자궁경부암에서 접합분자 E - cadherin 의 발현

오기석(Kie Suk Oh),주희재(Hee Jae Joo),김선영(Sun Young Kim),유희석(Hee Sug Ryu),정태영(Tae Young Chung),장기홍(Ki Hong Chang) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.2

N/A Objective: The aim of the present study was to evaluate the E-cadherin expression in normal cervical epithelium, carcinoma in situ of the cervix, and invasive carcinoma of the cervix, and to define the role of E-cadlherin expression in tumor invasion with respect to clinicopathologic parameters. Methods: We conducted immunodetection of E-cadherin in 58 cases of cervical carcinoma using immunohistochemistry in formalin-fixed, paraffin-embbeded sections, Rusults: E-cadherin expression was different between normal cervical epithelium and carcinoma in situ of the cervix, and between normal cervical epithelium and invasive carcinoma of the cervix(p<0.05). However, there was no difference in E-cadherin expression between carcinoma in situ and invasive carcinoma of the cervix. In invasive cervical carcinomas, expression of E-cadherin and the intensity of cytoplasmic E-cadherin expression did not correlate with histologic type, lymphvascular space invasion, lymph node metastasis, and stage of disease. Conclusion: It is mncluded that expression of E-cadherin is related to tumor invasion in cervical tissues, but further studies with regard toE-cadherin/catenin/cytoskeleton complex are needed to clarify the prognostic role of E-cadherin with respect to clinicopathologic parameters in invasive cervical carcinoma,

자궁경부암 환자에서 종양표지물질 CYFRA 21-1과 SCC Ag의 치료전 혈청치의 유용성

오기석(Kie Suk Oh),정태영(Tai Young Chung),정두용(Do Young Chung),유희석(Hee Sug Ryu),장기홍(Ki Hong Chang),전미선(Mi Son Chun),박찬희(Chan Hee Park),박영한(Young Han Park) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.12

목적: 폐(lung)의 비소세포암(non-small cell cancer) 뿐만 아니라 편평상피암의 진단에 사용되고 있는 CYFRA 21-1의 혈청치가 자궁경부암의 추적관찰 및 재발암을 예측하는데 있어 혈청종양표지물질로서 가장 널리 사용되고 있는 Squamous cell carcinoma antigen(SCC Ag)과 더불어 임상병리학적 변수로서의 부가적 가치에 대한 여부를 알아보고자 하였다. 연구방법: 1995년 11월부터 1997년 7월까지 아주대학교병원 산부인과에 내원한 중에서 CYFRA 21-1과 SCC Ag을 측정한 80명의 자궁경부암 환자와 정상 또는 부인과 양성질환자 59명을 대조군으로 후향적 연구를 하였다. 결과: 1. ROC curve에 의한 혈청 SCC Ag과 CYFRA 21-1의 정상 cut-off value는 각각 1.94ng/ml, 3.11ng/ml였다. 2. Cut-off point에 의한 SCC Ag의 민감도, 특이도, 양성예측율, 음성예측율은 각각 55, 95, 97, 46%, CYFRA 21-1은 각각 45, 91, 87, 55% 였으며 두 물질의 병용측정시 민감도는 62%로 증가하였고 특이도, 양성예측율, 음성예측율은 각각 72, 75, 58% 였다. 3. FIGO stage Ib-IIa 의 SCC Ag과 CYFRA 21-1의 혈청치는 각각 2.2±3.9ng/ml, 2.5±3.6ng/ml 였으며 stage IIb-IV 는 각각 12.2±15.2ng/ml, 10.8±11.2ng/ml 였다(p<0.05). 4. 종양종괴의 크기가 4cm 이하인 경우 SCC Ag과 CYFRA 21-1의 혈청치는 각각 3.3±9.0ng/ml, 4.5±7.6ng/ml 였으며 4cm 보다 큰 경우는 각각 11.8±11.9ng/ml, 7.7±9.3ng/ml 였다(p<0.05). 결론: CYFRA 21-1의 혈청치의 측정은 자궁경부암을 추적관리하는데 있어 SCC Ag 보다 민감도는 낮으나 병행측정시 보다 높은 민감도를 보이며 자궁경부암의 병기, 종양의 크기 등을 예측하는데 있어서 부가적 가치가 있는 물질로 사용가능할 것으로 사료된다. 또한 치료 후 추적관찰 중 재발암을 예측하는데 있어서도 SCC Ag 단독측정보다 CYFRA 21-1와의 병행측정시 더 효용성이 있을 것으로 생각되지만 보다 많은 환자를 대상으로 장기간에 걸친 연구가 필요할 것으로 생각된다. Objectives: SCC Ag(Squamous cell carcinoma antigen) is so far the most useful tumor marker in assisting clinical diagnosis of cervical cancer and follow-up after therapy. Elevated levels of cytokeratin 19-fragments(CYFRA 21-1) have recently been detected in large proportion of patients with non small cell cancer of the lung, and in particular those with squamous cell carcinoma. This study is to assess the clinical efficacy of CYFRA 21-1 with SCC Ag as the clinicopathologic parameter in cervical cancer. Method: Retrospective analysis of the serum tumor markers CYFRA 21-1 & SCC Ag in eighty cervical cancer patients was performed. Results: Cut off values for SCC Ag & CYFRA 21-1 were 1.94 ng/ml, 3.11 ng/ml respectively. Using the cut-off point, the sensitivity, specificity, positive predictive value(PPV), and negative predictive value(NPV) of serum SCC were 55, 95, 97, 46%, respectively. Serum CYFRA 21-1 showed a sensitivity of 45%, specificity of 91%, PPV of 87%, and NPV of 55%. The combination of SCC and CYFRA 21-1 increased the sensitivity to 62%, with a specificity, PPV, and NPV of 72, 75, 58%. Serum levels of both markers were compared with tumor stage, lesion size and were significantly related. In FIGO stage Ib-IIa, the serum levels of SCC Ag & CYFRA were 2.2±3.9, 2.5±3.6 ng/ml and in FIGO stage IIb-IV, 12.2±15.2, 10.8±11.2 ng/ml. In ≤4cm of lesion size the serum levels of SCC Ag & CYFRA were 3.3±9.0, 4.5±7.6 ng/ml and in >4cm of lesion size, 11.8±11.9, 7.7±9.3 ng/ml. Conclusion: These data seems to show that serum CYFRA 21-1 may be of additional value in assessing the state of disease in some patients with cervical cancer. The prediction of recurrent cervical cancer with SCC Ag were improved by the combination with CYFRA 21-1 but further investigation is needed.

태아의 이형성 신질환을 동반한 임신의 임상 양상 및 주산기 예후

오기석(Kie Suk Oh),김행수(Haeng Soo Kim),양정인(Jeong In Yang),오준환(Joon Hwan Oh),금승섭(Seung Seop Keum) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.1

목적: 태아의 이형성 신질환을 동반한 임신의 산전 진단과 적절한 산과적 처치 및 산전 상담에 도움이 되는 임상적 자료를 얻고자 하였다. 연구 방법: 1994년 6월부터 1999년 7월까지 아주대학교병원 산부인과에서 산전 초음파검사를 시행하여 태아의 이형성 신질환으로 진단되고 본원에서 분만한 13예를 대상으로 산전 초음파검사 소견, 주산기 결과, 모성 합병증, 동반된 기형의 유무, 부검 소견 등에 대해 후향적 조사를 시행하였다. 결과: 다발낭성 신 이형성증은 총 분만 9,591예 중 9예로 1,066분만 당 1예의 빈도를 보였으며, 다낭종신은 4예로 2,398분만 당 1예의 빈도를 보였다. 주산기 결과로는 다발낭성 신 이형성증 9예중 임신 24주에 진단된 1예에서 심한 구개순 및 구개열을 동반하여 임신 25주경 유도 분만에 의해 임신종결이 이루어졌고, 6예는 자연진통 혹은 유도분만에 의해 질식 분만되었으며, 이중 자궁내 태아사망으로 임신 36주에 분만이 유도된 1예를 제외한 5예는 정상 분만되었다. 또한 2예에서 제왕절개수술로 분만되었다. 생존한 신생아 7명은 현재까지 생존하여 6개월 간격으로 외래 추적 관찰 중이다. 다낭종신 4예 중 3예는 인위적으로 임신 종결을 하였으며, 1예는 임신 36주에 반복 제왕절개수술에 의해 분만되었는데 비후성 심근증이 동반되었으며, 생후 24시간 이내에 사망하였다. 산과적 합병증으로는 양수과소증 4예, 양수 과다증 2예, 전치 태반 2예, 태반 조기 박리 1예, 조기 양수파막 1예, 자궁경부 열창 1예, 빈혈 1예 등이 있었다. 주산기 합병증으로는 자궁내 발육지연 2예, 요로 감염 1예, 수신증 1예, 급성 호흡부전 1예, 급성 신부전 1예, 뇌실 주위출혈 1예, 후두 연화증 1예 등이 있었다. 결론: 태아의 이형성 신질환이 동반된 임신의 경우, 정밀 산전 초음파검사 및 염색체 검사 등을 시행하여 정확한 진단을 하고 다른 동반된 기형의 유무를 확인하는 것이 산과적 처치 결정 및 주산기 예후에 중요하다고 사료된다. Objective: To obtain clinically useful data regarding prenatal diagnosis, proper antepartum counseling and obstetric management in pregnancies with fetal dysplastic kidney disease. Methods: We retrospectively reviewed 13 cases of MCDK(Multicystic dysplastic kidney) and PCDK(Polycystic dysplastic kidney), diagnosed by antenatal ultrasound and delivered from June 1994 through July 1999 at Ajou University School of Medicine, Department of Obstetrics and Gynecology, with regard to prenatal ultrasonographic findings, perinatal outcomes, maternal complications and associated fetal anomalies. Results: The incidence of MCDK and PCDK was one in 1,066 and one in 2,398 births, respectively. Of the 9 cases of MCDK, one case was terminated due to severely associated anomaly, and 6 cases were delivered by spontaneous labor or pitocin induction at term, of which 1 case was delivered by pitocin induction at 36 weeks gestation due to intrauterine fetal death. Two cases were delivered by cesarean section. There were no neonatal deaths in 7 cases of MCDK and they have been followed up to date, and alive. Of the 4 cases of PCDK, 3 cases were terminated by induced abortion or induced vaginal delivery, and 1 case was delivered by cesarean section, which was combined with hypertrophic cardiomyopathy, and the baby died within 24 hours after birth. Perinatal complications consisted of small for gestational age, urinary tract infection, hydronephrosis, acute respiratory failure, acute renal failure, periventricular hemorrhage and laryngomalacia in the neonatal period. Conclusion: It is suggested that antenatal ultrasonography and genetic analysis to evaluate accurate diagnosis and associated anomalies should be performed to manage and councel properly the pregnancies with fetal dysplastic kidney disease.

High-flux mixed matrix membranes containing bimetallic zeolitic imidazole framework-8 for C₃H₆/C₃H₈ separation

Oh, Jin Woo,Cho, Kie Yong,Kan, Ming-Yang,Yu, Hyun Jung,Kang, Dun-Yen,Lee, Jong Suk Elsevier 2020 Journal of membrane science Vol.596 No.-

<P><B>Abstract</B></P> <P>Membrane-based gas separation requires highly delicate engineering of molecular structures for the desired separation performance. Herein, a new efficient approach to fabricate high-flux mixed matrix membranes (MMMs) for C<SUB>3</SUB>H<SUB>6</SUB>/C<SUB>3</SUB>H<SUB>8</SUB> separation is reported by utilizing ZnCo-mixed hybrid zeolitic imidazolate framework-8 (ZIF-8-67) with unexpectedly large aperture size. Our structural characterizations in molecular level reveal that the ZIF-8-67 exhibits a larger aperture size compared to ZIF-8. Such a large aperture size of ZIF-8-67 is attributed to the large angle between two neighboring ligands and the long metal-ligand bonding distance, which is confirmed by refining the computed XRD pattern until it matches the experimental one (Rietveld refinement). More importantly, the inclusion of ZIF-8-67 in the 6FDA-DAM matrix enhances the C<SUB>3</SUB>H<SUB>6</SUB> permeability by up to 240% with the moderate C<SUB>3</SUB>H<SUB>6</SUB>/C<SUB>3</SUB>H<SUB>8</SUB> selectivity improvement (70%), as compared to those of the polymeric counterpart. Furthermore, the temperature-dependent transport characterization verifies that the ZIF-containing MMMs improve the C<SUB>3</SUB>H<SUB>6</SUB>/C<SUB>3</SUB>H<SUB>8</SUB> energetic selectivity at the sacrifice of entropic selectivity due to a unique molecular sieving behavior of the ZIFs, thereby enhancing the diffusivity selectivity. This study proposes a simple strategy to enable the fine-tuning of the aperture size of parent ZIFs towards the desired gas separation performance.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The effect of mixed metals of ZIFs on structure and transport properties was studied. </LI> <LI> Bimetallic ZnCo metal-mixed ZIF-8 (ZIF-8-67) exhibited an unexpected aperture size. </LI> <LI> ZIF-8-67-containing MMMs significantly enhanced C<SUB>3</SUB>H<SUB>6</SUB> permeability. </LI> <LI> ZIF-containing MMMs improved C<SUB>3</SUB>H<SUB>6</SUB>/C<SUB>3</SUB>H<SUB>8</SUB> energetic selectivity due to breathable behavior. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

다낭성 난소증후군과 동반된 자궁내막암 1 예

오기석,이정필,유희석,주희재,안상태,박영한 대한부인종양 콜포스코피학회 2000 Journal of Gynecologic Oncology Vol.11 No.4

Polycystic ovary syndrome is characterized by symptoms of oligomenorrhea, amenorrhea, infertility, hirsutism and obesity. It is known that the women with such diseases would have higher risks to coronary heart diseases, hypertension, DM and endometrial cancer later on, Known risk factors of endometrial cancer are nullipara, late menopause, obesity, DM, unopposed estrogen, tamoxifen treatment, and atypical endometrial hyperplasia ect. 75% of endometrial cancer occurs in age over 50 and 4% of endometrial cancer occurs in age under 40. Particulary endometrial cancer concurrent polycystic ovary syndrome occurs usually in people under age 40 and is commonly well differentiated cell type and is related to good prognosis. We experienced a case of endometrial cancer with polycystic ovary syndrome, who was early dignosed, presented with infertility and got an operation in our hospital, and report this case with a brief review of literature.

액체추진 발사체의 추진제 소진시스템

조기주(Kie-Joo Cho),임석희(Seok-Hee Lim),정영석(Young-Suk Jung),오승협(Seung-Hyub Oh) 한국추진공학회 2006 한국추진공학회 학술대회논문집 Vol.2006 No.11

Optimization about Temperature and Velocity of the Pressurization Gas at Inlet of Propellant Tank using Weight Minimizing Design of Pressurization System for Propellant Tank

Young-Suk Jung(정영석),Kie-Joo Cho(조기주),Seok-Hee Lim(임석희),Gyu-Sik Cho(조규식),Seung-Hyub Oh(오승협),Bershadskiy V.A(베르샤드스키) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.5

In this paper, The optimum design method of temperature and velocity of the pressurization gas to minimize weight of propellant tank pressurization system on system design of propellant feed system of the liquid propellant rocket was suggested. We considered the influences of parameters of pressurization gas on the efficiency of the thermodynamic processes in the tank and on the design of components as gas tank, heat exchanger and diffuser. We have developed the program for determination of the optimum value of temperature and velocity of pressurization gas at the entrance of tank.

민주시민의식 형성을 위한 청소년 교육이념 및 정향에 관한 연구

오관석(Oh, Kwan-suk),신기현(Shin, Kie-hyun) 호남대학교 인문사회과학연구소 2008 人文社會科學硏究 Vol.21 No.-

본 연구는 청소년의 시민의식 함양에 관한 이념과 정향을 제도적 수준과 사회적 수준으로 분류하여 논의하였다. 논의의 결과, 청소년이 필요로 하는 민주시민교육은 연구에 따라 미미한 정도의 차이를 보이고 있다. 민주시민 교육은 인간의 존엄성과 공공질서와 의사결정 능력 그리고 민주주의 가치실현으로 나타나고 있다. 청소년을 위한 시민 교육의 함양은 어떻게 이루어져야 하는가에 대한 논의는 수준별 영역에서 차이를 보이고 있다. 가정은 윤리의식의 중요성을 많이 강조해 왔다. 교육기관은 민주의식에 대한 교육과 지도가 계획적으로 추진되어 왔다. 시민사회는 참여의식에 대한 중요성을 인식하는 정도이다. 공공기관은 시민의식을 고취하기 위한 재정적 지원과 교육 프로그램을 개발로 지원하여 왔다. 결론적으로 청소년의 시민교육은 가정에서 이루어지고 교육기관에 연장하여 제도화 되어왔다. 나아가 사회활동의 준거가 시민사회의 청소년 교육은 시민의식의 이념과 가치에 관한 교육체계는 미비한 수준이고 체계적 지원이 저조한 수준이다. This study was to research the citizenship's cultivation of adolescent which was divided educational ideas and orientation into social level and institutional's. As a result, the civic education of democracy which adolescent needed to is showed a little difference according to a matter of researches. The education of democratic citizen generally come out a dignity of human and the capability of rational decision making and the public order and realization value in the democracy. The cultivation of civic education for adolescent have studied how to accomplish researches which divided in to the domination of each other levels. Home environment have put the emphasis which is a lot of importance of ethics consciousness. Educational institution has leaded to a project in which education and leading being on the democratic consciousness. It is a degree that Non governmental organization(NGO) guided to cognition about consciousness of participation. Public institution has researched financial support and development of educational program for accomplishment of citizenship consciousness. In conclusion, the civic education for adolescent has accomplished the system from home to educational institution. And Adolescent' education of NGO not only which referred to social activities did not prepared the system of education for ideas and values of citizenship, but which was not sufficiency on systematic support.

Optimal Conditions for Thermal Control of LOX using GHe Bubbling Method

Young-Suk Jung(정영석),Seok-Hee Lim(임석희),Gyu-Sik Cho(조규식),Kie-Joo Cho(조기주),V.A. Bershadskiy(베르샤드스키),Seung-Hyub Oh(오승협) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.6

In this paper, the algorithm for calculating the thermophysical parameters of LOX in tank at the step of LOX thermal conditioning system using GHe bubbling during pre-launch operation is presented. The algorithm is based on a physical-mathematical models which integrally consider the characteristics and intensity of heat and mass transfer in LOX of the propellant tank and the experimental models which are used for the description of intensity of heat and mass transfer and the change of composition of gas and liquid phases in LOX. With the developed algorithm, the transient analysis of thermal conditioning system is executed on each condition as a temperature of injected GHe and pressure of tank, and the optimal conditions are proposed for an efficient thermal conditioning system using GHe bubbling.

개방형 액체로켓엔진의 안정성 분석 및 설계

정영석(Young-Suk Jung),이한주(Han-Ju Lee),임석희(Seok-Hee Lim),조기주(Kie-Joo Cho),조규식(Gy-Sik Cho),오승협(Seung-Hyub Oh) 한국추진공학회 2004 한국추진공학회 학술대회논문집 Vol.2004 No.10