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Paracrine Effects of Adipose-Derived Stem Cells on Keratinocytes and Dermal Fibroblasts
( Seung Ho Lee ),( Sang Yun Jin ),( Jin Seok Song ),( Kyle K. Seo ),( Kwang Hyun Cho ) 대한피부과학회 2012 Annals of Dermatology Vol.24 No.2
Background: Adipose-derived stem cells (ASCs) are mesenchymal stem cells that have recently been applied to tissue repair and regeneration. Keratinocytes and dermal fibroblasts play key roles in cutaneous wound healing. Objective: We investigated the paracrine effects of ASCs on HaCaT cells (i.e., immortalized human keratinocytes) and human dermal fibroblasts to explore the mechanism of the effects of ASCs on cutaneous wound healing. Methods: HaCaT cells and primary cultured human dermal fibroblasts were treated with 50% conditioned medium of ASCs (ASC-CM). Viability, in vitro wound healing, and fibroblast- populated collagen lattice contraction assays were conducted, and reverse transcription-polymerase chain reaction (RT-PCR) for the type I procollagen α1 chain gene was performed. Results: The proliferation of HaCaT cells and fibroblasts was increased by ASC-CM in the viability assay. ASC-CM promoted in vitro wound healing of HaCaT cells and increased the contraction of the fibroblast-populated collagen lattice. RT-PCR showed that the transcription of the type I procollagen α1 chain gene in fibroblasts was up- regulated by ASC-CM. Conclusion: The stimulatory effect of ASC on cutaneous wound healing may be partially mediated by paracrine effects of ASCs on other skin cells. Application of ASCs or ASC-derived molecules could be an innovative therapeutic approach in the treatment of chronic wounds and other conditions. (Ann Dermatol 24(2) 136∼143, 2012)
Bae, Jung-Hee,Choi, Da-Yae,Lee, Jae-Gi,Seo, Kyle K,Tansatit, Tanvaa,Kim, Hee-Jin Elsevier Science, Inc 2014 Dermatologic surgery Vol.40 No.12
<P>The botulinum neurotoxin Type A (BTX) injection into the masseter muscle often causes a change in the facial expression. There is as yet no precise anatomic evidence to support this etiologic factor of constrained facial expressions.</P>
( Mi Hye Lee ),( Ji Su Han ),( Jee Soo An ),( Chong Hyun Won ),( Hyun Sun Park ),( Jae Yoon Jung ),( Kyle K. Seo ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Recently botulinum toxin type B (BoNT-B) has been increasingly used as an off-label treatment of primary axillary hyperhidrosis. However, the optimal conversion ratios for botulinum toxin type A (BoNT-A) and BoNT-B remain to be determined. Objectives: The objectives of this study is to compare effectiveness, satisfaction level, and safety of BoNT-B with BoNT-A at a conversion ratio of 1:30 for the treatment of primary axillary hyperhidrosis. Methods: This was a bilaterally paired single subject study with each patient randomly treated on one axilla with 1500 U BoNT-B and 50 U BoNT-A contralaterally. Each patient returned at week 2, 12 and 20. Iodine-starch test was used to measure the hidrotic area as a primary objective outcome. Each patient was surveyed to assess the severity of his or her hidrotic symptoms and overall satisfaction Results: 24 patients completed the study. Both BoNT-A and BoNT-B sides showed comparable and efficacious anhidrotic effects throughout 20 weeks. Overall satisfaction with the treatment was equivalently high in the both the BoNT-A and BoNT-B sides. There were no significant differences in terms of the onset of action, anhidrotic area or mean duration of action between the BoNT-A and BoNT-B groups Conclusion: BoNT-A and BoNT-B show comparable anhidrotic effect for the treatment of axillary hyperhidrosis at a conversion ratio of 1:30.
( Hyun Sun Park ),( Jin Yong Kim ),( Yun Seon Choe ),( Won Seok Han ),( Jee Soo An ),( Kyle K. Seo ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.1
Background: Foremost fine hairs in the frontal hairline region are critical in hair transplantation for hairline correction (HTHC) in women. However, there are few studies on a nonsurgical revisionary method for improving an unnatural foremost hairline with thick donor hairs resulting from a previous HTHC. Objective: To investigate the efficacy and safety of using a hair removal laser (HRL) system to create fine hairs in Asian women with thick donor hairs. Methods: Through a retrospective chart review, the HRL parameters, hair diameter (measured with a micrometer before and after the procedures), subjective results after the procedures, adverse effects, and the number of procedures were investigated. The reduction rate of the hair diameter was calculated. Results: Twenty-four women who received long-pulse Neodymium-Doped:Yttrium Aluminum Garnet therapy after HTHC were included. The parameters were as follows: delivered laser energy, 35∼36 J/cm2; pulse duration, 6 ms; and spot size, 10 mm. The mean number of laser sessions was 2.6. The mean hair diameter significantly decreased from 80.0±11.5 μm to 58.4±13.2 μm (p=0.00). The mean rate of hair diameter reduction was .25.7% (range, .44.6% to 5.7%). The number of laser sessions and the hair diameter after the procedures showed a negative correlation (r=.0.410, p=0.046). Most of the patients (87.5%) reported subjective improvement of their hairlines. Most complications were transient and mild. Conclusion: HRL can be an alternative method for creating fine hairs and revising foremost hairline in Asian women with thick donor hairs. (Ann Dermatol 27(1) 21∼25, 2015)