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서기원(Seo Ki-Won),박주연(Park Ju-Yeon),이상남(Lee Sang-Nam),류희문(Ryu Hee-Moon),변윤섭(Byun Yeun-Sub) 한국철도학회 2009 한국철도학회 학술발표대회논문집 Vol.2009 No.5월
This paper presents a method for precisely localizing and parking of bimodal trams. In order to gain an automatically driving system for bimodal trams, precise up-to-date localization, velocity recognition, distance to next station and precise parking location estimation functions are required. This paper proposes a system consisting of control device, steering device, sensor input equipment, driving system, tachometer, vehicle-side sensors, magnetic markers and magnetic sensors. The tram recognizes the precise location via magnetic markers containing information. Parking position and precise distance calculation is embodied by a tachometer. The vehicle-side sensors are used to assure safe station approaching and parking magnetic markers provide improvement of precision while tram parking. This paper provides a system realizing localization and precise parking and afterwards the automatic drive test results are reported and analyzed.
학교체육 활성화 방안에 대한 연구(Ⅰ) : 강원대학교 교양체육 운영방법의 개선을 중심으로
이광재,문병용,노성규,박기동,홍관이,한상준,유옥재,엄기진,정청자,오수일,김윤래,박장평,부기원 江原大學校附設 體育科學硏究所 1986 江原大學校附設體育科學硏究所論文集 Vol.- No.11
Try to find a scheme for activation to College Physical Education, this Report informs the various kinds of Survey and process those were projected for improvement of management methods on Cultural Physical Education in Kang Weon National University. From experimentally carried out "Sports events Choosing System" not as usual be inforced "Total practical Skill System", Following Positive effects and sujestions were Presented; 1. "Sports events choosing system" gave birth to more students' interesting and more voluntary participation to the sports events they chose, and sports skill and instruction level was elevated due to charge of expert according to each sports events. This system would be managed continuously hereafter for it related to life sports. 2. This System needs to closed cooperations between College and Community, for the facilities of community are utilized by college. 3. To complete the plan for activation of college Physical Education, additionally, the successional study ; namely "autonomous extracurricular sports activity" should be excuted hereafter.
Insulation Coating of Fe–Si–Cr Soft Magnetic Powder by Selective Oxidation
Jae‑Young Park,Kwangsuk Park,Bosung Seo,Julien O. Fadonougbo,Tae‑Wook Na,Ki Beom Park,Hyeon‑Tae Im,Nong‑Moon Hwang,Hyung‑Ki Park 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.7
This study examines the insulation coating technology of Fe–Si–Cr powder via selective oxidation annealing, which oxidizeselements selectively by controlling the oxidation potential. The study calculated the oxidation driving force of Fe, Si, andCr, and conducted a thermodynamic analysis of oxidation and reduction conditions according to temperature and oxidationpotential. Based on the results, a selective oxidation annealing was performed in an atmosphere in which Fe is reduced andonly Si and Cr are selectively oxidized. The oxidation potential was controlled through the partial pressure ratio of hydrogenand water vapor. The XPS analysis results confirmed that a Si and Cr complex oxide layer formed on the powder surfaceafter the selective oxidation annealing. Afterward, withstanding voltages were analyzed to evaluate the insulation property. Then, the withstanding voltage of the powder applying the selective oxidation annealing increased significantly comparedto that of the initial powder. Further analysis showed that the powder annealed in an air atmosphere had a significantly lowersaturation magnetic flux density than the initial powder, while the powder applying the selective oxidation annealing hadonly a slightly reduced saturation magnetic flux density.
AMP-activated Protein Kinase 활성체인 Metformin의 모발 성장에 미치는 영향
문혜림 ( Hye-rim Moon ),박기영 ( Ki-young Park ),강현지 ( Hyun Ji Kang ),이우진 ( Woo Jin Lee ),원종현 ( Chong Hyun Won ),장성은 ( Sung Eun Chang ),이미우 ( Mi Woo Lee ),최지호 ( Jee Ho Choi ),박경훈 ( Gyeong-hun Park ) 대한피부과학회 2019 대한피부과학회지 Vol.57 No.4
Background: AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that plays a pivotal role in the balance of cellular energy metabolism. Recent studies have reported that AMPK has numerous roles in physiological conditions, and dysregulation of AMPK induces pathological processes and diseases. However, the role of AMPK and its activators have not yet been studied in the context of hair growth regulation. Objective: To investigate the effects of metformin on dermal papilla (DP) and outer root sheath (ORS) cells, as well as the role of the AMPK pathway in hair growth. Methods: We evaluated whether metformin, a well-known AMPK activator, had any beneficial effects on hair growth. In addition, to evaluate the molecular and cellular mechanisms that were involved, protein levels of AMPK and β-catenin were analyzed. Results: Metformin increased the cellular proliferation of human DP and ORS cells. Ki-67 expression was also significantly increased after metformin treatment in the ex vivo hair follicle organ culture. Furthermore, DP and ORS cells treated with metformin had a significant increase in AMPK phosphorylation, which in turn suppressed β-catenin degradation and enhanced its nuclear accumulation. Conclusion: We demonstrated that metformin promoted hair growth via the AMPK/β-catenin signaling pathway in vitro with DP and ORS cells. The hair-promoting effects of AMPK activators may potentially be used for the treatment of alopecia, and further investigation will be needed in the future. (Korean J Dermatol 2019;57(4):175∼ 181)
비강 및 비인두에 발생한 도립유두종과 편평상피암종의 p53단백 및 세포증식능에 관한 연구
한주호,윤기중,이재규,신대균,박근호,조향정,문형배 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2
The inverted papilloma and squamous cell carcinoma are common neoplasia in the sinonasal cavity and nasopharynx, but the incidence of these tumors are very low and the study on the oncogenesis or biological activity of the tumor cells are not well known. This study was designed to evaluate the oncogenic roles of the p53 gene and the proliferative activity of the tumor cells in the inflammatory polyp, inverted papilloma and squamous cell carcinoma. The experiment was carried by the immunohistochemical stains about the p53 protein, PCNA and Ki-67, histochemical stain about the AgNORs. and flow cytometric analysis about the DNA ploidy using the formalin fixed paraffin embedded tissues. The frequency of the expression of p53 protein was 0%(0/16 cases) in the inflammatory polyps, 18.8% (3/16 cases) in the inverted papillomas, and 87.5%(14/16 cases) in the squamous cell carcinomas. The labelling index(%) of the PCNA and Ki-67 was 5.3% and 3.3% in the inflammatoy polyps, 29.6% and 25.2% in the inverted papillomas, and 51.9% and 36.8% in the squamous cell carcinoma. The expression of the PCNA and Ki-67 was distributed in the periphery of the tumor islands of the inverted papilloma and was distributed in the both of center and periphery of the tumor islands of the squamous cell carcinoma. The number of nuclear AgNORs was increased in the order of inflammatory polyps (0.96), inverted papillomas(1.34) and squamous cell carcinoma(2.09). The frequency of the DNA aneuploidy was 0%(0/16 cases) in the inflammatory polyps, 18.8%(3/16 cases) in the inverted papillomas. and 12.5%(2/16 cases) in the squamous cell carcinomas. Above results indicates that the changes of the p53 gene and proliferative activity of the tumor cells are involved on the oncogenesis and the biological activity of the inverted papilloma or squamous cell carcinoma in the nasopharynx and sinonasa cavity.
홍관이,이광재,김두경,부기원,노성규,한상준,박기동,오수일,문병용,이철규,박장평,엄기진,박남환 江原大學校附設 體育科學硏究所 1984 江原大學校附設體育科學硏究所論文集 Vol.- No.9
This study is designed to grasp the elements and situations of stage fright in order to propose a part of ways to cope with it. We make 511 top-class high school players, male and female, in the central districts (Seoul, Inchon, Kyungki, Chungbuk, and Kangweon Province) on object of questionnaire, and get the following results. Through players generally have all-round characters they show weakness in the superiority and emotional stability while showing strength in the sonformity. This fact comes to be related to the elements which cause stage fright. Physiological changes also have many effects on the symptom of stage fright. Especially, stage fright increases when players show sensitive reaction to the self-consciousness of final consequence which comes from the tension or uneasiness of sympathetic nerve, Thus, it turns out that players make use of reducing psychological burden by physical exercise or adjusting the level of demanded result in order to release the stage fright.
문기혁,박영호 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1
The concept of using a therapy that might downsize or downstaging a cancer is not unique in oncology. Whereas chemotherapy is mostly used in other types of neoplasm, various types of neoadjuvant therapy have been extensively investigated prior to surgery in such solid tumors as breast cancer. In prostate cancer the real benefit of NHT prior to radical prostatectomy is far from proven. The initial thoughts that hormone-withdrawal therapy would convert extracapsular prostatic tumors into organ-confined ones have quickly dissipated. Only a few points are generally agreed regarding the effect of neoadjuvant therapy before radical prostatectomy. One involves a clinical downstaging that has been found in pathological examination in the majority of cases. This significant downstaging usually holds truth for clinical T2 diseases, but not necessarily for clinical T3 disease. The precise role of hormone therapy prior to surgery or radiotherapy is a topic of considerable controversy, and none of the studies conducted thus far has produced definitive answers. Therefore, at present these modes of treatment should be included in protocols. New trends include the use of both neoadjuvant therapy in the same patients, but data are not yet available. Other areas of research, including endpoints, comparison of drug efficacy, and effects on quality of life are certainly of importance in the management of prostate cancer. One should not forget these important issues.
해수에서 분리한 Vibrio sp. M-96 균주의 열감수성 alkaline phosphatase 성질
박문경,진덕희,김중균,공인수,김광현,홍용기 동의대학교 기초과학연구소 1997 基礎科學硏究論文集 Vol.7 No.1
A thermolabile alkaline phosphatase has been purified through steps of osmotic shock, ammonium sulfate salting-out, and DEAE-cellulose chromatography from the cultured broth of the marine Vibrio sp. M-96 strain. The optimal temperature for the enzyme activity was 35℃. The optimal pH was pH 11.0, and the range of pH stability was pH 10.4 to 12.0. Thermal inactivation occured within 6 minutes at 60℃. The enzyme was considerably inactivated by 0.1mM concentrations of Hg^2+, Ni^2+ and Zn^2+, whereas activated up to 234% by 1mM of Mn^2+. The activation energy and deactivation energy by the Arrhenius equation were 4.02 Kcal/mol and 9.09 Kcal/mol, respectively. The Km and Vmax values of the enzyme for p-nitrophenylphosphate were found to be 0.0465mM and 0.001335mM/min. respectively. Active from of the enzyme had a molecular weight of 57,000 dalton determined by the Sephadex G-200 gel filtration method.
교합-압박 골수정으로 치료한 대태골 간부 골절의 불유합
박윤수,문영완,성기선 대한골절학회 2003 대한골절학회지 Vol.16 No.2
목 적: 내고정술 후 발생한 대퇴골 간부 불유합에서 골절 부에 압박을 가할 수 있는 교합-압박 골수정(IC Nail??, Osteo, Switzerland)을 사용한 동적 압박 골 유합술의 임상적 결과를 보고하고자 하였다. 대상 및 방법: 20명, 21례의 대퇴골 간부 불유합율 교합-압박 골수정 고정술로 치료하였다. 평균 나이는 44 (18~69)세였으며, 골절 후 기준 수술까지 8에서 45 (중앙값 19)개월이 경과하였고, 추시 기간은 6에서 49 (평균 29)개월이었다. 천지료로 폐쇄적 골수정 삽입술이 10례, 개방적 골수정 삽입술이 10례, 금속판 삽입술이 1례였고 17례에서 골이식 및 동역화 (dynamization) 등 한 번 이상의 부가적 시술이 시행되었고, 과혈관성 불유합이 17례, 부혈관성이 3례였으며, 감염성은 1례였다. 시술은 골수강 확공 후 골수정 고정을 하였고, 근위부에 동적 교합 나사못을 삽입한 후 압박 나사를 이용하여 골절 부위를 압박하였고, 골이식은 하지 않았다. 결 과: 1례를 제외한 20례에서 임상적, 방사선학적 유합이 이루어졌다. 방사선학적 유합은 기준 수술 후 4에서 15 (평균 7.4)개월에 이루어졌다. 개방적 골수정 삽입술 후 1회의 골수정 치환술과 2회의 골이식을 받은 36세 남자에서 술 후 12개월까지 유합을 얻지 못했다. 결 론: 확공 후 교합-압박 골수정 삽입술은 초기 치료 방법에 상관 없이 대퇴 간부 불유합의 치료에 효과적인 방법이라 생각된다. 그런, 이전의 골수정 치환술이 실패한 무혈관성 불유합에서는 부가적인 시술이 고려되어야 할 것으로 사료된다. Purpose: To evaluate the effectiveness of a specially designed Interlocking-Compression Nail(IC Nail??, Osteo, Switzerland) which allows compression force across the nonunion site for the treatment of femoral shaft nonunions. Materials and Methods: Between Nov. 1998 and June 2002, twenty one nonunions of femoral shaft fractures in twenty patients were treated with reamed IC nails of larger diameters without bone grafting in 9 men and 11 women, 8 to 45 months after initial operations. Seventeen cases were hypervascular nonunions, 3 avascular, and 1 infected. For initial operation, 10 closed nailing, 10 open nailing and 1 plate fixation were performed. One or more additional procedures had been done in 17 cases prior to IC nailing. Results: The nonunion gap was considerably narrowed from 7.4㎜ to 3.1㎜ with IC nailing and bony unions were achieved in all but one case. The time for radiographic union was 4 to 15 months posteoperatively with an average of 7.4. Conclusion: Reamed IC Nail?? with a larger diameter is an effective procedure for femoral shaft fracture nonunion regardless of initial treatment modalities and even in 3 avascular nonunions, 2 have shown radiographic union without bone grafting. Additional procedures are to be considered in failed surgery of avascular nonunions.
한약재의 중금속 평가 연구 : 경북북부지역 한약재를 중심으로 Cultivated Herbal Medicines at North Gyeongbuk Area
박문기,김승영,황현욱 한국환경과학회 2004 한국환경과학회지 Vol.13 No.12
We compared with heavy metal concentration of herbal medicines in products of Gyeongbuk and the other area of Korea. The concentration of heavy metal were studied for the estimation of quality in herbal medicines which is Bupleuri Radix, Paeoniae Radix, Dioscoreae Rhizoma and Astragali Radix in products of north Gyeongbuk area. The average levels of heavy metal of herbal medicines in Gyeongbuk area are as follows : Mercury is 0.037mg/kg, Chromium is 0.093mg/kg, Nickel is 0.108mg/kg, Copper is 0.475mg/kg, Zinc is 3.14mg/kg, Manganese is 1.52mg/kg, Iron is 7.83mg/kg, and Cadmium, Lead and Arsenic is not detected. It was very lower in concentrations than those of average Korea area. Therefore, Gyeongbuk area appear to be more proper to cultivated land than other area. Minerals such as Ca and K were extracted more than Na and P in herbal medicines products of Gyeongbuk respectively. Minerals and heavy metal concentrations distributed in herbal medicines were analyzed. Little or no relationship was observed between minerals and heavy metals.