보리새우, Penaeus japonicus의 中腸에서의 Glycine Transport

朱鎭球,宋容圭,劉寬凞,朴來鉉,申埈國 충남대학교 자연과학연구소 1983 忠南科學硏究誌 Vol.10 No.2

Glycine transport through mucosal border of the columnar epithelium on the marin shrimp, P. japonicus midgut has been investigated with particular emphasis on the interaction to Na^+. The transmural fluxes of the amino acid across the midgut wall were also determined. 1. Mucosal glycine uptake occurred via Na^+-dependent and Na^+-independent carrier processes, and the passive movement of glycine. 2. Mucosal and serosal glycine uptakes in normal saline were higher than those in Na^+-free medium, but lower than those in Cl^--free medium. 3. L-alanine was acted like a competitive inhibitor of mucosal glycine entry process. 4. Exit process of glycine across the mucosal membrane was accelerated by the presence of L-alanine in the medium. 5. Prediction equation of saturable glycine uptake was derived from experimental data. 6. Turning point and regression coefficients of segmented linear regression for the high affinity and low affinity components of glycine carrier were determined by using computer. 7. Ultrastructural changes of mucosal epithelial cells related to the experimental treatments were observed through transmission and scanning electron microscope.

Intraoperative Neurophysiological Monitoring during Microvascular Decompression Surgery for Hemifacial Spasm

Park, Sang-Ku,Joo, Byung-Euk,Park, Kwan The Korean Neurosurgical Society 2019 Journal of Korean neurosurgical society Vol.62 No.4

Hemifacial spasm (HFS) is due to the vascular compression of the facial nerve at its root exit zone (REZ). Microvascular decompression (MVD) of the facial nerve near the REZ is an effective treatment for HFS. In MVD for HFS, intraoperative neurophysiological monitoring (INM) has two purposes. The first purpose is to prevent injury to neural structures such as the vestibulocochlear nerve and facial nerve during MVD surgery, which is possible through INM of brainstem auditory evoked potential and facial nerve electromyography (EMG). The second purpose is the unique feature of MVD for HFS, which is to assess and optimize the effectiveness of the vascular decompression. The purpose is achieved mainly through monitoring of abnormal facial nerve EMG that is called as lateral spread response (LSR) and is also partially possible through Z-L response, facial F-wave, and facial motor evoked potentials. Based on the information regarding INM mentioned above, MVD for HFS can be considered as a more safe and effective treatment.

The critical warning sign of real-time brainstem auditory evoked potentials during microvascular decompression for hemifacial spasm

Park, Sang-Ku,Joo, Byung-Euk,Lee, Seunghoon,Lee, Jeong-A.,Hwang, Jeong-Ho,Kong, Doo-Sik,Seo, Dae-Won,Park, Kwan,Lee, Hoon-Taek Elsevier 2018 CLINICAL NEUROPHYSIOLOGY - Vol.129 No.5

<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>The aim of this study was to define the critical warning sign of real-time brainstem auditory evoked potential (BAEP) for predicting hearing loss (HL) after microvascular decompression (MVD) for hemifacial spasm (HFS).</P> <P><B>Methods</B></P> <P>Nine hundred and thirty-two patients with HFS who underwent MVD with intraoperative monitoring (IOM) of BAEP were analyzed. We used a 43.9 Hz/s stimulation rate and 400 averaging trials to obtain BAEP. To evaluate HL, pure-tone audiometry and speech discrimination scoring were performed before and one week after surgery. We analyzed the incidence for postoperative HL according to BAEP changes and calculated the diagnostic accuracy of significant warning criteria.</P> <P><B>Results</B></P> <P>Only 11 (1.2%) patients experienced postoperative HL. The group showing permanent loss of wave V showed the largest percentage of postoperative HL (<I>p</I> < 0.001). No patient who experienced only latency prolongation (≥1 ms) had postoperative HL. Loss of wave V and latency prolongation (≥1 ms) with amplitude decrement (≥50%) were highly associated with postoperative HL.</P> <P><B>Conclusions</B></P> <P>Loss of wave V and latency prolongation of 1 ms with amplitude decrement ≥50% were the critical warning signs of BAEP for predicting postoperative HL.</P> <P><B>Significance</B></P> <P>These findings elucidate the critical warning sign of real-time BAEP.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Critical warning sign of real-time BAEP during MVD for hemifacial spasm have been studied. </LI> <LI> Loss of wave V and the significant change of both latency and amplitude are the critical signs. </LI> <LI> Isolated wave V latency prolongation of >1 ms without amplitude loss >50% is not saaociated with postoperative hearing loss. </LI> </UL> </P>

A Study on Manufacturing Asbestos Removal Equipment of Soils and its Field Applications

Chang Ku Park,Myung Chae Jung,Jeong Wook Kim,Kwan In Park 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

임신 20주 이상 지속된 선천성 자궁기형 환자에서의 산과적 예후

구연희 ( Yeon Hee Ku ),김건우 ( Kun Woo Kim ),한지혜 ( Jee Hye Han ),박현수 ( Hyun Soo Park ),박찬욱 ( Chan Wook Park ),박중신 ( Joong Shin Park ),전종관 ( Jong Kwan Jun ),윤보현 ( Bo Hyun Yoon ),신희철 ( Hee Chul Syn ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.5

목적: 선천성 자궁 기형이 있는 여성에서 임신 20주 이상 지속된 경우 산과적 예후를 알아보고자 한다. 연구 방법: 1990년 1월부터 2005년 12월까지 16년간 서울대학교병원 산부인과에서 선천성 자궁 기형으로 진단받은 환자 106명을 대상으로 의무기록을 이용한 후향적 연구방법을 사용하였다. 선천성 자궁 기형은 쌍각자궁, 이중자궁, 중격자궁, 궁상자궁, 단각자궁으로 분류하였으며 각 형태에 따른 산과적 예후를 알아보았다. 결과: 전체 자궁 기형 중 쌍각자궁이 59.5% (63/106), 이중자궁이 17.9% (19/106), 중격자궁이 15.1% (16/106), 궁상자궁이 4.7% (5/106), 단각자궁이 2.8% (3/106)이었다. 전체 자궁 기형에서 조기 분만율은 22.6% (24/106)이었고 제왕절개술은 74.5% (79/106)에서 시행하였다. 제왕절개술 빈도가 높은 것은 자궁성형술, 비정상 태위 및 자궁 기형 자체 때문이었다. 조기분만율과 제왕절개술 빈도는 각 기형 형태에 따라 통계적으로 유의한 차이를 보이지는 않았다. 사산이 5예 있었으며 태반조기박리로 인한 신생아기 사망이 1예 있었다. 전체 take-home baby 비율은 94.3% (100/106)이었다. 모성 사망은 없었으며 산후 출혈이 1예 있었다. 결론: 선천성 자궁 기형이 있는 여성에서 임신 20주 이상 지속된 경우에는 비교적 양호한 산과적 예후를 기대할 수 있다. Objective: To evaluate the pregnancy outcomes of women with congenital uterine anomaly exceeding 20 weeks of gestation. Methods: We reviewed retrospectively the birth records of the Seoul National University Hospital between January 1, 1990, and December 31, 2005. We grouped congenital uterine anomalies into five classes, namely bicornuate, didelphys, septate, arcuate, and unicornuate uterus. We compared the pregnancy outcomes with each anomaly. Results: We found 106 cases of congenital uterine anomaly within a given period of time. There were 63 cases of bicornuate uterus, 19 cases of didelphys, 16 cases of septate uterus, 5 cases of arcuate uterus, and 3 cases of unicornuate uterus. The overall preterm delivery rate was 22.6% (24/106) and cesarean section rate was 74.5% (79/106). A high cesarean section rate was due to metroplasty, abnormal fetal presentation, and uterine anomaly itself. The preterm delivery rate and cesarean section rate of each uterine anomaly did not differ statistically from one another. Five fetuses were stillborn, and one fetus died after birth because of a placenta abruption. The overall take-home baby rate was 94.3% (100/106). There was no maternal mortality and only one case was suffered from postpartum bleeding. Conclusion: Our results suggest that the most of women with uterine anomaly exceeding 20 weeks of gestation may take their baby home.

경주지역 여고생의 초경과 체성장간의 관계

김준섭,권오구,박진석,오종수,박정현,박제식,안세한,이용환,서정호,신태섭,최영배,김덕수,이관,박수경 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1

본 연구는 경주지역 1개 고등학교 3학년 여고생을 대상으로 초경 시작 전인 초등학교 4학년부터 고등학교 2학년까지의 키, 몸무게, 가슴둘레 수치와 초경 연령을 파악하여 여성의 초경이 빠를수록 체성장 속도의 변화가 있을 것이라는 가설을 기초로 두 요인간의 관련성을 파악하고자 시행되었다. 경주시 1개 여자고등학교 3학년생 총 317명에 대해 ㅊ경 나이, 초경시 심리 상태, 초경이 시작되었을 때의 상담 여부와 상담하였던 사람, 부모 신장과 초경전후의 식사 규칙성, 다이어트 경험, 수면시간, 스트레스, 음주/흡연 여부, 질병력 등에 대한 설문 조사를 시행하였고, 초등학교 4학년부터 고등학교 2학년까지의 키, 몸무게, 가슴둘레에 대한 정보는 건강기록부에서 확보하였다. 상기 대상자 중 건강기록부가 분실된 39명, 초경나이에 대해 응답하지 않았던 29명 및 결석 등으로 조사를 하지 못하였던 42명을 제외한 조사 대상자는 206명으로 선정하였다. 대상자들의 초경연령 평균값(Mean±SD)은 13.0±1.11이었고, 초등학교 4학년부터 고등학교 2학년까지의 초경 이후 신장 성장률은 감소하였으며, 초경연령이 빠른 군이 초등학교 때는 신장에 있어서 우위를 차지하나 고등학교에 오면서 신장은 비슷한 수준이 되었다. 초경후 1-2년 사이에 체중과 흉위의 증가율은 감소하였고, 초경연령이 빠른 군이 초등학교와 고등학교 사이에 체중과 흉위에서 모두 우위를 차지하였다. 본 연구의 결과는, 흔히 이차 성징의 시작 시점 혹은 사춘기의 시작 시점으로 보고있는 초경 연령이 청소년기의 성장과 밀접한 관련성이 있고, 특히 체중과 흉위의 성장 속도와 밀접한 관련성이 있음을 시사한다. To understand the onset of menarche in relation to changes in physical growth that take place during female adolescence, especially the changes in height and weight velocity. The 207 senior in one women high school of Kyongju were investigated in April 3 to 8, 2001. We collected the information, relation in the age at menarche, height & weight of parents, regularity of eating, and obesity diet, duration of sleeping, sickness & stress near age at menarche, by self-recording. The status of height, weight & chest circumference between the 4th grade of primary school and the junior of high school was collected by individual Health Record. The results were followed; The average age at menarche was 12.95±1.11 years old and the most frequent age of menarche is 13 years. After menarche, the velocity of height, weight and chest circumference were decreased. The most rapid group of menarche hold dominant position in height during elementary school. As time passed, they dont hold dominant position in height. The most rapid group of menarche get an advantage in the weight and the girth of chest after elementary school. The height of subjects is directly proportional to the height of their parents. These results suggest that the starting age at menestuation can be closely associated with physical growth and development.

Negative myoclonus associated with pregabalin

( Kwan-do Park ),( Min-ku Kim ),( Se-jin Lee ) 영남대학교 의과대학 2018 Yeungnam University Journal of Medicine Vol.35 No.2

Negative myoclonus (NM) is a jerky, shock-like involuntary movement caused by a sudden, brief interruption of muscle contraction. An 80-year-old man presented with multifocal NM and confusion. Two days before the onset of NM, he commenced the intake of pregabalin at a dose of 150 mg/day for neuropathic pain. His NM resolved completely and mental status improved gradually after the administration of lorazepam intravenously and the discontinuation of pregabalin. Our study suggests that pregabalin can cause NM even in patients without a history of seizures.

Preceding Intravenous Thrombolysis in Patients Receiving Endovascular Therapy

Park, Hong-Kyun,Chung, Jong-Won,Hong, Jeong-Ho,Jang, Min Uk,Noh, Hyun-Du,Park, Jong-Moo,Kang, Kyusik,Lee, Soo Joo,Ko, Youngchai,Kim, Jae Guk,Cha, Jae-Kwan,Kim, Dae-Hyun,Nah, Hyun-Wook,Han, Moon-Ku,Kim S KARGER AG 2017 Cerebrovascular Diseases Vol.44 No.1

<P>Background: The beneficial effects of endovascular therapy (EVT) in acute ischemic stroke have been demonstrated in recent clinical trials using new-generation thrombectomy devices. However, the comparative effectiveness and safety of preceding intravenous thrombolysis (IVT) in this population has rarely been evaluated. Methods: From a prospective multicenter stroke registry database in Korea, we identified patients with acute ischemic stroke who were treated with EVT within 8 h of onset and admitted to 14 participating centers during 2008-2013. The primary outcome was a modified Rankin Scale (mRS) score at 3 months. Major secondary outcomes were successful recanalization defined as a modified Treatment in Cerebral Ischemia score of 2b-3, functional independence (mRS score 0-2), mortality at 3 months, and symptomatic hemorrhagic transformation (SHT) during hospitalization. Multivariable logistic regression analyses using generalized linear mixed models were performed to estimate the adjusted odds ratios (ORs) of preceding IVT. Results: Of the 639 patients (male, 61%; age 69 +/- 12; National Institutes of Health Stroke Scale score of 15 [11-19]) who met the eligibility criteria, 458 received preceding IVT. These patients showed lower mRS scores (adjusted common OR, 1.38 [95% CI 0.98-1.96]). Preceding IVT was associated with successful recanalization (1.96 [1.23-3.11]) and reduced 3-month mortality (0.58 [0.35-0.97]) but not with SHT (0.96 [0.48-1.93]). Conclusion: In patients treated with EVT within 8 of acute ischemic stroke onset, preceding IVT may enhance survival and successful recanalization without additional risk of SHT, and mitigate disability at 3 months. (C) 2017 S. Karger AG, Basel</P>

High-modulus and strength carbon nanotube fibers using molecular cross-linking

Park, Ok-Kyung,Choi, Hoikil,Jeong, Hanbin,Jung, Yeonsu,Yu, Jaesang,Lee, Jae Kwan,Hwang, Jun Yeon,Kim, Seung Min,Jeong, Youngjin,Park, Chong Rae,Endo, Morinobu,Ku, Bon-Cheol Elsevier 2017 Carbon Vol.118 No.-

<P>We present a systematic and simple approach to produce high-strength carbon nanotube fibers (CNTFs) with electrical conductivity in the high performance range (> 1000 S/cm). We studied several critical parameters to improve the mechanical properties of CNTFs by aryl cross-linking reaction. Both the molecular dynamics (MD) simulations and experimental results showed that the mechanical properties strongly depended on the degree of cross-linking, length of cross-linkers, and CNT diameter. The monobenzene (MB) covalent bonding between CNTF with double-walled CNTs (DWCNTs) showed the highest load transfer, resulting in significantly enhanced specific tensile strength (3.7 N/tex) and Young's modulus (210 N/tex) which are superior to the strongest commercial carbon fiber (3.6 N/tex and 180 N/tex), respectively. Furthermore, the mechanical properties of aryl cross-linked CNTF exhibited no significant change in strength with sample size of CNTFs, showing uniformity of strength with increasing degree of cross-linking. The electrical conductivity of the MB cross-linked CNTFs was similar to 1400 S/cm, which is higher than the best value of commercial carbon fibers (715 S/cm). These results demonstrate that aromatic linker between CNTFs can significantly enhance mechanical properties without significant loss of electrical conductivity. These molecular engineering with MD simulations provide an important route to design and develop ultra-high-performance fibers. (C) 2017 Elsevier Ltd. All rights reserved.</P>

Enhanced Mechanical and Electrical Properties of Nitrogen Doped Carbon Nanotube Fibers Using Pyrolyzed Amino Acid

Park, Ok-Kyung,Jeong, Youngjin,Lee, Jae Kwan,Ku, Bon-Cheol American Scientific Publishers 2017 Science Of Advanced Materials Vol.9 No.2