측두엽 간질의 선택적인 후대뇌동맥 Sodium Amytal 검사 2예

이경열,김옥준,서범천,이병인,김원주 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

신이식환자에서 Thiopurine Methyltransferase의 활성이 Azathioprine 치료에 미치는 영향

조주연,배균섭,유경상,이소영,장인진,신상구,김상준,하종원,안규리 大韓臨床藥理學會 2000 臨床藥理學會誌 Vol.8 No.1

알코올 의존 환자의 Tryptophan Hydroxylase 유전자 다형성

홍주봉,이상익,신철진,김헌,지경환,정인원 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 알코올 의존 환자에서 세로토닌 합성 조절 효소인 tryptophan hydroxylase(TPH) 유전자 다형성 빈도를 정상 대조군과 비교함으로써 알코올 의존의 유전적 요인을 추적하고, 임상변인과 이 유전자 다형성과의 관련성을 알아보고자 하였다. 방 법 : DSM-IV진단기준에 부합되는 알코올 의존 환자 100명과 정상 대조군 100명을 대상으로 TPH유전자 다형성을 증합효소 연쇄반응과 제한효소 처리법을 이용하여 동정하였다. 여기서 분리된 대립 유전자와 유전자형에 따른 빈도의 차이를 서로 비교하였으며, 알코올 의존 환자군의 여러 임상 변인에 따른 차이를 비교하였다. 결 과 : 알코올 의존 환자군과 대조군 간에 TPH의 A216C 유전자형 및 대립유전자 빈도에서의 통계적으로 유의한 차이는 관찰되지 않았으나, 조기 발병한 환자의 경우는 유전자형의 빈도가 AA,AC,CC형이 0.57, 0.39, 0.04, 후기 발병한 환자의 경우 0.34, 0.45, -.21로, 조기 발병한 환자군에서 대조군과 비교하여 통계적으로 유의하게 A 대립 유전자의 빈도가 높은 것이 관찰되었다.(by chi-square test, p<0.05). 결 론 : 이는 조기 발병형 알코올 의존의 경우 TPH유전자 다형성과 관련이 있으며, 일부 알코올 의존 환자에서 유전적으로 세로토닌계의 이상이 있다는 사실을 시사한다. Objectives : This study was performed to explore the association of tryptophan hydroxylase (TPH) gene with diagnosis of alcohol dependence and/or clinical characteristics such as age of onset, family history, and severity of symptoms in Korean alcoholics. Methods : The genotype and allele frequencies of TPH in 100 male hospitalized patients who met DSM-IV criteria for alcohol dependence were investigated using polymerase chain reaction and restriction fragment length plymorphism and were compared with 100 age-matched healthy male control subjects. And the associations between gene polymorphisms and clinical characteristics in alcoholic patients were explored. Results : The distributions of TPH genotype and allele in alcohol dependent patients were not different from control subjects. However, the frequencies of TPH genotype in early-onset alcoholic patients, which were 0.57, 0.39, and 0.04(AA, AC and CC, respectively), were significantly different from those of late-onset alcoholics(0.34, 0.45, and 0.21, respectively). "A" allele was found more frequent in early-onset alcoholics. Conclusion : The result suggests that TPH gene polymorphism is associated with early-onset alcioholic patients possibly related with inherited abnormalities of serotonin system.

순천향의대에서 문제중심학습의 실행 및 평가

김주자,이경재,원종호,이동환,안의태 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1

Background and Objects : Problem based learning (PBL) was practiced the 2nd grade students of Soonchunhyand medical school for two weeks from Dec. 10th through 24th, 2001. This is to evaluate the effect of the PBL practice Materials and Methods : On study module was discussed each week for 17 small groups. Each group had 6-7 students and 1 tutor. Questionnaire was applied to both students and 20 tutors. The questions were grouped in 6 categories, that is, understanding and satisfaction about the PBL, the process of small group discussion and group activity in self-learning method, PBL module and tools for study, opinion about tutors evaluation method etc. And advantages, disadvantages and other opinions were described in self-administration. Results : Both students and tutors had satisfied the PBL practice positively. Practices of "self-learning and active discussion instead of spoon-feeding methods", "problem-solving ability and medical reasoning" were described as advantages, "inefficiency and loss of time because of poor process during the discussion", "time consuming and much loading problems in self-learning practice because lack of training" "time consuming and mush loading problems in self-learning practice because lack of training" "lack of study room" were described as disadvantages.

韓國·美國·日本의 老人住宅政策

신경주,황원경 漢陽大學校 韓國生活科學硏究所 1995 韓國 生活 科學 硏究 Vol.- No.13

This study was to investigate the tendency of the elderly housing policy in Korea, America, and Japan. The content analysis method was used to achieve the purpose of this study with laws, books and articles related to welfare and housing policy. The result are followed : 1.The elderly housing policy of Korea was started at facility house for homeless elderly in 1960s and then three generation sharing houses have been built in 1980s. 2.The elderly housing policy of U.S.A. was started in 1950s and the housing with fulfillment of elderly needs was provided in 1960s. The elderly housing with housework service was introduced in 1960s, but the elderly housing for low-income was decresed in 1980s. Vauteur program helped meet the various needs of the elderly. 3.The elderly housing policy of Japan was started in 1960s, The pair housing that was near child's house was provided in 1970s and the financial support programs for the elderly was started. Care service was added in the elderly housing with the pursuit of the quantative improvement in the sharing houses in Japan. The elderly housing policy in Japan is under stable stage in 1990s.

중금속물질이 생쥐 신장사구체에 미치는 영향에 대한 미세구조 연구

김주원,고정식,양남길,안의태,박경호 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

본 실험은 중금속물질이 섭취되었을 때 신장사구체의 미세구조적 변화를 알아보기 위하여 시행하였다. 실험동물로는 체중 25gm내외의 성숙한 마우스(IRC)를 사용하였는데 실험군은 염화제이수은(HgCl₂)을 2mg/kg, 5mg/kg, 10mg/kg씩, 중크롬산칼륨(K₂Cr₂O7)을 5mg/kg, 10mg/kg, 20mg/kg씩 피하주사하여 사용하였다. 각 실험군은 주사 후 6시간, 3일, 2주일에 희생시킨 후 신장조직을 떼어내어 2.5% glutaraldehyde- 1.5% paraformaldehyde혼합액(0.1M Millonig's phosphate buffer, pH 7.3)에 다시 고정한 다음, 1% osmium tetroxide(0.1M Millonig's phosphate buffer, pH 7.3)에 다시 고정하였다. 고정된 조직은 ethyl acohol과 acetone으로 탈수하여 araldite 혼합액에 포매하였으며 포매된 조직은 LKB-V Ultramicrotome으로 얇은 절편을 만들어 uranyl acetate와 lead citrate액으로 염색한 후 JEM 100CX-Ⅱ전자 현미경으로 관찰하여 다음과 같은 결론을 얻었다. 1. 사구체기저막의 경우, 염화제이수은 투여군은 5mg/kg, 10mg/kg투여군에서, 중크롬산칼륨 투여군은 10mg/kg, 20mg/kg투여군에서 실험초기(6시간과 3일)에 사구체기저막의 전자밀도가 다소 불규칙하고 혹 모양의 물질이 기저막에 침착되었으나 2주일군에서 거의 정상군의 것에 비하여 별다른 변화를 볼 수 없었다. 2. 내피세포의 경우, 염화제이수은 투여군은 2mg/kg, 5mg/kg, 10mg/kg, 투여군에서, 중크롬산칼륨투여군은 10mg/kg, 20mg/kg투여군에서 실험초기( 6시간군과 3일 )에 내피세포 내에 공포와 myelin구조가 자주 관찰되었다. 3. 문어발세포의 경우, 염화제이수은 투여군은 2mg/kg, 5mg/kg, 10mg/kg 투여군에서, 중크롬산칼륨투여군은 10mg/kg, 20mg/kg 투여군에서 실험초기( 6시간군과 3일) 에 팽창된 과립형질내세망의 수조와 납작한 Golgi복합체 수조가 관찰되었다. 4. 혈관사이세포의 경우, 염화제수은 투여군은 2mg/kg, 5mg/kg, 10mg/kg 투여군에서, 중크롬산칼륨 투여군은 10mg/kg, 20mg/kg투여군에서 실험초기( 6시간군과 3일)에 기질내에 전자밀도가 높은 침착물이 관찰되었으며 혈관사이세포의 세포돌기가 내피세포 쪽으로 돌출되어 내피세포의 세포질판에 의해 둘러싸여 있는 모습이 자주 관찰되었다. 이상의 결과를 종합해보면 마우스가 일정량의 염화제이수은 또는 중크롬산칼륨을 한번 섭취하면 급성사구체신염의 형태학적 특징을 보이나 2주일정도가 지나면 사구체의 경우에는 거의 정상상태로 회복하며, 염화제이수은이 중크롬산칼륨에 비하여 사구체에 더 많은 손상을 준다고 생각된다. This experiment was performed to study the Ultrastructural changes of the renal glomerulus, induced by heavy metallic agents. Healthy adult mice weighing 25gm each were divided into normal an dexperimental grouops. Mercuric chloride(2mg/kg, 5mg/kg, 10mg/kg) or potassium bichromate(5mg/kg, 10mg/kg, 2-mg/kg) were injected subcutaneously to the animals. Animals were sacrificed at 6 hours, 3 days and 2 weeks following the injections. Pieces of tissues were taken from renal corticies, prefixed with 2.5% glutaraldehyde- 1.5% paraformaldehyde(0.1M Millonig's phosphate buffer, pH 7.3), and followed by post-fixation with 1% osmium tetroxide(0.1M Millonig's phosphate buffer, pH 7.3) Fixed blocks were dehydrated with alcohols and acetone, embedded in araldite mixture, cut with LKB V-ultratome. The ultrathin sections stained with uranyl acetate and lead citrate were observed with a JEM 100CX-II electron microscope. The results were as follow: 1. Glomerular basal laminae of the experimental groups showed some alterations, especially in the earlier stage-(6 hours and 3 days) of mercuric chloride-(5mg/kg. 10mg/kg) and potassium bichromate-(10mg/kg, 20mg/kg) treated groups. Irregularity of the electron density and accumulation of electron dense materials were observed. But morphological changes occurred in the basal laminae are generally recovered to normal appearance within 2 weeks. 2. In the glomerular endothelial cells of the mercuric chloride-(2mg/kg, 5mg/kg, 10mg/kg) and the potassium bichromate-(10mg/kg, 20mg/kg) treated groups. a large number of vacuoles and some myelin figures were observed frequently, especially in the earlier grous-(6 hours and 3 days). 3. In the podocytes of the mercuric chloirde-(2mg/kg, 5mg/kg, 10mg/kg) and potassium bichromate-(10mg/kg, 20mg/kg) treated groups. swollen cistern of rough endoplasmic reticulum and flattened cistern of the Golgi complexes were observed in the earlier groups-(6 hours and 3 days). 4. In the mesangial cell of the mercuric chloride-(5mg/kg, 10mg/kg) and potassium bichromate-(10mg/kg, 20mg/kg) treated groups. electron dense deposits were seen within the matrix and protruding cytoplasmic processes of the cells were surrounded by the cytoplasmic plates of the endothelial cells. From the above results. it was concluded that. the mercuric chloride or potassium bichromate induces acute glomerulonephritis on the mice, but ultrastructural changes occurred in the glomerulus after injection of the heavy metallic agents were recovered to normal appearance within 2 weeks. Mercuric chloride was more harmful on the renal glomerulus than potassium bichromte.

韓國人의 環境保護態度形成을 위한 行政的接近

朴鍾珠,辛京勳,鄭甲源 圓光大學校 1982 論文集 Vol.16 No.1

Many developing countries are faced today with serious problems emanating from environmental deterioration with limited resources and technologies, they face the need to increase industrial production and simultaneously to control environmental problems attendant on such expansion. They are in dilemma since environmental pollution is often a problem where solutions run counter the continued and uninterrupted industrial growth. Korea is a case in point. During the past two decades the country enjoyed one of the highest economic growth rates among the developing nations. But the rapid expansion of industries and the emergence of densely populated urban areas during the period have placed heavy strains on the quality of the country's environment. The Korean government, cognizant of the seriousness of the problem, began taking measures aimed at curbing environmental deterioration. The meaning of environment is differentiated in accordance with the disciplines which systematically deals with the environmental problems or with the practical positions and approaches, since the environmental problems appear to be important social and daily life problems. Broadly speaking, environment is the whole which influence each other in and out of a group of organisms. In these regards, the environment of which center is human beings can be called a human environment or a human ecosystem. Human environment is a complex one composed of the human beings and their environmental conditions, that is to say, man-society-biotic and abiotic beings and their conditions. The human environment is different from and more complex than any environments in terms of fact that the man, being quite a component of the system, is able to change the structure of the system by his intellectual activities. The purpose of the present study aims at gathering basic attitudinal data relating to the environment and preparing the usable policy alternatives in Korea. Data for the study were collected from sample survey (367 persons) conducted in Junrabukdo province, using a standardized interview schedule. Major findings of the research can be summarized as follows: (1) satisfaction with the existing quality of the daily environment was expressed by higher level, relatively. So it may be reasonably assumed that the satisfaction they expressed reflected more than the objective realities of their environment. (2) public knowledge of conservation or pollution control programmes was very low despite the concerted effort of both governmental and civilian conservation organizations to arouse public consciousness for environmental protection in conservation programmes was also very low. (3) considering that conservation movements had not been widely known and that partictpation had been very low, public support for environmental protection was very strong. Approximately two-thirds of the sample were found willing to pay an additional one percent of their current tax as a special environmental tax. Almost unanimously, respondents were in favor of establishing environmental education as part of the regular academic curricula from the elementary school up. (4) Environmental personality test shows that Koreans have a strong tendency to view their environment as an object to be developed and modified to suit his immediate needs and desires.

우리나라 환경대책의 담당주체별 경향

신경주,이영심,황원경 漢陽大學校 韓國生活科學硏究所 1999 韓國 生活 科學 硏究 Vol.- No.17

This study was performed to investigate the changes of the environmental counterpane in Korea. The subject groups discussed it to the trends of the environmental counterplan, the classification of the subject groups, and the content analysis of the environmental counterplan. The content analysis method was used to perform the study, and articles were a daily newspaper's topics related to the environmental counterplan. The adapted data were 488 articles related to the environmental counterplan at the Dong-A daily newspaper during 1920-1997. The results were shown: 1.The number of articles on the environmental counterplan has been increased since 1963. 2.The articles were categorized to five aspects: the government, the public, the enterprise, the education institute, and the international organization. 3.With respect to the environmental counterplan by the government, it has discussed the environmental law, the environmental policy, the investment about the technology (to develop the technique to keep the environment clean and to reduce environmental pollution), the environmental education, and the environmental movement. With respect to the environmental counterplan by the public, it has mentioned the environmental movement, the environmental education, the investigation to protect the environment, and the proposal to make and decide the environmental policy. With respect to the environmental counterplan by the enterprise, it has reviewed the investment about the technology, the proposal to make and decide the environmental policy, the environmental education, and the environmental movement. With respect to the environmental counterplan by the education institute, it has discussed the investigation to search the way (to keep the environment clean and protect the environment from the pollution), the proposal to decide the environmental policy, the environmental education and the environmental movement. With respect to the environmental counterplan by the international organization, it had mentioned the environmental education and the environmental movement.

완전 고환성 여성화 증후군 1례

이원주,김택훈,권경익,김종인,조남규,박세출 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.2

저자들은 외형상 여성으로써 원발성 무월경과 양측 외음부 종양 촉지를 주소로 입원한 complete testicular feminization syncrome 1례를 경험하였기에 이를 문헌고찰과 함께 보고하는 바이다 The 46, XY individual with complete testicular feminization syndrome is a phenotypic female who is usually somewhat tall, has excellent breast development and presents to the gynecologist because of primary amenorrhea and an inguinal mass. In complete testicular feminization syndrome, axillary and pubic hair are sparse or absent and some degree of virilization such as clitorial hypertrophy, partial labioscrotal fusion and hirsutism doesn't occur at puberty. We report a case of complete testicular feminization syndrome with the brief review of literatures.

중복비트 제거를 이용한 SPIHT 알고리즘의 개선에 관한 연구

설경호,이원효,주동현,김태형,김두영 동아대학교 정보기술연구소 2003 情報技術硏究所論文誌 Vol.11 No.1

This paper presents improvement of compression rate for SPIHT algorithm through redundancy bit removing. Proposed SPIHT algorithm uses a method to select of optimized threshold from feature of wavelet transform coefficients and removes sign bit only if coefficient is LL area. Experimental results show that the proposed algorithm achieves more improvement bit rate and more fast progressive transmission with low bit rate.