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薛光烈,梁盛烈,李相豊 한국잠사학회 1991 한국잠사곤충학회지 Vol.33 No.2
Disinfection of the rotatory cocooning frame is difficult under a multiple rearing system as the work is successively done. Accordingly, to investigate the effect of formalin fumigation on the rotatory cocooning frame during mounting period the mulberry leaves smeared with the water extract of dust collected from cocooning frame after treatment were fed on the just molted 3rd instar larvae, 82% of them died with disease during 6 days, and negative effect of formalin fumigation takes place in terms of the cocoon reelability, showing 41% of it.
당뇨유발 마우스에서의 hollow fiber 로 캡슐화한 췌장소도의 이종이식
이무열(Moo Yeol Lee),우정택(Jeong Taek Woo),김성운(Sung Woon Kim),양인명(In Myung Yang),김진우(Jin Woo Kim),김영설(Young Seol Kim),김광원(Kwang Won Kim),최영길(Young Kil Choi),서광식(Kwang Sik Suh) 대한내과학회 1994 대한내과학회지 Vol.46 No.3
N/A Background: We have investigated whether xenograft of the pancreatic islets encapsulated in hollow fiber (Amicon, H1P 30~43 type) could normalize blood glucose levels and could secrete insulin normally in perifusion system. Method: Mice (ICR) made diabetic with 180 mg/kg streptozotocin were intraperitoneally transplanted with encapsulated rat pancreatic islets, Hollow fibers (Amicon, H1P30~43 type, nominal cutoff MW; 30,000) have been used for encapsulation of rat islet cells. Result: Rat islets in the hollow fibers secreted insulin normaly in perifusion system. Xenograft of rat islets in the hollow fibers produced and maintained temporarily normoglycemia in the recipient mice. Conclusion: These results suggest that xenograft of rat islets in the hollow fibers need further study for biocompatability, transplantation site, and islet cell counts.
LCA기법을 이용한 플라스틱 파렛트 풀링시스템에 대한 환경성 평가
이영설 ( Young-seol Lee ),박광호 ( Kwang-ho Park ),위대형 ( Dae-hyeong Wie ),서병륜 ( Byong-yoon Suh ),김덕열 ( Deok-yeol Kim ) 한국전과정평가학회 2020 한국전과정평가학회지 Vol.21 No.1
플라스틱 파렛트는 물류산업현장에서 한 번 사용이 끝난 플라스틱 파렛트를 다시 회수하고 풀링시스템을 통해 반복 사용하는 리터너블 물류 운반 도구로 Closed-loop 순환 시스템을 통해 신품의 생산을 최소화하는 자원순환형 제품이다. 본 연구에서는 전과정평가(LCA) 기법을 이용하여 플라스틱 파렛트 풀링시스템의 파렛트 반복·재사용에 따른 환경영향을 정량적으로 평가하였으며, 이를 이용하여 1회 사용 대비 풀링시스템의 환경적 개선효과를 분석하였다. 시스템 경계는 원료취득단계, 제조단계, 사용(유통)단계, 세척단계, 폐기 및 재활용단계로 설정하였으며, 사용(유통)단계는 생산공장, 사용자, 도착지, 회수센터, 세척센터 등으로 세분화하여 분석하였다. 환경적 개선효과 분석결과, 플라스틱 파렛트 풀링시스템은 1회 사용 대비 6대 영향범주 기준 평균 73.3% 감소하는 것으로 나타났으며, 영향범주 중 자원고갈 영향범주가 91.5% 감소하여 효과가 가장 큰 것으로 나타났고, 지구온난화에 대한 환경적 개선효과는 72.8%로 나타났다. The plastic pallet is a resource-circulating product that minimizes the production of new products through a closed-loop circulation system as a returnable logistics transport tool that recovers plastic pallets that have been used once in the logistics industry and uses them repeatedly through a pooling system. In this study, the environmental impacts of repetition and reuse of plastic pallet evaluated using LCA. And the results were used to compare with single used plastic pallet. The system boundary was set to raw material extraction stage, product manufacturing stage, use (distribution) stage, cleaning stage, and disposal and recycling stage. And use (distribution) stage was analyzed by subdividing into production plants, users, destinations, collection centers, and washing centers. As a result of the analysis of environmental improvement effects, the plastic pallet pooling system showed an average decrease of 73.3% based on the six impact categories compared to single use, and the impact category of resource depletion among the impact categories decreased by 91.5%, showing the greatest effect, and 72.8% environmental improvement effect on global warming.
Kang, Kyeong-Rok,Kim, Jae-Sung,Kim, Tae-Hyeon,Seo, Jeong-Yeon,Lim, HyangI,Park, Jong-Hyun,Yang, Kwang Yeol,Yu, Sun-Kyoung,Kim, Heung-Joong,Kim, Chun Sung,Chun, Hong Sung,Lee, Dong-Seol,Park, Joo-Cheol The Korean Academy of Oral Biology 2021 International Journal of Oral Biology Vol.46 No.1
Alpha-lipoic acid (ALA) is a naturally occurring antioxidant and has been previously used to treat diabetes and cardiovascular disease. However, the autophagy effects of ALA against oxidative stress-induced dopaminergic neuronal cell injury remain unclear. The aim of this study was to investigate the role of ALA in autophagy and apoptosis against oxidative stress in the SH-SY5Y human dopaminergic neuronal cell line. We examined SH-SY5Y phenotypes using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay (cell viability/proliferation), 4′,6-diamidino-2-phenylindole dihydrochloride nuclear staining, Live/Dead cell assay, cellular reactive oxygen species (ROS) assay, immunoblotting, and immunocytochemistry. Our data showed ALA attenuated hydrogen peroxide (H2O2)-induced ROS generation and cell death. ALA effectively suppressed Bax up-regulation and Bcl-2 and Bcl-xL down-regulation. Furthermore, ALA increased the expression of the antioxidant enzyme, heme oxygenase-1. Moreover, the expression of Beclin-1 and LC-3 autophagy biomarkers was decreased by ALA in our cell model. Combined, these data suggest ALA protects human dopaminergic neuronal cells against H2O2-induced cell injury by inhibiting autophagy and apoptosis.
심재익 ( Jae Ik Shim ),김택선 ( Taik Seon Kim ),이성종 ( Sung Jong Lee ),이석하 ( Suk Ha Lee ),김영배 ( Young Bae Kim ),윤정로 ( Jong Ro Yoon ),설의상 ( Eui Sang Seol ),박광열 ( Kwang Yeol Park ),강대웅 ( Dae Woong Kang ) 대한골절학회 2001 대한골절학회지 Vol.14 No.3
목적: 대퇴골 간부 골절치료 후 발생한 불유합의 수술적 치료 결과를 임상적 및 방사선학적으로 분석하고자 하였다. 대상 및 방법: 1993년 1월부터 1999년 12월까지 대퇴골 간부 불유합으로 수술한 환자 21예를 대상으로 하였으며 추시 기간은 평균 15개월이었다. 초기 골절의 원인, 형태와 분류 및 불유합의 원인을 임상적 및 방사선학적으로 분석하였다. 불유합의 수술 방법으로 자가골 이식술과 교합성 골수강내 금속정을 이용한 견고한 내고정술을 시행하였으며 골유합의 기간과 결과를 분석하였다. 결과: 평균 골유합 기간은 22주이었으며 21예중 18예(85.7%)에서 골유합 소견을 보였고 합병증으로는 하지 단축과 파행이 2예, 관절 부분 강직이 2예, 천부 감염이 2예이었다. 결론: 대퇴골 간부 불유합의 치료시 그 원인과 형태에 따라 자가골 이식술과 교합성 골수강내 금속정을 이용한 견고한 내고정술로 양호한 결과를 얻을 수 있을 것으로 생각되었다. Purpose: The purpose of this study is to analyze the clinical and radiological result of surgical treatment for femoral shaft nonunion. Materials and methods: From January 1993 to December 1999, 21 cases of femoral shaft nonunion were treated surgically and followed for an average of 15 months. We analyzed initial cause of injuries, classification of fractures, and cause of nonunion in clinically and radiologically. The authors analyzed the average time to union and results after surgical treatment by rigid internal fixation with interlocking intramedullary nail and autogenous bone graft. Results: The mean duration of bony union was 22 weeks and bony union achieved in 18 cases(85.7%) of 21 cases. The complications were shortening of leg length and limping gait in 2 cases, partial limitation of knee joint in 2 cases, superficial infection in 2 cases. Conclusion: Rigid internal fixation with interlocking intrameduallary nail and bone graft is useful method of treatment for femoral shaft nonunion according to cause and type of nonunion.