seong Bae Park,Yoon Pyo Nam,Kyung Rim Sung,Michael S. Kook 대한안과학회 2009 Korean Journal of Ophthalmology Vol.23 No.3
Purpose: To evaluate and compare correlations between structural and functional loss in glaucoma as assessed by optical coherence tomography (OCT), scanning laser polarimetry (GDx VCC, as this was the model used in this study), standard automated perimetry (SAP), and the Humphrey Matrix (Matrix). Methods: Ninety glaucomatous eyes identified with SAP and 112 eyes diagnosed using Matrix were independently classified into six subgroups, either S1/M1 (MD>-6dB), S2/M2 (-12<MD<-6dB) or S3/M3 (MD<-12dB), according to the mean deviation (MD) of each test. Average and sectoral retinal nerve fiber layer (RNFL) thickness and percentage of abnormal classifications using the internal normative databases of OCT and GDx VCC were compared among the six subgroups. Results: In the SAP subgroups, RNFL thickness values obtained by OCT in the nasal and temporal quadrants and the inferior averages of GDx VCC did not differ between the S1 and S2 subgroups (p=0.137, 0.738 and 0.149, respectively). In the Matrix subgroups, no measurement parameters differed between the M1 and M2 groups except for the overall mean and average inferior RNFL thickness given by OCT and the NFI values of GDx VCC (p=0.013, 0.016 and 0.029, respectively). When abnormal classifications were compared, all measurement parameters, without exception, were significantly different in both the SAP and the Matrix subgroups. Conclusions: SAP subgroups showed a good correlation of structural and functional defects when assessed using OCT and GDx VCC. These correlations were weaker in the Matrix subgroups, especially in the early stages of glaucoma. Korean J Ophthalmol 2009;23:176-182
정성훈,국문석 울산대학교 의과대학 1996 울산의대학술지 Vol.5 No.1
The goal of glaucoma filtration surgery(GFS) is to lower the intraocular pressure(IOP) by maintaining a fistula between the anterior chamber and the subconjunctival space for the drainage of aqueous humor. This is usually successful in eyes with various types of glaucoma that have not had previous operations. Risk for GFS failure include previously failed filtering surgery, aphakia, pseudophakia, his tory of uveitis, young age and neovascularization of the anterior segment. The natural wound healing process and scarring at the surgical site is the most common cause of GFS failure. Much attention has been directed toward controlling and modulating the wounding healing response wish different pharmacological agents.
Sun Young Lee,Dong Wook Ha,Michael S,Kook 대한안과학회 2004 Korean Journal of Ophthalmology Vol.18 No.1
We investigated the ability of the GDx-Nerve Fiber Analyzer (NFA) to discriminate between normal and early glaucomatous eyes among Korean individuals by reviewing the medical records of 217 consecutive subjects: 61 early glaucoma patients, 68 ocular hypertensive patients, and 88 normal subjects. GDx parameters were compared using ANOVA. The Receiver Operating Characteristics (ROC) curve for each GDx-NFA variable was used to diagnose each parameter, and Pearson correlation coefficients were calculated to assess the association between GDx-NFA parameters and visual field indices in early glaucoma. The best GDx parameters to discriminate between early glaucomatous and normal subjects were the number, maximum modulation, ellipse modulation and inferior ratio (i.e. area under the ROC curve > 0.8). A value for the Number of equal to or greater than 27 was optimal for detecting early glaucoma, with a sensitivity of 80.3% and specificity of 80.7%. In addition, symmetry was positively correlated with the corrected pattern standard deviation (CPSD) among visual field indices in early glaucoma.