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HCV, Acute, LT : IL28B Gene Polymorphisms in Myanmar Patients with Chronic HCV Infection
( Mk Kyaw ),( Km Win ),( Nmkt Hlaing ),( Amm Kyaw ),( Ah Bwa ),( St Aung ),( Lt Lwin ),( Wt Lwin ),( S Hlaing ),( Sl Htet ),( Zm Aung ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Introduction: IL28B gene is a gene which is located on the human chromosome 19. Recently, it was discovered that favourable IL28B gene polymorphisms is associated with the viral clearance and achievement of sustained virological response (SVR) in the treatment of chronic hepatitis C infection. Therefore, studies of IL28B gene polymorphisms can help us to predict whether the treatment of chronic hepatitis C will attain SVR or not. The prediction of SVR by IL28B will be useful in genotype 1 patients because our real life experience showed that SVR rate in Myanmar patients with G 1 is around 80 % (Less than 50 % in Western countries with unfavourable gene polymorphisms in majority of the cases) and that may be due to favourable IL28B gene polymorphisms in Myanmar patients with chronic HCV infection. Up to now there is no data on the prevalence of different IL28B gene polymorphisms in Myanmar patients. Conduct of the Study Study Population: This study consists of 171 patients from Yangon GI and Liver Centre and Mandalay Specialists Centre. Blood samples were sent to National University Hospital, Singapore, and two types of IL28B gene polymorphisms were determined viz. rs12979860 (CC favourable genotype) and rs8099917 (TT favorable genotype). Results: Out of 171 patients who participated, the results showed that about 86% of all genotypes (i.e.149 patients) are of CC/TT type. Among G1 patients 36 out of 41 patients (89%) are favourable genotype CC/TT. Conclusion: As CC/TT is favorable genotype for SVR, it is concluded that Myanmar patients with G1 unlike Western patients with G1, will have a high SVR rate of more than 80% with the current standard of care (SOC). Therefore, Directly Acting Antivirals (DAA) may not be necessary for the naive Myanmar patients with G1 chronic HCV patients. Recommendation: It is recommended to continue the study of SVR rates among different IL28B genotypes in Myanmar patients with chronic HCV patients who are receiving antiviral therapy.
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