Profile of the First Dementia Friendly Universal Home Guidelines according to 21 User Benefit Dimensions

Paz, Maria Victoria(마리아 빅토리아 파즈),Lee, Yeun-Sook(이연숙),Hwang, Yoon-Seo(황윤서) 한국주거학회 2018 한국주거학회 논문집 Vol.29 No.4

Universal Design (UD) has been emerging as a design strategy to cope with the increasing elderly population including dementia one. Unlike previous studies that focused on institutional settings, in 2015 the Irish Govt. initiated the first national UD home guidelines for dementia. This research paper profiles the benefits that can be obtained through the use of Ireland’s Universal Design Guidelines “Dementia Friendly Dwellings for People with Dementia, their Families and Carers’. Through content analysis of each of the 340 guidelines items using Murtha and Lee’s framework of 21 User Benefits, this analysis found that the incidence ratio of Sensory Initiation was found dominant consistently across the different spatial types. The environmental affordances according to space type, were varied depending on the function of the space and particularly among sub areas of the interior spaces. Perceptual Maintenance related benefits were found with high ratios in many interior spaces except in kitchen and bathroom areas, where safety hazard regulation was especially emphasized. Finally, profiles of 21 user benefits were delineated. The result of this research is expected to give more detailed insight into studying and creating dementia friendly residential environments.

Genome-wide methylation and expression profiles in cervical intraepithelial neoplasia and cervical cancer

( Maria Lee ),( Sung Jong Lee ),( Joo Hee Yoon ),( Yong Il Kwon ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

Cervical carcinoma is one of the most common cancers in females. This cancer begins with precancerous stages and can evolve to carcinoma over 10 years or more. Cervical cancer is a multistep process with accumulation of genetic and epigenetic alterations in regulatory genes, leading to activation of oncogenes and inactivation or loss of tumor suppressor genes. We aimed to identify genetic alterations associated with pre-cancerous stage and also with cervical cancer. For this purpose, microarray comparative genomic hybridization (Illumina 450K and Illumina Expression HT12 Human CGH Whole-Genome Arrays) was performed with 16 cases of cervical intraepithelial neoplasia (CIN) of different stages and 3 cases of carcinoma. We identified epigenetic inactivation of TSGs by hyper- or hypo-methylation which has been recognized as an important and alternative mechanism in tumorigenesis. Here we discuss these epigenetic alterations in cervical intrapeithelial neoplasia and cervical cancer focusing on DNA methylation.

Analyses for Identification of Methacrylamide Graft-Polymerized Silk

Lee, Yong Woo,Maria Rosaria Massafra,Gian Maria Colonna 한국잠사학회 1987 한국잠사곤충학회지 Vol.29 No.1

Left Atrial Strain Derived From Cardiac Magnetic Resonance Imaging Can Predict Outcomes of Patients With Acute Myocarditis

Lee Jimin,Choo Ki Seok,Jeong Yeon Joo,Lee Geewon,Hwang Minhee,Abraham Maria Roselle,Lee Ji Won 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.6

Objective: There is increasing recognition that left atrial (LA) strain can be a prognostic marker of various cardiac diseases. However, its prognostic value in acute myocarditis remains unclear. Therefore, this study aimed to evaluate whether cardiovascular magnetic resonance (CMR)-derived parameters of LA strain can predict outcomes in patients with acute myocarditis. Materials and Methods: We retrospectively analyzed the data of 47 consecutive patients (44.2 ± 18.3 years; 29 males) with acute myocarditis who underwent CMR in 13.5 ± 9.7 days (range, 0–31 days) of symptom onset. Various parameters, including feature-tracked CMR-derived LA strain, were measured using CMR. The composite endpoints included cardiac death, heart transplantation, implantable cardioverter-defibrillator or pacemaker implantation, rehospitalization following a cardiac event, atrial fibrillation, or embolic stroke. The Cox regression analysis was performed to identify associations between the variables derived from CMR and the composite endpoints. Results: After a median follow-up of 37 months, 20 of the 47 (42.6%) patients experienced the composite events. In the multivariable Cox regression analysis, LA reservoir and conduit strains were independent predictors of the composite endpoints, with an adjusted hazard ratio per 1% increase of 0.90 (95% confidence interval [CI], 0.84–0.96; P = 0.002) and 0.91 (95% CI, 0.84–0.98; P = 0.013), respectively. Conclusion: LA reservoir and conduit strains derived from CMR are independent predictors of adverse clinical outcomes in patients with acute myocarditis.

Makorin Ring Finger Protein 1 as Adjunctive Marker in Liquid-based Cervical Cytology

Lee, Maria,Chang, Min Young,Shin, Ha-Yeon,Shin, Eunah,Hong, Sun Won,Kim, Kyung-Mi,Chay, Doo Byung,Cho, Hanbyoul,Kim, Jae-Hoon Williams & Wilkins Co 2016 Medicine Vol.95 No.3

<P><B>Abstract</B></P><P>To assess the utility of makorin ring finger protein 1 (MKRN1) as a marker of cervical pathology.</P><P>A PROspective specimen collection and retrospective Blinded Evaluation study was conducted. Liquid-based cytology samples were collected from 187 women, embedding all residuals as cell blocks for immunohistochemical staining of MKRN1 and P16 <SUP>INK4a</SUP>. Results of liquid-based cervical cytology, immunostained cell block sections, and human papillomavirus (HPV) hybrid capture (with real-time polymerase chain reaction) were analyzed. Clinical outcomes were analyzed overall and in subsets of specimens yielding atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesions.</P><P>Makorin ring finger protein 1 positivity and grades (1–3) of cervical intraepithelial neoplasia (CIN) increased in tandem (CIN1, 32.4%; CIN2, 60.0%; and CIN3, 80.0%), reaching 92.3% in invasive cancer. Sensitivity, specificity, positive predictive value, and negative predictive value in detecting CIN2+ via MKRN1 were 73.8%, 76.8%, 75.6%, and 75.0%, respectively. The performance of liquid-based cytology was poorer by comparison (61.3%, 69.5%, 66.2%, and 64.8%, respectively), and HPV assay (versus MKRN1 immunohistochemical staining) displayed lower specificity (67.7%). Combined HPV + MKRN1 testing proved highest in sensitivity, specificity, positive predictive value, and negative predictive value (71.8%, 85.5%, 82.3%, and 76.5%, respectively), whereas corresponding values for cytology + HPV (60.6%, 81.8%, 75.4%, and 69.2%) and cytology + MKRN1 (58.8%, 84.1%, 78.3%, and 67.7%) were all similar. In instances of atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesions, the HPV + MKRN1 combination performed best by above measures (100%, 72.7%, 73.9%, and 100%), followed by cytology + MKRN1 (100%, 50.0%, 60.7%, and 100%).</P><P>Makorin ring finger protein 1 displayed greater sensitivity and specificity than liquid-based cytology and proved more specific than HPV assay. In combination testing, MKRN1 + HPV showed the highest sensitivity and specificity levels. The MKRN1 biomarker may be a useful adjunct in primary cervical cytology screening.</P>

Hydrogen-bond promoted nucleophilic fluorination: concept, mechanism and applications in positron emission tomography

Lee, Ji-Woong,Oliveira, Maria Teresa,Jang, Hyeong Bin,Lee, Sungyul,Chi, Dae Yoon,Kim, Dong Wook,Song, Choong Eui The Royal Society of Chemistry 2016 Chemical Society reviews Vol.45 No.17

<P>Due to the tremendous interest in carbon-fluorine bond-forming reactions, research efforts in this area have been dedicated to the development of facile processes to synthesize small fluorine-containing organic molecules. Among others, PET (Positron Emission Tomography) is one of the most important applications of fluorine chemistry. Recognizing the specific requirements of PET processes, some groups have focused on fluorination reactions using alkali metal fluorides, particularly through S(N)2-type reactions. However, a common 'misconception'' about the role of protic solvents and hydrogen bonding interactions in this class of reactions has hampered the employment of these excellent promoters. Herein, we would like to review recent discoveries in this context, showing straightforward nucleophilic fluorination reactions using alkali metal fluorides promoted by protic solvents. Simultaneous dual activation of reacting partners by intermolecular hydrogen bonding and the enhancement of the 'effective fluoride nucleophilicity'', which is Nature's biocatalytic approach with the fluorinase enzyme, are the key to this unprecedentedly successful nucleophilic fluorination.</P>

GG-10 : Risk factors for negative impacts on sexual activity and function in younger breast cancer survivors

( Maria Lee ),( Myung Jae Jeon ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

목적: To examine changes in sexual activity and function among younger breast cancer survivors who were sexually active before diagnosis and to investigate risk factors for negative impacts on them. 방법: A prospective observational study enrolled 304 premenopausal and sexually active women diagnosed with early-stage breast cancer. Questionnaires were completed, and sexual activity was measured at two time points: after surgery, to assess sexual activity and function before diagnosis, and then at least 12 months after the completion of chemotherapy or endocrine therapy. For each domain of the Female Sexual Function Index, a score below 3 was classified as indicative of a sexual problem. Each sexual problem was considered to be dysfunctional if it was associated with distress. 결과: The median age at the last survey was 46.0 years (range: 23-57). Of the participants, 35 (11.5%) became sexually inactive after treatment. Among the 269 women who remained sexually active, 31.6% were currently experiencing sexual dysfunction, which was significantly higher compared with the frequency before diagnosis. In the multivariate logistic regression model, chemo-related menopause, thyroid dysfunction, and depression were independent risk factors for sexual inactivity. Chemo-related menopause was a significant risk factor for sexual dysfunction. 결론: Chemo-related menopause was significantly associated with both sexual inactivity and dysfunction after treatment. Thyroid dysfunction and depression were risk factors for sexual inactivity in younger breast cancer survivors.

Patterns and utility of routine surveillance in stage III-IV endometrial cancer

( Maria Lee ),( Seungmee Lee ),( Hee Seung Kim ),( Hyun Hoon Chung ),( Jae-weon Kim ),( Noh Hyun Park ),( Yong Sang Song ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

목적: To evaluate surveillance methods and their utility in detecting recurrence of disease in stage III-IV endometrial cancer. 방법: We performed a retrospective chart review of women diagnosed with advanced stage endometrial cancer between the years 2000 and 2011. Surveillance data was abstracted and analyzed. Surveillance method leading to detection of recurrence was identified and compared by stage of disease and site of recurrence. 결과: Ninety one patients met the criteria for inclusion. At a median follow-up of 71 months, the 5-year rate of relapse was 39% and of death from endometrial cancer was 11%. CA-125 and CT imaging were used frequently in advanced stage patients, but vaginal cytology was utilized less. Thirty-five percent of patients experienced a recurrence and the majority of initial recurrences (40.6%) had a distant component. Modalities that detected cancer recurrences were: symptoms (31.3%), physical exam (6.2%), surveillance CT (56.2%), CA-125 (6.2%), and vaginal cytology (3.1%). The majority of loco-regional and distant recurrences (87.5%) were detected by symptoms or surveillance CT, 12.4% were detected by physical exam or CA 125. One loco-regional recurrence was identified by vaginal cytology but no recurrences with a distant component detected by this modality. 결론: Symptoms and CT identify the majority of advanced endometrial cancer recurrences, while vaginal cytology is the least likely surveillance modality to identify a recurrence. The role and follow-up policy of CT and CA-125 surveillance outside of a clinical trial needs to be further reviewed.

Copy number alterations affecting pre-cancerous and carcinoma stage of cervical cancer

( Maria Lee ),( Sung Jong Lee ),( Joo Hee Yoon ),( Yong Il Kwon ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

Cervical cancer is one of the common cancers in females. This cancer begins with pre-cancerous stages and can evolve to carcinoma over 10-15 years or more. We aimed to identify genetic alterations associated with pre-cancerous stage and also with carcinoma stage of cervical cancer. For this purpose, microarray comparative genomic hybridization (array-CGH) was performed with 37 normal samples, 55 cases of cervical intraepithelial neoplasia (CIN) of different stages, 6 cases of carcinoma and 7 unknown stage samples. We identified 5 significant CNV regions (P<0.05) and performed the validation test with genomic quantitative polymerase chain reaction (qPCR) to confirm these regions. As a result, copy number alterations on 1p36.22 and 12q21.33 loci identified by array- CGH were consistently appeared in array-CGH and genomic qPCR analysis. The 1p36.22 region showed increased copy number losses in carcinoma, compared with normal samples. On the contrary, 12q21.33 region presented increased copy number gains in carcinoma and CINs, compared with normal samples. Immunohistochemistry analysis also found increased PDG expression in cervical intraepithelial neoplasia and cervical cancer tissues. Confirmed loci will be applied as clinical diagnosis markers of cervical cancer.

Trends in Ubiquitous Multimedia Computing

Maria R. Lee,Tsung Teng Chen 보안공학연구지원센터 2009 International Journal of Multimedia and Ubiquitous Vol.4 No.2

Ubiquitous multimedia computing becomes a major focus in scientific research due to recent flourishing of wireless communication infrastructures such as 3G, WiMax and RFID. There have been many surveys were written based on various ubiquitous multimedia computing related topics. If we can find a way to dash out the latest development in this particular science and technology field, it would be valuable to scientist and researchers. However, it is a challenging task to promptly and efficiently penetrate information for elevating scholastic research efficiency in large volume of information. The goal of this paper is to help us comprehend the scope and major themes of ubiquitous multimedia computing research. Different perspectives and methods were introduced to analyze leading research theme in particular in ubiquitous computing field is proposed. Factor analysis, pathfinder network and context-based ontology techniques are presented to display research directions by clustering scientific papers taken from the ISI web (CiteSeer papers). The results obtained show that recent popular research towards to pursue ubiquitous applications in particular in m-health. The beneficiary of the proposed methods could be for someone new to a specific domain in research study, who wishes to analyze and understand current development status of intended research study field.