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RISS 인기검색어
- 검색키워드
- 저자 : ( Ko Chiao Yen ) (검색결과 2 건)
- 무료
- 기관 내 무료
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Lan Ting-Yuan,Lin Yen-Chun,Tseng Tai-Chung,Yang Hung-Chih,Kao Jui-Hung,Cheng Chiao-Feng,Lee Tai-Ju,Huang Shang-Chin,Lu Cheng-Hsun,Li Ko-Jen,Hsieh Song-Chou 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.2
Background/Aims: Rituximab is known to be associated with high hepatitis B virus (HBV) reactivation rate in patients with resolved HBV infection and hematologic malignancy. However, data regarding HBV reactivation (HBVr) in rheumatic patients receiving rituximab is limited. To assess the HBVr rate in hepatitis B surface antigen (HBsAg)-negative patients receiving rituximab for autoimmune diseases in a large real-world cohort. Methods: From March 2006 to December 2019, 900 patients with negative HBsAg receiving at least one cycle of rituximab for autoimmune diseases in a tertiary medical center in Taiwan were retrospectively reviewed. Clinical outcome and factors associated with HBVr were analyzed. Results: After a median follow-up period of 3.3 years, 21 patients developed HBVr, among whom 17 patients were positive for hepatitis B core antibody (anti-HBc) and four were negative. Thirteen patients had clinical hepatitis flare, while eight patients had HBsAg seroreversion without hepatitis. Old age, anti-HBc positivity, undetectable serum hepatitis B surface antibody level at rituximab initiation and a higher average rituximab dose were associated with a higher HBVr rate. There was no significant difference in the HBVr risk between rheumatoid arthritis and other autoimmune diseases. Among anti-HBc-negative patients, subjects without HBV vaccination at birth had an increased risk of HBVr (4/368, 1.1%) compared with those who received vaccination (0/126, 0%). Conclusions: In HBV endemic areas where occult HBV is prevalent, anti-HBc-negative patients, may still be at risk for HBVr after rituximab exposure. HBVr may still be considered in HBsAgnegative patients developing abnormal liver function after rituximab exposure, even in patients with negative anti-HBc.
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( Chao Wei Huang ),( Ko Chiao Yen ),( Chao Feng Yu ),( Ying Chen Lu ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Many Gram-positive bacteria, particularly lactic acid bacteria, are known to secrete proteins that have antimicrobial activity. These proteins, known as bacteriocins, have been shown to display inhibitory activity against many pathogens. Use lactic acid bacteria fermented herb has many advantages, such as increase the extraction rate of herb, produce new active compounds, reduce waste etc. In this study, 270 strains of lactic acid bacteria were screened for bacteriocin producing ability, and Lactobacillus gasseri LYC400 was found to have highest bacteriocin activity. Lactobacillus gasseri LYC400 was used to ferment MRS broth with various concentration, 0, 2, 4, 6%, respectively, wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) powder. The fermentation broths were centrifuged and the supernatants were collected follow by protein extraction to analyze bacteriocin activity. The results showed wild bitter melon powder was able to support good growth of the lactic acid bacterium. The bacterial number, lactic acid concentration and the E. coli inhibition ability of protein extractions were positive correlated with bitter melon powder concentration. However, the Staphylococcus aureus inhibition ability of protein extractions were increased with 2, 4% bitter melon powder but decreased at 6% bitter melon powder. Fermentation wild bitter melon via Lactobacillus gasseri LYC400 increases its antibacterial activity with putative anti-diabetic activities may have great potential for health food.
KCI
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