알코올이 Dynamic Posturography에 미치는 영향

이진춘,고의경,장민호,이병주,백무진,노환중,왕수건,전경명 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.2

인체에서 carvedilol의 심혈관계 작용에 대한 PK/PD modeling

백인환,윤민혁,윤휘열,남진경,권광일 충남대학교 약학대학 의약품개발연구소 2007 藥學論文集 Vol.22 No.-

The objective of the present study was to determine and characterize the relationship between the cardiovascular effect and plasma concentration of carvedilol by PK/PD modeling in human. A group of 32 healthy males received oral doses of 25 mg carvedilol, and blood samples were collected thirteen times for up to 30 hours after the drug administration. The effect of carvedilol on blood pressure was measured during the same period. This experiment was analyzed using the liquid-liquid extractions of carvedilol by HPLC with fluorescence detection. Pharmacokinetics parameters of carvedilol were calculated using the two-compartment model with first-order absorption. The average value of C_(max), T_(max), CL/F (apparent clearance), V/F (apparent volume of distribution) and half-life of carvedilol were 62.74 ± 20.12 ng/ml, 1.26 ± 0.86 hrs, 94.64 ± 46.01 L/hr, 1561.78 ± 941.94 L, 12.47 hr, respectively. To explain the relationship between the cardiovascular effect and plasma concentration of carvedilol, plasma drug concentrations were linked to the observed SBP and DBP via a effect compartment with a sigmoid Emax model. The model parameters were estimated by using ADAPT Ⅱ program. This PK/PD model could describe the relationship between plasma concentrations of carvedilol and cardiovascular effect such as the aspects of decreasing blood pressure and the time delay between plasma concentration and pharmaco-dynamic data.

RUS법에 의한 Micro-Crack을 가진 Ferrule의 주파수 특성 평가

백경윤,이길성,양순호,김성훈,조영재,민한기,양인영 朝鮮大學校 機械技術硏究所 2003 機械技術硏究 Vol.6 No.2

광섬유 정렬부품으로 사용되는 페롤은 극히 높은 정밀도를 요하는 제품으로서, 높은 치수 정밀도와 결함이 포함되지 않는 등 높은 신뢰성이 요구되는 제품이다. 이러한 페롤의 형상결함평가에 종래의 광학현미경 평가법과는 달리. 본 논문에서는 공명초음파법(ResonantUltrasound Spectroscopy)을 이용하고자 한다. 공명초음파법이란 결함이 없는 시험편을 기계적으로 진동시켰을 때의 공진 주파수와 시험편 내에 결함을 가지고 있을 때의 공명 주파수 양상을 비교 분석하여 결함유무를 검출해내는 방법이다. 본 연구에서는 양품과 크랙을 가진 시험편을 현장에서 직접 사용되고 있는 광학현미경에 의해 분류를 한 다음, 더욱 정확한 측정을 위해 SEM에 의해 다시 분류하였다. 각각에 대해 공진 주파수를 측정하였고, 이 데이터의 검증을 위해 FEM해석을 수행하였다. 실험으로부터 얻는 양품의 공진 주파수와 FEM해석을 통해 얻었던 양품의 공진 주파수의 오차는 1∼2%정도의 범위를 벗어나지 않음을 알 수 있었다. 또한 크랙에 대한 공진 주파수를 측정하여서, 양품의 공진 주파수와 비교를 행하였고, 이 데이터를 가지고 모드별로 히스토그램을 그려서, 그것으로부터 현장에서 실제로 이용 가능한 모드를 존재함을 확인하였다. The Ferrule which is used as the product optical fiber very precisely, is required high to set the optical axes of an dimensional precision, lack of defect and high expectation. Up to now the optical instrument has been used for the defect and shape inspection of the Ferrule, but in this paper we examined the detectable defect and expectation by using the Resonant Ultrasound Spectroscopy (RUS). The RUS is the measurement' which is to excite specimen and to inspect the difference of natural frequency pattern between acceptable specimen and specimen has some defects. In this paper, we classified specimens into three groups by using She optical instrument; acceptable specimen A-type, 3-type and specimen A-type which has crack. And we reclassified by Scanning Microscope to carry out the more exact measurement. We surveyed the resonant frequency of every specimen, and carried out the simulation from the explicit finite elements code, NasEran t o verify the experiment data. The average error between the resonant frequency of acceptable specimens which is obtained from experiment and that from FEM analysis is in the range of 1-2 percentage. Also, we measured the resonant frequency of specimen which has crack, and compared that of acceptable specimen. We drew histogram by using these data, and confirmed the available mode in the plant.

급성 충수염으로 진단된 예측 불가 염증성 맹장 종물에 대한 외과적 고찰

민경진,백무준,채만규,김성용,이문수,김창호,김재준,송옥평 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: An unexpected inflammatory cecal mass of uncertain etiology was encountered during surgery for presumed appendicitis. In this case, the surgeon couldn't exclude differential diagnosis which were severe appendicitis involving the cecal region, diverticular disease, other inflammatory bowel diseases, and neoplasm. Therefore, this finding leads to a therapeutic dilemma for the surgeon, when making surgical decisions during the operation. The aim of this study was to resolve this dilemma, a retrospective review was undertaken in this study. Methods: A retrospective study was performed to review the management of this problem at Soonchunhyang University Chunan Hospital for eight and half years from July 1991 to December 1999. A review of the emergency operation records identified 50 patients who had undergone ileocecal resection or right hemicolectomy for an inflammatory ileocecal mass of uncertain etiology when operated on for probable appendicitis. Results: Altogether, 39 patients underwent ileocecal resection, and 11 patients underwent right hemicolectomy. The final pathologic diagnosis was appendiceal abscess in 32 patients (63%), cecal diverticulitis in 7 patients (14%), neoplasm in 6 patients (12%), appendiceal phlegmon in 3 patients (6%), ileal tuberculosis in 1 patient (2%) and Anisakiasis in another patient (2%). The neoplasm of the 6 neoplasm patients was ascending colon cancer for 4 patients and cecal cancer for 2 patients. There was no mortality in this group. Conclusion: Although most inflammatory cecal masses are caused by benign disease, all cases in which the intraoperative diagnosis is unclear, any pathologic diagnosis including neoplasm cannot be ruled out. So this suggest ileocecal resection or right hemicolectomy to remove a possible underlying malignancy, and to decrease morbidity and mortality.

안지오텐신 변환효소 억제제와 안지오텐신 II 수용체 차단제 투여 후 발생한 급성 신부전과 폐부종으로 전원된 선천성 단일신 환자의 치료 1예

백두현,김경진,홍성철,강석형,송하응,김혜인,김수현,오현정,강혜원,김서우,유민아,류동열,최규복,강덕희 이화여자대학교 의과대학 2010 EMJ (Ewha medical journal) Vol.33 No.1

Blockers of renin-angiotensin system(RAS) including ACE inhibitor or ARB are one of the most frequently prescribed medications for the treatment of hypertension, heart failure and proteinuria. One of the major side effects of these RAS blockers is the deterioration of renal function, mainly due to a reduction of intraglomerular pressure. Therefore, close monitoring of renal function is recommended when RAS blockers are initially prescribed, especially for the patients with impaired renal function. We report a patient who was transferred to our hospital due to the sudden development of oliguria and dyspnea after treatment for hypertension with ACEi and ARB. She was finally diagnosed as RAS blocker-induced acute renal failure with pulmonary edema complicated on congenital solitary kidney. After hemodialysis and conservative treatment, her renal function was recovered with maintenance of normal urine output. Conclusion:This case highlights the necessity of the functional and structural evaluation of kidney to prevent the serious complication such as acute renal failure before the administration of ACEi and/or ARB.

동영상 분석 및 이동물체 추적을 위한 새로운 두단계 영역상응 방법

백경민,소영성 明知大學校 産業技術硏究所 1994 産業技術硏究所論文集 Vol.13 No.-

동영상 분석이 정지영상 분석보다 더 많은 3차원 정보를 전달해주기 때문에 컴퓨터 비전 분야에서 많은 주목을 받고있다. 동영상 분석의 대부분 연구자들은 어느 정도의 상응이 이미 해결되었다고 가정을한다. 그러나 상응의 입증은 그 자체가 매우 복잡한 문제이다. 이 논문에서는 두가지 일반적인 방법(거리와 유사도)을 혼합한 두 단계 영역 상응 방법을 제안한다.

일 지역 농업인의 근력강화운동이 정신사회 및 신체적 건강수준에 미치는 영향

정민예,양노열,유인규,고상백,이경숙,김경란,김효철 大韓産業醫學會 2008 대한직업환경의학회지 Vol.20 No.4

목적 농업인을 대상으로 근골격계질환의 예방과 관리를 위한 근력강화운동을 실시하여 심리상태와 신체능력에 미치는 효과를 밝힘으로써 농작업과 관련된 향후 치료프로그램의 기초자료를 제공하고자 하였다 방법 규칙적인 운동프로그램의 참여 경험이 없는 농작업 종사자 28명을 대상으로 8주간 주 3회 근력강화운동을 실시하여 4주 이상 규칙적으로 참여한 대상자의 정신사회적 수준(자아존중감 사회심리적 스트레스) 신체적 수준(장악력 민첩성 동 정적 균형능력 근지구력) 요통 수준의 변화를 측정하였다 결과 근력강화운동에 참여한 대상자들의 자아존중감은 운동전에 비하여 유의하게 향상되었고 사회 심리적 스트레스는 유의하게 감소하였다 장악력 민첩성 동 정적균형능력은 운동 후 모두 유의하게 향상되었으며 요통 수준 또한 유의하게 감소하였다 결론 농업인에게 근력강화운동의 적용은 심리적인 안정을 주고 신체능력을 향상시켜 근골격계질환을 예방하고 관리하는데 적합한 치료프로그램으로 사용될 수 있으며 요통 수준을 감소시키는데 유용한 프로그램이었다. Objectives To evaluate both the psychosocial and physical effects of muscle strengthening exercise on farmers and in so doing evaluate their effect on musculoskeletal disorders in farmers. Methods 28 subjects participated in our muscle strengthening exercise program. Mean age of subjects was 63±13 years. The exercise program was performed 3 times a week during the 8 week studys period Before and after training various measurements were made self esteem scale (SES), psychosocial well being index short form (PWI SF), static and dynamic balance ability grip strength arm curl, time up and go (TUG), functional reach, and oswestry disability index. Results The muscle strengthening exercise program increased the self esteem grip strength and static and dynamic balance of subjects, while psychosocial stress and low back pain levels were decreased significantly (P<0.05) Conclusions The muscle strengthening exercise improved psychosocial and physical status of test subjects. Thus exercise may be an effective strategy for enhancing the psychosocial and physical health of farmers.

한국산 독말풀에 대한연구(Ⅰ) : HPLC에 의한 Hyoscyamine 과 Scopolamine의 정량

도경삼,신민교,송호준,선중기,손인경,백승화 원광대학교기초자연과학연구소 1992 基礎科學硏究誌 Vol.11 No.3

A new method for quantitative determination of Hyoscyamine and Scopolamine in Datura stramonium L. by High Performance Liquid Chromatography(HPLC) was established. A reversed-phase system with a μ Bondapak C18 column using methanol in 0.2% aqueous phosphoric acid(40:60) with PIC A as a mobile phase was developed. Hyoscyamine and Scopolamine were detected at 254nm and the analysis was successfully carried out within 20min.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

공명초음파분광법을 이용한 광컨넥터용 결합소자의 비파괴 검사

김성훈,조영재,백경윤,양순호,민한기,양인영 朝鮮大學校 機械技術硏究所 2004 機械技術硏究 Vol.7 No.1

본 연구의 목적은 비파괴 평가방법인 공명초음파분광법(RUS)을 사용하여 세라믹제 페롤과 볼렌즈의 결함과 형상오차를 평가하는 것이다. RUS시스템은 스펙트럼에너라이저,파워 엠플리파이어,압전진동자센서와 지지프레임으로 구성되어진다. RUS 시스템에 의한 페롤과 볼렌즈의 비파괴평가를 위해 본 연구에서는 각 시험편에 대한 공진주파수를 측정하였으며,측정된 공진 주파수의 비교분석에 의해 결함의 유 · 무를 판별하였다. 그 결과 페롤의 경우,크랙을 갖는 페롤의 공진주파수 대역이 양품페롤의 공진 주파수 대역보다 고주파대역으로 이동함을 알 수 있었으며,볼렌즈의 경우,시험편 질량이 감소함에 따라 공진주파수 대역이 고주파 대역으로 이동함을 알 수 있었다. 또한 볼렌즈의 공진주파수가 측정되는 대역을 예측할 수 있는 파라메타인 β를 설정하여 그 결과를 고찰하였다. The objective of this paper is to evaluate the defect and shape error of a ceramic ferrule and ball lens by Resonant Ultrasound Spectroscopy(RUS) method. RUS system is consisted of spectrum analyzer, power amplifier, PZT sensor, and support frame. For nondestructive evaluate by using RUS system, first of all, we measured the natural frequency of each specimen, and we decided on the shape and size of flaw by measured natural ferquencies. And then, in the case of ferrule, natural frequency bandwidth of ferrule with crack was higher than acceptable ferrule. As mass of ball lens decreased, natural frequency bandwidth was shifting to high-frequency range. Thus, we discussed on the relationship between β and mass of ball lens, which β is parameter that we can predict measurable natural frequency bandwidth of ball lens.