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Original Articles : Patient with Kikuchi`s Disease: What Should Pain Clinicians Do?
( Kyeong Eon Park ),( Se Bin Kang ),( Seong Ho Ok ),( Ii Woo Shin ),( Ju Tae Sohn ),( Young Kyun Chung ),( Heon Keun Lee ) 대한통증학회 2012 The Korean Journal of Pain Vol.25 No.3
Kikuchi`s disease (KD) is an idiopathic and self-limiting necrotizing lymphadenitis that predominantly occurs in young females. It is common in Asia, and the cervical lymph nodes are commonly involved. Generally, KD has symptoms and signs of lymph node tenderness, fever, and leukocytopenia, but there are no reports on treatment for the associated myofacial pain. We herein report a young female patient who visited a pain clinic and received a trigger point injection 2 weeks before the diagnosis of KD. When young female patients with myofascial pain visit a pain clinic, doctors should be concerned about the possibility of KD, which is rare but can cause severe complications.
A Patient with Kikuchi's Disease: What Should Pain Clinicians Do?
Park, Kyeong-Eon,Kang, Se-Bin,Ok, Seong-Ho,Shin, Il-Woo,Sohn, Ju-Tae,Chung, Young-Kyun,Lee, Heon-Keun The Korean Pain Society 2012 The Korean Journal of Pain Vol.25 No.3
Kikuchi's disease (KD) is an idiopathic and self-limiting necrotizing lymphadenitis that predominantly occurs in young females. It is common in Asia, and the cervical lymph nodes are commonly involved. Generally, KD has symptoms and signs of lymph node tenderness, fever, and leukocytopenia, but there are no reports on treatment for the associated myofacial pain. We herein report a young female patient who visited a pain clinic and received a trigger point injection 2 weeks before the diagnosis of KD. When young female patients with myofascial pain visit a pain clinic, doctors should be concerned about the possibility of KD, which is rare but can cause severe complications.
Kyeong Eun Hyung,Soo Jeong Kim,Ye Won Jang,Da Kyoung Lee,Kee Hyeob Hyun,Byoung Seok Moon,Bongjoon Kim,Heeyoon Ahn,So-Young Park,Uy Dong Sohn,Eon Sub Park,Kwang Woo Hwang 대한생리학회-대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.3
Atopic dermatitis (AD) is an inflammatory skin condition accompanied by symptoms such as edema and hemorrhage. Kimchi is a traditional fermented Korean dish consisting of various probiotics. In this study, the therapeutic effect of <i>Lactobacillus plantarum</i> CJLP55 isolated from Kimchi was studied in AD-induced mice. Orally administered <i>Lactobacillus</i> strain, CJLP55, suppressed AD symptoms and high serum IgE levels. CJLP55 administration reduced the thickness of the epidermis, infiltration of mast cells and eosinophils into the skin lesion, enlargement of axillary lymph nodes, and increase in cell population in axillary lymph nodes. CJLP55 treatment decreased the production of type 2 cytokines, such as interleukin (IL)-4, IL-5, IL-10, IL-12, interferon (IFN)-γ, and IL-6,which were stimulated by house dust miteextracts, in the axillary lymph node cells. Orally administered CJLP55 exhibited a therapeutic effect on house dust mite-induced AD in NC⁄Nga mice after onset of the disease by altering immune cell activation. The <i>Lactobacillus</i> strain, CJLP55, isolated from Kimchi, suppressed AD. Our results suggest its possible use as a potential candidate for management of AD.
L-carnitine supplementation improves the cryosurvival and subsequent development of bovine embryos
Kyeong Yeob Kim,Youn Bae Park,Byeong Ho Kim,Jin Hee Lee,Ji Hye Lee,Chanuka Kulatunga,Dong Eon Kim,Kyu Hyun Kim,Ryeong Eun Kim,Yoon Seok Nam,Min Kyu Kim 한국수정란이식학회 2018 한국수정란이식학회 학술대회 Vol.2018 No.11
Cryopreservation of bovine embryos is used to efficiently implant surrogate mothers. It has been widely accepted that high lipid content in the oocyte interrupts its survival during freeze-thaw cycles. Serum component in the culture medium is thought to increase the embryo`s lipid contents. Conversely, L-carnitine stimulates lipid metabolism by transporting long chain fatty acids into the mitochondria. Objective of this study was to analyze the effect of L-carnitine supplementation in IVM medium and defined IVC medium on the development, lipid contents and the cryosurvival of bovine IVF embryos. 0.0, 1.5, 3.0 and 6.0 mM L-carnitine was supplemented in IVM medium, respectively (IVM-LC 0.0, LC 1.5, LC 3.0 and LC 6.0). Development rate from the 2cell to the morula stages was higher in IVM-LC 3.0 groups than those of IVM-LC 6.0 (p<0.05). But there were no significant differences among the other groups in the blastocyst rates and lipid content results. When 0.0, 1.5, 3.0 and 6.0 mM L-carnitine were supplemented in IVC medium (IVC-LC 0.0, LC 1.5, LC 3.0 and LC 6.0), development competence was not significantly different between those embryos. Lipid contents of embryos treated L-carnitine (IVC-LC 1.5, 3.0 and 6.0) were significantly lower than embryos of non-treated group. L-carnitine was supplemented 0.0, 1.5, 3.0, 6.0 mM during IVM and 3.0 mM during IVC (LC 0.0 - 3.0, LC 1.5 – 3.0, LC 3.0 – 3.0, LC 6.0 – 3.0) and cryosurvival of blastocysts confirmed after freezing-thawing. There were no significant differences on development, but LC 3.0 – 3.0 was significantly lower lipid contents than other groups. And LC 3.0 – 3.0 had better survival rates and hatched rates of blastocysts than LC 0.0 – 0.0. In conclusion, supplementation of L-carnitine in defined IVC medium decreases lipid contents. And L-carnitine supplementation improves cryosurvival and developmental ability of bovine IVF embryos.
APC와 Tree Encoding을 이용한 9 . 6 kbps 음성 데이타 감축
박영구,문상재,주언경 경북대학교 전자기술연구소 1989 電子技術硏究誌 Vol.10 No.1
A 9.6kbps APC/SQ speech data compression scheme using tree encoding has been suggested and investigated through computer simulation. The tree encoding is applied to encoding the error signal to obtain improved natural sound by reconstructing a closer waveform to the original speech signal. The simulation results of the speech data compression system show that high quality of speech can be obtained at the transmission rate of 9.6kbps.
Park, Kyeong Soon,Kang, Jin Hee,Sa, Keum Hee,Koo, Hee Beom,Cho, Hyun Jung,Nam, Eon Jeong,Youn, In Chan,Kim, Kwang Meyung,Kim, In San,Kwon, Ick Chan,Choi, Kui Won,Kang, Young Mo MIT Press 2012 MOLECULAR IMAGING Vol.11 No.5
<P>We demonstrated that arthritis could be visualized noninvasively using hydrophobically modified glycol chitosan nanoparticles labeled with Cy5.5 (HGC-Cy5.5) and an optical imaging system. Activated macrophages expressing Mac-1 molecules effectively phagocytosed HGC-Cy5.5, which formed spherical nanoparticles under physiologic conditions. We estimated the applicability of HGC-Cy5.5 to quantitative analysis of arthritis development and progression. Near-infrared fluorescence images, captured after HGC-Cy5.5 injection in mice with collagen-induced arthritis, showed stronger fluorescence intensity in the active arthritis group than in the nonarthritis group. According to the progression of arthritis in both collagen-induced arthritis and collagen antibody-induced arthritis models, total photon counts (TPCs) increased in parallel with the clinical arthritis index. Quantitative analysis of fluorescence after treatment with methotrexate showed a significant decrease in TPC in a dose-dependent manner. Histologic evaluation confirmed that the mechanism underlying selective accumulation of HGC-Cy5.5 within synovitis tissues included enhanced phagocytosis of the probe by Mac-1-expressing macrophages as well as enhanced permeability through leaky vessels. These results suggest that optical imaging of arthritis using HGC-Cy5.5 can provide an objective measurement of disease activity and, at the same time, therapeutic responses in rheumatoid arthritis.</P>
Park, Hwang-Seo,Jung, Suk-Kyeong,Bahn, Young-Jae,Jeong, Dae-Gwin,Ryu, Seong-Eon,Kim, Seung-Jun Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.6
Cdc25 phosphatases have been considered as attractive drug targets for anticancer therapy due to the correlation of their overexpression with a wide variety of cancers. We have been able to identify five novel Cdc25 phosphatase inhibitors with micromolar activity by means of a structure-based de novo design method with a known inhibitor scaffold. Because the newly discovered inhibitors are structurally diverse and have desirable physicochemical properties as a drug candidate, they deserve further investigation as anticancer drugs. The differences in binding modes of the identified inhibitors in the active sites of Cdc25A and B are addressed in detail.
Priority Encoder를 활용한 DTCAM-based PIM architecture 설계
이언경(Eon-Gyeong Lee),김경민(Kyeong-Min Kim),박성배(Seong-Bae Park),홍충선(Choong-Seon Hong),홍상훈(Sang-Hoon Hong) 대한전자공학회 2022 대한전자공학회 학술대회 Vol.2022 No.11
This paper describes the DTCAM structure that has increased utilization in artificial intelligence search. The inverter chain of the existing DTCAM structure was improved to reduce power consumption, and a detection module was added to facilitate data retrieval. In addition, it aims to accelerate artificial intelligence computation using memory through a Priority Encoder structure that sets priority to multiple searched memory addresses and outputs them. This is a method of solving the von Neumann bottleneck through PIM, and has various possibilities of expansion in the field of future artificial intelligence computation.
Fractal Dimension of Conducting Paths in Nickel Oxide (NiO) Thin Films During Resistance Switching
In Kyeong Yoo,Bo Soo Kang,Seung Eon Ahn,Chang Bum Lee,Myoung Jae Lee,Gyeong-Su Park,Xiang-Shu Li IEEE 2010 IEEE TRANSACTIONS ON NANOTECHNOLOGY Vol.9 No.2
<P>A resistance-switching model in nickel oxide thin film is proposed based on Poisson distribution of electrical switching power. Conductive percolating network in soft breakdown surface may be the source of resistance switching. The main body of network may remain unchanged, but a portion of network is broken and healed repeatedly during switching. Dependence of reset current on electrode area is explained by fractal dimension.</P>