A modified heteropoly acid catalyst with cetyltrimethylammonium bromide for methacrolein to methacrylic acid

Yun-Li Cao,Lei Wang,Li-Long Zhou,Bao-Hua Xu,Yan-Yan Diao,Suojiang Zhang 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.65 No.-

A novel type of heteropolyacids, CTAB-CsH3PMo11VO40 (CTA-CsPAV), was developed by a method of emulsion synthesis using cetyltrimethyl ammonium bromide (CTAB) as the structure promoter, which was applied as a catalyst in the oxidation of methacrolein (MAL) to methacrylic acid (MAA) with fixed-bed reactor. The structure and property of CTA-CsPAV were characterized by FT-IR, XRD, nitrogen adsorption-desorption, NH3-TPD, SEM, XPS, and so on. The structure-performance relationship of CTA-CsPAV was systematically studied, wherein the influence of surface area, acidity, redox property of CTA-CsPAV were focused and discussed. Importantly, the long-term performance of CTA-CsPAV was also investigated.

HOXB7 Predicts Poor Clinical Outcome in Patients with Advanced Esophageal Squamous Cell Cancer

Long, Qing-Yun,Zhou, Jun,Zhang, Xiao-Long,Cao, Jiang-Hui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4

Background: Esophageal squamous cell carcinoma (ESCC) accounts for most esophageal cancer in Asia, and is the sixth common cause of cancer-related deaths worldwide. Previous studies indicated HOXB7 is overexpressed in ESCC tissues, but data on prognostic value are limited. Methods: A total of 76 advanced ESCC cases were investigated. Immunohistochemistry (IHC) was used to detect the expression levels of HOXB7 and Kaplan-Meier curves and Cox regression models to determine prognostic significance. Stratified analysis was also performed according to lymph node (LN) status. Results: Kaplan-Meier curve analysis indicated that HOXB7 positive patients had significantly shorter overall survival (OS) than HOXB7 negative patients. Multivariate analysis using the Cox proportional hazards model indicated only TNM stage and HOXB7 expression to be independent predictors of overall survival of advanced ESCC patients. HOXB7 indicated poor OS in both lymph node negative (LN-) and lymph node positive (LN+) patients. Conclusion: HOXB7 predicts poor prognosis of advanced ESCC patients and can be applied as an independent prognostic predictor.

Concurrent Pleural and Pericardial Involvement in a Patient With De Novo Pure Erythroid Leukemia

Zhang Yun,Li Kechao,Li Xue,Wang Hui,Li Ting,Long Fang 대한진단검사의학회 2024 Annals of Laboratory Medicine Vol.44 No.2

A cavitation performance prediction method for pumps: Part2-sensitivity and accuracy

Long, Yun,Zhang, Yan,Chen, Jianping,Zhu, Rongsheng,Wang, Dezhong Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.11

At present, in the case of pump fast optimization, there is a problem of rapid, accurate and effective prediction of cavitation performance. In "A Cavitation Performance Prediction Method for Pumps PART1-Proposal and Feasibility" [1], a new cavitation performance prediction method is proposed, and the feasibility of this method is demonstrated in combination with experiments of a mixed flow pump. However, whether this method is applicable to vane pumps with different specific speeds and whether the prediction results of this method are accurate is still worthy of further study. Combined with the experimental results, the research evaluates the sensitivity and accuracy at different flow rates. For a certain operating condition, the method has better sensitivity to different flow rates. This is suitable for multi-parameter multi-objective optimization of pump impeller. For the test mixed flow pump, the method is more accurate when the area ratios are 13.718% and 13.826%. The cavitation vortex flow is obtained through high-speed camera, and the correlation between cavitation flow structure and cavitation performance is established to provide more scientific support for cavitation performance prediction. The method is not only suitable for cavitation performance prediction of the mixed flow pump, but also can be expanded to cavitation performance prediction of blade type hydraulic machinery, which will solve the problem of rapid prediction of hydraulic machinery cavitation performance.

Evaluation of storage period of fresh ginseng for quality improvement of dried and red processed varieties

Na Zhang,Xin Huang,Yun-Long Guo,Hao Yue,Chang-Bao Chen,Shu-Ying Liu 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.2

Background: Dried and red ginseng are well-known types of processed ginseng and are widely used as healthy food. The dried and red ginseng quality may vary with the storage period of raw ginseng. Therefore, herein, the effect of the storage period of fresh ginseng on processed ginseng quality was evaluated through multicomponent quantification with statistical analysis. Methods: A method based on ultrahigh performance liquid chromatography coupled to triple quadrupole mass spectrometry in multiple-reaction monitoring mode (UPLC-MRM-MS) was developed for quantitation of ginsenosides and oligosaccharides in dried and red ginseng. Principal component analysis and partial least squares discriminant analysis were conducted to evaluate the dynamic distributions of ginsenosides and oligosaccharides after different storage periods. Results: Eighteen PPD, PPT and OLE ginsenosides and nine reducing and nonreducing oligosaccharides were identified and quantified. With storage period extension, the ginsenoside content in the processed ginseng increased slightly in the first 2 weeks and decreased gradually in the following 9 weeks. The content of reducing oligosaccharides decreased continuously as storage time extending, while that of the nonreducing oligosaccharides increased. Chemical conversions occurred during storage, based on which potential chemical markers for the storage period evaluation of fresh ginseng were screened. Conclusion: According to ginsenoside and oligosaccharide distributions, it was found that the optimal storage period was 2 weeks and that the storage period of fresh ginseng should not exceed 4 weeks at 0 °C. This study provides deep insights into the quality control of processed ginseng and comprehensive factors for storage of raw ginseng.

Single Nucleotide Polymorphisms of NLRP12 Gene and Association with Non-specific Digestive Disorder in Rabbit

Liu, Yun-Fu,Zhang, Gong-Wei,Xiao, Zheng-Long,Yang, Yu,Deng, Xiao-Song,Chen, Shi-Yi,Wang, Jie,Lai, Song-Jia Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.8

The NLRP12 (NLR family, pyrin domain containing 12) serves as a suppressor factor in the inflammatory response and protects the host against inflammation-induced damage. In the present study, we aimed to study the polymorphisms of NLRP12 gene and its association with susceptibility to non-specific digestive disorder (NSDD) in rabbits. We re-sequenced the entire coding region of the rabbit NLRP12 gene and detected a total of 19 SNPs containing 14 synonymous and five non-synonymous variations. Among them, the coding SNP (c.1682A>G), which would carry a potential functional implication, was subsequently subjected to genotyping for case-control association study (272 cases and 267 controls). The results revealed that allele A was significantly protective against NSDD with an odds ratio value of 0.884 (95% confidence interval, 0.788 to 0.993; p = 0.038). We also experimentally induced NSDD in growing rabbits by feeding a fibre-deficient diet and subsequently investigated NLRP12 mRNA expression. The mRNA expression of NLRP12 in healthy status was significantly higher than that in severe NSDD (p = 0.0016). The highest expression was observed in individuals carrying the protective genotype AA (p = 0.0108). These results suggested that NLRP12 was significantly associated with the NSDD in rabbits. However, the precise molecular mechanism of NLRP12 involving in the development of rabbit NSDD requires further research.

CD64 Expression Is Increased in Patients with Severe Acute Pancreatitis: Clinical Significance

( Hao Zhang ),( Xian Long Ling ),( Yu Yun Wu ),( Mu Han Lu ),( Hong Guo ),( Peng Bin Zhang ),( Xiao Yan Zhao ),( Shi Ming Yang ) 대한소화기학회 2014 Gut and Liver Vol.8 No.4

Background/Aims: Upregulated CD64 expression on neutrophils is the most useful marker for acute bacterial infections and systemic inflammation. However, it is unknown whether CD64 is involved in the pathogenesis of acute pancreatitis (AP). This study was designed to determine whether CD64 is implicated in severe acute pancreatitis (SAP), and thus, is a suitable marker for SAP. Methods: SAP was induced in rats with an intraperitoneal injection of L-arginine. CD64 expression in the rat pancreas was determined by quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry. Additionally, the CD64 mRNA expression in peripheral blood leukocytes from 21 patients with mild acute pancreatitis (MAP) and 10 patients with SAP was investigated at the time of admission and during remission by qRT-PCR. Results: CD64 mRNA and protein expression in the pancreas was significantly higher in rats with SAP, compared to the controls. The CD64 expression was higher in the patients with SAP than in the patients with MAP. During remission, CD64 mRNA decreased in both the MAP and SAP patients. The area under the curve of CD64 expression for the detection of SAP was superior to both the Ranson and the Acute Physiology and Chronic Health Evaluation II scores. Conclusions: The CD64 level was significantly increased in correlation with the disease severity in SAP and may act as a useful marker for predicting the development of SAP. (Gut Liver 2014;8:445-451)

Pan-cancer Analysis of Tumor Mutational Burden and Homologous Recombination DNA Damage Repair Using Targeted Next-Generation Sequencing

Hai-Yun Wang,Ling Deng,Ying-Qing Li,Xiao Zhang,Ya-Kang Long,Xu Zhang,Yan-Fen Feng,Yuan He,Tao Tang,Xin-Hua Yang,Fang Wang 대한암학회 2021 Cancer Research and Treatment Vol.53 No.4

Purpose Current variability in methods for tumor mutational burden (TMB) estimation and reporting demonstrates the urgent need for a homogeneous TMB assessment approach. Here, we compared TMB distributions in different cancer types using two customized targeted panels commonly used in clinical practice. Materials and Methods TMB spectra of 295- and 1021-gene panels in multiple cancer types were compared using targeted next-generation sequencing (NGS). The TMB distributions across a diverse cohort of 2,332 cancer cases were then investigated for their associations with clinical features. Treatment response data were collected for 222 patients who received immune-checkpoint inhibitors (ICIs) and their homologous recombination DNA damage repair (HR-DDR) and programmed death-ligand 1 (PD-L1) expression were additionally assessed and compared with the TMB and response rate. Results The median TMB between gene panels was similar despite a wide range in TMB values. The highest TMB was eight and 10 in patients with squamous cell carcinoma and esophageal carcinoma according to the classification of histopathology and cancer types, respectively. Twenty-three out of 103 patients (22.3%) were HR-DDR–positive and could benefit from ICI therapy; out of those 23 patients, seven patients had high TMB (p=0.004). Additionally, PD-L1 expression was not associated with TMB or treatment response among patients receiving ICIs. Conclusion Targeted NGS assays demonstrated the ability to evaluate TMB in pan-cancer samples as a tool to predict response to ICIs. In addition, TMB integrated with HR-DDR–positive status could be a significant biomarker for predicting ICI response in patients.

A Novel Capacitive Negative Electrode Material of Fe3N

Zhi-Yun Zhao,Wei-Bin Zhang,Xue-Jing Ma,Kai Li,Yue Zhao,Jian-Fei Gao,Long Kang,Ling-Bin Kong 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.1

A capacitive negative electrode material of Fe3N has been synthesized via a simple precursor ammoniation treatment. Electrochemical measure shows that the electrode exhibits a specific capacitance of 270 F · g -1 at a current density of 0.5A · g -1 in 6M KOH, 66% of the initial value remains at a specific current density of 5A · g -1. Capacitance retention after 5000 cycles is about 61.5% of the initial capacitance. The electrochemical performance is relatively great in comparison with the literature reports of some Fe-based compounds. Because of the low cost and simple preparation method of Fe3N, the material is promising in electrochemical capacitive energy storage applications.

Correlations of Tumor-associated Macrophage Subtypes with Liver Metastases of Colorectal Cancer

Cui, Yun-Long,Li, Hui-Kai,Zhou, Hong-Yuan,Zhang, Ti,Li, Qiang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Objective: This work aimed to investigate the correlations of tumor-associated macrophages (TAMs) and their subtypes M1 and M2 with liver metastasis of colorectal cancer, and provide useful references for seeking predictors of liver metastasis and studying mechanisms. Methods: 120 patients with colorectal cancer from 2000 to 2009 were divided into low, middle and high liver metastasis groups (group A, B and C, respectively). S-P immunohistochemical staining and microscopic observation were conducted to compare expression in CD68-positive cells (TAMs), CD80-positive cells (M1) and CD163-positive cells (M2) in three groups. Correlations of TAMs, M1, M2, and M2/M1 ratio with clinical and pathological parameters were analyzed. Results: With increase of liver metastatic ability, the number of TAMs decreased gradually, with no significant difference between any two of the three groups (P > 0.05), while the numbers of M1 and M2 were significantly decreased and increased, respectively, with significant difference between any two of three groups (P < 0.05 or P < 0.01). In addition, the M2/M1 ratio increased with increase of liver metastatic ability (P < 0.01). There was no statistical significance of correlation of TAMs with each clinical and pathological parameter. M1 was negatively related with lymphatic metastasis and liver metastatic ability. M2 was positively correlated with preoperative CEA level, lymphatic metastasis, tumor differentiation degree and liver metastatic ability. The same was the case for the M2/M1 ratio. Conclusions: Effects of TAMs on liver metastasis of colorectal cancer do not depend on the total number of TAMs, but on the number and proportion of functional subtypes M1 and M2. M2 number and M2/M1 ratio are more accurate predictors for liver metastasis of colorectal cancer.