서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

‘임상간호연구’ 학술지 게재논문(1995-2008년)의 연구동향 분석

최명애,정재심,임경춘,김주현,김금순,권정순,김성재,김경희,곽찬영,박광옥,이경은,김을순,이경숙 병원간호사회 2010 임상간호연구 Vol.16 No.2

Purpose: The purpose of this study was to identify the research trend of 341 studies published in Journal of Korean Clinical Nursing Research from 1995 to 2008. Methods: This study was conducted from May to November, 2009. The tool for analysis developed through literature reviews and discussions of researchers consisted of 7 categories such as characteristics of researchers, research designs, subjects, data collection methods, ethical consideration, nursing interventions, and dependent variables. Data were analyzed by frequency and percentage. Results: The mean number of author per study was 4.7, and clinical nurses were the most frequent as the first author (79.7%) and as a corresponding author (67.1%). Quantitative study was 97.6% and nonexperimental study was 51.7%. The most frequently used research designs were quasi-experimental study (73.9%) among experimental studies and survey study (79.1%) among nonexperimental studies. Patients were the most frequent subjects for studies (55.8%). 46.1% of studies gathered data with questionnaire, 57.7% of studies had consent from patients, and 44.3% of studies used nursing skills for nursing interventions, and 60.0% of studies used clinical end points for dependent variables. Conclusion: The research trend of clinical nursing studies shows that clinical nurses mostly perform quasi-experimental researches to solve patients' problem and frequently use nursing skills for nursing intervention and explore the effect of nursing interventions on clinical end points.

자율에이전틀 이용한 침입탐지 시스템

김영균,김성윤,장경훈,김경식 제주대학교 산업기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.1

A networked environment has the possibility of the illegal access to the thread of a network attack. The new IDS(intrusion detection system) using autonomous agent is proposed in this paper, this IDS allow it easily extended, configured and modified, either by adding new components, or by replacing components when they need to be updated.

자율에이전트를 이용한 침입탐지 시스템

김영균,김성윤,장경훈,김경식 濟州大學校 産業技術硏究所 2001 산업기술연구소논문집 Vol.12 No.1

A networked environment has the possibility of thw illegal access to the thread of a network attack. The new IDS(intrusion detection system) using autonomous agent is proposed in this paper. this IDS allow it easily extended. configured ans modified. either by adding new components. or by replacing components when they need to be updated.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

21세기 지식기반 사업을 벤처디자인 전문회사 창업시뮬레이션 연구 : Centering around the Case of the Establishment of a Venture Enterprise, KDI(Kim, Kyung-Hun Design Institute) 벤처기업 KDI(김경훈디자인연구소) 창업 사례를 중심으로

김경훈 한국비쥬얼디자인학회 1999 한국디자인포럼 Vol.4 No.-

In the 21st century knowledge-and-information-oriented age, individual diversity is emphasized, and information acquisition and consumption levels are heightened. This trend of the times refuses to accept the mass production system centering around the competition in price. In consequence, inevitably does come the age of value created in which quality goods are produced by the multikind and small quantitiy production system. Design along with information and communication as 21st century knowledge-based business is gaining ground as a main factor national competitiveness is dependent upon in this age. Accordingly, the purpose of this study is to analyze the process and realities of the establishment of a firm specialized in venture design, both one of knowledge-based business and one factor which decides whether in the knowledge-and-information-oriented age, the millennium, our country will gain ground as one of the leading countries in the world or it will set in the west just like the twilight of the 20th century, and try to pave the way to promote the establishment of design venture required by this age. In a knowledge-based economic society, working methods are more important than working hours, and technical knowledge is more important than general knowledge. Desire for self-achievement is to be stronger than unilateral sense of loyalty to an organization. For the country in which there are many men of great originality who can enhance value added through incessant self-improvement, self-development and self -reformation can secure competitiveness among nations in the upcoming century.

자연휴양림 이용자 요구사항 및 만족

서경석 ( Kyung Seok Seo ),윤성훈 ( Sung Hun Yoon ),김갑열 ( Gab Youl Kim ) 한국감정평가학회 2011 감정평가학논집 Vol.10 No.2

The research was studied about measure how each element affect to recreational forest visitors. And I can provide the useful information for the strategic decision-making to make value-up through characterization and differentiation of recreational forest. Those who use recreational forest were studied. Survey area was divided into five regions; Kyung-gi province, Kang-won province, Chung-chong province, Kyung-sang province and Jeon-ra province. And then national and local governments, individuals were classified as operating principals. Empirical analysis were analyzed by applying the Kano model. The questionnaire was analyzed by statistical methods; for data processing, along with a test of reliability in the measuring tools, frequency analysis. Human services and nature management components of recreational forest were classified as one-dimensional quality. Most users are more concerned about these elements. Recreational forest visitors are more concerned about quality associated with software components rather than hardware components. Recreational forest visitors with high interests and a high level of satisfaction about recreational forest has more concerned about the quality.

전내장역위증에서의 충수염 천공 : a case report 치험1예

안성훈,이경호,김경환,윤영철,김원율,김홍용 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.3

Appendicitis is one of the most common disease in emergency department(ED), but produces perplexing diagnostic problems. A complete understanding of the anatomy, pathophysiology, and presenting signs and symptoms of appendicitis, combined with thorough history and physical examination, will be the most important factors in allowing emergency physician to make the correct diagnosis of appendicitis. Situs inversus totalis is a rare congenital anomaly occurring in every 10,000 to 50,000 people. It's etiology is obscure but apparently dose not influence normal health or life expectancy. We present a case of perforated appendicitis with situs inversus totalis in a 24-year-old woman whose chief complaint was pain on the left lower quadrant of the abdomen. Chest and abdominal X-ray showed situs inversus totalis, but these typical findings of situs inversus totalis were missed before performing abdominal ultrasonography in ED. We must carefully consider whether congenital anomaly is or not by physical examination and X-ray finding. For patients whose diagnosis is less clear, additional diagnostic tool, for instance ultrasonography is recommended in ED.

고삼투압성 비케톤성 상태의 예후인자

안성훈,김양원,김미란,진헌철,안지영,이상래,류석용,김홍용,김성준,이병권,김경환 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2

Background: A hyperosmolar nonketotic state has been known to have a high mortality, and even now, despite this high mortality, only a few studies of this disease have been performed. We studied the prognostic factors for the hyperosmolar nonketotic state. Methods: We retrospectively studied the cases of 40 patients who were in a hypersomolar nonketotic state when admitted to Sanggye Paik Hospital during the 6-year Period from 1995 through 2000. We divided the hyperosmolar nonketotic patients into two groups, the complete recovery group and the incomplete recovery group, and compared the clinical features, the laboratory findings, and the precipitating factors between two groups. Results: 1) A total of 40 patients were studied: 24 in the complete recovery group and 16 patients in the incomplete recovery group. The mortality rate was 32.5%. 2) No significant statistical difference existed among the clinical features of the two groups, except for the sex(p<0.01). 3) Among the laboratory findings of both groups, analysis revealed that the effective osmolarity was significantly higher among those in the incomplete recovery group(p<0.01). Serum sodium concentration was also significantly higher among those in the incomplete recovery group(p<0.01). Serum creatinine was also significantly higher among those in the incomplete recovery group(p<0.05). Serum bicarbonate concentration, on the other hand, was significantly lower among those in that group(p<0.05).4) Infection was identified as the most common precipitating factor(62.5%). Among the precipitating factors of the two groups, there were significant statistical difference in pneumonia, UTI, and inappropriate glucose control. 5) A significant statistical difference existed among the initial level of consciousness of both groups(p<0.05). 6) The only significant independent factor responsible for prognosis of nonketotic hyperosmolar state patients was the sex. Conclusion: The sex was only significant independent prognostic factor of nonketotic hyperosmolar state patients.