중국거주 조선족 여성의 영적 안녕정도가 정신건강에 미치는 영향

정성덕,이종범,김진성,서완석,배대석,박순재,주열,염형욱,김승원,김구묘,안영록,황대홍,표미자,조창열,정태길 영남대학교 의과대학 2004 Yeungnam University Journal of Medicine Vol.21 No.2

자아초월 정신의학이 체계화되면서 영성(spirituality)은 인성의 한 부분이라는 이론이 대두되었는데 이 영성은 정신건강에 큰 영향을 미친다고 했다. 인간의 성향 중 영적 안녕 정도를 파악하여 그 정도가 정신건강 중 허위성 경향, 정신병적 경향 및 불안과 우울 경향 등에 어떠한 영향을 미치는지를 조사하고저 본 연구를 실시하였다. 대상은 중국의 연변 조선족 자치구에 거주하는 여성 400명을 대상으로 하여 한국판 영적 안녕척도를 사용하여 영적 안녕정도를 파악하였다. 영적 안녕척도의 총점과 이 척도의 2개 하위 척도인 종교적 안녕과 실존적 안녕 척도 양자로 평가한 성적이 불안-우울통합척도와 정신분열증 척도 및 허위성 척도로 평가한 성적에 미치는 영향을 검증하기 위하여 상관관계분석 및 회기분석을 실시하였다. 그 결과는 다음과 같다. 1) 영적 안녕척도로 평가한 조선족 여성의 총점은 68.29로 한국의 기독교 여성이 평가한 100.65보다 훨씬 낮은 점수였다. 2) 불안·우울통합척도로 평가한 총점은 44.88로 연변노인이 평가한 점수와 일개지역의 한국농촌주민이 평가한 점수와 비슷한 결과였다. 3) 허위성 척도로 평가한 성적은 평균 74.57로 70점 이상이 86%(344명)이었으나 영적 안녕 성적과 허위성 성적 간에는 유의한 상관이 없었다. 4) 영적 안녕총점은 정신분열증 척도로 평가한 정신병적 경향에 유의한 영향을 미치지 않았으나 종교적 안녕하위척도의 성적은 정신병적 경향을 높여준데 비하여 실존적 안녕하위척도의 성적은 정신병적 경향을 낮게 해주었다. 5) 영적 안녕척도의 총점 및 두 하위척도인종교적 안녕과 실존적 안녕은 불안과 우울에유의한 상관을 보였는데 영적 안녕총점이 높을수록 불안·우울 총점이 다소 낮아지는 경향을 보였다. 6) 종교적 안녕 하위척도와 불안과 우울과의 관계는 종교적 안녕점수가 높을수록 불안과 우울을 각각 다소 유의하게 높여주었으며 이에 비하여 실존적 안녕하위척도와 불안과 우울과의 관계는 실존적 안녕정도가 높을수록 불안 및 우울점수는 유의하게 낮아졌다. 이와 같은 성적을 미루어볼 때 연변에 거주하는 조선족 여성이 평가한 영적 안녕정도는 정신병적 경향과 불안 및 우울에 유의한 상관을 보였으면 이 척도의 하위 척도인 종교적 안녕정도는 정신건강에 부정적인 영향을 미치는 반면 실존적 안녕정도는 정신건강에 긍정적 영향을 미친 결과로 평가되었다. 이러한 결과는 공산주의 사회에서 실존적 안녕은 긍정적인 가치관으로 평가되는 반면 종교적 안녕은 정신건강에 부정적으로 작용한 것을 입증해 주었다고 하겠다. Background: Spirituality has been an important part of Transpersonal Psychology and is believed to have a large effect on the mental health because it has been systematized. The aim of this study was to determine the level of spiritual disposition on human beings along with its effects on one's mental health. Materials and Methods: The study targeted 400 women residing in Youn-Gil city of JiLin Prov., which is a district of the Cho-Sun tribe in China. Their spiritual well-being was studied using the Spiritual Well-being Scale-Korean Version. The spiritual well-being scale consists of 2 sub-scales of religious well-being and existential well-being. The study was evaluated using a lie scale, psychotic trend, and a combined anxiety-depression scale. The results were considered to be factors of one's mental health. The correlation between the spiritual well-being and each tendency was analyzed by regression analysis. Results: The total score of the Cho-Sun tribal women according to the spiritual well-being scale was 68.29 which was much less than the 100.65 of Korean Christian women. There was no significant correlation between the spiritual well-being and the Lie trend. However, it was found that 86%(344) of Cho-Sun tribal women scored above 70 in the Lie trend with a mean score of 74.57 which is higher than normal populations. Regarding the correlation between the spiritual well-being and psychotic trend, the psychotic trend became significantly higher when the religious well-being was at a high level. On the other hand, the psychotic trend became significantly lower when the existential well-being was at a high level. Regarding the correlation between the spiritual well-being and anxiety, the anxiety was significantly higher when the religious well-being was at a high level. However, the anxiety level was significantly low when the existential well-being was at a high level. Regarding the correlation between the spiritual well-being and depression, the depression level was somewhat significantly high when the religious well-being was at a high level. However, the depression level was significantly low when the existential well-being was at a high level. Conclusion: This study evaluated the effects of spiritual well-being on a person's mental health among Cho-Sun tribal women in Youn-Gil city of JiLIn Prov., P.R. of China. The results found that the religious well-being, which is a sub-scale of spiritual well-being, had negative effects while the existential well-being had positive effects on the mental health. These results proved that a person's religious disposition had negative effects on their mental health in a communitarian society.

Hair Growth Promotion by δ-Opioid Receptor Activation

( Mei Zheng ),( Nahyun Choi ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.6

Literature has revealed that the delta opioid receptor (DOR) exhibited diverse pharmacological effects on neuron and skin. In the present study, we have investigated whether the activation of DOR has hair-growth promotion effects. Compared with other opioid receptor, DOR was highly expressed in epidermal component of hair follicle in human and rodents. The expression of DOR was high in the anagen phase, but it was low in the catagen and telogen phases during mouse hair cycle. Topical application of UFP- 512, a specific DOR agonist, significantly accelerated the induction of the anagen in C₃H mice. Topical application of UFP-512 also increased the hair length in hair organ cultures and promoted the proliferation and the migration of outer root sheath (ORS) cells. Similarly, pharmacological inhibition of DOR by naltrindole significantly inhibited the anagen transition process and decreased hair length in hair organ cultures. Thus, we further examined whether Wnt/β-catenin pathway was related to the effects of DOR on hair growth. We found that Wnt/β-catenin pathway was activated by UFP-512 and siRNA for β-catenin attenuated the UFP-512 induced proliferation and migration of ORS cells. Collectively, result established that DOR was involved in hair cycle regulation, and that DOR agonists such as UFP-512 should be developed for novel hair-loss treatment.

Functional Regulation of Dopamine D₃ Receptor through Interaction with PICK1

Zheng, Mei,Zhang, Xiaohan,Min, Chengchun,Choi, Bo-Gil,Oh, In-Joon,Kim, Kyeong-Man The Korean Society of Applied Pharmacology 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.5

PICK1, a PDZ domain-containing protein, is known to increase the reuptake activities of dopamine transporters by increasing their expressions on the cell surface. Here, we report a direct and functional interaction between PICK1 and dopamine $D_3$ receptors ($D_3R$), which act as autoreceptors to negatively regulate dopaminergic neurons. PICK1 colocalized with both dopamine $D_2$ receptor ($D_2R$) and $D_3R$ in clusters but exerted different functional influences on them. The cell surface expression, agonist affinity, endocytosis, and signaling of $D_2R$ were unaffected by the coexpression of PICK1. On the other hand, the surface expression and tolerance of $D_3R$ were inhibited by the coexpression of PICK1. These findings show that PICK1 exerts multiple effects on $D_3R$ functions.

Functional Regulation of Dopamine D₃ Receptor through Interaction with PICK1

( Mei Zheng ),( Xiaohan Zhang ),( Chengchun Min ),( Bo-gil Choi ),( In-joon Oh ),( Kyeong-man Kim ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.5

PICK1, a PDZ domain-containing protein, is known to increase the reuptake activities of dopamine transporters by increasing their expressions on the cell surface. Here, we report a direct and functional interaction between PICK1 and dopamine D₃ receptors (D₃R), which act as autoreceptors to negatively regulate dopaminergic neurons. PICK1 colocalized with both dopamine D₂ receptor (D₂R) and D₃R in clusters but exerted different functional influences on them. The cell surface expression, agonist affinity, endocytosis, and signaling of D₂R were unaffected by the coexpression of PICK1. On the other hand, the surface expression and tolerance of D₃R were inhibited by the coexpression of PICK1. These findings show that PICK1 exerts multiple effects on D₃R functions.

In vitro and In vivo Anti-Helicobacter pylori Activities of Centella asiatica Leaf Extract

Zheng, Hong-Mei,Choi, Myung-Joo,Kim, Jae Min,Lee, Kye Wan,Park, Yu Hwa,Lee, Don Haeng The Korean Society of Food Science and Nutrition 2016 Preventive Nutrition and Food Science Vol.21 No.3

Helicobacter pylori infection is associated with an increased risk of developing upper gastrointestinal tract diseases. However, treatment failure is a major cause of concern mainly due to possible recurrence of infection, the side effects, and resistance to antibiotics. The aim of this study was to investigate the activities of Centella asiatica leaf extract (CAE) against H. pylori both in vitro and in vivo. The minimum inhibitory concentrations (MICs) against 55 clinically isolated strains of H. pylori were tested using an agar dilution method. The MICs of CAE ranged from 0.125 mg/mL to 8 mg/mL, effectiveness in inhibiting H. pylori growth was 2 mg/mL. The anti-H. pylori effects of CAE in vivo were also examined in H. pylori-infected C57BL/6 mice. CAE was orally administrated once daily for 3 weeks at doses of 50 mg/kg and 250 mg/kg. CAE at the 50 mg/kg dose significantly reduced H. pylori colonization in mice gastric mucosa. Our study provides novel insights into the therapeutic effects of CAE against H. pylori infection, and it suggests that CAE may be useful as an alternative therapy.

THE THIRD-PERSON EFFECT IN THE CONTEXT OF PERSONAL BROADCASTING CONTENTS’ HARMFUL EFFECTS AND REGULATIONS

Mei-ling Zheng 한국엔터테인먼트산업학회 2018 한국엔터테인먼트산업학회 학술대회 논문집 Vol.2018 No.7

This study explored the third-person effect with respect to harmful contents of personal internet broadcasting including profanities, violence and suggestive content. The summary and discussion of its findings are as follows. A questionnaire survey was conducted to verify third-person effect in the context of personal internet broadcasting and its hazards. Results of the study revealed viewers" biased perception toward others in regard to the harmful effects of personal internet broadcasting and partially confirmed the presence of third-person effect in connection with social distance. Self-esteem had influence on the regulating attitude toward profanities and suggestive content. Study results revealed that perceived effects of personal internet broadcasting on oneself may influence viewers" support of regulations. And also reveald that the magnitude of perceptive bias was less in adults when compared to college students, who have less social distance between one another.

Dual regulation of mast cell degranulation through IgE receptor-mediated modulation of $M_2$-type pyruvate kinase

Zheng, Mei,Cho, Dong-Im,Le, Hang Thi,Cheon, Seung Hoon,Kim, Kyeong-Man 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.9

It was reported that mast cell degranulation is inversely related to the enzymatic activity of $M_2$-type pyruvate kinase ($M_2PK$). This study shows that activation of high-affinity IgE receptor ($Fc{\varepsilon}RI$) evokes a sequential dual regulation of $M_2PK$, i.e., an immediate decrement followed by slow phase increment of enzymatic activities. Changes in the activities of $M_2PK$ and mast cell degranulation showed similar time course after antigenic stimulation of $Fc{\varepsilon}RI$. The immediate inhibition of $M_2PK$ involved tyrosine phosphorylation, and subsequently led to a cellular accumulation of glycolytic intermediates, including fructose 1,6-biphosphate (FBP), a feedforward activator of $M_2PK$. As the cellular levels of FBP were increased, both the enzymatic acitivity of $M_2PK$ and mast cell degranulation slowly returned to near basal levels. A-Raf, when exogenously introduced into RBL-2H3 cells, phosphorylated $M_2PK$ on the serine residues, elevated enzyme activities of $M_2PK$, and resulted in the inhibition of degranulation. These results suggest that dual regulation of $M_2PK$ which involves the phosphorylation of $M_2PK$ and accumulation of a feedforward activator of $M_2PK$ plays important roles in the control of mast cell degranulation.

KRC 408, inhibitor of hepatic growth factor receptor (c-Met) suppress growth of gastric cancer through antiproliferation and antianigogenic antitumor activity

ZHENG Hong-Mei,HONG Sang-Won,CHOI Myung-Joo,KIM Da-Young,AHN Su-Mi,SHIN Moon-Geun,CHO Sung-Yun,KIM Hyoung-Rae,LEE Jong-Kook,LEE Don-Haeng,HONG Soon-Sun 大韓藥學會 2012 大韓藥學會 總會 및 學術大會 Vol.2012 No.1

Dual regulation of mast cell degranulation through IgE receptor-mediated modulation of M2-type pyruvate kinase

Mei Zheng,조동임,Hang Thi Le,전승훈,김경만 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.9

It was reported that mast cell degranulation isinversely related to the enzymatic activity of M2-typepyruvate kinase (M2PK). This study shows that activationof high-affinity IgE receptor (FceRI) evokes a sequentialdual regulation of M2PK, i.e., an immediate decrementfollowed by slow phase increment of enzymatic activities. Changes in the activities of M2PK and mast cell degranulationshowed similar time course after antigenic stimulationof FceRI. The immediate inhibition of M2PK involvedtyrosine phosphorylation, and subsequently led to a cellularaccumulation of glycolytic intermediates, including fructose1,6-biphosphate (FBP), a feedforward activator ofM2PK. As the cellular levels of FBP were increased, boththe enzymatic acitivity of M2PK and mast cell degranulationslowly returned to near basal levels. A-Raf, whenexogenously introduced into RBL-2H3 cells, phosphorylatedM2PK on the serine residues, elevated enzymeactivities of M2PK, and resulted in the inhibition ofdegranulation. These results suggest that dual regulation ofM2PK which involves the phosphorylation of M2PK andaccumulation of a feedforward activator of M2PK playsimportant roles in the control of mast cell degranulation.

Dual regulation of mast cell degranulation through IgEreceptor-mediated modulation of M2-type pyruvate kinase

( Mei Zheng ),( Dong Im Cho ),( Hang Thi Le ),( Seung Hoon Cheon ),( Kyeong Man Kim ) 전남대학교 약품개발연구소 2014 약품개발연구지 Vol.23 No.-

It was reported that mast cell degranulation is inversely related to the enzymatic activity of M2-type pyruvate kinase (M2PK). This study shows that activation of high-affinity IgE receptor (PCER!) evokes a sequential dual regulation of M2PK, i.e., an immediate decrement followed by slow phase increment of enzymatic activities. Changes in the activities of M2PK and mast cell degranulation showed similar time course after antigenic stimulation of FCER!. The immediate inhibition of M2PK involved tyrosine phosphorylation, and subsequently led to a cellular accumulation of glycolytic intermediates, including fructose 1,6-biphosphate (FBP), a feedforward activator of M2PK. As the cellular levels of FBP were increased, both the enzymatic acitivity of M2PK and mast cell degranulation slowly returned to near basal levels. A-Raf, when exogenously introduced into RBL-2H3 cells, phosphorylated M2PK on the serine residues, elevated enzyme activities of M2PK, and resulted in the inhibition of degranulation. These results suggest that dual regulation of M2PK which involves the phosphorylation of M2PK and accumulation of a feedforward activator of M2PK plays important roles in the control of mast cell degranulation.