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RISS 인기검색어
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- 저자 : ( Kumsun Cho ) (검색결과 2 건)
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Cho, Kumsun,Min, Sang-il,Ahn, Sanghyun,Min, Seung-Kee,Ahn, Curie,Yu, Kyung-Sang,Jang, In-Jin,Cho, Joo-Youn,Ha, Jongwon American Chemical Society 2017 Journal of proteome research Vol.16 No.8
<P>Remote ischemic preconditioning (RIPC) is a strategy to induce resistance in a target organ against the oxidative stress and injury caused by ischemia and reperfusion (IR). RIPC harnesses the body's endogenous protective capabilities through brief episodes of IR applied in organs remote from the target. Few studies have analyzed this phenomenon in the kidney. Furthermore, the window of protection representing RIPC efficacy has not been fully elucidated. Here, we performed a multiomics study to specify those associated with protective effects of RIPC against the IR injury. A total of 30 mice were divided to four groups: sham, IR only, late RIPC + IR, and early RIPC + IR. We found that IR clearly led to tubular injury, whereas both preconditioning groups exhibited attenuated injury after the insult. In addition, renal IR injury produced changes of the metabolome in kidney, serum, and urine specimens. Furthermore, distinctive mRNA and associated protein expression changes supported potential mechanisms. Our findings revealed that RIPC effectively reduces renal damage after IR and that the potential mechanisms differed between the two time windows of protection. These results may potentially be extended to humans to allow non- or minimally invasive diagnosis of renal IR injury and RIPC efficacy.</P>
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Genetic Effects on Leukotriene Production in Aspirin Exacerbated Respiratory Disease
( Ga-young Ban ),( Kumsun Cho ),( Seung-hyun Kim ),( Moon Kyung Yoon ),( Ji-hye Kim ),( Yoo-seob Shin ),( Young-min Ye ),( Dong-ho Nahm ),( Hae-sim Park ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Background: It is widely known that there have been strong genetic associations with aspirin exacerbated respiratory diseas (AERD) development. Leukotriene overproduction is the major feature of AERD. Genetic polymorphisms of CysLTR1 and HLA-DPB1*0301 were associated with the phenotypes of AERD. Objective: To investigate the genetic effects on leukotriene production in AERD. Subjects and Methods: A total of 95 AERD and 94 aspirin tolerant asthma (ATA) patients were enrolled. Serum samples were collected from all of the study subjects whereas urine samples were collected from 45 AERD and 44 ATA patients when the asthma was stable. The metabolites of LTE4 were analyzed using liquid chromatography with mass spectrometry. HLA-DPB1 high-resolution genotyping wasobtained from direct sequencing method and polymorphism of CysLTR1 was genotyped using SNaP shot ddNTP primer extension kit. Results: The frequency of HLA-DPB1*0301 allele was significantly higher in AERD compared with ATA (p=0.004, OR=4.178). The TT genotype frequency at CysLTR1 -634C>T is significantly higher in AERD compared to ATA (p 0.006, OR= 2.891). Serum and urine LTE4 levels were significantly higher in AERD than in ATA (19.10 ± 14.14 pg/mL vs. 13.59 ± 10.10 pg/mL, p=0.002; 7.36 ±13.19 pmol/mg creatinine vs. 2.69 ±3.62 pmol/mg creatinine, p=0.047, respectively). The levels of urine LTE4 were significantly higher in patients carrying HLA-DPB1*0301 (p=0.041), while no differences were found in serum LTE4. The asthmatic patients with the TTgenotype at -634C>T had a significantly higher levels of urine LTE4 (p=0.015), but no differences were found in serum LTE4 levels. The levels of urine LTE4 correlated significantly with fall of FEV1% after lysine aspirin bronchoprovocation test (r=0.463, p=0.008). Conclusions: HLA-DPB1*0301 and genetic polymorphisms of CysLTR1 -634C>T affect cysteinyl leukotriene overproduction which can contribute to develop the phenotypes of AERD.
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