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한주은,강경아 대한류마티스 건강전문학회 2000 근관절건강학회지 Vol.7 No.1
The arthritis patients suffer from psychological, social and spiritual problems as well as physical problems because the arthritis is not curable and has chronic pain, joint deformity, limitation of activity and physical dysfunction for all of his life. Especially if they do not fond the meaning in their lives, they will experience spiritual distress seriously. Therefore, it is important that nurses help the patients to find the meaning in their lives and to reduce spiritual distress. The purpose of this study is to provide a basis for nursing intervention strategies to minimize the arthritis patients' spiritual distress and understand the relationship between the meaning of life and the spiritual distress in arthritis patients. The samples were composed of 157 arthritis patients. Data collection was carried out from October 1, 1998 to February 28, 1999. Data were analyzed using a SAS Program for descriptive statistic, Pearson correlation, t-test, ANOVA, linear regression. The results were as follow, 1. The scores on the meaning of life scale ranged from 51 to 130 with a mean of 93. 2. The scores on the spiritual distress scale ranged from 26 to 91 with a mean of 60. 3. There were significant correlations between the meaning of life and the spiritual distress(r=.53, p=.00). 4. The linear regression analysis showed that the meaning of life explained 13% of the spiritual distress. 5. In the degree of the meaning of life and the spiritual distress according to the general characteristics, the level of the meaning of life in arthritis patients was different by the duration of incidence(F=2.71, p=.03). In conclusion, the nursing intervention strategies to reduce the spiritual distress in arthritis patients must take into account the meaning of life.
인체 간 Microsome에서의 우슬 추출물의 Cytochrome P450 약물 대사효소에 대한 억제작용
김경아,이지숙,박히준,김진우,김창주,심인섭,한승무,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-
Objective : Achyranthes bidentata radix (Usul) has been used as anti-arthritic, antiallergic, antidiuretic and so on Recently extracts of Achyranthes bidentata radix have shown anti-inflammatory and cancer preventive effects in vitro and in vivo. Methods : We therefore evaluated the inhibitory potential of ehtanol extracts of Achyranthes bidentata radix on cytochrome P450(CYP) isoforms-catalyzecd reactions, which relate to causes of cancer and inflammation, including CYP1A2, CYP2C9, CYP2C19, CYP2E1, CYP2D6, CYP2C8, and CYP3A4, using human liver microsomal preparations. Results : The extracts showed weak or negligible inhibitory effects on CYP2C9-catalyzed (S)-warfarin 7-hydroxylation, CYP2C19-catalyzed S-mephenytoin 4-hydroxylation, and CYP2D6-catalyzed dextromethorphan O-demethylation with each IC50 over 1750 g/㎖, respectively. However, it showed relatively significant inhibitory effect on CYP1A2-catalyzed phenacetin O-deethylation and CYP2E1-catalyzed chloizoxazone 6-hydroxylation with IC50s of 970.5 g/㎖ and 821.4 g/㎖, respectively. Conclusions : These results suggest that extracts of Achyranthes bidentata radix have inhibitory effects on CYP-catalyzed reactions, expeciallyCYP1A2 and CYP2E1, in human liver microsomes. These effects appear to relate to anti-inflammatory and cancer prevention following decrease of reactive oxygen species formed by CYP, especially CYP1A2 and CYP2E1, by Achyranthes bidentata radix. However, further evaluation is necessary to demonstrate and to confirm its effects in human.
RAW 264.7 세포에 대한 중국산 천연 광물성 섬유 TAFMAG의 독성효과
임영,한진구,김지홍,김현욱,김은경,김경아,장황신 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.3
Objectives : This study was designed to evaluate cytotoxicity of TAFMAG, which is a trade name of natural mineral fiber mined and produced in China. Methods : The cytotoxicity of TAFMAG was evaluated by measuring iron content, lipid peroxidation, erythrocyte hemolysis, and cytotoxicity in vitro. These results were compared with the data of chrystotile and wollastonite as a positive and negative control, respectively. Results : There was significant increase of Fenton activity in TAFMAG and chrysotile with dose-response pattern. The iron chelating agent, desferrioxamine, significantly decreased Fenton activity of the particulates except wollastonite. TAFMAG and chrysotile fibers significantly increased malondialdehyde concentration from lipid peroxidation of the red blood cell membrane. In erythrocyte hemolysis test, TAFMAG & chrysotile had stronger effect on erythrocyte hemolysis than wollastonite with the concentration of 1,000g/ml. Furthermore, TAFMAG was more hemolytic than chrysotile with the concentration of 5,000g/ml. There was a significant cytotoxic effect in TAFMAG and chrysotile on RAW cell compared with wollastonite. Conclusions : In vitro study suggested that TAFMAG may have a similar health hazard as usual asbestos.
( Kyoung Ah Han ),( Hyun Jung Kim ),( Hyo Jin Byon ),( Jin Tae Kim ),( Hee Soo Kim ),( Chong Sung Kim ),( Seong Deok Kim ) 대한마취과학회 2010 Korean Journal of Anesthesiology Vol.59 No.2
Tension pneumothorax during ventilating bronchoscopy for foreign body removal is a rare but life-threatening complication. The authors present a case of cardiac arrest caused by tension pneumothorax in a 9-month-old girl who underwent ventilating bronchoscopy for foreign body (peanut) removal. Tension pneumothorax was due to tracheobronchial lacerations caused by a bronchoscope. The patient was successfully resuscitated by cardiopulmonary resuscitation and chest tube insertion. The airway injury was effectively repaired by thoracotomy under extracorporeal membrane oxygenation. (Korean J Anesthesiol 2010; 59: 123-126)
체외수정 후 일측 두개 뇌류를 동반한 쌍태 임신에서 임신 중반기 선택적 유산
한경희 ( Kyoung Hee Han ),한혁동 ( Hyuk Dong Han ),홍민 ( Min Hong ),이향아 ( Hyang Ah Lee ),정진경 ( Jin Kyung Chung ),김나옥 ( Na Ok Kim ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.2
Selective termination can be used to preserve normal fetus from the other fetus with chromosomal, structural abnormality in multifetal pregnancy. This case is about twin pregnant patient who had undergone in vitro fertilization and embryo transfer. In 18
치료교육의 실태 및 개선방안 연구 : Issues and Future Delivery System
안수경,김영태,전헌선,정동일,한현민 국립특수교육원 2005 연구보고서 Vol.- No.5
본 연구는 2005년 3월 특수교육진흥법 개정에 의하여 특수학교 치료교육교사의 확대배치 및 일반학교 특수학급에의 치료교육 담당교원 배치 등 치료교육 분야의 발전이 예상되는 가운데, 개정법률이 실제 교육현장에 보다 실효성있게 적용되기 위하여 우리나라 특수교육 공교육 상에서 이루어지고 있는 치료교육활동의 실태와 요구를 파악하고 보다 적합한 치료교육을 위한 개선방안을 찾고자 한 정책연구이다. 이를 위하여 본 연구에서는 치료교육의 개념, 역사, 외국 사례 등에 관한 문헌을 탐색하였으며, 설문조사를 통하여 치료교육의 실태와 요구를 분석하였고, 이를 바탕으로 한 치료교육의 개선방안을 도출하였다. 본 연구의 설문조사를 위하여 전국의 142개 특수학교와 182개 지역교육청을 대표하는 1,078명의 교사들로 조사단을 구성하여 설문지를 배부하였다. 그 결과 전국의 16개 시·도교육청에 소속된 142개 특수학교 중 140개 특수학교에서 설문응답에 참여하였으며, 182개 모든 지역교육청에 소속된 교사들이 설문응답에 참여하여, 총 1,046부의 설문지가 수합되었음을 밝힌다. 이 조사를 통하여 치료교육 담당인력의 양적 부족, 치료교육의 내용과 형식에 대한 합의 부족으로 인한 교육실제 상의 혼란이 현 특수학교 치료교육의 대표적인 문제로 제기되었으며, 특수아동 요구의 다양성과 치료교육의 효과성을 동시에 충족하기 위한 치료교육 담당교원의 자격제도 및 배치방법의 해결과 치료교육을 실시하기 위한 공간 확보의 문제가 일반학교 특수학급에서의 치료교육을 위한 주된 요구로 제기되었다. 이와 같은 설문조사의 결과를 바탕으로, 다섯 명의 연구진 중 대학에 재직 중인 세 명의 공동연구자들이 서로 다른 각도에서 치료교육의 문제점과 개선방안을 조명하였다. 따라서 세 가지의 큰 학문적 흐름을 가지고 방안이 주창되었으나, 그 방안 속에서 논해진 구체적인 하나하나의 제안들은 각자의 학문적 입장에서만이 아니라 다양한 현실적 상황을 고려하여 심사숙고된 결과임을 밝힌다. 마지막으로 본 연구의 맺는 말에서는, 일단은 특수교육진흥법과 특수학교 교육과정에 근거하여 교육서비스로서 행해지고 있는 치료교육 시스템의 견고한 틀 안에서의 개선을 논하는 것이 최선일 것으로 보고, 세 가지 큰 흐름의 방안들에서 최소한의 공통되는 제안들을 다음과 같이 종합하였다. 우선 첫째, 치료교육 교사 양성에 있어서의 전공 분야 세분화가 필요하다. 둘째, 기존의 치료교육 교사들이 세부 전공 영역의 전문성을 가질 수 있도록 하는 보완적 교육이 행해져야 한다. 셋째, 특수교사로서의 치료교육교사에 의한 치료교육 제공을 교실교육과 순회교육을 기본 원칙으로 하되, 순회가 불가능한 지역이나 일반학교 일반학급, 일반 유치원 내의 특수아동들을 위하여 필요한 경우에는 교육기관 외의 기관에 소속되어 있는 치료사 인력들을 활용할 수 있는 권역별 인력풀 제도를 마련한다. 넷째, 특수교육과 치료교육의 관계 및 내용적 정체성 확립을 위한 근본적인 재조명이 필요하다. The purpose of the present study is to investigate the current practice of the therapeutic education in Korea. The survey data were collected and analyzed from 332 therapeutic educators, 367 special school teachers, and 347 special classroom teachers. Results of the present study were summarized and discussed by three of the researchers based on their academic standpoints. The problems of current therapeutic education analyzed by this study are the lack of therapeutic educators, confused understanding of the contents and methods of therapeutic education, low professionalism of the therapeutic educators, and the lack of space to carry out therapeutic education in general schools, etc. The common suggestions from the three researchers were summarized as follows: first, the courses of universities for training therapeutic teachers have to be more specialized. Second, some kind of training programs for the existing therapeutic teachers are needed to get them more specialized certificates. Third, the community human resource pool including not only therapeutic teachers but also professional therapists should be available. Fourth, the identity of the therapeutic education in special education delivery system needs to be reestablished academically and practically.
Two New Phenolic Compounds from the Rhizomes of <i>Gastrodia elata</i> <small>Blume</small>
Han, Ah‐,Reum,Ji ,Shin, Hyun,Rim ,Jeon, Ha,Lee, Je‐,Hyun,Lee, Dongho,Seo, Eun‐,Kyoung WILEY‐VCH Verlag 2011 Helvetica chimica acta Vol.94 No.7
<P><B>Abstract</B></P><P>Phytochemical investigation of the rhizomes of <I>Gastrodia elata</I> <SMALL>Blume</SMALL> (Orchidaceae) led to the isolation and identification of twelve compounds, including two new phenolic compounds, 4‐hydroxybenzyl vanillyl ether (=4‐{[(4‐hydroxyphenyl)methoxy]methyl}‐2‐methoxyphenol; <B>1</B>) and 4‐{{4‐[4‐(methoxymethyl)phenoxy]benzyl}oxy}benzyl methyl ether (=1‐[4‐(methoxymethyl)phenoxy]‐4‐{[4‐(methoxymethyl)phenoxy]methyl}benzene; <B>2</B>). The structures of <B>1</B> and <B>2</B> were elucidated by spectroscopic data analysis including 1D‐ and 2D‐NMR experiments.</P>