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최승필,권태욱,황주일,김세경 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2
Objective: Several studies suggest that a low cholesterol concentration is associated with a greater than normal risk of mortality from suicide. The authors sought to determine whether a low cholesterol level is associated with a history of serious suicide attempts among drug ingested ED patients. Method: serum cholesterol levels of attempted suicide of 89 patients, aged 20-72 years, were obtained from the ED admission biochemical profiles. Results: The seriousness of suicide attempt was associated with low serum cholesterol concentration in all age subgroups. Conclusions: Low cholesterol concentration should be futher investigated as a potential biological marker of suicide risk.
Plyometric Training 박스의 높이 차이가 남자 핸드볼 선수의 점프력에 미치는 영향
장창현,김승권,한주욱 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6
Twenty four male middle school and high school handball players were involved an adapted Plyometric Training program which was composed of depth jump and box jump, 3 days a week for B weeks. The jump ability factor before and after the training was analyzed, and the following conclusions were drawn 1. The group trained with higher box showed greater increase in their vertical jump ability than the group trained with lower box for both middle and high school players. 2. The group trained with higher box showed greater increase in their vertical running jump ability than the group trained with lower box for both Middle and high school players. 3. The group trained with higher box showed greater increase in the ability of staying in the air than the group trained with lower box for both middle and high school players. 4. The middle school players showed greater increase in the jump ability than the high school students.
증례 : 광방기에 의해 발생한 Chinese Herb Nephropathy 1예
이재욱 ( Jay Wook Lee ),손민정 ( Min Jung Sohn ),허남주 ( Nam Joo Heo ),주권욱 ( Kwon Wook Joo ),정윤철 ( Yoon Chul Jung ),이정상 ( Jung Sang Lee ),한진석 ( Jin Suk Han ) 대한내과학회 2006 대한내과학회지 Vol.71 No.2
본 증례의 환자는 근위부 신세뇨관 산증, 진행성 만성 신부전증, 세뇨관 위축 및 간질 섬유화 등 CHN에 잘 맞는 임상 증상 및 조직 소견을 보였고, 복용하던 한약재에서 AA가 검출되어 AA에 의한 CHN 또는 AAN으로 진단할 수 있었다. 이러한 환자의 신조직에서 AA-DNA adduct를 추가로 검출할 수 있다면 진단의 정확성을 더욱 높일 수 있을 것으로 보인다. Chinese herb nephropathy (CHN) is characterized by progressive tubulointerstitial nephritis and development of renal failure in a couple of years after diagnosis. Aristolochic acid (AA) is believed to be associated with the development of CHN. The authors report a case of CHN in which AA in the herb regimen was identified by high-performance liquid chromatography (HPLC). A 32-year-old female presented with nausea, vomiting and generalized weakness. She had been taking Chinese herbs for symptomatic care. Clinical and laboratory examinations revealed Fanconi syndrome, renal failure, and severe anemia. Renal biopsy showed severe tubulointerstitial nephritis with moderate tubular atrophy and interstitial fibrosis. She developed end-stage renal failure 4 months after diagnosis. The herb she had been taking was Aristolochia fangchi. HPLC technique was used to identify AA and to measure its concentration in the herb. From the clinical and laboratory data, the patient was diagnosed with CHN caused by aristolochic acid.(Korean J Med 71:224-228, 2006)
Chromosome 11-Centric Human Proteome Analysis of Human Brain Hippocampus Tissue
Kwon, Kyung-Hoon,Kim, Jin Young,Kim, Se-Young,Min, Hye Kyeong,Lee, Hyoung-Joo,Ji, In Jung,Kang, Taewook,Park, Gun Wook,An, Hyun Joo,Lee, Bonghee,Ravid, Rivka,Ferrer, Isidro,Chung, Chun Kee,Paik, Young American Chemical Society 2013 Journal of proteome research Vol.12 No.1
<P>Human chromosome 11 is the third gene-rich chromosome having 1304 protein-coding genes. According to the GeneCards, this chromosome contains 240 genes related to diseases, as it is well known as a disease-rich chromosome. Although there are many protein-coding genes, the proteomic identification ratio is rather low. As a model study, human hippocampal tissues from patients suffering from Alzheimer’s disease and epilepsy were prepared to evaluate the gene-centric statistics related to the gene expression and disorders of chromosome 11. A total of 8828 protein coding genes from brain tissues were extensively off-gel fractionated and profiled by a high resolution mass spectrometer with collision induced dissociation and electron transfer dissociation. Five-hundred twenty-three of the proteins from brain tissues were determined to belong to chromosome 11, representing 37% of the proteins reported in the Global Proteome Machine Database. We extracted gene clusters from a specific biological process or molecular function in gene ontology, among which the olfactory receptor genes showed the largest cluster on chromosome 11. Analysis of the proteome data set from the hippocampus provides a significant network associated with genes and proteins and leads to new insights into the biological and genetic mechanisms of chromosome 11-specific diseases such as Alzheimer’s disease.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jprobs/2013/jprobs.2013.12.issue-1/pr3008368/production/images/medium/pr-2012-008368_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/pr3008368'>ACS Electronic Supporting Info</A></P>
IgA 신병증에서 Haas의 조직학적 분류에 따른 임상적 예후
권영주,김형규,최창원,차대룡,김상욱,신진호,조원용,원남희,표희정,한상엽,조상경 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.1
Objectives:IgA nephropathy is a common type of primary glomerulonephritis and may present with a wide variety of histologic patterns on renal biopsy. IgA nephropathy may progress to end stage renal disease. But it is difficult to predict the prognosis of IgA nephropathy. Methods:In an attempt to identify prognostic indicators in this disease, the clinical data from 158 patients with IgA nephropathy were analyzed and compared to the pathologic subclassification proposed by Haas. Results: 1)The mean age of 158 patients with IgA nephropathy was 31.5 yrs(M:F=1:1.04) and there were 17 patients in subclass I, 5 patients in subclass II, 80 patients in subclass III, 34 patients in subclass IV, 22 patients in subclass V. 2)The significant correlation between renal survival rate and histologic subclass in 114 patients who were followed-up for more than 12 months was showed in order of I, II$gt;III, IV$gt;V. 3)Active crescents were a significant negative prognostic indicator in renal survival in subclass III, but not in subclass IV. 4) The presence of immune complex deposits in the glomerular capillary loops in addition to the deposits in mesangial areas was associated with poor prognosis in progression to end stage renal disease of IgA nephropathy 5)With a respect to clinical presentation, hypertension, serum creatinine of?1.5mg/dL, and proteinuria of?2.0g/day were significant negative prognostic indicators for renal survival but the presense of gross hematuria was not associated with increased renal survival rate by an univariate analysis. Conclusion:These results suggest that histologic subclassification proposed by Haas may be a useful prognostic indicator for the clinical outcome of IgA nephropathy, as well as the amount of proteinuria, serum creatinine level and hypertension at the time of initial renal biopsy.
Evaluation of Drilling Efficiency by Percussion Testing of a Drill Bit with New Button Arrangement
Kwon, Ki-Beom,Song, Chang-Heon,Park, Jin-Young,Oh, Joo-Young,Lee, Jae-Wook,Cho, Jung-Woo 한국정밀공학회 2014 International Journal of Precision Engineering and Vol.15 No.6
Rock drilling machines are commonly used for surface drilling, soil nailing reinforcement, tunnel excavation, and underground mining. These machines use drill bits that directly impact into the rock and are operated by percussive force and torque. Drill-bit buttons need to be designed to increase drilling efficiency; here, we present the results of a series of single blow tests on granitic rock samples using a piston drop type percussion testing system that enable us to compare the drilling efficiency of a new button arrangement design with conventional arrangements. Drilled rock volumes were measured by laser scanner after testing, and drilling efficiencies were evaluated by calculating percussive energies and drilled volumes. The results indicate that the new button arrangement design can be used to improve the drilling efficiency.