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- 저자 : ( Kyoung Ae Nam ) (검색결과 85 건)
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강남이,이경애 서울保健大學 1993 論文集 Vol.13 No.1
This study was performed to investigate the correlation between cognitive function and other relating factors by the blood glucose level of 124 elder1y Koreans aged 60 through 79. Relating factors considered are the socioeconomic status, nutrient and food intake, anthropometric indicators, diabetic symptoms & complications, duration of diabetes, diet therapy, cognitive function subitems. To examine these aspects, data were collected by interviewing 47 males and 77 females living in Seoul at Eulji hospital Diabetic Clinic. Nutrient and food intakes were measured by the 24 hour recall method. First, nutrient and food intake status, anthropometric indicators, cognitive function according to age were investigated. Second, the correlation between cognitive function and dietary intakes were examined. Finally, Degree of cognitive function of diabetic eldely were estimated on different fasting glucose levels. The results of the study are as follows ; 1. Cognitive function was declining in the course of aging, especially rate of decline was greater in female cases. 2. About the correlation between cognitive function and nutrients, more intake of protein, fat, calcium, P, and vit B2 resulted in the higher cognitive function.
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권경주,정성애,심기남,정정화,강석형,송도경,전승정,김혜인 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.1
Until recently, colorectal polyps were classified predominantly as hyperplastic or adenomatous. While adenomatous polyps are well-characterized precursor lesions of adenocarcinomas, hyperplastic polyps have been considered as benign lesion. However, some hyperplastic polyps with serrated morphology of the crypts have been recognized to have distinctive features and these polyps were termed ‘serrated adenomas’. Recent data show that sessile serrated adenomas (SSA) might be the precursors of serrated colonic cancers, underlining the necessity of identifying them. SSA is approximately 3% of all polyps, commonly appears as flat or sessile and yellowish due to mucus production. In the pathogenesis of SSA, progression to high grade dysplasia or early invasive carcinoma may be associated with serrated neoplasia pathway different from adenoma-carcinoma sequence. We report a case with a colon polyp diagnosed as sessile serrated adenoma with high grade dysplasia after endoscopic submucosal dissection.
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Nam E Kang,Ae Wha Ha,Ji Young Kim,Woo Kyoung Kim 한국영양학회 2012 Nutrition Research and Practice Vol.6 No.6
This study attempted to investigate the effects of resveratrol on the differentiation of adipocytes. After cells were treated with various concentrations of resveratrol (0, 10, 20, and 40 μmol/L), adipocyte proliferation, the protein expression of transcription factors, and MMPs’ activities were determined. Cell proliferation was inhibited more within 4 days of incubation (P < 0.05), and lipid accumulation in adipocyte was significantly inhibited by 93.8%, 92.4% and 91.5%, respectively, after two days of 10, 20, and 40 μmol/L resveratrol treatment (P < 0.05). Six days of incubation with the three resveratrol concentrations caused a significantly decreases of 63%, 59.9%, and 25.1% GPDH activity as a dose-dependent response. The triglyceride concentration also decreased significantly with the increase of resveratrol concentration (P < 0.05). The protein expression of CCAAT/enhancer-binding protein (C/EBPβ) was decreased significantly by 56% and 30% while PPARγ was significantly reduced by 57% and 15% with resveratrol treatments of 20 and 40 μmol/L, respectively (P < 0.05). The protein expression of C/EBPα was decreased by 83%, 74%, and 38% to increased dosage levels, with significance determined for this decrease from 20 μmol/L of resveratrol. The protein expression of fatty acid binding protein (FABP4) was decreased significantly by 88%, 72%, and 46% with the increase of resveratrol concentration. The activity of MMP-2 was decreased significantly by 84%, 70%, and 63% while MMP-9 activity was decreased significantly by 74%, 62%, and 39% with the increased resveratrol concentrations of 10, 20, and 40 μmol/L, respectively (P < 0.05).
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Ae Wha Ha,Woo Kyoung Kim,Jung Hwan Kim,Nam E Kang 한국영양학회 2015 Nutrition Research and Practice Vol.9 No.3
BACKGROUD/OBJECTIVES: This study was conducted in order to investigate the effect of peanut sprout extracts (PSE) on health indices in overweight and obese women (BMI ? 23 kg/m²). SUBJECTS/METHODS: Subjects were divided into three groups by double-blind randomized trial; the Placebo group (n = 15) and the Low PSE group (2.6 g PSE/day, n = 15), and the High PSE group (5.8 g PSE/day, n = 15). Subjects consumed 12 capsules per day, three times a day, 30 min before meals, for 4 weeks. Anthropometric data, blood biochemical variables, and dietary intake were evaluated before and after the experiments. RESULTS: In the Low and High PSE group, the waist circumference showed a significant decrease between pre- and post-test. In the Low PSE group, the reduction of systolic blood pressure between pre- and post-test was statistically significant. Serum LDL or triglyceride levels in both Low and High PSE groups were significantly decreased, and serum alanine transaminase and aspartate transaminase were significantly decreased only in the Low PSE group. The parameters regarding erythrocyte and leucocyte counts showed no significant differences between pre- and post-test among groups, which suggested the safety of intake of peanut sprouts as a dietary supplement. CONCLUSIONS: This study indicates that PSE supplementation improves abdominal obesity and overall health indices. Therefore, an appropriate amount of peanut sprouts may be a plausible effective agent for obesity and obesity related health problems in obese women.
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Ae Wha Ha,Su Youn Jeong,Nam E Kang,Woo Kyoung Kim 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.4
BACKGROUD/OBEJECTIVES: It is hypothesized that obese people with dyslipidemia is more likely to have increased oxidative stress and decreased antioxidant status, in comparison with the controls who were obese without dyslipidemia. Thus, the aims of the present study were to determine the dietary intakes, plasma adipokines, and antioxidative systems between obese with dyslipidemia and obese without dyslipidemia were investigated. SUBJECTS/METHODS: Female subjects who were between 20 and 55 years old, and whose BMI was 23 or greater were recruited. Subjects who met the criteria of BMI ≥ 23, total cholesterol ≥ 200 mg/dL, LDL cholesterol ≥ 130 mg/dL, and TG ≥ 110 mg/dL were categorized Obese with dyslipidemia. Anthropometric measurements and blood biochemical tests were conducted. The diet survey was conducted by a trained dietitian using two days of 24 hour dietary recall. The lipid peroxidation, the plasma total antioxidant capacity (TAC), the activities of antioxidantive enzymes, and various antioxidantive vitamins levels were determined. RESULTS: Plasma adiponectin and leptin levels were also determined. There were no significant differences for age, Body Mass index (BMI), and body fat (%), waist-size between two groups. Obese with dyslipidemia had significantly high levels of total cholesterol, triglyceride, LDL-cholesterol, the ratio of total cholesterol/HDL-C, and the ratio of HDL-C /LDL-C, respectively. Blood alkaline phosphatase level was statistically different between the two groups (P < 0.05). No statistical significance in dietary intake between two groups was shown. In case of obese with dyslipidemia group, the levels of GSH-Px (P < 0.05) and catalase (P < 0.05) as well as adjusted blood retinol (P < 0.05) and tocopherol level (P < 0.05) were significantly low. However, the plasma concentration of leptin was significantly high (P < 0.05). CONCLUSIONS: Obesity with dyslipidemia was shown to have high arthtrogenic index, depleted antioxidant status, and higher blood leptin levels which suggest higher risks of oxidative stress and cardiovascular diseases.
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Antioxidant Activity of Rubus crataegifolius Bge. Fruit Extracts
Kyoung Mi Moon(문경미),Ji Eun Kim(김지은),Hae Young Kim(김해영),Jae Seol Lee(이재설),Gi Ae Son(손기애),Soo-Wan Nam(남수완),Byung-Woo Kim(김병우),Jong-Hwan Lee(이종환) 한국생명과학회 2011 생명과학회지 Vol.21 No.9
식물자원으로부터 항산화 물질을 확보 하기위해 한국 등에서 전통적으로 phytotherapy로 이용되어 온 Rubus crataegifolius Bge. 열매를 조사하였다. R. crataegifolius의 열매를 메탄올로 추출하였고 순차적으로 n-hexane, diethyl ether, and ethyl acetate로 분획화하였다. 각 분획물의 항산화 활성은 DPPH와 H2O2에 대항 인간 primary 세포인 keratinocyte (HK)를 이용하여 세포 독성 및 효능을 검증하였다. R. crataegifolius 열매 추출물은 비타민C와 비슷한 강력한 DPPH (75.04%, 50%)와 H2O2 (79.9%, 54.1%)소거능을 보였다. 분획물의 DPPP에 대한 소거능을 측정하였는데 n-hexane fraction (HF)은 20.3%, diethyl ether fraction (DF)은 68.8%, ethyl acetate fraction (EF)는 67.1% 그리고 residue fraction (RE)은 67.1%의 소거능을 보였으며 H2O2에 대해서는 2.2%, 1.6%, 10%, 그리고 50%로 각각 나타내었다. H2O2에 대한 HK의 세포 보호능을 확인하기 위해 산화적 스트레서 모델을 확립하였고(1 mM) 0.005-0.02%의 RE 분획물에서 H2O2에 대한 보호능을 발휘하였다. 따라서. R. crataegifolius의 열매 추출물은 H2O2유발 상처에 대하여 HK세포의 보호능을 가지며 강력한 항산화 활성을 가지고 있다. We investigated the fruits of Rubus crataegifolius Bge, a plant which has been traditionally used in Korea in phytotherapy, to describe antioxidant materials from plant sources. R. crataegifolius fruits were extracted with methanol and further fractionated into n-hexane, diethyl ether, and ethyl acetate. The antioxidant activity of each fraction and the residue was assessed using a 1,1-diphenyl-2-picrylhydrazyl (DPPH), H2O2 radical scavenging method, and their cytotoxicity on human primary kerationcyte (HK) was determined by an MTS assay. The R. crataegifolius fruit methanol extract showed strong antioxidant activity (75.04%, 50%) compared with vitamin C (79.9%, 54.1%) by the DPPH, and H2O2 method, respectively. The measured activity from the subsequent extracts of the methanol extract were 20.3% for n-hexane fraction (HF), 68.8% for diethyl ether fraction (DF), 67.1% for ethyl acetate fraction (EF), and 67.1% for the residue fraction (RE) by DPPH and 2.2% for HF, 1.6% for DF, 10% for EF, and 50% for the RE by H2O2 assay. An oxidative stress model of HK was established under a suitable concentration (1 mM). The cell viability of the RE treated group increased and the percentage of apoptotic cells decreased at concentrations of 0.005-0.02% RE compared with the H2O2 treated group. Fruit extracts of the medicinal plant R. crataegifolius showed potent antioxidant activity and the ability to relieve cell damage from H2O2 induced injury to HK.
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Nam E Kang,Ae Wha Ha,Hye Won Woo,Woo Kyoung Kim 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.2
BACKGROUD/OBEJECTIVES: This study aims to find out the effects of peanut sprout extracts on weight controls and protein expressions of transcription factors related to adipocyte differentiation and adipocytokine in rats under high-fat diets. MATERIALS/METHODS: Four week-old Sparague-Dawley (SD) were assigned to 4 groups; normal-fat (NF) diets (7% fat diet), high-fat (HF) diets (20% fat diet), high fat diets with low peanut sprout extract (HF + PSEL) diet (20% fat and 0.025% peanut sprout extract), and high fat diets with high peanut sprout extract (HF + PSEH) diet (20% fat and 0.05% peanut sprout extract). Body weight changes, lipid profiles in adipose tissue, and the mRNA protein expressions, such as peroxisome proliferator-activated receptor γ (PPARγ), CCAAT element binding protein α (C/EBP α), leptin, and adiponectin, were determined. RESULTS: After 9 weeks of feeding, the HF + PSEH group had significantly less weight gains than the HF group (P < 0.05). However, the total dietary intakes or food efficiency ratios among groups were not significantly different. The weight of epididymal fat in HF + PSEH group, 3.61 ± 0.5 g, or HF + PSEL group, 3.80 ± 0.7 g, was significantly lower than the HF group, 4.39 ± 0.4g, (P < 0.05). Total lipids and total cholesterol in adipose tissue were significantly decreased in HF + PSEH group compared to those in the HF group, respectively (P < 0.05). PSEH supplementation caused AST and ALT levels to decrease when it compared to HF group, but it was not statistically significant. The protein expression of PPARγ in HF + PSEH group was significantly lower than the HF group (P < 0.05). Comparing with the HF group, the protein expression of adiponectin in HF + PSEH group was significantly increased (P < 0.05). The protein expressions of C/EBP α and leptin in HF + PSEH group were lower than the HF group, but it was not statistical significant. CONCLUSIONS: In conclusion, peanut sprout extract has anti-obesity effect by lowering the expressions of PPARγ which regulates the expression of adiponectin.
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Woo Kyoung Kim,Nam E Kang,Myung Hwan Kim,Ae Wha Ha 대한지역사회영양학회 2013 Nutrition Research and Practice Vol.7 No.3
3T3-L1 preadipocyte were differentiated to adipocytes, and then treated with 0, 10, 20, and 40 μg/mL of peanut sprout ethanol extract (PSEE). The main component of PSEE is resveratrol which contained 5.55 mg/mL of resveratrol. The MTT assay, Oil-Red O staining, glycerol-3-phosphate dehydrogenase (GPDH) activity, and the triglyceride concentration were determined in 3T3-L1 cells. MMP-2 and MMP-9 activities as well as mRNA expressions of C/EBP β and C/EBP α were also investigated. As the concentration of PSEE in adipocytes increased, the cell proliferation was decreased in a dose-dependent manner from 4 days of incubation (P < 0.05). The GDPH activity (P < 0.05) and the triglyceride concentration (P < 0.05) were decreased as the PSEE treatment concentration increased. The mRNA expression of C/EBPβ in 3T3-L1 cells was significantly low in groups of PSEE treated, compared with control group (P < 0.05). The MMP-9 (P < 0.05) and MMP-2 (P < 0.05) activities were decreased in a dose-dependent manner as the PSEE concentration increased from 20 μg/mL. In conclusion, it was found that PSEE has an effect on restricting proliferation and differentiation of adipocytes.
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