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Upper Limit of Normal for Alanine Aminotransferase Level in Korean Population: Effect of Age
( Jae Keun Lee ),( Han Chu Lee ),( Koung Hoon Lee ),( Kang Mo Kim ),( Young Suk Lim ),( Young Hwa Chung ),( Yung Sang Lee ),( Dong Jin Suh ) 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.3(S)
Lee, Sung-Hee,Lim, Seul Ye,Choi, Ji Ha,Jung, Jae-Chul,Oh, Seikwan,Kook, Koung Hoon,Choi, Youn-Hee Nature Publishing Group 2014 Experimental and molecular medicine Vol.46 No.6
<P>The aim of the present study was to identify a new candidate anti-inflammatory compound for use in the active stage of thyroid-associated ophthalmopathy (TAO). Benzylideneacetophenone compound JC3 [(2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one] was synthesized based on a structural modification of yakuchinone B, a constituent of the seeds of <I>Alpinia oxyphylla</I>, which belongs to the ginger family (Zingiberaceae), has been widely used in folk medicine as an anti-inflammatory phytochemical. Orbital fibroblasts were primarily cultured from patients with TAO, and the potential of JC3 to suppress the interferon (IFN)-γ-induced protein (IP)-10/CXCL10 production in these cells was determined. IFN-γ strongly increased the level of IP-10/CXCL10 in orbital fibroblasts from patients with TAO. JC3 exerted a significant inhibitory effect on the IFN-γ-induced increase in IP-10/CXCL10 in a dose-dependent manner; its potency was greater than that of an identical concentration of yakuchinone B with no toxicity to cells at the concentration range used. Moreover, the constructed dimer and trimer polystructures of JC3, showed greater potency than JC3 in suppressing the IFN-γ-induced production of IP-10/CXCL10. JC3 significantly attenuated the IP-10/CXCL10 mRNA expression induced by IFN-γ, and a gel-shift assay showed that JC3 suppressed IFN-γ-induced DNA binding of signal transducer and activator of transcription-1 (STAT-1) in TAO orbital fibroblasts. Our results provide initial evidence that the JC3 compound reduces the levels of IP-10/CXCL10 protein and mRNA induced by IFN-γ in orbital fibroblasts of TAO patients. Therefore, JC3 might be considered as a future candidate for therapeutic application in TAO that exerts its effects by modulating the pathogenic mechanisms in orbital fibroblasts.</P>
Lee, Jung Eun,Kim, Koung Li,Kim, Danbi,Yeo, Yeongju,Han, Hyounkoo,Kim, Myung Goo,Kim, Sun Hwa,Kim, Hyuncheol,Jeong, Ji Hoon,Suh, Wonhee DOVE MEDICAL PRESS 2017 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.12 No.-
<P>Pathological angiogenesis is one of the major symptoms of severe ocular diseases, including corneal neovascularization. The blockade of vascular endothelial growth factor (VEGF) action has been recognized as an efficient strategy for treating corneal neovascularization. In this study, we aimed to investigate whether nanoparticle-based delivery of apatinib, a novel and selective inhibitor of VEGF receptor 2, inhibits VEGF-mediated angiogenesis and suppresses experimental corneal neovascularization. Water-insoluble apatinib was encapsulated in nanoparticles composed of human serum albumin (HSA)-conjugated polyethylene glycol (PEG). In vitro angiogenesis assays showed that apatinib-loaded HSA-PEG (Apa-HSA-PEG) nanoparticles potently inhibited VEGF-induced tube formation, scratch wounding migration, and proliferation of human endothelial cells. In a rat model of alkali burn injury-induced corneal neovascularization, a subconjunctival injection of Apa-HSA-PEG nanoparticles induced a significant decrease in neovascularization compared to that observed with an injection of free apatinib solution or phosphate-buffered saline. An in vivo distribution study using HSA-PEG nanoparticles loaded with fluorescent hydrophobic model drugs revealed the presence of a substantial number of nanoparticles in the corneal stroma within 24 h after injection. These in vitro and in vivo results demonstrate that apatinib-loaded nanoparticles may be promising for the prevention and treatment of corneal neovascularization-related ocular disorders.</P>
남경훈 ( Koung Hoon Nam ),이달희 ( Dal Heui Lee ),정성래 ( Sung Rae Chung ),정교철 ( Gyo Cheol Jeong ) 대한지질공학회 2014 지질공학 Vol.24 No.1
본 연구의 목적은 토양침식에 관련되는 강우특성, 토양경사도, 그리고 지질특성의 상대적인 중요도를 규명하는데 있다. 이 목적을 달성하기 위하여, 강우강도, 토양경사도, 지질특성의 각각 다른 조건에서 실내 인공강우실험 및 현장조사를 실시하였다. 실내시험 결과에 의하면, 토양침식 량은 토양 경사도가 강우강도보다 크게 영향을 받았다. 유출량은 강우량에 비례하며, 점토함량이 높을수록 증가한다. 따라서 토양의 유기물과 점토 함량이 큰 토양에서 토양침식 량이 크게 증가 하였다. 현장시험 결과로는 토양경사가 큰 지역 및 퇴적암 지역보다 변성암 지역에서 보다 큰 침식량이 계산되었다. 이러한 실험의 결과는 토양침식 량을 예측하는 모델개발에 있어서 기반암 풍화의 산물인 토양에서의 지질특성이 침식 및 침식후의 퇴적특성을 잘 반영하고 있음을 보여준다. This study aims to elucidate the relative importance of geological characteristics, soil slope, and rainfall intensity in relation to soil erosion. To this end, indoor rainfall simulation experiments were carried out under different conditions of rainfall intensities, soil slope, and geological characteristics. The test results show that the factors affect soil erosion in the order of soil slope > rainfall intensity > organic content in the soil. Erosion rates were proportional to rainfall, and increase with increasing clay content. Therefore, the soil erosion rate increases strongly with increasing organic content and clay content. The results show that the soil erosion rate in areas of metamorphic rocks shows a marked increase compared with areas of steep slope and sedimentary rocks. These results indicate that the geological characteristics to produce soil are closely related to sedimentation before and after erosion, providing basic information for the development of models to predict soil erosion rates.
논문 : 가축매몰지 오염지하수 정화를 위한 오염범위 및 양수량 평가
남경훈 ( Koung Hoon Nam ),이학윤 ( Hak Yun Lee ),김건하 ( Geon Ha Kim ),정교철 ( Gyo Cheol Jeong ) 대한지질공학회 2015 지질공학 Vol.25 No.1
가축매몰지로부터 확산되는 침출수를 양수하여 정화하기 위해서는 시추공의 적절한 위치 및 개수 선정이 필요하다. 침출수 분포에 대한 간단하고 광역적 조사에 효율적으로 알려진 전기비저항탐사를 활용하여 지하수 오염범위, 유동방향 및지질구조의 특성을 분석하였다. 경기도 이천시 가축매몰지 4개 Site의 전기비저항탐사 자료 해석결과, GL. - 8 m 이내에서 저비저항 이상대는 20~200 ohm-m로 나타났다. 침출수 정화를 위한 영향반경 및 양수량을 산출한 결과 Site 1부터 4까지 각각 영향반경은 12.9 m, 13.7 m, 10.1 m, 18.0 m로 산출되었으며 양수량은 2,040 m3, 479.8 m3, 1,492.3 m3,691.9 m3로 추정되었다. Site 1부터 4까지 시추공을 각각 5개, 2개, 4개, 2개를 설치한다면 모든 범위의 오염지하수 양수및 정화가 가능한 것으로 판단된다. Purifying leachate discharged from animal carcass disposal sites requires decisions regarding the locations and numbers of boreholes. An electrical resistivity survey, known to be effective for investigating leachate distribution, was performed to evaluate the range extent of contamination due to local hydrological properties, such as groundwater flow direction, and geological structure. Results of the survey at four sites at a landfill near Icheon and Anseong, Gyeonggi Province, showed low-resistivity zones (20-200 ohm-m) at a depth of 8 m from the surface. Sites 1-4, which contain 5, 2, 4, and 2 boreholes, respectively, were estimated to have a contaminated groundwater acquisition capability of 12.9 m, 13.7 m, 10.1 m, and 18.0 m, and measured pumping capacity of 2,040 m3, 479.8 m3, 1,492.3 m3, and 691.9 m3, respectively.
논문 : 산사태 취약성 분석: ASTER 위성영상을 이용한 점토광물인자 추출 및 공간데이터베이스의 SVM 통계기법 적용
남경훈 ( Koung Hoon Nam ),이명진 ( Moung Jin Lee ),정교철 ( Gyo Cheol Jeong ) 대한지질공학회 2016 지질공학 Vol.26 No.1
ASTER 위성영상을 이용하여 팽창성 점토광물인 일라이트 인자 추출 및 SVM 통계분석을 통해 산사태 취약성을 평가하였다. 연구지역의 산사태 발생지역은 항공사진 판독 및 현장 조사를 통해 분석하였다. GIS 기반 공간데이터베이스로는 지형도, 토양도, 임상도, ASTER 위성사진을 이용하였다. 수치지형도에서는 경사 및 경사방향, 곡률도, 계곡과의 거리, 도로와의 거리, 토양도에서는 유효토심, 토질, 토양지형, 토양 배수정도 및 토양 모재, 임상도에서는 경급, 영급 및 밀도를 위성사진에서는 일라이트 인자를 추출하였다. 산사태 발생요인 데이터베이스와 SVM 통계분석 및 가중치 계산을 통해 각 요소간의 상관관계 취약성도를 구하였다. AUC 검증 결과 일라이트 인자 적용결과는 76.46%의 예측 정확도를 보였으며 일라이트 인자 미적용 모델은 74.09%의 예측 정확도를 나타내었다. 이는 일라이트 인자가 산사태 취약성도 작성에 있어 중요한 자료로 사용될 수 있음을 나타낸다. This study evaluates landslide susceptibility using statistical analysis by SVM (support vector machine) and the illite index of clay minerals extracted from ASTER(advanced spaceborne thermal emission and reflection radiometer) imagery which can be use to create mineralogical mapping. Landslide locations in the study area were identified from aerial photographs and field surveys. A GIS spatial database was compiled containing topographic maps (slope, aspect, curvature, distance to stream, and distance to road), maps of soil properties (thickness, material, topography, and drainage), maps of timber properties (diameter, age, and density), and an ASTER satellite imagery (illite index). The landslide susceptibility map was constructed through factor correlation using SVM to analyze the spatial database. Comparison of area under the curve values showed that using the illite index model provided landslide susceptibility maps that were 76.46% accurate, which compared favorably with 74.09% accuracy achieved without them.