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이규철,유근민,김경석,박홍태 울산대학교 1996 공학연구논문집 Vol.27 No.2
본 연구에서는 주위 환경 열화에 따른 복합절연재료의 절연특성과 수명을 향상시키기 위해 고온에서 흡습량을 변화시켰을 때와 탈습량을 변화시켰을 때 흡십시료와 탈습시료의 전기적 특성 및 기계적 특성을 조사하였다. 유리섬유 각층의 흡습상수는 각각 1층에서 0.0117, 2층에서 0.0123, 3층에서 0.0152를 나타냈다. 전기적 특성 및 기계적 특성은 복합재료의 흡습에 따라 크게 떨어졌다. 70℃에서 습기가 완전히 건조되어도 흡습전의 전기적 및 기계적 특성을 얻기가 어려운 것으로 나타났다. 수분에 의해 발생한 복합절연재료내에 존재하는 많은 결함들은 에폭시 메트릭스와 필라사이에 존재하였다. The electrical and mechanical properties of moisture absorbed and moisture desorbed specimens were investigated to improve the insulating characteristics and the reliability of composite materials against environment aging. Moisture absorption constants with the layers of glass fiber showed 0.0117 in 1 layer, 0,0123 in 2 layer and 0.0152 in 3 layer, respectively. Although moisture was removed at 70℃, it was impossible to obtain the initial electrical and mechanical properties. Many defects induced by moisture were observed at the interface between epoxy matrix and filler in composite materials.
( Bong-kyu Song ),( Kyeng Min Kim ),( Kang-duk Choi ),( Wan-taek Im ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 Journal of microbiology and biotechnology Vol.27 No.7
The ginsenoside Rh2 has strong anti-cancer, anti-inflammatory, and anti-diabetic effects. However, the application of ginsenoside Rh2 is restricted because of the small amounts found in Korean white and red ginsengs. To enhance the production of ginsenoside Rh2-MIX (comprising 20(S)-Rh2, 20(R)-Rh2, Rk2, and Rh3 as a 10-g unit) with high specificity, yield, and purity, a new combination of enzymatic conversion using the commercial enzyme Viscozyme L followed by acid treatment was developed. Viscozyme L treatment at pH 5.0 and 50°C was used initially to transform the major ginsenosides Rb1, Rb2, Rc, and Rd into ginsenoside F2, followed by acid-heat treatment using citric acid 2% (w/v) at pH 2.0 and 121°C for 15 min. Scale-up production in a 10-L jar fermenter, using 60 g of the protopanaxadiol-type ginsenoside mixture from ginseng roots, produced 24 g of ginsenoside Rh2-MIX. Using 2 g of Rh2-MIX, 131 mg of 20(S)-Rh2, 58 mg of 20(R)-Rh2, 47 mg of Rk2, and 26 mg of Rh3 were obtained at over 98% chromatographic purity. Then, the anti-cancer effect of the four purified ginsenosides was investigated on B16F10, MDA-MB-231, and HuH-7 cell lines. As a result, these four rare ginsenosides markedly inhibited the growth of the cancer cell lines. These results suggested that rare ginsenoside Rh2-MIX could be exploited to prepare an anti-cancer supplement in the functional food and pharmaceutical industries.
Han, Sang-Beom,Kwak, Da-Hee,Park, Hyun Suk,Park, Jin-Young,Ma, Kyeng-Bae,Won, Ji-Eun,Kim, Do-Hyoung,Kim, Min-Cheol,Park, Kyung-Won Elsevier 2018 Journal of Power Sources Vol.393 No.-
<P><B>Abstract</B></P> <P>(2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) with no free radical and non-volatile characteristic can be utilized as a liquid catalyst instead of O<SUB>2</SUB> at the cathode in a chemical regenerative redox fuel cell with H<SUB>2</SUB> as a fuel at the anode. In this study, the electrochemical properties and performance of TEMPO dissolved in sulfuric acid solution are investigated using half and unit cells. In the half-cell, TEMPO shows an activation energy of 1.27 kcal mol<SUP>−1</SUP> K<SUP>−1</SUP> for the reduction. A chemical regenerative redox fuel cell (CRRFC) using TEMPO as the liquid catalyst exhibits an open circuit voltage of 0.7 V and a maximum power density of 90 mW cm<SUP>−2</SUP> at 30 °C with a low activation loss. The regeneration cycling test of the CRRFC is performed at a constant voltage of 0.4 V under a flow rate of the oxygen-bubbled TEMPO solution. The performance of the CRRFC deteriorates, i.e., a power density of zero measured at >200 min. Thus, a highly efficient regeneration system needs to be developed for a high-performance CRRFC using TEMPO used as a liquid-type oxidant. Furthermore, stable liquid oxidants with relatively high standard reduction potentials can be proposed through various organic compounds.</P> <P><B>Highlights</B></P> <P> <UL> <LI> CRRFC was proposed using TEMPO instead of O<SUB>2</SUB> at the cathode. </LI> <LI> TEMPO showed fairly fast transport and low activation energy for the reduction. </LI> <LI> CRRFC exhibited an open circuit voltage of ∼0.7 V at 30 °C. </LI> <LI> CRRFC exhibited a maximum power density of ∼90 mW cm<SUP>−2</SUP> at 30 °C. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Galactosylated cucurbituril-inclusion polyplex for hepatocyte-targeted gene delivery
Kim, Soo Kyung,Park, Kyeng Min,Singha, Kaushik,Kim, Jeeyeon,Ahn, Youngjoo,Kim, Kimoon,Kim, Won Jong Royal Society of Chemistry 2010 Chemical communications Vol.46 No.5
<P>The work demonstrates a judicious approach to achieve hepatocyte cell-targeted highly efficient gene delivery by utilizing a supramolecular complex of galactosylated cucurbituril and dextran–spermine conjugates.</P> <P>Graphic Abstract</P><P>Judicious utilization of a biocompatible, nontoxic supramolecular assembly of galactosylated cucurbit[6]uril and dextran–spermine conjugate enables asialoglycoprotein receptor mediated efficient hepatocyte-targeted gene delivery. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b920753h'> </P>
Direct Synthesis of Polymer Nanocapsules with a Noncovalently Tailorable Surface
Kim, Dongwoo,Kim, Eunju,Kim, Jeeyeon,Park, Kyeng ,Min,Baek, Kangkyun,Jung, Minseon,Ko, Young ,Ho,Sung, Wokyung,Kim, Hyung ,Seok,Suh, Ju ,Hyung,Park, Chan ,Gyung,Na, Oh WILEY-VCH Verlag 2007 Angewandte Chemie Vol.46 No.19
<B>Graphic Abstract</B> <P>Hollow out your pumpkin: The direct synthesis of approximately 100-nm-diameter polymer nanocapsules was carried out in the absence of preorganized structures or templates. The method appears to be applicable to any monomer that has a flat core and multiple polymerizable groups at the periphery (see picture). The surface properties of the polymer shell, which comprises cucurbituril, can be easily tailored through host–guest chemistry. <img src='wiley_img/14337851-2007-46-19-ANIE200604526-content.gif' alt='wiley_img/14337851-2007-46-19-ANIE200604526-content'> </P>
Functionalized cucurbiturils and their applications
Kim, Kimoon,Selvapalam, Narayanan,Ko, Young Ho,Park, Kyeng Min,Kim, Dongwoo,Kim, Jeeyeon Royal Society of Chemistry 2007 Chemical Society reviews Vol.36 No.2
<P>Cucurbit[<I>n</I>]uril (CB[<I>n</I>], <I>n</I> = 5–10), a new family of molecular hosts comprising <I>n</I> glycoluril units, have gained much attention in the new millennium for their exceptional molecular recognition ability. The CB homologues have brought dynamism to CB chemistry, as witnessed by the heightened interest in the field for the last several years. Compared to the chemistry of cyclodextrins and calixarenes, however, that of CB[<I>n</I>] has developed slowly until recently, which may be attributed mainly to their poor solubility in common solvents, and inability to functionalize these molecules. The direct functionalization method of CB[<I>n</I>] propelled CB chemistry to a new height as this new method not only solved the solubility problem but also opened up the gateway to the generation of tailor-made CB[<I>n</I>] derivatives. The functionalization of CB[<I>n</I>] led us to investigate numerous applications including artificial ion channels, vesicles, stationary phases in chromatography, ISEs, polymers, nanomaterials, and many others. This tutorial review describes the recent advances and challenges in the functionalization of CBs along with the applications of functionalized CBs.</P> <P>Graphic Abstract</P><P>The recent advances and challenges in the functionalization of cucurbiturils (CBs) along with the applications of functionalized CBs are described. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b603088m'> </P>
Park, Kyeng Min,Lee, Don-Wook,Sarkar, Bijay,Jung, Hyuntae,Kim, Jeeyeon,Ko, Young Ho,Lee, Kyung Eun,Jeon, Hyesung,Kim, Kimoon WILEY-VCH Verlag 2010 Small Vol.6 No.13
<P>The design and synthesis of a novel reduction-sensitive, robust, and biocompatible vesicle (SSCB[6]VC) are reported, which is self-assembled from an amphiphilic cucurbit[6]uril (CB[6]) derivative that contains disulfide bonds between hexaethylene glycol units and a CB[6] core. The remarkable features of SSCB[6]VC include: 1) facile, non-destructive, non-covalent, and modular surface modification using exceptionally strong host–guest chemistry; 2) high structural stability; 3) facile internalization into targeted cells by receptor-mediated endocytosis, and 4) efficient triggered release of entrapped drugs in a reducing environment such as cytoplasm. Furthermore, a significantly increased cytotoxicity of the anticancer drug doxorubicin to cancer cells is demonstrated using doxorubicin-loaded SSCB[6]VC, the surface of which is decorated with functional moieties such as a folate–spermidine conjugate and fluorescein isothiocyanate–spermidine conjugate as targeting ligand and fluorescence imaging probe, respectively. SSCB[6]VC with such unique features can be used as a highly versatile multifunctional platform for targeted drug delivery, which may find useful applications in cancer therapy. This novel strategy based on supramolecular chemistry and the unique properties of CB[6] can be extended to design smart multifunctional materials for biomedical applications including gene delivery.</P> <B>Graphic Abstract</B> <P>Biocompatible vesicles based on cucurbit[6]uril (CB[6]) can undergo surface modification by host–guest chemistry, internalization into targeted cells by receptor-mediated endocytosis, and triggered release of entrapped drugs in cytoplasm. They serve as a highly versatile multifunctional platform for targeted drug delivery. <img src='wiley_img_2010/16136810-2010-6-13-SMLL201000293-content.gif' alt='wiley_img_2010/16136810-2010-6-13-SMLL201000293-content'> </P>
전자빔 조사에 의한 방향성 전기강판의 철손 감소를 위한 소형 전자빔 조사장치 설계
김민(Min Kim),조경재(Kyeng-jai Cho),차인수(In-Su Cha),조성오(Sung-Oh Cho),이종민(jong-Min Lee) 전력전자학회 2000 전력전자학술대회 논문집 Vol.2000 No.11
A nonconstact technique for reducing the core loss of a grain oriented silicon steel has been developed by the use of mechanical scribing, Q-switched laser, plasma jet or electron beam irradiation.<br/> Among these methods electron beam irradiation has advantages of domain refining without any deformation or damage of insulating film on the surface of a grain oriented SI- Fe.<br/> Over the past years, this processing was performed in vaccum of 10-4 Torr or below causing the problem of high cost and difficulty of continuous works.<br/> In this paper, a miniature electron permeable window through which electron beam energy 40-80keV and average current 0.1-2mA were obtained for electron beam Irradiating on air was designed and manufactured
Kang, Youngnam,Kim, Jeesu,Park, Junbeom,Lee, Yeong Mi,Saravanakumar, Gurusamy,Park, Kyeng Min,Choi, Wonseok,Kim, Kimoon,Lee, Eunsung,Kim, Chulhong,Kim, Won Jong Elsevier 2019 Biomaterials Vol.217 No.-
<P><B>Abstract</B></P> <P>Nitric oxide (NO) is widely known as an effective vasodilator at low concentrations. Drug delivery systems combined with NO can dilate blood vessels surrounding tumor tissues, and the drug accumulation in tumors is accelerated by the enhanced permeability and retention effect, leading to an improvement in the anti-tumor effect. N-heterocyclic carbene-based NO donors (e.g., 1,3-bis-(2,4,6-trimethylphenyl)imidazolylidene nitric oxide (IMesNO) have been developed for stable NO storing in air and water, and NO release by thermolysis. Herein, we demonstrated on-demand NO release by high-intensity focused ultrasound (HIFU) as a stimulus, which generated high heat and exerted an ablation effect when treated <I>in vivo</I>. We demonstrated IMesNO to be a HIFU-responsive NO donor and its potential application <I>in vivo</I> using IMesNO-loaded micelles. Moreover, IMesNO-loaded micelles mixed with drug-loaded micelles (IMesNO/DOX@MCs) showed acceleration of drug accumulation in tumor sites and enhanced tumor growth inhibition. Thus, our findings suggest a potential clinical bioapplication of NO-releasing drug-loaded micelles owing to the therapeutic function of NO and HIFU treatment for anti-cancer therapy.</P>