Novel diether compounds inhibiting differentiation of osteoclasts

Doh, Kyung Eun,Kang, Ju-Hee,Ting, Zheng,Yim, Mijung,Choo, Hea-Young Park Springer-Verlag 2016 Archives of Pharmacal Research Vol.39 No.2

<P>Osteoporosis is a disorder in which bone mass decreases and is responsible for many degenerative bone diseases. The excessive formation and activity of osteoclasts results in pathological disorders of the bone. Receptor Activator of Nuclear Factor kappa B Ligand (RANKL) is regarded as a key regulator of osteoclast activity and as a new therapeutic target for treating osteoporosis. Herein, we have synthesized several new small molecules and tested their inhibition activity on RANKL-induced osteoclast formation. The active compounds 2c and 4d showed inhibitory activity against RANKL-induced osteoclast differentiation (IC50 = 1.56 and 2.20 mu M, respectively). The most active compound 2c prevented LPS-induced osteoclastogenesis in vivo. These data imply that the compound may be the potential candidate for a new therapeutic drug for treatment of bone resorption-associated diseases.</P>

자녀의 정서표현에 대한 부모의 태도, 남녀 아동의 정서조절 능력 및 사회적 능력간의 관계

김은경(Eun Kyung Kim),도현심(Hyun Sim Doh),김민정(Min Jung Kim),박보경(Bo Kyung Park) 한국아동학회 2007 아동학회지 Vol.28 No.3

1학년세미나의 발전방안 연구 : 연세대학교 사례를 중심으로

이원경(Won Kyung Lee),김은정(Eun Jeong Kim),나정은(Jeong Eun Nah),도경선(Kyung Sun Doh) 한국교양교육학회 2008 교양교육연구 Vol.2 No.1

The purpose of this study is to develop an improved course design for first year seminars, based on the analysis of the effects of first year seminars at Yonsei University. First, this study reviews the background of developing first year seminars such as the demographic changes of college students and the changes of educational settings, and then categorizes various first year seminars into those with structured programs and with individual themes according to their characteristics and purposes. The main section of this study analyzes the effects of Gateway to College (GTC), a structured first year seminar of University College, Yonsei University. This one credit seminar course was devised to help first year students make successful transition to college life and explore their majors and careers. To make it an efficient joint-advising program, GTC was designed as a team teaching course between academic advisors of University College and faculties of related majors. The typical contents of GTC consist of Yonsei spirit, study skills, college life planning, global leadership, and major/career exploration. A part of contents may vary depending on the major and college. We conducted the evaluation surveys from students and instructors at the end of the semester. The results and several suggestions are as follows. First, GTC was an effective course for freshmen to develop a sense of solidarity to Yonsei community, to increase knowledge about majors and careers, and to elevate their motivation for college life. It could be utilized as an efficient sphere of systematic academic advising for freshmen. Second, for the improvement of a structured first year seminar course; themes of seminar courses should be coherent and concrete; the concerns of majors or colleges need to be reflected in the program ; class size needs to be maintained under 50 to achieve better educational outcome; collaborative system between academic advisors and major faculties should be established before the classes begin; peer leaders who had attended the same course could facilitate effective interactions between instructors and students, and also among the students.

Case Reports : Chronic Necrotizing Bronchopulmonary Aspergillosis With Elements of Bronchocentric Granulomatosis

Doh Hyung Kim,Jae Hyun Lee,Byung Ha Kim,Eun Kyung Choi,Jae Seok Park,Keun Youl Kim,Young Hi Choi,Na Hye Myong,Kye Young Lee 대한내과학회 2002 The Korean Journal of Internal Medicine Vol.17 No.2

Chronic necrotizing pulmonary aspergillosis (CNPA) is an unusual form of pulmonary aspergillosis arising in the setting of mildly immune compromised state or altered local defense system. CNPA rarely shows histological findings mimicking bronchocentric gra

유아의 또래관계 증진을 위한 학급 단위 프로그램의 개발 및 효과 검증

도현심,김민정,박보경,황영은 이화여자대학교 생활환경대학 인간생활환경연구소 2007 인간생활환경연구소 논집 Vol.- No.5

The purpose of this study was to develop a program for improving peer relations of preschoolers and to investigate its effectiveness, which was held in the natural setting of a classroom. The contents are consisted of understanding emotion, controlling negative emotion, and improving self-esteem, communication skills, and prosocial behaviors. The participants for the study were 105 4-year-o1d preschoolers who were divided into two groups such as experimental and control groups. Among them, 57 children were assigned for the experimental group, and 48 children for the control group. The experimental group participated in the program for 40-50 minutes per day once a week for 12 weeks during both the spring and fall semesters, while the control group received no treatment. As compared to the control group, children in the experimental group showed a significant increase in peer acceptance after they participated in the program, especially for both semesters.

현재 사용되는 여성 자켓의 사이즈에 관한 연구

도경석,송보형,오명신,오은정,유주연,윤우현,이수미,정선아 연세대학교 생활과학대학 1995 婦學 Vol.28 No.-

약용식물로부터 오이흰가루병에 대한 항균성물질 탐색 및 동정

경석헌,백수봉,도은수,오연선,박병근 한국환경농학회 1994 한국환경농학회지 Vol.13 No.3

50종의 약용식물추출액을 공시하여 횐가루병에 대한 방제효과를 검정하고 생리활성 물질을 분리, 동정하였다. 공시약용식물중에서 대황의 물추출액은 200배의 희석농도에서도 100%의 포자발아억제 효과를 나타내서 가장 효과가 있었고, 대황의 물추출액 50배, 알콜추출액 100배, 조물질 500배, 표준품 1000배 희석농도까지도 60%이상의 발병억제효과가 있었으며, 조물질 500배액에서 2회 이상 살포하면 100% 발병억제 효과가 있었다. 그리고 조물질 100배 액에서는 약해가 있었으나 500배액에서는 약해가 없었다. 대황에 함유되어 있는 생리활성물질은 anthraquinone유도체인 1,8-dihydroxy-3-methyl-9,10-anthracenedione과 1,8-dihydroxy-3-methoxy-6-menthyl-9,10-anthracenedione으로 잠정 동정되었다. This experiment was conducted to test the fungicidal activity of extracts from 50 medicinal plants to powdery mildew (Sphaerotheca fulinginea) and identify the bioactive substances. Among the medicinal plants tested, the water extract of Rheum undulatum was the most effective in spore germination inhibition, which inhibited by 100% at 200-fold dilution. Also, 50-fold dilution of water extract, 100-fold dilution of alcohol extract, 500-fold dilution of crude extract from Rheum undulatum and even 1000-fold dilution of reference chemical inhibited powdery mildew of cucumber more than 60%. 500-fold dilution of crude extract inhibited powdery mildew of cucumber 100% by twice spray treatment. There was phytotoxcity at the 100-fold dilution, but was not recognized this injury at the 500-fold dilution of crude extract. From our research to identify bioactive substance using HPLC, GLC and Mass spectrum analysis, it indicated that Rheum undulatum extract contained tentatively 1,8-dihydroxy-3-methyl-9,10-anthracenedione and 1,8-dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione.

아동이 지각한 부모의 양육행동과 남녀 아동의 공격성 및 친사회성간의 관계

도현심(Doh Hyun-Sim),김민정(Kim Min-Jung),박보경(Park Bo-Kyung),황영은(Hwang Young-Eun) 가정과삶의질학회 2005 가정과삶의질연구 Vol.23 No.3

임신기 부부의 첫 부모됨 적응과정에 대한 근거이론 연구

김은혜 ( Eun Hye Kim ),이선희 ( Sun Hee Rhee ),이운경 ( Woon Kyung Lee ),김민주 ( Minjoo Kim ),도현심 ( Hyun-sim Doh ) 한국가족복지학회 2017 한국가족복지학 Vol.22 No.1

The purpose of this study was to examine first-time pregnant couples` adaptation processes to parenthood by using the grounded theory approach. The participants were six pregnant couples who were experiencing pregnancy for the first time in their lives. Data were collected through individual in-depth interviews, and then analyzed through the processes of open coding, axial coding, and selective coding based on the grounded theory method. As a result of open coding, thirty concepts, eighteen subcategories, and seven categories were discovered. Following the paradigm analysis of the axial coding, causal conditions, contextual conditions, phenomenon, intervention conditions, and action/interaction strategies that lead to the consequence of “adjustment to parenthood” were analyzed. “Overcoming conflicts during first-time pregnancy and positive adjustment to parenthood” was suggested as the core category after selective coding was carried out. The two types of the adaptation processes were the “gradual adjustment type” and the “active change type.” The results of this study can be used as a basis for developing parent education and family relationship programs for first-time pregnant couples as well as for improving understanding of them.

대도시 상점가 간판 언어의 양상과 특성

노석은 ( Seok Eun Noh ),차준경 ( Joon-kyung Cha ),도원영 ( Won-young Doh ) 한민족문화학회 2016 한민족문화연구 Vol.54 No.-

이 논문은 서울을 비롯한 전국 대도시 상점가의 간판을 대상으로 그언어 사용 실태를 조사하는 것을 목적으로 한다. 2014년 7월부터 8월까지의 전국 13곳의 중심 상점가의 간판 언어를 조사하였으며, 각 지역별3,000건의 간판을 수집하여 총 39,566건의 간판을 연구대상으로 하였다. 먼저, 간판을 주표제와 부표제로 나누어 주표제를 대상으로 하여 간판에 사용된 언어의 어종, 어원, 구조, 문자에 대해 조사하였다. 첫째, 간판의 어종은 고유어, 한자어, 외래어(외국어), 혼종어, 기타로 구분할수 있다. 전체 39,564건의 간판 중 고유어 간판은 2,089개, 한자어 간판은 8,948개, 외래어 간판은 553개, 외국어 간판은 11,715개, 두 개 이상의 언어가 섞인 혼종어 간판은 16,215개, 기타 간판이 44개로 나타났다. 둘째, 간판에 쓰인 언어는 모두 33개다. 총 12,268개의 외래어.외국어중 영어는 10,527개로 85.81%이다. 혼종어에 쓰인 어휘를 제외하고 살펴본 결과 프랑스어 572개, 일본어 508개, 이탈리아어 266개, 독일어91개, 스페인어 86개, 베트남어 41개 순으로 나타났다. 셋째, 간판 언어의 구조를 단어, 구, 절, 문장, 담화로 구분하였다. 그중 단어(94.9%),구(4.6%), 절(0.3%), 담화(0.037%) 순서로 나타났으며, 단어가 가장 많이 출현하였다. 넷째, 간판 언어의 표기문자를 분석하면 어원과 상관없이 모두 한글로 적은 것은 66%이고 로마자가 25%, 여러 문자가 섞여 있는 것이 6.73%였다. 한자는 0.02%, 일본의 가나문자는 0.0033%이다. 간판 언어의 분석을 통해 알 수 있는 것은, 첫째, 간판 언어에 비규범적 표기나 표현을 사용한 간판이 증가하고 있다는 점이다. 둘째, 중의적인 간판, 상호명을 사용하는 것이다. 상점주들이 상호명을 지을 때 두가지 이상의 의미를 담아 여러 표현 방식으로 나타내는 경우가 많다. 셋째, 간판에 쓰인 언어는 매우 다양하다. 복잡한 문자구조를 가지거나 어원이 다양하며, 표현적으로 다양한 간판이 많다. 넷째, 간판은 시대상을 반영한다. 새로 만들어지는 간판은 신어나 유행어들이 적극적으로 반영된다. 또한 상점이 문을 열 당시의 언어상황을 반영한다. 이러한 간판언어에는 시대상, 언어상 등이 반영되므로 사회언어학적으로 연구의 의의가 있을 것이다. In this paper, We need to study the language of signboard. We have surveyed 39,566 cases, each 3,000 stores of 13 cities of Korea in 2014. The language of signboards are also mixed and confused by native Korean words 2,089(5.2%), sino-Chinese words 8,948(22.6%), borrowing words 553(1.3%) and non-Korean words 11,715(29.6%). The 88% of borrowing w ords are the English, French, Unidentified words, German, Konglish, Italian, and etc. The Linguistic units of signboard name are word, phrase, clause, sentence, and text. The ratio of word type is 94.9%, phrase type is 4.6%, sentence type is 0.3% and text type is 0.037%. The letter types of signboard are Hangeul, Chinese letter, Roman alphabet, Japanese letter, and etc.. The ratio of Hangeul type is 67%, Roman alphabet type 28%, Chinese letter type 0.02%, Japanese letter type 0.003%. In this analysis of signboard languages, first, there are many ungrammatical expressions in signboard languages. Second, signboard languages and business names are ambiguous. Third, the structure of signboard languages are various, there are so many complicated structure and etymology. Fourth, Signboard languages reflect the phase of times. Especially newly-coined words and popular words are reflected