심근경색의 위험인자로서 Thrombomodulin유전자변이의 의의

박현영,김영미,권혁문,지선하,조승연,정남식,심원흠,장양수 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

국내에서 발생하고 있는 사람 브루셀라증의 임상적 특성

김연숙,최영실,오원섭,권기태,이혁,이선희,손준성,김신우,장현하,정숙인,고관수,박미연,백경란,송재훈 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

배경 : 2002년 내국인에서의 첫 사람 브루셀라증의 증례 보고 이후 국내에서 사람 브루셀라증이 빠른 증가를 보이고 있다. 이에 연구자들은 국내에서 발생하는 브루셀라증의 임상적 특성을 연구하고자 하였다. 방법 : 2003년부터 2006년 7월까지 7개 대학병원에 내원한 환자들을 대상으로 WHO의 진단기준에 의하여 확진된 브루셀라증 환자들의 의무기록을 후향적으로 조사분석 하였다. 배양된 균은 삼성서울병원에 의뢰하여 16S rRNA 유전자 분석방법을 이용하여 종을 확인하였고, 표준시험관응집검사는 국립보건원에 의뢰하여 시행하였다. 결과 : 34예의 환자들이 브루셀라증으로 확진되었고, 31명이 남자였다. 혈액에서 B. abortus가 증명된 경우가 8예, 표준시험관 응집검사상 의미 있는 항체가 상승을 보인경우가 26예이었다. 환자들은 대부분 축산업관련 종사자였고, 추후 브루셀라증으로 확진된 소와의 직접 접촉을 통해 감염된 것으로 여겨진다. 국내 사람 브루셀라증의 가장 흔한 증상은 발열이었고, 위장관계 합병증이 가장 흔히 동반되었다. 치료로는 doxycycline/rifampicin이 24예의 환자에서 doxycycline/aminoglycoside (streptomycin 혹은 gentamicin)이 10예의 환자에서 6주 이상의 기간 동안 투여되었다. 치료에 반응을 보이지 않는 환자는 없었고, 재발이 1예 있었다. 결론 : 국내에서 발생하는 사람 브루셀라증의 원인균으로 현재까지 분리 동정된 것은 B. abortus이며, 소 브루셀라증의 증가로 인해 인체감염사례가 함께 증가하는 것으로 사료된다. 위험 직업군 종사자들에서 감염된 소와의 직접 접촉을 통해 주로 발생하고 있는 브루셀라증의 임상종상은 국외에서 발생하는 경우와 유사한 양상을 보이고 있으며 치료에 대한 반응은 비교적 좋은 편이긴 하나, 추후 보다 많은 환자들을 대상으로 한 연구가 필요하리라 사료된다. 사람 브루셀라증의 조절을 위해서는 소 브루셀라증의 조절이 필수적이며, 브루셀라증의 조절에 성공한 선진국의 사례를 적극적으로 도입해야 할 것으로 생각된다. Background : Since the first Korean case of human brucellosis was reported in 2002, the incidence of human brucellosis has been rapidly increasing. We performed this study to evaluate the clinical characteristics of human brucellosis occurring in South Korea. Materials and Methods : Demographic features, clinical manifestations, and therapeutic outcomes of cases confirmed as brucellosis according to WHO diagnostic criteria were evaluated. Species of Brucella isolates were identified with 16S rRNA gene sequencing method. Serologic diagnosis was performed with standard tube agglutination test (STA). Results : A total of 34 cases were enrolled from 2003 to 2006 in six hospitals. Eight cases were confirmed with the isolation of Brucella from blood and 26 cases were confirmed with titer of antibodies ≥1:160 by STA. Male (31) was predominant and most of the patients were cattle farmers. The most common transmission route was direct contact with infected or their cattle byproducts. Fever was the most prominent symptom and fatigue followed. Gastrointestinal and musculoskeletal systems were commonly complicated. Patients were treated with doxycycline and rifampin or aminoglycosides for more than 6 weeks. All patients responded well to the therapeutic regimens, but one patient relapsed 10 months after treatment. Conclusion : Brucellosis occurring in Korea has been caused by B. abortus, whose preferred natural host animals are cattle. Korean patients were infected through direct contact with bovine brucellosis. Clinical manifestations of brucellosis were similar to those occurring worldwide. Therapeutic outcomes were good among patients with brucellosis in Korea. In order to prevent human brucellosis, measures to eradicate bovine brucellosis should precede.

갈바니 전지와 전해전지 관련 개념에 대한 예비화학교사들의 개념 유형 분석

김연미,이종백,이상권 이화여자대학교 교과교육연구소 2007 교과교육학연구 Vol.11 No.1

이 연구의 목적은 사범대학 화학교육과 4학년에 재학하고 있는 예비교사를 대상으로 갈바니 전지와 전해전지에 대한 개념을 이해하는 데 어려움을 알아보고자 하였다. 예비교사들에게 나타나는 오개념을 유형별로 분류하고, 그 원인을 분석하였다. 연구 결과 대부분의 예비교사들은 갈바니 전지와 전해전지에서 전극의 부호 및 용어 사용에 있어서 (+)극, (-)극 그리고 산화전극, 환원전극을 바르게 선택하였으나, 그렇게 선택하게 된 이유에 대해서는 올바른 과학 개념이 부족한 것으로 나타났다. 그리고 기전력 측정의 정량적인 면에서는 대부분의 예비교사들이 정확하게 알고 있었으나 전기화학 원리에 대한 정성적인 면에서는 전문적인 지식이 부족하다는 것을 알 수 있었다. 또한 다니엘 전지의 염다리 역할에 대해서는 염다리를 통한 이온의 이동에 의해 용액의 전기적 중성이 유지된다는 사실은 대부분 정확하게 알고 있었으나 그 외에 이온의 이동에 의해 회로가 완성된다는 포괄적인 개념은 가지고 있지 못하였다. 그리고 대부분의 예비교사들은 수용액의 전기분해에서는 표준 전극전위값을 적절하게 활용하지 못하였으며 이온만이 전기분해 반응에 관여한다고 생각하여 물의 반응은 고려하지 못하였다. The purpose of this study was to analyze conception types related to Galvani and electrolytic cells. Sanger and Greenbowe's interview protocols for the cells were used with modifications in this study. These questions were administered and follow-up interviews were conducted to pre-service chemistry teachers. This study revealed that several pre-service teachers in the sample were confused about identifying the anode and cathode, understanding the charge on the anode and cathode, understanding the need for a standard half-cell, predicting the products of electrolysis, and understanding current flow in Galvani and electrolytic cells. In the case of the purpose of the salt bridge, it was shown that pre-service teachers only thought that the salt bridge is for ion movement of two solutions involving electrodes, but they didn't have the conception that the salt bridge has a roll of connecting a circuit. Most pre-teachers had misconception in electrolysis of solution taking no account of water electrolysis. As the results of this study, it was possible that pre-service teacher's conceptual difficulties and misconceptions were caused by insufficient expert knowledge, insufficient explanations of the textbooks, and teachers having misconceptions.

STS powder의 무전해 니켈 도금

이종권,박소연,하미영,김소연 순천향대학교 부설 산업기술연구소 2006 순천향 산업기술연구소논문집 Vol.12 No.1

Nickel was electroless-plating on 304L stainless steel powder. To obtain uniform coating and dispersion of powder, the bath was continuously agitated with magnetic stirrer. The pH and bath temperatures were varied. The tested conditions were in the range of pH4∼10, 65℃ respectively. The coating morphologies were examined by SEM/EDS. The optimum condition was pH9 at 65℃.

청소년기 여성의 가족폭력 피해에 관한 연구

김경희,권혜진,최미혜,정연강 韓國學校保建學會 1996 韓國學校保健學會誌 Vol.9 No.2

This study is designed to contribute to the intervention of adolescent domestic violence by understanding the experience of the victims, better. The data were coiiected through a series of interviews with 3 subjects singled out at each stage of research. With the permission of the subjects, the interviews were recorded and transcribed. The interviews lasted from two and a half to 8 hours. The data were analyzed in the framework of grounded theory as mapped out by Strauss & Corbin (1990). The major findings of this research are as follows : The core category was found to be the adaptation of "Jitnulim" or "Being suppressed" . The sub-categories identified in the process of grounded data analysis were 'roughness', 'wildness', 'driving', 'challenging', 'being strapped', 'being pressed', 'erupting', 'being horrified', 'being hardened', 'being connected', 'being seen', 'being helpful', being led', 'sprouting', 'being off , 'being cast out', 'shaking off,' getting out', 'covering-up', 'waiting', 'ruling', 'common placeness', 'overcoming', 'getting united', 'fa11ing behind', 'falling in', 'being mixed up', 'ruthlessness', 'estrangement', 'difficulty', 'being overwhelmed', 'feeling regreful', 'being pressed','hesitating', and 'shying off'. These categories were again grouped into 11 categories including 'threatening', 'straightjacketing', 'alliance', 'phenomenon','pattern of support','system of support','challenging','calming-down','being relieved','being hardened and entangled','being entangled'. The following four theses were confirmed on the basis of the reifetitive relation: 1) If the episodes of violence are frequent and serious, with the resulting straightjacketing being stronger the victim's family relations are coherent and the subject's support pattern is highly mature. Concrete the responses to the straighjacketing regulted in a'calming-down' which gradually relieved. 2) If the episodes of violence were frequent and serious, with the resulting straightjacketing being strong the victim's family relations and incoherent and the suhjects supporter is immature but strong the support type is superficial and the responses to the straightjacketing result in a bouncing-off which gets entangled with the passage of time. 3) If the episodes of the violence are frequent and serious, the straighljacketing is strong, but the family relations are and the subject's support system is mature and strong the responses to the straightjacketing result in a calming-down which gets partly relieved but partly entangled. 4) If the episodes of the violence are frequent and serious with the resulting straightiacketing being strong, the victim's family relations are incoherent, the subject's support system is immature, and the support type is immature the responses to the straightjacketing result in a 'bouncing-off' which gets entangled and partly hardened with time.

회귀분석(regression analysis)을 이용한 개인별 혈중알콜농도의 감소율 계산

홍성욱,권미아,최혜진,박용훈,인상환,김동우,정주연,우상희,박혜성 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

일개 농촌지역의 지역사회 영양정보에 관한 조사연구 : 경기도 남양주군 수동면을 중심으로 Su-Dong Myun, Nam Yang-Ju Gun, Kyung-Gi Do

계난이,권계숙,송미희,이연주 이화여자대학교 의과대학 1988 梨花醫學誌 Vol.- No.20

From September to November in 1987, the study was conducted a survey of Su-Dong Myun, Nam Yang-Ju Gun, Kyung-Gi Do, a comprehensive rural care demonstration area of Ewha Womans University. The purpose of this survey has been to examine into community nutrition informathrough preventive medicine training of sophomores of medical course. The result were as follows 1) Female respondent was 88.2% of all whose age was the forties and fifties at the highest rate of 22.6% respectively and whose educational level was uneducated at rate of 31.2%. 2) Agriculture(66.7%) was the common householder's occupation whose main income was from their own farm products(67.7%). 3) A family of five(24.7%) and two generations(e.g parent and children) (55.9%) was the most common family. 4) The housewife(98.9%) was the most common cook and 35.5% of all cook was not able have sufficient time to prepare for their meal. 5) On food purchase, main food was largely self provided(65.6%) and subsidiary food with self-provision and outside purchase(51.6%). 6) On the self sufficient food rice(77.4%) was most common as main food and vegetable(81.7%) as subdiary food. 7) On the frequency of purchasing food, main food was about 2-3 times a month, subsidiary food 1-3 times a week. On the market place, main food mainly self sufficient(59.1%) and subsidiary food was largely purchased from the peddlers and market on the move(35.5%) 8) On the means of transportation of purchased food, main food was conveyed by bus or another kinds of vehicles and subsidiary food(52.7%) was in the same way. 9) On the consumer's difficulty in purchasing food, meat and fish were rated 76.3% and vegetable 78.5%, 76.3% of all consumer had difficulty in purchasing meat and fish, 78.5% in purchasing grocery. 10) 94.6% was in possession of electric refrierator and 89.2% possessed their own wells. 11) The respondent had such fuels for cooking as propanegas(66.6%), wood(18.3%) briquet(10.8%). 12) the present state of nutrition was that the mean points was 2.7 in the group 1, 2.2 in the group 2, 3.9 points in the group 3, 2.8 points in the group 4, 3.1 points in group 5 and 2.7 points in the group 6. 13) Most families' favorite food was kimchi or kimchi soup and distasteful was meat including dog meat. 14) 48.4% of all respondents took no interest in taking in adequate nutrition owing to the lack of money and time to spare.

전국 단위 감시체계의 현황과 전망

강성규,안연순,지영구,김형옥,하미나,권호장,백남종,김성아,홍윤철,김재용,강대희,정혜선,하은희 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

국내 설사환자로부터 분리된 Escherichia coli 균의 혈청군 및 Verocytotoxin 생성능

김호훈,강연호,김성한,박미선,유재연,이복권 대한감염학회 1998 감염 Vol.30 No.5

목적: 국내 설사 환자에게서 분리 동정된 인체 감염 유래 E. coli 균의 혈청군, verocytotoxin 생성능을 구명하여 EHEC 균의 인체 감염 실태를 구명하고, 동물 및 식품 유래 분리균주의 성상과 비교 검토하여 인체 감염 위험성에 대한 기초적 자료를 의학계에 제공하고자 하였다. 방법: EHEC 감염의심 설사 환자 분변 검체로부터 분리된 균주 중 생화확적 성상에 따라 대장균을 분리하였고 이들 균주 중 E. coli O157:H7를 분리하기 위해서는 Dsorbitol 음성균을 선별하였으며, 분리균에 대하여 항혈청으로 응집 시험을 실시하여 혈청군을 구명하였다. 혈청군이 확인된 균주에 대하여 중합효소 연쇄반응 (PCR) 및 역수동라텍스 응집시험 (Reversed Passive Latex Agglutination:RPLA) 으로 verocytotoxin 생성능을 구명하였다. 결과: 장출혈성 대장균 감염 의심설사 환자의 분변검체로부터 25주의 E. coli 균을 분리 동정하였으나 이들 균주는 모두 verocytotoxin을 생성하지 않았다. 분리 동정된 대장균으로부터 확인된 혈청군은 16종으로서 E. coli O1, O6, O8, O15, O20, O25 O26, O28, O29, O44, O86a, O119, O126, O128, O152, 및 O157:H-였으며 E. coli O157:H-혈청형 균주와 E.coli O25 혈청군 균주가 각각 3주씩 분리되어 비교적 높은 분리율을 보였다. 결론: 장출혈성 대장균 감염 의심설사 환자 분변 가검물로부터 총 25주의 E. coli균을 분리 동정하였으나 verocytotoxin을 모두 생산하지 않았다. Background: Since 1982, many countries has reported outbreaks or sporadic cases caused by enterohaemorrhagic Escherichia coli (EHEC) serogroup strains, mainly E. coli O157:H7 type strain. However, systemic investigation about EHEC agents, including E. coli O157:H7, have not been done in Korea. Therefore, we investigated serogroup and verotoxin productivity of E. coli strains isolated from diarrheal patients and estimated risk of human infection in comparison with EHEC strains isolated from cow, pig, and food material in Korea. Methods: Diarrheal patient stool samples were collected and E. coli strains were isolated, according to biochemical characteristics. In order to isolate E. coli O157:H7, D-Sorbitol negative strains were selected. Serogrouping of the E. coli isolates was done by agglutination test. Verocytotoxin productivity was investigated by polymerase chain reaction (PCR) and reversed passive latex agglutination (RPLA). Human infection risk was estimated in comparison with EHEC strains isolated from cow, pig and food materials in Korea. Results: Twenty-five E. coli strains were isolated from the diarrheal patients who were suspected to be infected with EHEC. However, none of these E. coli strains produced verocytotoxin. Out of 25 E. coli isolates, 16 serogroups of E. coli O1, O6, O8, O15, O20, O25, O26, O28, O29, O44, O86a, O119, O126, O128, O152 and 157:H-were found. In each of the E. coli O157:H-and O25 serogroups 3 strains were found. Conclusion: None of 25 E. coli isolated from diarrheal patients who were suspected of EHEC infection produced verocytotoxin producing E. coli have been reported recently in Korea.

발관리 교육프로그램이 노인 당뇨병 환자의 발관리 이행과 족부합병증에 미치는 효과

노영숙,전시자,권연숙,임미숙,심강희 노인간호학회 2007 노인간호학회지 Vol.9 No.2

Purpose : Diabetic foot complications are significant problems in diabetes mellitus and often result in lower extremity amputation. This study was conducted to verify the effects of foot care education on compliance with foot care and diabetic foot complications when the patient is an elder with diabetes. Method: A group pretest-posttest design was used to examine the effects of 6 months of foot care education with a group of 13 elders with diabetes. The major dependent variables including foot care compliance and diabetic foot complications were measured at the beginning and end of the treatment period to examine the effects of foot care education. Result : There were no significant differences in total foot care compliance scores and presence of diabetic foot complication after 6 months, Conclusion : Interventions involving problem based education and pursuing long-time effects may be more effective in implementing and sustaining improvements than just group education or one time interventions for elders with diabetes.