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Antimicrobial Agent from Schima wallichii ssp. liukiuensis against Candida spp.
Kuem Shin,Ji-Yun Min,Seung-Mi Kang,Dong-Jin Park,Hyun-Jin Song,Oh-Woong Kwon,Jae-Kyung Yang,Chandrakant S. Karigar,Myung-Suk Choi 한국약용작물학회 2009 한국약용작물학회지 Vol.17 No.1
This study carried out development of a natural antimicrobial agent from Schima wallichii ssp. liukiuensis. Compound I exhibiting potent antimicrobial activity against Candida spp. was isolated from the methanol extracts of Schima wallichii ssp. liukiuensis. The structure of I identified as a sterol glycoside consisted of a trisaccharide and α1-sitosterol. Trisaccharide composed of L-rhamnose, D-galactose and D-glucose residues. The antimicrobial activity of I was selective on yeast rather than bacteria or other fungi. Compound I was demonstrated to be ineffective against toxicity to mouse liver cells where as protective to human dermal fibroblast cells at low concentrations. Thus, it is reasonable to expect a sterol glycoside (I) as a valuable alternative for synthetic antifungal.