조산의 예측 지표로서의 fetal fibronectin의 유용성

정집광,이해혁,이정재,이석민,이순곤,남계현,이임순,이권해 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Objective: The purpose of this study was to evaluate clinical efficacy of fetal fibronectin as a marker to predictor of preterm labor. Materials & Methods: The study group consisted of sixty-eight healthy pregnant women, at gestational age between 24 and 36 weeks, who visited our department with vaginal discharge from April, 1995 to December, 1997. For comparison, we divided all of the pregnant women into two groups by the result of ROM-Check^®, positive groups(N=21) and negative groups(N=47). When preterm labor appeared, 50mg of ritodrine hydrochloride(Yutopar^®) mixed I liter of 5% dextrose solution was administered slowly intravenously. Results: 1) The gestational age at delivery and the interval time from admission to delivery in the positive groups were significantly shorter than those of the negative groups(p<0.05). 2) The positive groups had significantly lower birth weight and Apgar scores than the negative groups(p<0.05). 3) Among the negative groups, in case of tocolytics administration, the interval time from admission to delivery significantly delayed more than that time in case of no tocolytics administration(p<0.05). Conclusions: The detection of the fetal fibronectin in vaginal discharge had a useful method as a predictor of preterm labor. Tocolytics was more effective in the negative groups than in the positive groups.

폐경기 여성에서 호르몬 대치 요법시 병행 투여된 프로제스토젠 투여 방법에 따른 혈청 지질 및 지단백에 미치는 영향

이임순,전섭,이순곤,이해혁,이권해,정집광,이석민 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

Objective : The purpose of our study is to evaluate the effect of different administration method of progestogen on lipid profiles including total cholesterol, LDL(low density lipoprotein)-cholesterol, HDL(high density lipoprotein)-cholesterol, triglycerides during hormone replacement therapy in postmenopausal women. Methods and Materials : Seventy-one postmenopausal women who were assigned to following groups (Group I : conjugated equine estrogen(CEE), 0.625 mg/day plus continuous medroxyprogesterone acetate (MPA), 2.5mg/day, Group II : CEE, 0.625 mg/day plus cyclic MPA, 5mg/day for 12days/month. And we measured serum total cholesterol, high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol, and triglycerides before hormone replacement therapy(HRT) and 12 months later after hormone replacement therapy. Results: 1. Total cholesterol decreased in group I,III. 2. HDL-cholesterol increased in group I,II,III. 3. LDL-cholesterol decrease in group I,II. 4. Triglycerides increased in group I,II,III. There was significance in serum total cholesterol and LDL-cholestrerol among three groups. Conclusions : Estrogen alone or in combination with progestogen both in cyclic and continuous use improves lipid profiles, so medroxyprogesterone acetate(MPA) does not seem to blunt estrogenic effect on lipid profiles.

대전시 노은 도매시장 채소류의 농약 잔류 실태 및 식이섭취량 추정

한국탁,이규승,이은경,이용재,고광용,원동준,이정원,권순덕 한국환경농학회 2003 한국환경농학회지 Vol.22 No.3

대전시 노은 도매시장에서 채취한 6종의 채소류 중 농약잔류량을 조사한 후 이에 대한 위해성 평가를 실시하였다. 전체 100건의 분석시료 중 농약이 검출된 시료의 비율은 46.0%이었고, 잔류허용기준 초과비율은 6.0% 이었다. 검출비율이 높은 시료는 상추(85.0%), 깻잎(80.0%), 오이(60.0%) 순이었고, 상추 3건, 깻잎 3건이 허용기준을 초과하였다. 살균제는 dicar-boximide계, 유기염소계, azole계 농약, 살충제는 유기인계, 합성 pyrethroid계 농약이 많이 검출되었다. 검출빈도가 높은 성분은 procymidone, chlorpyrifos, chlorothalonil, cypermethrin, EPN의 순이었다. 위해성을 평가하기 위해서 각 농작물에 대한 농약의 추정 섭취량과 ADI를 비교한 결과, 허용기준을 초과한 깻잎의 bitertanol, triflumizole, iprobenphos가 다른 성분에 비하여 높은 비율을 보였다. 그러나 각 농산물의 식이섭취량이 적어 ADI에 대한 추정섭취량의 비율이 0.46%이하로 나타나 그 영향이 매우 낮은 것으로 판단되었다. Pesticide residues in some vegetables collected at Noeun wholesale market in Daejeon were surveyed and assessed their risk In 100 samples, the detection rate of pesticide was 46.0% and the rate exceed MRL was 6.0%. Commodities showing high detection rate were lettuce(85.0%), perilla leaf(80.0%) and cucumber(60.0%). Dicarboximide, organochlorine, and azole fungicides and organophosphorus and pyrethroid insecticides were detected. Detection frequency of pesticide was in the order of procymidone, chlorpyrifos, chlerothalonil, cypermethrin and EPN. When the estimated intake amount of the pesticides were compared with ADI to assess their risk, bitertanol, triflumizole and iprobenphos in perilla leaf were higher rate than the other vegetables. However the total amounts of intake of pesticides were estimated to less than 0.46% of ADI.

Rocuronium의 애별투여방법이 모지내전근의 이완에 미치는 영향

최영균,김승수,이원진,조광래,이상은,김영환,임세훈,이정한,이근무,정순호,김영재,신치만 인제대학교 2009 仁濟醫學 Vol.30 No.-

Objective : There are controversies in pnmmg technique of rocuronium whether it can or can't shorten the onset time. We want to compare the effects of two different priming doses and intervals of rocuronium. Materials and Methods : After giving propofol, 50 patients were randomly assigned to 5 groups. Group I received a placebo, followed 3 min later by rocuronium 0.6 mg/kg. Priming doses and intervals of Group II, Ill, N, V were 0.06 rng/kg and 2 min, 0.12 mg/kg and 2 min, 0.06 rug/kg and 3 min, 0.12 mg/kg and 3 min, respectively. Total dose of rocuronium was 0.6mg/kg. Train of four (TOF) count or ratio and 1st twitch height of TOF (T1) were monitored with 15 secondsintervals. TOF ratio of each groups just before bolus injection, duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were compared. Results : Duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were decreased in priming groups compared to Group 1 (P < 0.01) In group V, significant depression of TOF ratio just before bolus injection was seen (P < 0.05). Conclusion : Priming technique with rocuronium is effective method to shorten the onset of neuromuscular block. But priming dose of rocuronium itself could cause hypoxia and aspiration in awake patients and should be used carefully. Priming dose of rocuronium 0.06 mg/kg and 2 minutes interval maybe relatively safe method.

전격성 경과를 취한 만성 호산구성 폐렴 환자 1예

윤호상,진춘조,유광하,이상엽,이수인,정상만,김선두,이순제,이길도,전혜정 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Chronic eosinophilic pneumonia(CEP) is a rare disease of unknown etiology characterized by chronic infiltration of the lung with eosinophils. It presents with profound systemic symptoms comprising fever, night sweats, weight loss, dyspnea and blood eosinophilia with nonsegmental air-space consolidation confined to the outer third of the lung, the "photographic negative of pulmonary edema". Histopathologic features of chronic eosinophilic pneumonia are intraalveolar and interstitial infiltrations with eosinophils, histiocytes, giant cells, scattered lymphocytes and plasma cells. Glucocorticoid therapy cause prompt resolution of symptoms as well as disappearans of blood eosinophils, elevated serum Ig E levels and the roentgenographic lesions. Infrequent radiographic findings include nodular infiltrates, consolidations, cavitations, atelectasis and pleural effusions. Deaths from CEP although rare, have been reported, but the majorities of CEP have benign courses and do not need a therapy with ventilator. We report a case of chronic eosinophilic pneumonia, which had a sudden course associated with diffuse pneumonic consolidations on the both lung and bilateral pleural effusion.

Fulminant Hepatits 治驗 2例

李承魯,陸淳劑,柳浩相,金吉洙,高侊道 中央醫學社 1976 中央醫學 Vol.31 No.5

Calculous anuria is one of the complications of upper urinary tract calculi and may be caused by mechanical obstruction at some point of the tract, renal insufficiency, and a combination of obstructive and renal factors. The clinical features may vary from a complete absence of symptom to the time when the patient observes he could not pass urine. An immediate roentgenogram and catheterization of the ureters in an attempt to restore the excretion of urine are always recommended and in from 50 to 55 per cent of the patients the calculus is expelled. Even if anuria recurs after withdrawal of the catheter, the patient is in better condition for surgical intervention as a result of the removal of accumulated nitrogenous waste products. Uric acid calculi comprise from 3.5 to 4 percent of urinary calculi. A low purine diet, allopurinol and alkalinization of urine are proved very effective in management of it. Recently we have experienced a case of calculous anuria due to bilateral ureteral stones in 41 years old man and present it with the review of the literatures.

Tetracaine이 개의 大腦皮質 Na^+-K^+-ATPase의 活性에 미치는 影響

이진영,김광용,서영,서경종,박영순 圓光大學校 基礎自然科學硏究所 1990 基礎科學硏究誌 Vol.9 No.1

본 實驗은 tetracaine이 개의 大腦皮質의 Na^+ - K^+ - ATPase의 活性에 어떻게 影響을 미치는 가를 알아보기 위하여 실시한 것이다. 그 酵素에 대한 tetracatine의 沮害效果와 그 機作은 酵素反應速度論的 分析方法 즉 Dixon-plot, Lineweaver-Burk plot, Arrhenius-plot 등으로 分析하였다. 그 結果는 다음과 같다. 1. Na^+ - K^+ - ATPase는 全 ATPase와 Mg^++ - ATPase의 活性보다 tetracaine에 의하여 더 많은 沮害를 받는다. 2. Tetracaine의 50% 沮害效果는 沮害常數 5㎎/㎖와 동일하였다. 3. Tetracaine은 그 酵素의 Km값을 변화시키지 못하였으나 最高速度(Vmax)는 변화시키기 때문에 tetracaine은 可逆的 非競爭的 沮害劑로 作用한 것 같다. 4. Q_10 값은 tetracaine의 농도가 증가함에 따라 감소되는데 이 값으로 Arrhenius-plot를 作成해 본 結果 切點(transition state)이 나타나지 않으므로 tetracaine은 脂質에는 작용하지 않고 오직 Na^+ - K^+ - ATPase에 작용하는 것 같다. The present experiments were disigned to investigate the effect of tetracaine on the dog brain cortex Na^+ - K^+ - ATPase activity. The inhibitory effects of tetracaine on the enzyme avtivity and its mechanism were analyzed by Dixon plot, Lineweaver-Burk plot, and Arrhenius plot. The results obtained here were as follows : 1. The Na^+ - K^+ - ATPase activity was inhibited more than the total ATPase and Mg^++ - ATPase in the presence of tetracaine. 2. The concentration of 50% inhibition for tetracaine was identical with the inhibition constant (Ki), the Ki value was 5 ㎎/㎖ for tetracaine. 3. In this study tetracaine did not change the Km value (2.5) but decreased the Vmax of the Na^+ - K^+ - ATPase activity, suggesting that tetracaine acts as reversible and noncompetitive inhibitor on the enzyme. 4. Q_10 value and energies of activation (20.1 Kcal/mole) decreased as the concentrations of trtracaine increased and the transition state did not appeared. These results suggest that trtracaine inhibits the enzyme activity by reversible and noncompetitive inhibition.

흑연 표면에 흡착되는 영족 기체의 초기 제2분자층 형성 과정

李慶哲,李廣純 聖心女子大學校 1983 論文集 Vol.15 No.-

비활성 기체 Ar, Kr 및 Xe의 in-registry??out-of-registry의 구조 상전이 현상으로부터 흡착제 표면에서의 분자간 상호작용을 고찰하였다. 단분자층 완성 영역인 Knee band 부근에서의 제2분자층의 기여를 구하였다. 제1분자층은 lattice gas로 보고 quasi-chemical theory를, 제2분자층은 2차원 기체로 보고 virial 상태방정식을 적용하였다. 이 결과로부터 제2분자층의 기여와 단분자층 용량을 구하였다. 이 단분자층 용량에 분자 단면적을 곱하여 흡착제 표면적을 구하였다. In this work, intermolecular interaction on surface of adsorbent have been theoretically studied as considering the phenomenon of in-registry??out-of-registry structual phase transition. The contributions of the 2nd layer in knee band region of completing monolayer have been calculated. For the 1st layer assumed as a lattice gas, quasi-chemical theory and for the 2nd layer assumed as a two-dimensional gas, virial equation of state are applied. The isotherm which combines two isotherms, the 1st layer and the 2nd layer isotherm, is calculated and is compared with experimental isotherm. And then the contribution of the 2nd layer and monolayer capacity are calculated. The surface area of adsorbent is calculated using calculated monolayer capacity and cross sectional area of an adsorbed molecule.

TiO₂미세분말 제조에 관한 연구

이광래,안순철,송근호,김종수 강원대학교 석재복합신소재제품연구센터 1998 석재연 논문집 Vol.3 No.-

역마이셀 기법에 의하여 TiO₂ 분말을 제조하였으며, TiO₂ 분말 제조에 미치는 공정변수들인 계면활성제의 종류 및 보조계면활성제가 생성입자의 입도분포에 미치는 영향을 규명하였다. 비이온계면활성제인 Span 80을 사용하였을 경우에는 입도분포가 unimodal형태였으나, 음이온계면활성제인 Aerosol-OT(AOT)를 사용하였을 경우, bimodal형태를 나타내었다. 에탄올(ethanol)을 cosurfactant로 첨가한 계로 부터 생성된 입자는 평균입경이 0.12㎛ 으로서 미세할 뿐아니라 입도분포도 매우 좁은 것을 알 수 있다. Titanium dioxide (TiO₂) fine particles were produced by the reverse micelle technique. The effects of process variables such as surfactant and cosurfactant on particle size distribution were investigated. The particle size distribution curve was unimodal for a nonionic surfactant (Span80), but was bimodal for an anionic surfactant (AOT). The addition of ethanol as a cosurfactant resulted in narrow particle size distribution and 0.12㎛ of smaller average particle diameter.

바이오용 마이트로 핀의 제작에 관한 연구

이영수,김광순,김병희 강원대학교 산업기술연구소 2003 産業技術硏究 Vol.23 No.A

The bio-micro pin is usually used for biochemistry analysis The capability of manufacturing the micro-pin and array with effective and low-cost way is very important to developers. The micro-pin is composed of sample channel- putting liquid into already fixed volume. 'flat tip, having connection with printing quantity. and head part for preventing it from rotation of pin in the holder. We analyzed out printing variation in accordance with shape and tip size of the micro-pin point channel In this study, me suggested the manufacturing progress and shape demand condition of the micro-pin which could put 0.2㎕-biochemist교 material into the sample volume. and will be able to produce the micro-pin which can put 10nℓ-biochemistry matenal into the sample volume in the future