우리 나라 치과기공사의 직업성 질병과 관련요인에 대한 조사연구

임병철,민경진 韓國保健敎育.健康增進學會 2001 보건교육건강증진학회지 Vol.18 No.2

This study was performed to identify the occupational diseases in the dental technicians working in Korea, and to elucidate the maul related affecting factors for the occurrence of the occupational diseases. The research was carried out using a mail questionnaire and data collection was done for two months from April 15, 2000. The questionnaires were delivered to 1000 dental technicians working at 250 dental laboratories which were chosen among the total 1330 dental laboratories in south Korea. And 763 questionnaires were collected, then 739 questionnaires were used for a logistic and a multiple regression analyses. The results obtained ill this study are summarized as follows: 1.The occupational diseases in the dental technicians included pneumoconiosis, chronic bronchitis, asthma, pneumonia, hyposmia, allergic dermatitis, eczema, contagious dermatitis, contral nervous disorder, dysfunction of finger, vertebral disorder, dysfunction of interphalangeal joint, ophthalmitis, auditory dysfunction, otitismedia, optic trauma, and burn. 2.The main related affecting factors for the occurrence of the occupational diseases in the dental technicians were elucidated as follows: On the ccurrence of chronic bronchitis, vibration of equipment and job career were affected positively. On the ccurrence of asthma, job career and career on current working part were affected positively, but exhaust ventilation, work hour were affected negatively. On the occurrence of eczema, career on current working part and vibration of equipment were affected positively, but personal protective equipment, local exhaust ventilation, isolation of gas source were affected negatively. And eczema was occurred more in methyl methacrylate work than in any other work part. On the occurrence of finger dysfunction, vibration of equipment and noise of work place were affected positively. But personal protective equipment, local exhaust ventilation, isolation of dust and gas source were affected negatively. But finger dysfunction was occurred more in metal polishing than in any other work part. On the occurrence of auditory dysfunction, noise of work place were affected negatively. The results obtained in this study can give a valuable information for a prevention of the occupational diseases in the dental technicians working in Korea, and for keeping them in healthy. This study also can be helpful for a researcher who is aiming at a identification of occupational diseases and a elucidation of related affecting factors in a similar occupation.

알코올사용장애의 유형별 특징

임명호,백기청,이경규,홍성도,김현우,이민규 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.5

대체적으로 알코올성 장애는 이질적인 집단으로 이해되어지고 있으며, 이는 알코올성 장애의 예후와 치료가 유형에 따라 다르다고 보기 때문이다. 이러한 알코올성 장애는 음주 형태, 의존유형, 유전적 취약성(genetic vulnerability), 성격유형, 정신병리적 측면에 따라 여러 유형으로 나눌 수 있다. 본 논문은 Babor등(1992)이 분류한 A형, B형의 아형분류가 우리나라에서도 이용가능한 지를 알아보는 예비적 조사논문으로써 알코올리즘의 진단 및 이해를 기하고자 하였다. 만 18세 이상부터 만 65세 이하의 알코올중독 남자 환자 94명을 대상으로 15개의 변인에 따라 군집분석을 시행하였으며, A형과 B형의 두 아형군 및 정상대조군과의 인구학적 특성, 임상양태의 차이를 비교하였다. 결과는 다음과 같다. 1) A형, B형, 그리고 정상대조군간의 연령, 학력, 결혼상태, 종교 등의 인구학적 특성의 차이는 없었다. 2) B형은 음주시작연령, 과다한 음주를 시작한 연령, 문제를 일으킨 연령에서 A형에 비해 세 항목 모두에서 일찍 발현하는 것으로 나타났다. 또한 B형에서 A형보다 의존 정도가 더 심하며, 평균음주량 및 가장 많이 과음한 양에 있어서도 A형보다 많이 마시는 것으로 나타났다. 3) A형보다 B형에서 좀 더 1차가족 중에 알코올로 인한 문제가 있는 사람이 많이 있는 것으로 나타났다. 4) B형은 A형보다 소아청소년기에 있어서 좀 더 많은 행동문제가 있음을 나타냈다. 5) 내과적 합병증, 신체생리적 후유증 및 사회적 후유증 및 생활사 후유증 또한 B형에서 좀 더 심한 분포를 보이고 있었다. 6) 정신병리요소에서 B형은 우울, 불안, 적대감에 있어서 A형보다 모두 유의하게 심한 증상을 보였다. 7) A형, B형, 정상대조군의 세 군간에서 모두 유의한 차이를 보이는 신뢰성있는 척도는 음주일수, 의존정도척도, 생활사정도 척도, 내과적 합병증, 사회적 후유증등이었다. 8) 음주 사용척도는 두 아형군과 정상대조군을 구분하는데 매우 신뢰성이 있는 척도로 나타났다. 상기의 결과를 종합해보면, 알코올사용장애에 대하여 Babor등(1992)이 분류한 A형, B형의 아형분류는 우리나라에서도 비슷한 양상을 보였으며, 이의 적용은 향후 알코올사용장애의 진단 및 이해에 이용가능할 것으로 평가한다. Objective : Multiple typologies of alcoholics have been studied, such as Jellineck's disease concept classification, Cloninger's neurobiological learning model, Zucker's developmental model, DSM Ⅲ-R and DSM Ⅳ classification, and Babor's multidimensional typology. To study if Babor's typology modification could be used to classify Korean alcoholics, we grouped 95 male inpatient alcoholics into Babor's typology modification. Methods : This study employed cluster analysis of measures representing several dimensions : premorbid risk and vulnerability dependence severity and alcohol-related problems, chronicity and alcohol-related consequences, and comorbid psychopathology. We compared demographic and clinical characteristics among Babor's type A and type B alcoholics and normal control group. Results : Type B alcoholics showed more characteristic symptoms in family history, more childhood behavior problems, earlier onset, more drinking amount, and more dependence severity, more medical, social, physical problems, more life time severity, more depressive, anxiety, hostility, compared with type A alcoholics. The statistically significant variables differentiating three groups(type A, type B, normal control group) were drinking days, dependence severity, lifetime severity, medical, social consequence. Alcohol Use Inventory to Babor's typology of alcoholism was very useful scale differentiating three groups. Conclusion : Babor's typology of alcoholism was useful for classification of inpatient alcoholics of Korea. It can be helpful and applicable to clinical diagnosis and research in Korean alcoholic patients.

12-O-Tetradecanoylphorbol-13-Acetate에 의한 HL-60 세포 분화유도중 Vimentin 유전자 전사조절에 대한 AP-1의 역할

임규,김진희,권도원,김승민,이명선,윤경아,손미영,박종일,윤완희,황병두 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

Purpose: To gain insight on the role of AP-1 in transcriptional regulation of vimentin gene during differentiation of HL-60 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA), the levels of vimentin mRNA and AP-1 have been investigated with Northern blot hybridization and DNA mobility shift assay. Materials and Methods: HL-60 cells were grown in RPMI 1640 medium supplemented with 10% heat-inactivated fetal calf serum and antibiotics in a humidified 5% CO_(2) at 37°C. Total RNA was prepared by a modification of the method of Karlinsey et al. Northern blot hybridization was performed by the method of Virca et al. EcoRI fragment of pVIM-GEM was used as probe for vimentin mRNA. DNA mobility shift assay was performed by the method of Lim et al. End labeled DNA probe(Upper strand, 5'-CGCTTGATGAGTCAGCCG- 3') for AP-1 binding activity was mixed with nuclear extracts in a 20 μl reaction volume containing 300 mM KC1, 60 mM HEPES, pH 7.9, 25 mM MgCl_(2), 1 mM EDTA, 1 mM DTT, 60% glycerol, and 2μg of poly[dI-dC]. Results: TPA increased vimentin mRNA levels, with maximal stimulation reached at 24 hr. The level of vimentin mRNA was induced in proportion to the concentration of TPA. TPA-induced vimentin mRNA was almost reduced by actinomycin-D pretreatment. TPA-induced stimulation of vimentin gene was completely reduced by staurosporin pretreatment. In DNA mobility shift assay, AP-1 newly appeared at 24 hr during TPA-induced differentiation and was almost not detected after the pretreatment of staurosporin. Conclusions: These results suggest that the induction of vimentin mRNA during TPA-dependent differentiation in HL-60 cells may be mediated by protein kinases C signal transduction and AP-1 is important to transcriptional regulation.

12-O-Tetradecanoylphorbol-13-Acetate에 의한 HL-60 세포 분화유도중 Vimentin 유전자 전사조절에 대한 AP-1의 역할

임규,김진희,권도원,김승민,이명선,윤경아,손미영,박종일,윤완희,황병두 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-

Purpose: To gain insight on the role of AP-1 in transcriptional regulation of vimentin gene during differentiation of HL-60 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA), the levels of vimentin mRNA and AP-1 have been investigated with Northern blot hybridization and DNA mobility shift assay. Materials and Methods: HL-60 cells were grown in RPMI 1640 medium supplemented with 10% heat-inactivated fetal calf serum and antibiotics in a humidified 5% CO_2 at 37℃. Total RNA was prepared by a modification of the method of Karlinsey et al. Northern blot hybridization was performed by the method of Virca et al. EcoRI fragment of pVIM-GEM was used as probe for vimentin mRNA. DNA mobility shift assay was performed by the method of Lim et al. End labeled DNA probe(Upper strand, 5'-CGCTTGATGAGTCAGCCG- 3') for AP-1 binding activity was mixed with nuclear extracts in a 20 μl reaction volume containing 300 mM KCI, 60 mM HEPES, pH 7.9, 25 mM MgCI_2, 1 mM EDTA, 1 mM DTT, 60% glycerol, and 2 ㎍ of poly[dI-dC]. Results: TPA increased vimentin mRNA levels, with maximal stimulation reached at 24 hr. The level of vimentin mRNA was induced in proportion to the concentration of TPA. TPA-induced vimentin mRNA was almost reduced by actinomycin-D pretreatment. TPA-induced stimulation of vimentin gene was completely reduced by staurosporin pretreatment. In DNA mobility shift assay, AP-1 newly appeared at 24 hr during TPA-induced differentiation and was almost not detected after the pretreatment of staurosporin. Conclusions: These results suggest that the induction of vimentin mRNA during TPA-dependent differentiation in HL-60 cells may be mediated by protein kinases C signal transduction and AP-1 is important to transcriptional regulation.

Clomiphene citrate에 의한 배란유도 후의 임신율에 관한 연구

임춘근,이민용,권경익,박세출,이두룡,남동호,양숙경 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.3

From March 1990 to February 1993, we evaluated completely follow-uped 68 cases of amenorrhea, oligomenorrhea, infertility(anovulation). The ratio of primary to secondary is 31: 37. Ovulation rate and pregnancy rate of 68 cases which were completely treated with clomphene citrate is 72%, 71.8% respectively. Among these 23 pregnat cases, 19 cases were full term delivered, 1 case is ongoing pregnant, and 3 cases were spontaneously aborted. No one of multiple pregnancy and congenital abnormality was noted.

당귀의 휘발성분의 항균효과에 관한 연구

閔慶雅,徐基林 카톨릭대학교 성심교정 1996 論文集 Vol.3 No.-

당귀의 휘발성분은 몇가지 세균의 증식을 억제하였다. 세균의 중식을 억제하는 휘발성분 최저 억제농도는 E. coli에 대하여 1000 ppm 그리고 S. aureus에 대하여 1500 ppm이 었다. 그러나 S. enteritidis에 대하여는 이 휘발성분의 억제 효과가 낮았으며 3000 ppm에서 조금 억제되었다. 휘발성분의 최고 억제율은 E.coli에 대하여 92%, S. aureus에 대하여 82%였다. The volatile components of Angelica gigas have the growth inhibitory effect against several bacteria. The minimum inhibitory concentrations of the components were 1000 ppm for E. coli and 1500 lpm for S. aureus. But the inhibirory effect against S. enteritidis was low and even at 3000 ppm concentration the bacterium was inhibited slightly. The inhibitory activity was considered as static effect rather than cidal effect. The maximum inhibition percentages of the volatile components were 92% for E.coli and 82% for S. aureus.

Gullian Barre Syndrome 患者 1例에 대한 症例報告

임승민,안정조,최영,조현경,김민상,유병찬,오병렬,김윤식,설인찬 대전대학교 한방병원 2002 惠和醫學 Vol.11 No.1

Gullian Barre Syndrome is an acute symmetric polyradiculoneuropathy that typically presents as a progressive flaccid paralysis. The pathology is believed to be caused by both cellular and humoral immune processes The possibility of death is 3-5% and About 20% of patients require mechanical ventilaton. Recently We have experienced a patient who had suspected Gullian Barre Syndrome for 60days, his condition weakness and pain was impoved through the herb and acupucture Therefore I reported it for the treatment.

폐탄광지 토양에서 내생균근균 접종과 시비가 자귀나무 유묘 생육에 미치는 영향

임경민, 구창덕, 박용우 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.1

Effects of arbuscular mycorrhizal inoculation and fertilization on the growth of Albizzia julibrissin seedlings were investigated in coal mine tailings soil. Spores inoculation of arbuscular mycorrhizal fungus, Glomus etunicatum, into sterilized tailings soil formed Arum-type mycorrhiza and vesicles massively in the roots. Fertilization did not affect spores formation but reduced mycorrhizal formation by 20% in the seedlings. Nitrogen-fixing root nodules formation was increased by mycorrhizal inoculation and fertilization treatment. Leaf nitrogen content in A. julibrissin seedlings were the highest in the fertilized treatment by 1.2%, phosphorus was the highest in the mycorrhiza inoculated by 1.3mg/kg, zinc content was the highest in the mycorrhiza inoculated by 0.030 mg/kg. And the nitrogen content was higher in fertilization treatments than in mycorrhizal inoculation only. Seedling height growth was higher in the fertilized treatment with 20.7 cm than in the other treatment with 11.5 to 16.7 cm. Shoot dry weight of seedlings in mycorrhizal inoculation+fertilization treatment with 8.9 g was higher than in mycorrhizal inoculation with 4.1 g. Root dry weight was highest in the mycorrhiza+fertilizer treatment with 8.1 g. S/ R ratio was 0.52 in the mycorrhizal inoculated compared to 0.91 in the mycorrhiza+fertilized treatment. This means that root development is relatively higher than shoot growth. Consequently, A. julibrissin seedling growth in coal mine tailings soil was greatly improved with the treatment of mycorrhizal inoculation and fertilization.

얼굴 연조직 강화를 위한 자가지방 이식 후 발생한 급성 경계부위 뇌경색

민경현, 이혜림, 여민주, 김지선, 이성현, 이상수, 신동익 충북대학교 의과대학 충북대학교 의학연구소 2016 忠北醫大學術誌 Vol.26 No.1

본문참고

The Relationship between the Salivary IgA against Ag I/II of S.mutans and Dental Caries Experience among Children and Adults

임수민,김재곤,백병주,양연미,김수경,이경열 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.4

치아 우식증은 감염성 질환의 하나로 치아우식의 원인균은 Streptococcus mutans(S. mutansJ와 같은 mutans stepto-cocci로 알려져 있다. S. mutans가 치면에 접착하여 군집을 형성하는 능력은 균독성에 중요한 역할을 하는데. Agl/IT와 같은 세포 표면의 섬유성 단백질을 매개로 한다. Secretory 1gA는 타액이나 누 · 비액, 초유, 그리고 폐나 소화기관의 분비액에서 선택적으로 다량 발견되는데 타액에서 se cretory 19A는 S. mutans의 대사활동을 억제하고 치면으로의 부착을 방해한다. 이전의 몇몇 연구에서 S. mutans에 특이적인 타액 내 IgA와 우식경험도는 역상관관계를 보인다고 발표하였다. 그러나 다른 연구에서 통계적 유의성이 없다고 보고하기도 하였다. 본 연구의 목적은 소아 성인의 치아우식증과 S. mutans의 Ag I/II에 특이적인 타액 내 IgA와의 관계를 알가위한 것이다. 이를 위해 소아(평균6세) 28명, 성인(20-30세) 18명을 대상으로 Group I(deft index ≤ 3). Group II (deft index ≥ 4), Group III (DMFT index ≤ 3), Group IV (DMFT index ≥ 4)로 분류하였다. 그리고 caries resistant group(CR group, deft or DMFT index ≤ 3)과 caries susceptible group(CS group. deft or DMFT index ≥ 4)으로 분류하였다. S. mutans 수와 우식 경험도 간에는 통계적으로 유의 한 상관관계를 나타냈다. Agl/II 특이 salivary IgA titer는 Group III 이 Group II 보다 통계적으로 유의하게 더 컸으며, CR group이 CS group보다 유의하게 크게 나타났다. AgI/II of Streptococcus muiens(S. mutens) is an important virulence factor that contributes to the pathogenesis of S. mutans-induced dental caries. In oral cavity, salivary IgA antibodies act as safeguards against enormous challenges from oral bacteria. IgA antibodies inhibit adherence of cariogenic microorganisms to hard surfaces. Analysis of salivary IgA against AgI/II can be very useful diagnostic and powerful communication tools to the dental caries The purpose of this study was to investigate correlation between salivary AgI/II specific IgA and incidence of dental caries among children and young adults. Subjects consisted of 28 children and 18 adults. They were as￢signed to four groups: Group I (deft index ≤ 3), Group lI (deft index ≥ 4), Group Ill (DMFT index ≤ 3), Group IV (DMFT index ≥ 4) and they was divided two groups into caries resistant group and caries susceptible group. The study group were examined caries activity and their salivary IgA was evaluated by enzyme-linked immunosorbent assay. The results are as follows : 1. There was a positive correlation between the number of S. mutans and caries activity. 2.The titer of salivary IgA against the AgI/II was significantly higher in caries resistant group than caries susceptible group(p<0.01). 3. The titer of salivary IgA against the AgI/II in Group Ill was significantly higher than Group II (p<0.05).