고빌리루빈혈증을 동반한 자가면역성 간염 1례

서영범,김성욱,장재식,강혁주,이중현,윤병구,김욱년,이광헌,이구,유석동,양창헌,이정호,이영현,이창우,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

자가면역성 간염은 대개 만성 경과를 가지며, 혈중 자가면역항체와 혈청 글로불린치의 상승, 그리고 조직학적으로 괴사 염증성 변화를 특징으로 하는 질환으로 아직 정확한 병인이 밝혀져 있지 않은 상태이다. 발병연령은 대개 젊은 영자(15-25세)에서 호발한다. 이 질환은 급성 간염의 임상경과를 보일 수 있으나, 심한 급성 간염이나 전격성 간염으로도 나타날 수 있는데, 이 경우 아주 나쁜 예후를 보인다고 한다. 치료는 자가면역성 간염 임상 경과의 다양성이나 병인, 병리기전의 불확실성에도 불구하고 대개 steroid 치료에 반응하는 것으로 알려져 있으며 대개 80%의 관해율을 나타내며 궁극적으로 간경변으로의 진행을 막을 수 있는 것으로 보인다. 저자들은 58세 남자에서 발생한 급성의 경과를 가지고 심한 황달을 동반한 자가면역성 간염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level. The age of onset of AIH show a peak between the age of 15 and 25 years. AIH can develop and be manifested as acute hepatitis, but severe form of acute hepatitis or fulminant hepatic failure has a poor prognosis. Although AIH is likely to progress from chronic active hepatitis to cirrhosis, steroid therapy can control the disease activity, prolong survival, improve the quality of life , and defer liver transplantation. In the present report we describe a 58-year-old man who admitted because of progressive jaundice and fatigue. He was diagnosed with AIH from laboratory test result showing positivity for antinuclear antibodies, anti-smooth muscle antibodies, and negativity for hepatitis viral markers and from liver biopsy. Steroid therapy, oral administration of prednisolone, was effective in improving the liver function test. Following liver biopsy 6 months after onset shows markedly improved necroinflammatory activity.

고기능성 미립 실리카 제조

이재장,노범식,김동수,장광택 강원대학교 부설 석재복합신소재 제품연구센터 2000 석재연 논문집 Vol.5 No.-

본 연구에서는 attrition mill을 활용하여 분쇄시 발생하는 오염물질을 방지하고 고분자 유기물질의 첨가로 평균 입도 2-3㎛의 미립 실리카 분체에 가능성을 부여하여 규석 관련 첨단산업용 고부가가치 상품을 개발하고자 하였다. 실험결과 용기 내부의 코팅재에 따른 미립화 효율은 세라믹 > 텅스텐 카바이드 > 스테인레스 > 포리우레탄 > 테프론의 순이었으며 오염방지 효과는 세라믹 > 폴리우레탄 > 텅스텐 카바이드 > 테프론 > 스테인레스의 순이었다. 고분자 유기물질의 첨가에 의해 분쇄효율이 증가하였으며, 첨가제의 일부가 표면에 코팅되어 원관의 백색도 85에서 92까지 상승되었다. 형상 조절 실험 및 백색도 향상 실험결과 첨가에에 의한 분쇄 산물은 원광보다 구형에 가까운 것을 알 수가 있었다. This study focused on manufacture of the high value-added products for a high-technology industry related to silica. The silica fines less than 3㎛ was manufactured using laboratory attrition mills with various coated liner and analysed the pollutions added from the grinding test. Ground particle's shape was investigated by adding polymer. In the grinding test, coated material of cylinder affects size reduction rate by order of ceramic, tungsten carbide, stainless steel, polyurethane, teflon. In contamination tests the coated liner affects in order of stainless steel, teflon, tungsten carbide, polyurethane, ceramic. It was found also that the result of additive test showed an instant effects of grinding and whiteness.

뇌실내출혈로 인한 급성 수두증에서 관찰된 해리증후군

김광기,이경민,이정주,오종배,안태범,정상욱,남현우,박성호 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5

비대칭 군집분석법의 소개 및 사례분석

이광진,김범준 목원대학교 사회과학연구소 1998 社會科學硏究 Vol.- No.2

전통적인 군집분석 이론에서는 대칭인 거리행렬을 바탕으로 군집현상을 파악한다. 본 연구에서는 비대칭 상사성행렬이 주어진 경우 이를 거리행렬로 변환하지도 않으면서 비대칭 상사성행렬이 주어진 경우 이를 거리행렬로 변환하지도 않으면서 그리고 비대칭성도 그대로 유지하면서 개체들간의 군집 또는 결합현상을 분석할 수 있는 비대칭 군집분석(asymmetric cluster analysis)의 내용을 간략하게 정리하여 소개하면서, 두 개의 실 제자료를 통해 이의 유용성을 보이고자 함이 목적이다.

Posterior available space의 crowding과의 상관관계 및 변화에 관한 연구

이노범,김광원 대한치과교정학회 1994 대한치과교정학회지 Vol.24 No.3

The research work has been conducted in order to establish facts on posterior available space in patients with crowding. The relation between crowding and posterior available space was worked out through a cross sectinal study of fifty eight patients showing class I malocclusion. In addition, a longitudinal overlapping study was done by examing twenty patients who had their bicuspid extracted and forty nine patients who did not, at the orthodontic department of dental clinic affiliated in Chosun University. The patients had been examined for three years and eight months on a regular basis, and the study yielded the following conculusion. 1. There was a great difference in posterior available space between patients with serious crowding and those with slight crowding. The former marked 15.2mm of posterior available space and the latter 19.9mm. 2. Posterior crowding index was acquired by joint consideration of the diameter of posterior teeth and posterior available space, and manifested the highest relationship with crowding among measured items. 3. Patients who had their bicuspids extracted exhibited increase in posterior available space of 1.6mm/year and those who did not, 1.8mm/year. 4. The absorption of anterior border of ramus turned out to be most deeply related with the increase of posterior available space. 5. Anterior border of ramus was absorbed at average rate of 0.7mm/year during the period of observation. 6. The extraction of bicuspids had little influnce on the change in posterior available space.

정전 열 접합을 이용한 Multi-Substrate Bonding

이덕중,주병권,최우범,한정인,조경익,이광배,장진,오명환 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

We performed silicon-to-glass bonding using silicon direct bonding followed by anodic bonding(SDAB). Initial bonding between glass and silicon was caused by the hydrophilic surfaces of silicon and glass ensemble using silicon direct bonding(SDB) method. We found that the bonded specimen using SDAB process had higher strength than one using anodic bonding process only. We performed multiple layer bonding by SDAB, which is glass- silicon -glass as sandwich structure. In the silicon wafer, the (1mm x 2mm x 500μm)-sized cavity was formed by the anisotropic etching of the silicon substrate in EPW(Ethylendiamin-Pyrocatechol-Water). And, the cavity was sealed with glass wafers by SDAB method.

통계적 실험계획에 의한 PECVD로 증착된 실리콘 산화막의 특성 분석

李晟準,金洸範,崔鑛泉,漢秀一,尹知原,金劉邏,朴宰賢,洪尙眞 명지대학교 산업기술연구소 2006 産業技術硏究所論文集 Vol.25 No.-

According as the current needs of low temperature in semiconductor manufacturing process, PECVD using low temperature and high deposition rate is becoming more of a concern. However, PECVD equipment has the defect possibility on the interface between substrates and gate oxide layer, because ions or electrons with much high energy clash the interface. In this study, we embarked on the experiment with Statistical Design of Experiment and then also analyze which parameters influence on the characteristic of silicon dioxide filems. We finally made a constructive proposal for process optimization conditions.

순·구개열 환자의 두부규격방사선사진상을 이용한 친자간의 유사성에 관한 연구

이언경,나승목,고광준,조수범 大韓口腔顎顔面 放射線學會 1994 Imaging Science in Dentistry Vol.24 No.2

The purpose of this study was to determine whether any similarity existed in craniofacial morphology between parents and offspring in cleft lip with or without cleft palate. Thirty three measurements of the various regions of cranium and face were obtained from lateral cephalometric radiograms in 28 families comprising 28 fathers, 28 mothers and 28 cleft patients. The measurements of cleft patients were compared with those of their fathers, mothers and midparents. The obtained results were as follows: 1. There were similar measurements between the cleft patients and their father; ramal height(Ar-Go), mandibular angle(∠MP-RP). 2. There were similar measurements between the cleft patients and their mothers; cranial base angle(∠NSBa), relation of maxilla to the cranial base(∠SNA), relation of maxilla to the cranial base(soft tissue:∠BaN"Sn), angle of inferior border of mandible(∠SNL-MP) and convexity of nose apex(soft tissue:N"PrnPog"). 3. There were similar measurements between the cleft patients and their mdparents; ramal height (Ar-Go), cranical base angle(∠NSBa), relation of maxilla to the cranial base(soft tissue:∠BaN"Sn), Y axis angle(∠NSGn) and mandibular angle(∠MP-RP). 4. There was no similar measurements between the cleft patients and their fathers and mothers simultaneously.

모사 이동층 반응-분리기의 해석에 관한 연구 Ⅱ. 비선형 등온식 영역에서의 고찰

이광남,태범석 안성산업대학교 2002 論文集 Vol.33 No.-

The advanced esterification conversion of phenethyl acetate was predicted by using a Simulated Moving Bed Reactor (SMBR). The plug flow model with the reaction term was presented to estimate the concentration profiles of SMBR. The numerical values could be calculated by orthogonal collocation method with 10th Jacobi orthogonal polynomial P_10^(0.0). The performance was compared with the batch reactor through the numerical calculation. To get the desired concentration profiles in the nonlinear isotherm of Langmuir type, the criteria of proper flow condition suggested in this work should be satisfies. With the proper flow conditions, the esterification conversion was increased to 95.7% beyond the equilibrium conversion of 63%.

WTO 體制下 우리 나라 産業被害救濟制度의 運營上 問題點과 補完方向

李光範 청주대학교 대학원 1998 우암논총 Vol.20 No.-