브루셀라균에 노출된 미생물 검사실 직원들에 대한 예방적 항생제 요법과 혈청학적 추적검사

이창섭,이혜수,이재현,박진희,최영실,황규잠,이흥범 대한감염학회 2008 감염과 화학요법 Vol.40 No.2

The aerozolization is one of possible Brucella transmission mechanisms, particularly in air-borne exposed laboratory workers. In this study, seven laboratory workers were potentially exposed to B. abortus via aerosols. Two laboratory workers who sniffed an agar plate several times were considered to be at high risk for acquiring the disease, 5 workers who did not work directly with the strain were be considered at low risk of infection. Prophylactic antibiotics of doxycycline 200 mg/day and rifampin 600 mg/day were offered for 6 weeks in high risk workers and 3 weeks for low risk workers respectively. Enrolled workers were advised to check for serological testing of Brucella species every 3 weeks during a total period of 12 weeks. Compliance with taking medicine was 57.1% (4/7) and compliance for completing the serological tests was 85.7% (6/7). None of the laboratory workers developed clinical disease or tested positive serologically during 3 months of seroloaical testing and 1 year of clinical follow-up.

급성백혈병의 화학요법에서 조혈간세포 보충요법

이규보,배선근,손상균,이재태,이건수,이경혜,서장수 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1

1. 목적 급성백혈병의 화학요법에 있어서 관해유도 요법시에 보다 더 강력한 항암화학요법을 시행하고 골수억제의 회복을 위하여 말초혈액에서 채취한 조혈모세포의 투여로 그 효과를 증대시키고자 시도하였다. 2. 방법 관해유도 화학요법후에 골수억제시기로부터 회복단계로서 백혈구감소증이 호전도면서 단핵세포가 증가될 때에 말초혈액에서 조혈간세포(stem cell)로 인정되고 있는 CD34+세포의 함유량이 1% 이상되는 시기를 찾아내고 그 때부터 평균 4차례의 단핵구를 분리채집을 하여 -74。C에 냉동보관하였다가 제2차 화학요법후에 해동시켜서 정맥주입하였다. 3. 결과 대상 급성백혈병환자는 6명에 23회의 조혈간세포를 함유한 단핵구 채집을 시행하였고 유효한 단핵구의 채집은 4례에서 가능하였고 2례에서는 유효한 채집이 못되었다. 채집효율은 39.0-74.5%로서 평균 49.8%였다. 채집 후에 혈액학적 변화는 혈색소의 약간 감소 (평균 1.34g/dl)와 혈소판의 감소 (평균20.25%)를 나타내었다. 해동 단핵구를 투여할시에 일과성인 불쾌감, 기침, 흉부압박감, 호흡곤란 등이 있었다. 4. 결론 자가골수이식에서 자기말초혈액조혈간세포이식으로 관심이 이행되는 현시점에 자가조혈간세포를 채집하여 수혈하는 기술이 확립되는 기초를 이루었다고 본다. 이번 대상들은 재발된 금성백혈병들에 시행하였으나, 향후에는 초발시에 제일차 관해유도 화학요법 과정에 시도해야할 것으로 생각한다. Object: Peripheral blood stem cells(PBSC) were collected after remission induction chemotherapy and reinfused after intensified chemotherapy in order to increase the chemotherapeutic efficacy. Method: Collection of mononuclear cells (MNC) was started when CD34+ cells above 1% and WBC above 1,000/ul with mononuclear cell percentage above 30%, the collection procedures were done 2-6 time in each patient of total 6 cases. The collected MNCs were stored in - 750C and reinfused after thawing in the water bath at 370C Results: Twenty three collection procedures from the 6 cases of acute leukemia had made effective MNC collection in 4 cases and mean collection efficiency was 49.8%(from 39.0% to 74.5%). Hematological changes after the procedure were mean reduction of hemoglobin 1.34g/dl and mean 20.25% of decreased platelet count. There were noticed transient symptoms of discomfort, coughing, chest tightness and dyspnea in association with the infusion of stored cells. Conclusion: The basic process for the peripheral blood stem cell transplantation (PBSCT) was accomplished with this supportive care for the consolidation chemotherapy of acute leukemia. Effective PBSCT would be warrented with more qualified process and high does chemotherapy. (Korean J Blood Transfus 6(2) : 41~47,1995)

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

상악 6전치부의 후방견인시 저항중심의 수직적 위치에 관한 3차원 유한요소법적 연구

이혜경,정규림 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.4

이 연구는 3차원 유한요소법을 이용하여 상악 6전치부에 피질골 절단술을 시행한 경우와 시행하지 않은 경우에서 상악 6전치부를 하나의 단위로 하여 다양한 후방견인력을 가하였을 때 상악 6전치의 초기 치아이동을 통하여 저항중심의 수직적 위치를 계측, 비교하고 저항중심의 변화양상을 관찰하며, 힘의 크기변화에 따른 저항중심의 위치변화양상을 분석하기 위하여 시행되었다. 상악 6전치와 치주인대 및 치조골의 3차원 유한요소모델을 제작한 후, 상악 6전치부에 부착된 설측장치와 이 장치가 부착된 치아군을 한 개의 견고한 연결체로 가정하였다. 유한요소모델에서 사용된 전체요소의 수는 14,584개, 전체 절점의 수는 17,292 개였고, 힘 체계의 분석을 위해 미국 Swanson Analysis System사의 범용 유한요소 프로그램인 AN-SYS(Ver. 5.5A)를 사용하였다 저항중심은 힘이 가해질 때 치아가 평행 이동될 수 있는 힘의 적용부위라 정의하고, 설측 장치에서 연장된 Extension arm의 7개의 Level에 편측당 각각 200 gm, 250 gm, 300 gm, 350 gm의 설측 후방견인력을 가하였을 때 치아의 절단연과 치근첨에서의 변위를 읽어 평행이동이 일어나는 위치를 복원법으로 계산하여 저항중심의 위치를 계측, 분석하여 다음과 같은 결과를 얻었다. 1.상악 6전치부의 초기치아이동에서 저항중심의 수직적 위치는 Level 4와 Level 5사이, 즉 치경부에서 치근단 쪽으로 6.76 mm, 44.32% 떨어진 거리에 위치하였다. 2.피질골 절단술 시행후, 상악 6전치부의 후방 견인시 저항중심의 수직적위치는 Level 4와 Level 5사이, 즉 치경부에서 치근단 쪽으로 7.09 mm, 46.38%떨어진 거리에 위치하였다. 3.후방견인력의 크기가 커짐에 따라 치아의 변위량은 커졌으나, 피질골 절단술 시행 유무에 관계없이 후방견인력의 크기변화는 저항중심의 수직적 위치에 별다른 영향을 미치지 않았다. 4.피질골 절단술 시행시에 저항 중심의 수직적 위치는 치근단 쪽으로 이동하였고, 그 변위량은 피질골 절단술 시행시가 컸다. 이상의 결과로 볼 때 상악 6전치부 후방견인시 저항중심의 수직적 위치는 치경부에서 치근단 쪽으로 치근길이의 44.32%떨어진 거리에 위치하였고, 피질골 절단술 시행시에 저항중심의 수직적 위치는 치경부에서 치근단 쪽으로 치근길이의 46.38% 떨어진 거리에 위치하여 피질골 절단술 시행하지 않은 경우보다 치근단 쪽으로 이동되었으며, 후방견인력의 크기 변화에 따라 저항 중심의 수직적 위치는 변하지 않았다. (주요 단어 : 저항 중심, 상악 6전치부 후방견인, 3차원 유한요소법, 피질골 절단술) The delivery of optimal orthodontic treatment is greatly influenced by clinician's ability to predict and control tooth movement by applying well-known force system to dentition. It is very important to determine the location of the centers of resistance of a tooth or teeth in order to have better understanding the nature of displacement characteristics under various force levels. In this study, three dimensional finite element analysis was used to measure the initial displacement of the consolidated teeth under loading. The purpose of this study was to define the location of the centers of resistance at the upper six anterior segment. To observe the changes of six anterior segment, 200gm, 250gm, 300gm, and 350gm forces at right and left hand side each were imposed toward lingual direction. For this study, two cases, six anterior teeth and six anterior teeth after corticotomy, were reviewed. In addition, it was reviewed the effects of changes on the location of the center of resistance in both cases based on different degree of forces aforementioned. The results were that : 1.The Instantaneous center of resistance for the six anterior teeth was vertically located between level 4 and level 5, which is, at 6.76mm, 44.32 % apical to the cementoenamel junction revel. 2.The instantaneous center of resistance for the six anterior teeth after corticotomy was located vertically between level 4 and level 5, that is, at 7.09mm, 46.38% apical to the cementoenamel junction level. 3.Changes of force showed little effect on the location of the center of resistance in each case. 4.It was observed that the location of the instantaneous center of resistance for the six anterior teeth after corticotomy was changed more than the six anterior teeth without corticotomy to the apical part, and the displacement of the consolidated anterior teeth moved further in case of the consolidated teeth after corticotomy. ※Key words : Center of resistance, Maxillary six anterior teeth retraction, Three dimensional finite element analysis, Corticotomy.

척추수술환자에서 급성 동량성 혈액희석 및 유도저혈압을 병용한 마취관리

이규탁,민진혜,정창우 관동대학교 의과학연구소 2000 關東醫大學術誌 Vol.4 No.1

Due to the discovery that blood transfusion can evoked several side effects, there has been increased interest in technologies that reduce the amount of homologous blood used during and after surgery. Acute normovolemic hemodilution is known as a convinient and effective blood conservation method, and drug-induced hypotension can reduce the amount of intraoperative bleeding with better operative field. Combination of these two techniques was suggested to reduce homologous blood requirements in various surgeries. Therefore, to minimize homologous blood transfusion, we conducted general anesthesia using acute normovolemic hemodilution combined with induced hypotension in patient undergoing spinal fusion surgery. We think that the routine careful combination of these techniques can be carried out safely in many surgeries.

2-Methylbutyryl-CoA Dehydrogenase 결핍 1례

이문숙,박호진,이인규,최규철,윤혜란 대한소아과학회 2004 小兒科 Vol.47 No.1

한국인 집단의 DXYS17 좌위 초변이성의 유전적 특성

이하규,신혜원 가톨릭대학교 자연과학연구소 1996 자연과학논문집 Vol.17 No.-

인간의 게놈(genome)내에는 특정 염기서열의 반복 횟수의 차이에 따라 높은 변이성이 나타나는 부위가 있는데, 이런 반복염기 배열들을 초변이성 부위(variable number of tandem repeat ; VNTR)라 한다. 이 VNTR 마커들은 연관분석, 개체 동정이나 친자 확인을 포함한 법의학 분야 뿐만 아니라 집단유전학 연구에 상당히 유용하다. 본 연구에서는 DXYS17 VNTR 좌위에 대해 PCR방법을 이용하여 100명을 대상으로 연구한 결과, 대립유전자 빈도 분포는 대립유전자 18(7.5%)과 27-28(각각 21.5%)이 높은 빈도로 나타났으며, 95% 신뢰구간(confidence interval)을 조사한 결과 모든 대립유전자들은 구간내에 포함되었다. PIC(polymorphism information content)값은 0.85로 다형성이 높은 것으로 나타났으며, 친자확인시 이용되는 POE(power of exclusion)값은 0.68로 관찰되었으며, 개체동정시 이용되는 MP(matching probability)는 0.03으로 유용성이 높은 마커로 판명되었다. VNTR (variable number tandem repeat) loci in the genome are characterized as their copy number of the same repeat unit and are extremely polymorphic having potentially hundreds of alleles at a single locus. In this study, allele distribution on the DXYS17 VNTR marker was analyzed by PCR (polymerase chain reaction) in Korean population (100 individuals). Sixteen alleles were identified in the DXYS17 VNTR locus and alleles 27 (21.5%) and 28 (21.5%) showed highest peaks. The allele frequency of DXYS17 VNTR locus is in the 95 % confidence interval. PIC (polymorphism information content) value calculated on DXYS17 VNTR loci was 0.85. POE (power of exclusion) value used in paternity cases was 0.68. MP (matching probability) used in forensic identification was 0.03. In conclusion, statistical data from DXYS17 VNTR locus showed this locus is a very useful genetic marker for the linkage study, evolutionary genetics and forensic application.

우편 집중국 수구분 작업 개선에 대한 연구

이해원,김인수,김혜규,최호식,김기동 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.A

Recently, the public postal service of Korea confronts with business environment changes such as the opening of postal market and appearance of the domestic competitive enterprises. It is the current state that the public postal service of Korea should have a competitive edge by the productivity improvement of business processes. In this paper, we proposed new working tables for manual letter sorting which is one of the important process in mail center. We suggested standard working method and standard time in a mail center Based on these, we established the procedure for setting up a fair day's work in other mail centers. By the result of this research, we expect that the productivity of the mail sorting operation will be increased.

골밀도 검사에서 골다공증의 관련인자 분석

김혜완,김희상,안경회,김덕윤,이규훈,황치문 大韓再活醫學會 1999 Annals of Rehabilitation Medicine Vol.23 No.1

비전 변형률 측정 시스템을 이용한 마이크로 박판소재의 물성평가 기술

이혜진,이낙규,최석우,이근안,신준희,김태주,주은덕 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

This paper is concerned with the precision material property measurement of a micro metal thin foil (Ni-99.9%) that is used in MEMS technology. Since these MEMS components require great precision and accuracy, evaluation of reliability such as the life cycle endurance test, impact test, and residual stress test is necessary for these components. However, in practice, real reliability tests are not easy to perform due to consideration of various factors. Rather than actual testing, it would be much easier to evaluate the reliability of components by the analytical approach. Although the analytical method is utilized by numerical software tools, it is obviously necessary to acquire fundamental properties of materials through real test methods. But the acquisition method of micro strain data is so difficult in micro tensile testing, because the micro tensile testing specimen has several micros thickness and small size of shape. So we research on the measurement method of micro strain data using a vision image analysis.