생약제제인 이공산(異功散)의 Cisplatin 유도 신장독성 보호 및 항산화 효과

Lee, Kyung-Tae,Ahn, Kyoo-Seok,Chang, Sung-Goo,Oh, Soo-Myung,Jung, Jee-Chang 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung-Tae Lee, Kyoo-Seok Ahn¹, Sung-Goo Chang², Soo-Myung Oh²and Jee-Chang Jung²¹College of Pharmacy, ²Oriental Medicine and ³College of Medicine, and East-West Medical Reserch Institute, Kyung Hee University, Seoul, Korea. Preventive and Antioxidative Effects of Crude Drug Preparation(E-kong-san) on Cisplatin Induced Nephrotoxicity. Proceedings of International Symposium on East-West Medicine, Seoul. 201-211, 1999. -Nephroprotective effects of a crude drug-prearation (E-kong-san) were determined from cisplatin on rabbit kidney proximal tubule and human renal cortical cells by MTT assays and sustained glucose consumption on ciplatin-induced human renal cortical tissue. Levels of creatinine and blood ure nitrogen(BUN) in serum after administration of cisplatin(0.75mg/kg,i.p.) to E-kong-san(0.75g/kg/day,p.o.)-pretreated rats were markedly lower compared to those of cisplatin-treated rats. Moreover, the administration of E-kong-san significantly inhibited the loss of body weight of cisplatin injected rts. These findings suggest that E-kong-san on the cisplatin induced nephrotoxicity led us to investigate whether the effect of this water extract was a result of anti-oxidation. E-kong-san showed strong free radical scavenger activities on 1,1-dipheny1-2picrylhydrazil(DPPH) radical and xanthine/xanthine oxidase(XOD) generated superoxide anion radical(O2-). We further studied the effects of E-kong-san on lipid peroxidation in rat liver microsomes induced by enzymatic and nonenzymatic methods. E-kong-san exhibited significant inhibition on both ascorbic acid/Fe2+and ADP/NADPH/Fe3+ induced lipid peroxidation in rat liver microsomes. Based on these results, we suggest that-E-kong-san attenuate the cisplatin induced cytotoxicity and its mechanism can be eplained by antioxidant.

2자유도 PI 제어기를 이용한 BLDC 전동기의 벡터제어에 관한 연구

이종현,성낙규,이상집,이승환,오봉환,이훈구,한경희 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

This paper describes the speed control method of BLDC Motor using TDOF PI ( Tow-degree of freedom PI ). PI control method generally used has difficulty in efficient speed control because speed response and load torque response interfere each other. It can't decrease the overshoot of motor speed w rm, and shorten the response time of load torque TL, at the same time according to the step alternation of speed reference w rm. Therefore TDOF PI is applied to BLDC Motor in order to supply these weak points of PI control method in this paper. TDOF PI can get the torque characteristic of short response time as well as stable and prompt speed adjustment by separate control for speed response and load torque response. The results from the tests of C program simulation and system construction show that TDOF PI is superior to PI control system in speed adjustment and load torque response.

한 자동차 제조 사업장의 산업재해 분석

이경종,박재범,정호근,김종구 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목 적 : 우리나라 자동차 산업업체의 산업재해 발생 현황을 파악하고 산재예방에 필요한 기초자료를 마련하기 위하여 한 완성 자동차 제조공장에서 1997년도에 발생한 산업재해를 분석하여 다음과 같은 결과를 얻었다. 방 법 : 1년간 산업재해보상보험에 요양 급여를 신청한 근로자들의 재해일지, 건강진단 결과등을 가지고 단면적 연구를 시행하였다. 결 과 : 연령별 재해율은 45-49세 군이 1.6 %로 가장 높았고 35-3971 군이 1.3 %, 40-44세 군, 30-34세 군이 각각 0.9 %, 25-29세 군이 0.6 %, 20-24세 군이 0.4 % 순이며, 근무경력별로는 25년 이상 근로자가 2.7 %으로 가장 높아 연령이 증가할수록, 근무경력이 길수록 재해율이 증가하였다. 작업형태별로는 숙련 작업이 2.3 %로 재해률이 가장 높았고 고정작업이 1.2 % 순 이었다. 작업시간별 발생율은 10-11시(21.4 %)와 오후 2-3시(17.9 %)에 높았다. 요일별로는 금요일(20.5 %), 수요일(17.9 %), 월요일(16.2%), 화요일(15.4 %), 토요일(12.0 %), 목요일(11.1%), 일요일(6.8 %) 순이었다. 월별 발생률은 5월(17.9 %), 3월(11.1 %), 4월(11.1 %) 순으로 봄철이 높았고 8월(10.3 %), 1월(9.4 %) 순이었다. 재해발생 부위는 허리가 41.0 %로 가장 많이 많았고, 다음으로 손가락이 17건(14.5 %), 다리(9.4 %), 손(7.7 %), 머리(6.0 %) 순이었다. 손상 종류별로는 염좌가 38.5 %로 가장 많았고 골절(22.2 %), 요추간판 탈출증(11.1 %), 타박상(9.4 %) 순이었다. 재해의 원인으로는 중량물 취급(34.2 %), 전도(17.1 %), 협착(16.2 %), 낙하비래(6.8 %) 순이었다. 결 론 : 자동차 제조업에서는 중량물 취급과 점심식사 전후나 금요일 등 피로한 시간대에 발생이 많은 근골격계 손상에 대한 주의가 필요해 보인다. Objeetives : To know the present conditions of industrial accidents in automobile facto-ries in Korea and make the basic materials essential to prevention of industrial accidents Methods : We reviewed and analyzed the records of industrial accidents occurred in an automobile factory in 1997 by time of occurrence, job categories (fixed production, skilled trades, mechanical material handling, and clerical & technical), type of injury, kind of accident, and location of injury. Results 1. By age groups, the accident rate was the highest in age 45-49(1.6 %) followed by age 35-39(1.3 %), 40-44(0.9 %), 30-34(0.9 %), 25-29(0.6 %), and 20-24(0.4 %) and by working duration, it was highest in group of experience over 25 years, and so we could see that the more age or working duration increases the more accident rate increases. 2. By work time, the accident rate was the highest in 10-11 a. m. (21.4 %) followed by 2-3 p.m. (17.9%). By the day of the week, it was as follows, Friday(20.5 %), Wednesday(17.9%), Monday(16.2 %), Thesday(15.4 %), Saturday(12.0 %), Thursday(11, 1 %), Sunday(6.8 %) in order. By the month, it was high in May(17.9%), March(11.1 %), and April(71.1 %) followed by August(10.3 %) and January(9.4%) , so we could see it was high in spring. 3. The most frequent injury was in the back by 41.0 % followed by 17 cases in fingers(14.5 %), legs(9.4 %), hands(7.7 %), head(6.0 %) In order. And by the type of Injuries, the sprain was most frequent by 38.5% followed by fracture(22.2 %), lumbar HNP(11.1 %), and contusion(9.4 %) in order. The causes of accident were handling heavy materials(34.2 %), upset(17.1 %), stenosis(16.2 %), and falling(6.8 %) in order. Conclusions : By the above results, to prevent the industrial accidents in automobile factories in Korea, preventive activities for handling heavy materials and back and continuous industrial education are necessary.

한국인의 항파상풍 항체 역가

구홍두,최옥경,장석준,정구영,이정운,김승호 대한응급의학회 1993 대한응급의학회지 Vol.4 No.2

Inspite of immunization, TETANUS remains a disease with a high morbidity and mortality rate. Tetanus has been still occurred more frequently in developing countries where immunization programs are inadequate. In Korea, there is a routine immunuzation schedule with diphtheria, pertussis, and tetanus(DPT) vaccines at 2,4,6 month after birth at 18 month. But further prophylactic programs are not exist. Moreover, we have usually used only passive immunization, tetanus antitoxin, as a prophylactic regimen for injured patients instead of guidelines of Center for Disease Control. The purpose of this study was to assess the baseline tetanus immunity state and to suggest the proper immunization schedule and adequate prophylactic guideline for injured patients in Korea. One hundred thirty one trauma patients from emergency department of Severance hospital from September to November of 1993 were included. Antietanus antibody titers of the patients were analyzed by ELISA assay. The mean antitetanus antibody titer was 0.728 ±0.236IU/mL. The titers were diminished rapidly with age. In pediatric group(age under 15), the mean titer was 3.251 ±0.426 IU/mL and in geriatric group(age over 64), the mean titer was 0.007 ±0.002 IU/mL which was below the minimal protective antibody titer(0.01 IU/mL). While all of the pediatric patients have protective antibody titer, only 69.2% of young adults(15-39, n=65), 56.7% of adults(40-64, n=30), and 57.2% of geriatrics(>65, n=14) have protective antibody titer. Our results suggest that tetanus prophylaxis is unnecessary in the age under 14. In other age groups, however, our data strongly support the need of prophyulaxis.

Trimethylamine 및 Ranitidine의 N-산화대사능을 이용하여 측정한 FMO 활성도와 FMO3 유전자형의 상관성

이경훈,성송기,차영남,신상구 大韓臨床藥理學會 2000 臨床藥理學會誌 Vol.8 No.1

한국인 환자에서 Vancomycin의 집단약동학 (Population Pharmacokinetics)에 관한 연구

유경상,배균섭,이주연,조주연,장인진,신상구,신완균 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2

만성신부전 환자에서 Recombinant Human Erythropoietin(rhEPO)의 피하주사시 생체이용율

김경수,이경훈,이영수,김광호,김용식,신상구,박찬웅 大韓臨床藥理學會 1993 臨床藥理學會誌 Vol.1 No.1

오토대제의 제국이념

李景求 전북대사학회 1992 전북사학 Vol.15 No.-

太谿穴의 臨床 活用에 대한 文獻考察

구성태,송문영,강정묵,김용명,박보라,이은석,홍정아,김경식,손인철 한국전통의학연구소 2003 한국전통의학지 Vol.13 No.1

Literally, the mean of Tae-gye is highest brook. And on the basis of the acupuncture theory, Tae-gye point is the Soo earth point and source point of the Kidney Channel as well. In addition, Tae-gye point is one of the Yang-Returning Nine points. We were trying to study bibliographically on the Tae-gye point because Tae-gye point can be used very broadly across the symptoms in the theoretical aspect described above. As a results, we found out that according to the classical books of acupuncture, Tae-gye point is entering point of the Meridian Water as a source point and can be used at both Kidney-Sufficient Syndrom and Kidney-Deficient Syndrom. And Tae-gye can be applied to the disease of kidney or bladder that is urogenital symtoms, Also, Tae-gye is an useful option of tooth-ache, asthma, indigestion, constipation, edema etc whose cause is related with decrease of Kidney ki.

장기재배 시험에 의한 중금속 오염토양의 식물정화

정구복,김원일,이종식,김경민 한국환경농학회 2002 한국환경농학회지 Vol.21 No.1

중금속 오염토양에 대한 식물학적 복원에 적합한 식물종 탐색을 위하여 수목류 5종, 화홰류 2종 및 잔디를 대상으로 제련소인근 중금속 오염지 포장에서 3년간 재배하여 연차별로 식물중에 흡수된 중금속 함량을 조사하였다. 식물의 건물중은 양황철, 팽나무, 적단풍, 사철나무, 회양목 순이었고, 연차별 건물중의 증가도 팽나무, 양황철, 적단풍이 높게 나타났다. 식물의 중금속은 지하부가 지상부보다 높은 함량을 보였으며, 식물중 회양목은 뿌리에서 매우 높게 나타났다. 공시식물의 3년차 총 흡수량은 카드뮴이 양황철, 팽나무, 단풍나무, 구리가 팽나무, 양황철, 회양목, 납이 양황철, 팽나무, 단풍나무, 비소가 회양목, 단풍나무, 양황철 순으로 높게 나타났다. 이상의 결과에서 식물의 건물중과 중금속 흡수량을 볼 때 양황철, 회양목, 단풍나무 및 팽나무 등이 중금속으로 오염된 토양에 대한 정화 식물로 이용할 수 있을 것으로 생각되었다. In order to select proper plants for phytoremediation at heavy metal contaminated areas, eight species of non-edible plants were cultivated at the heavy metal contaminated soils near a metal smelter. The content of the absorbed heavy metals (Cd, Cu, Pb and As) at different part of the plants were analyzed. Plants included five tree species (Populus nigra x P. maximowiczii, Euonymus japonica, Acer palmantum, Celtis sinensis, Buxus microphylla), two flower species (Rhododendron lateritium, Calendula officinalis), and lawn (Zoysia japonica). Biomass yield of tree species was higher than those of flower or lawn species. Heavy metals were highly accumulated in roots compared to those in leaves and stems. The concentrations of Cd, Cu, Pb, and As in Buxus microphylla were greater than those in other plant species. Total absorbed Cd and Pb contents, from high to low by each plant in experimetal plots were in the order of Populus nigra x P. maximowiczii, Celtis sinensis and Acer palmantum. They were Celtis sinensis, Populus nigra x P. maximowiczii and Buxus microphylla for Cu, and Buxus microphylla, Acer palmantum and Populus nigra x P. maximowiczii for As. It was estimated that among eight plant species used in the experiment Populus nigra x P. maximowiczii, Buxus microphylla, Acer palmantum, and Celtis sinensis were the most effective species for phytoremediation in the heavy metals polluted areas considering biomass yield and heavy metal uptake.