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Ciprofloxacin의 동물유래 병원세균에 대한 시험관내 항균효과시험
장경수,장치훈,김일택,박승춘,윤효인,전무형 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-
In this study the antimicrobial spectrum and sensitivity of ciprofloxacin(CFX) against the major pathogenic bacteria isolated from the diseased poultry, pig, cattle in Korea were evaluated in comparison with morfloxacin(NFX), enrofloxacin(EFX), nalidixic acid(NA), gentamicin(GM), tetracycline(TC), erythromycin(EM), streptomycin(SM) and penicillin(PC). Increasing by paper disk diffusion test for total of 439 isolates from poultry, pig and cattle, CFX showed remarkably higher sensitivity(>83%) as compared with other drugs. When three quinolones such as CFX, NFX and NA were compared for the inhibition activity against 4 major pathogens, CFX induced significantly larger diameter of inhibition zone through all of the tested concentration than NFX and NA. As MICs of all drugs for 11 bacterial species isolated from poultry were measured, the MIC range of CFX was 0.125 - 40 ㎍/㎖ in Gram positives, ≤ 0.005 - 2.5 ㎍/㎖ in Gram negatives and 0.08 - 1.25 ㎍/㎖ with 12 isolates of Mycoplasma. MIC_50 and MIC_90 of CFX in these cases revealed consistently lower as compared with those of NFX, GM and PC. When the MICs of the drugs were tested with 11 bacterial species from the diseased pigs, MIC range of CFX was 0.05 - 3.5 ㎍/㎖ in Gram positives, ≤ 0.005 - 0.8 ㎍/㎖ with Gram negatives and 0.5 - 9.0 ㎍/㎖ with 11 isolates of Mycoplasma. MIC_50 and MIC_90 of CFX and NFX were remarkably lower than those of GM and PC. As MICs of CFX, NFX, GM and PC for 10 bacterial species isolated from cattle were tested, the MIC range of CFX was found 0.01 - 4.0 ㎍/㎖ in Gram positives, and ≤ 0.005 - 0.2 ㎍/㎖ in Gram negative bacteria. The MIC_50 and MIC_90 of CFX in cases of cattle appeared remarkably lower than those of the other drugs. CFX, as compared with the other drugs, showed invariably lower MIC_50 and MIC_90 in both of GRam positives and negatives. As MICs of CFX, NFX and PC for 12 reference bacteria were examined, MIC of CFX was 0.03 - 0.25 ㎍/㎖ that was much lower drug concentration than those of NFX(0.25 - 1.0 ㎍/㎖) and PC(0.5 - 16.0㎍/㎖).
천연 점토질 재료를 이용한 고실리카 제올라이트의 합성에 관한 연구
구경완,임경천,황재효 永同大學校 1999 硏究論叢 Vol.5 No.1
본 논문에서는 천연 고령토로 고실리카 제오라이트인 ZSM-5를 합성하는 방법을 제안한다. 합성시, 알칼리 종으로 KOH를 첨가하였다. 또한, ZSM-5의 합성을 위해 회전반응을 수행하는 원통형 합성장치를 제작하였다. 이 장치는 회전속도 및 반응온도를 제어할 수 있도록 설계되었다. ZSM-5의 합성영역을 밝히기 위하여 SiO_2/Al_2O_3의 몰비와 K_2O/SiO_2를 조절하였다. 그 결과, 몰비에 대응하는 결정생성물의 영역 및 ZSM-5의 합성영역을 밝혔다. In this paper, a synthesis method of high silica zeolite (ZSM-5) using Koryung clay from Kyungnam Province is proposed. We select KOH as alkali seed. We fabricate the synthesis apparatus which attends rotative reaction. The synthesis apparatus controls rotation speed and reaction temperature. To reveal the synthesis range of ZSM-5, we adopt various mole ratio of SiO_2/Al_2O_3 and K_2O/SiO_2. As the results, synthesis range of ZSM-5 which corresponds to mole ratio is appeared.
이관복,박승춘,한경오,윤호인 충남대학교 수의과대학 동물의과학연구소 1994 動物醫科學硏究誌 Vol.1 No.-
It is important to study the activity of drug biotransformation enzymes, because from a pharmacological and therapeutic point of view these enzymes are resposible for eliminating most drugs. Their level is ciritical when deciding the dose regimen. (From a toxicological perspective, the role of these enzymes varies, with some of them being directly responsible for activation of certain chemicals to reactive intermediates with deleterious consequence to the animal.) Experiments were designed to measure in vitro, the activity of drug metabolizing enzymes in liver of Korean native cattle. The microsomal monooxygenase activities were evaluated utilizing specific substrates. The activities of BPDM and TST 6β-hydroxylase were seemed to be high level relatively to other monooxygenzses such as ECOD, EROD and AH. Interestingly, TST 16α-hydroxylase which is a maker enzyme for CYP ⅠLA was not detected in Korean native cattle. These results sugest that Korean native cattle have high contents of CYP IIB1 and CYP IIIA.
그람양성구균에 대한 Teicoplanin과 Vancomycin의 시험관내 항균력
최태열,김경숙,전용관,서일혜,김정욱,이웅수,안정열,김홍석,정재용,최효선,김덕언,유진우 대한감염학회 1994 감염 Vol.26 No.1
An increasing frequency of methicillin resistant S. aureus(MRSA), methicillin resistant coagulase negative staphylococci(MRCNS) and Enterococcal infection have been observed in recent years. Teicoplanin is a new glycopeptide antibiotic obstained from the Actinoplanes teicomycetius. The molecular structure and spectrum of antimicrobial activity of teicoplanin is simillar to those of vancomycin, and has been reported to have an excellent in vitro and in vivo effect against various gram-positive infections. Therefore, we evaluated the in vitor susceptibility of gram positive cocci, such as, S. aureus, coagulase negative Staphylococci(CNS), and Enterococci to teicoplanin and vancomycin. The total 253 strains consisted of MSSA(40), MRSA(53), MSCNS(47), MRCNS(48), and Enterococci(65). They were assayed by disc diffusion and agar dilution. During the study, 57% of S. aureus and 49% of CNS showed resistance to methicillin. The inhibitory diameter of teicoplanin was 15-20mm in MSSA, 12-19mm in MRSA, 13-24mm in MSCNS, 11-23mm in MRCNS, and 15-22mm in Enterococci respectively, and showed sensitivity in all but 8 strains(3.2%). The range of the minimum inhibitory concentration (MIC) of teicoplanin to MSSA, MRSA, MSCNS, MRCNS and Enterococci were 9.12-2.0㎍/ml, 0.25-2.0㎍/ml, & 0.25-32㎍/ml, 0.12-1.0㎍/ml respectively. One case of S. haemolyticus was resistant to teicoplanin (32㎍/ml) by the agar dilution method. Eight minor (3.2%) and one major(0.4%) error was observed when the MIC and disk diffusion data were correlated with teicoplanin. As for vancomycin the inhibitory diameter was 17-21mm in MSSA, 15-21mm in MRSA, 18-26mm in MSCNS, 18-25mm in MRCNS, and 16-22mm in Enterococci respectively. The range of the MIC of vancomycin to MSSA, MRSA, MSCNS, MRCNS, and Enterococci were 0.25-1.0㎍/ml, 0.25-4.0㎍/ml, 0.5-2.0㎍/ml and 0.5-2.0㎍/ml respectively. One minor error (0.4%) was seen with the vancomycin disk. The MIC90 of MSSA and MRSA exhibited the same results in teicoplanin (1.0㎍/ml, 1.0㎍/ml), and vancomycin(2.0㎍/ml, 2.0㎍/ml). MSCNS and MRCNS exhibited greater MIC90 with teicoplanin(4.0㎍/ml, 8.0㎍/ml) than vancomycin(2.0㎍/ml, 2.0㎍/ml). Incontrase Enterococci were more susceptible to teicoplanin(0.5㎍/ml) than to vancomucin (2.0㎍/ml). Results from this analysis indicated that both teicoplanin and vancomycin were very excellent for gram positive infections, especially those resistant to methicillin.
Kyung Hyo Chun 서울대학교 통일평화연구원 2022 Asian Journal of Peacebuilding Vol.10 No.1
With around 34,000 North Korean defectors having arrived in South Korea (asof June, 2021), perceptions toward them remain ambiguous and unbalanced. Thedominant discourse about North Korean defectors centers on adaptation, andcultural difference is often identified as one of the most challenging obstacles. This article examines how a specific conceptualization of culture is utilized toalienate North Korean defectors, while securing the belief in a single ethnicity ofall Koreans. As a result, North Korean defectors are rendered as cultural other inSouth Korean society. While cultural difference is often believed to be the basis ofdiscrimination for North Korean defectors, this article argues that social prejudiceand discrimination reproduce and reinforce the discourse about cultural differenceof North Korean defectors.
( Kyung Hyo Chun ) 서울대학교 통일평화연구원 2020 Asian Journal of Peacebuilding Vol.8 No.1
This article looks into how media representations of North Korean defectors reproduce the images of North Korean defectors, while paying particular attention to the contrasting voices of North Korean defectors which reflect self-presentation. The media-perpetuated image of North Korean defectors as displaced victims whose memories are mostly clustered around the oppressive regime fails to grasp the intersection of aspiration, determination, and agency of North Korean defectors. The self-presentation of North Korean defectors reveals that they are eager to be in charge of constructing and controlling their own images, which goes beyond hitherto nationalized, gendered, and ethnicized identities. Self-presentation, at the same time, is a product of strategic choices conditioned by social discourse and media representation.
“미역과 콘부”전을 통해 본 접촉지대로서의 한일의 바다
천경효(CHUN, Kyung Hyo) 한국아시아학회 2021 아시아연구 Vol.24 No.3
한국과 일본은 지리적 인접성으로 인해 문화, 종교, 경제적인 면에서 오랜 교류와 접촉의 역사를 지니고 있다. 일본 제국주의의 조선병합과 식민지배로 인해 악화된 양국의 관계는 현재에도 외교, 군사, 경제, 사회, 문화 등 다양한 분야에서 갈등의 양상을 보인다. 한국과 일본을 잇는 바다는 불편한 한일관계 속에서 대립과 침탈의 장으로 인식되어왔고, 특히 독도 영유권과 동해의 명칭을 둘러싸고 벌어진 논쟁 속에서 한일 사이의 바다는 공존과 교류의 장이 아니라, 배타적 소유와 침탈의 대상으로 인식되어왔다. 이 논문은 경계를 넘어서는 바다의 특성에 초점을 맞추어, 한일관계에서 기존의 대립과 이분법적 경쟁의 내러티브를 넘어서는 새로운 관점을 제시하는 대안적 접근의 한 가지로 바다가 제시되는 사례를 살펴본다. 이를 위해 국립민속박물관에서 2019년 10월부터 2020년 2월까지 진행되었던 “미역과 콘부: 바다가 잇는 한일의 일상” 기획전에 초점을 맞추어, 한일의 바다가 갖는 접촉지대로서의 특성을 분석한다. 바다로 이어지는 한일의 해양민속과 어업기술에서 보이는 평행성과 유사성, 그리고 차이성에 대한 전시 분석을 통해, 갈등과 충돌의 장으로 구성되어 온 한일 사이의 바다에 대한 기존의 언어를 넘어서는 해석틀의 가능성을 진단한다. Despite the geographical proximity and long-term interactions between each other, Korea and Japan have continued to build a tangled relationship mainly due to the historical experience of Japanese colonization of Korea (1910-1945). There has been a lot of tension between the two nation-states in diplomatic, military, economic, and sociocultural areas in the recent years, too. In particular, the ocean that mediates the Korean peninsula and the Japanese archipelago has been regarded as a prominent site of conflict and provocation. Territorial disputes around Dokdo/Takeshima and the controversy surrounding the name of the East Sea/Sea of Japan further contributed in turning the ocean into an object for exclusive territoriality and and sovereignty rather than an environment of mutual exchange and coexistence. This article examines exemplary exhibition as an alternative perspective that transcends the hitherto predominant narrative of Korea-Japan relationship that have been based on dichotomous opposition and confrontation. The case in point is a special exhibition of “Miyok and Konbu: A Voyage into Maritime Cultures of Korean and Japan,” which was held at the National Folk Museum of Korea from October, 2019 to February, 2020. This exhibition was a result of long-term collaboration between the National Folk Museum of Korea and the National History Museum of Japan. In examining the special exhibition, the concept of “contact zone” is redefined and applied to the exhibit itself and the cooperation between the curatorial staff of Korea and Japan, to the ecological characteristics of the ocean, and to the maritime culture of Korea and Japan. Focusing on the similarities, parallels, and variations observed in maritime culture of Korea and Japan, this article explores a possibility of a new language that goes beyond the narrative of conflict and tension.