창덕궁 주합루 취병 복원에 따른 화계 정비 방안

백종철,김용기,사공영보 한국전통조경학회 2003 한국전통조경학회지 Vol.21 No.1

This study was a development project of restoration for the Chybyong(flower screen) on the Hwagye(flower terrace) space in the Juhapru area at the Changdeokgung Palace. The Hwagye space in the Juhapru was different from that of Qujanggaockdo drawn at 1776 or Donggwoldo drawn at 1824~1827. The question is how to restore the original form and to conserve it under the present circumstances. These two subjects were opposite problems. Approaches to the two subjects in this study was directed to search for the main object of restoration and to build the main target under the present circumstances. The main object of restoration in this study was Chybyong. The purpose of this study was to repair those trees planted on the Hwage after building the Chybyong.

심인성 어지럼증 환자의 정신과적 증상에 관한 연구

이경규,이지영,김현우,이정엽,백기청,김재일,이근호 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.5

연구목적 : 어지럼증을 호소하는 환자들 중에 심인성 어지럼증 환자가 상당수 있다는 것은 알려져 있고, 이러한 심인성 어지럼증과 동반되는 정신질환으로는 불안장애, 우울장애, 인격장애 등이 있다. 이에 본 연구에서는 심인성 어지럼증 환자들의 빈도와 정신과적 증상을 알아보고자 하였다. 방 법 : 어지럼증 환자들에게 평형검사, 자세운동측정검사, 자세변화검사, caloric testing을 시행하여 심인성, 말초성 및 중추성의 3군으로 분류한 후 각각 14명, 16명, 32명을 대상으로 하였다. 대상환자들에게 한국판 Beck 우울척도검사(K-BDI), Spielberg의 상태-특성 불안검사(STAI). 간이정신진단검사(SCL-90-R)를 이용하여 정신과적 증상을 측정하여 이들 세 군을 비교분석하였다. 결 과 : 1) 심인성 어지럼증을 가진 환자는 어지럼증을 나타내는 환자 총 62명중에서 14명으로 22.6%를 차지하였다. 2) K-BDI에 따른 세 군간의 비교에서는 세 군간에 유의한 차이를 보이지 않았다. 3) STAI에 따른 세 군간의 비교에서 상태불안(STAI-S) 및 특성불안(STAI-T) 모두에서 세 군간에 유의한 차이를 보이지 않았다. 4) SCL-90-R에 따른 세 군간의 비교에서는 9개의 척도 중에서 공포불안척도에서만 중추성 어지럼증군이 47.56±6.90, 말초성 어지럼증 군이 53.50±13.74, 심인성 어지럼증 군이 58.50±16.05로 심인성 어지럼증 환자군이 중추성 어지럼증 환자군에 비하여 유의하게 높은 것으로 나타났다(p<0.01). 5) 통증 증상에 있어서는 세 군간에 유의한 차이를 보이지 않았고, 위장관 증상과 성기능 장애 증상은 중추성과 말초성 어지럼증 군이 심인성 어지럼증 군에 비하여 유의하게 높은 것으로 나타났다(p<0.01). 결 론 : 상기 결과를 토대로 했을 때 어지럼증 환자들에 대한 정신과적 접근을 위하여 각 군을 나누는 것은 별 의미가 없으며 어지럼증 환자들의 어지럼증 자체에 대한 직접적이고 집중적인 치료가 더욱 필요할 것으로 생각된다. Objectives : This study was aimed to investigate psychiatric symptoms in patients with psychogenic dizziness and compare these findings with those of patients with central and peripheral dizziness. Methods : A total of 62 patients with dizziness was the subject of investigation, and patients were classified into 32 with central type, 16 with peripheral type, and 14 with psychogenic type. Korean standardized Beck Depression Inventory(K-BDI), State and Trait Anxiety Inventory(STAI), and Korean standardized edition of Symptom Checklist 90 Revised(SCL-90-R) were used for the assessment. Statistically, Pearson's chi-square test and one-way ANOVA with Scheffe's test were used with SPSS/PC for windows 6.0. Results : The results were as follows : 1) The proportion of psychogenic dizziness was 22.6% of the total subjects. 2) Total scores of K-BDI were not significantly different among the 3 groups. 3) Total scores of state anxiety and trait anxiety were not significantly different among the 3 groups. 4) In SCL-90-R, psychogenic dizziness group showed significantly higher score of phobic anxiety only(p<0.01) than central dizziness group. And others were not significantly different among the 3 groups. 5) In additional somatic symptoms, pain score was not different among the 3 groups, but gastrointestinal and sexual symptoms scores of central and peripheral dizziness group were significantly higher than those of psychogenic dizziness group(p<0.01). Conclusion : These results suggest that psychiatric symptoms in patients with psychogenic dizziness are not different from those of patients with central or peripheral dizziness. Therefore, the more direct and intensive treatment may be necessary regardless of the type of dizziness.

온실에서 동양란인 심비디움 재배에 공생균의 효과에 관한 연구

이상선,이준기,이정우,박소영,백기엽 충북대학교 첨단원예기술개발연구센터 2000 연구보고서 Vol.5 No.-

The orchid symbiotic fungus (Tulsanella repens P-01; OSF) was cultured on the soil materials by solid culture and inoculated in the two varieties of GwanUm and SaGae of Cymbidium hybrids with the barks. The two varieties of the oriental orchid were measured after 12 months' cultivation under the conditions of greenhouse; fresh weight, numbers of bulb, and rate of dead bulb for an individual plant. The fresh weight of plants were measured to be different for the individual plant. The fresh weight of plants were measured to be different for the individual plants treated with the OSF or not, depending on the varieties, but the rates of dead bulb were significant, disregarding with the varieties. The roots of the plants treated were observed to be more health and heavier weight than those not treated. The bulbs of the plants not treated were measured to be dead at the rate of 20% for a year's cultivation. The roots of two varieties were also observed by naked eyes and by microscope; Several peletons were observed to be in the root cells in the individual plants treated with OSF, but not in the individual plants treated without the OSF. Further, the pathogenic fungal hyphae were observed to be in the roots under the dead bulbs of both varieties not treated; appessorium or hasutorium on the epidermal cells of root. The inoculation of OSF was speculated to stimulate the growth of plants by absorption of mineral nutrition and defense the invasions of soil pathogenic fungi for the cultivations of Cymbidium hybrids.

대장암종에서 암관련 유전자들의 Promoter Methylation과 암종 발생 및 진행과의 관게에 대한 연구

정동준,이정은,민영기,조성우,백무준,양승하,김의한,김창진 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

The colorectal corcinoma is one of the most common malignant tumor in Korea and its carcinogenic mechanism has not been elucidated exactly yet. So far, the most common carcinogenic mechanism has been known to be multiple genetic changes. But, the CpG island hypermethylation has been revealed to be one of the most important carcinogenic mechanism second to the genetic changes. The epigenetic changes characteristically imprint and transfer to the next generation without changes of nucleotide sequences. When the CpG island of promoter or 5'- exon 1 of a specific gene is methylated by DNA methyltrasferases (DNMTs), the gene expression is inhibited. Carcinogenic mechansisms by promoter methylation has been well known, but the progression of the cancer has not been elucidated yet. The molecular researches on the carcinogenic mechanisms largely depended on the tumor tissue containing various components of cell, due to difficulties in harvesting pure homogeneous tumor cells. Promoter methylatonof the cancer related genes as APc, hMLH2, p16, DAP-K and MGMT in 50 cases of sporadic colorectal carcinoma was studied. The pure normal colorectal epithelial cells, and cancer cells from superficial and deep invasive portion were harvested respectively by laser captured microdissection(LCM), and DNA was extracted from them. The promoter methylation was studied by methylation specific poymerase reaction (MSP) after bisulfite modification of the DNA and the expression of the genes by immunohistochemistry. The results suggests that promoter methylation of the cancer related genes are closely related with the colorectal carcinogenesis and it occurrs from early phase of carcinogenesis, progressing constantly to the late stage. And the promoter methylation of normal epithelial cells increased by age. The p15, known to be the genes related to hematologic malignancy, was closely related to the colorectal carcinoma as well.

Cap-dependent translation without base-by-base scanning of an messenger ribonucleic acid

Paek, Ki Young,Park, Sung Mi,Hong, Ka Young,Jang, Sung Key Oxford University Press 2012 Nucleic acids research Vol.40 No.15

<P>‘Ribosome scanning’ is the generally accepted mechanism for explaining how a ribosome finds an initiation codon located far removed from the ribosome recruiting site (cap structure). However, the molecular characteristics of ribosome scanning along 5′ untranslated regions (UTRs) remain obscure. Herein, using a rabbit reticulocyte lysate (RRL) system and artificial ribonucleic acid (RNA) constructs composed of a capped leader RNA and an uncapped reporter RNA annealed through a double-stranded RNA (dsRNA) bridge, we show that the ribosome can efficiently bypass a stable, dsRNA region without melting the structure. The insertion of an upstream open reading frame in the capped leader RNA impaired the translation of reporter RNA, indicating that a ribosome associated with the 5′-end explores the regions upstream of the dsRNA bridge in search of the initiation codon. These data indicate that a ribosome may skip part(s) of an messenger RNA 5′UTR without thoroughly scanning it.</P>

Translation initiation mediated by RNA looping

Paek, Ki Young,Hong, Ka Young,Ryu, Incheol,Park, Sung Mi,Keum, Sun Ju,Kwon, Oh Sung,Jang, Sung Key National Academy of Sciences 2015 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.112 No.4

<P><B>Significance</B></P><P>“Ribosomal scanning” is the generally accepted hypothesis for explaining how eukaryotic 40S ribosomal subunits find initiation codons. Some recently described phenomena cannot be explained by the ribosomal scanning hypothesis, however. Here we show that 43S ribosomal complexes recruited to locations downstream of a reporter gene can direct translation of the reporter independent of the 5′ end, suggesting that 43S ribosomal complex recognizes the initiation codon by “RNA looping” of the intervening mRNA segment between the ribosome recruiting site and the initiation codon. Moreover, we provide a mathematical model for the RNA looping hypothesis. The RNA looping hypothesis provides a logical explanation for translational augmentation by translation-enhancing elements located upstream and/or downstream of a protein-coding region.</P><P>Eukaryotic translation initiation commences at the initiation codon near the 5′ end of mRNA by a 40S ribosomal subunit, and the recruitment of a 40S ribosome to an mRNA is facilitated by translation initiation factors interacting with the m<SUP>7</SUP>G cap and/or poly(A) tail. The 40S ribosome recruited to an mRNA is then transferred to the AUG initiation codon with the help of translation initiation factors. To understand the mechanism by which the ribosome finds an initiation codon, we investigated the role of eIF4G in finding the translational initiation codon. An artificial polypeptide eIF4G fused with MS2 was localized downstream of the reporter gene through MS2-binding sites inserted in the 3′ UTR of the mRNA. Translation of the reporter was greatly enhanced by the eIF4G-MS2 fusion protein regardless of the presence of a cap structure. Moreover, eIF4G-MS2 tethered at the 3′ UTR enhanced translation of the second cistron of a dicistronic mRNA. The encephalomyocarditis virus internal ribosome entry site, a natural translational-enhancing element facilitating translation through an interaction with eIF4G, positioned downstream of a reporter gene, also enhanced translation of the upstream gene in a cap-independent manner. Finally, we mathematically modeled the effect of distance between the cap structure and initiation codon on the translation efficiency of mRNAs. The most plausible explanation for translational enhancement by the translational-enhancing sites is recognition of the initiation codon by the ribosome bound to the ribosome-recruiting sites through “RNA looping.” The RNA looping hypothesis provides a logical explanation for augmentation of translation by enhancing elements located upstream and/or downstream of a protein-coding region.</P>

Evaluation of Snow Load Using a Wind Tunnel on the Arched House

Paek, Sun Young,You, Jang Youl,You, Ki Pyo,Kim, Young Moon Trans Tech Publications, Ltd. 2014 Advanced materials research Vol.919 No.-

<P>A damage occurrence of single-span type greenhouse by heavy snowfall in Korea, M shape collapse where excessive snow load of the roof occurs frequently regardless of the area damaging all the roof rafters. Therefore, in this paper, the snowdrift pattern of the arched house by shape using snow wind tunnel simulation is necessary. Experimental results indicated that the snowfalls on the roof of the arched house occur variously depending on the shape and location. As a result of estimating the load standard by roof slope angle and the values of snow loads using wind tunnel experiment, roof slopes showed 30% in 0°-15°and 80% in 45°-70° respectively, which were significant percentages in the snowdrift experiment.</P>

Poster Session : AUF1/hnRNP D enhances HCV IRES-dependent translation

( Ki Young Paek ),( Jong Heon Kim ),( Sung Key Jang ) 한국생화학분자생물학회 (구 한국생화학회) 2006 생화학분자생물학회 춘계학술발표논문집 Vol.2006 No.-

Snow Wind Tunnel Experiment for Snowdrift Prediction of Domed Stadium

Paek, Sun Young,Nam, Byung Hee,You, Jang Youl,You, Ki Pyo,Kim, Young Moon Trans Tech Publications, Ltd. 2014 Advanced materials research Vol.919 No.-

<P>As baseball gets more and more popular the interest of fans increases. Since baseball game in its nature is influenced very much by weather the necessity of a domed stadium has been raised. At this moment a membrane structured domed stadium is under construction. As can be understood from the roof collapse of Minnesota Metrom by a heavy snowfall in 2011, the snow load occupies a very important part in membrane structure. To calculate the snow load snowdrift prediction is necessary and snow is piled mainly at the side or roof of a building. Hence, in this study a snowdrift wind tunnel test of a domed stadium was made to simulate snowdrift; using it the maximum depth of fresh snowdrift is estimated to be in the range of 3.4cm-37cm on the roof of a domed stadium.</P>

화암사 기류특성에 대한 실측 및 CFD 해석

백선영(Paek, Sun-Young),유장열(You, Jang-Youl),김영문(Kim, Young-Moon),남해경(Nam, Hae-Kyeong),유기표(You, Ki-Pyo) 대한건축학회 2016 대한건축학회 학술발표대회 논문집 Vol.36 No.2

There are various studies on the vulnerabilities of traditional Korean architecture caused by material characteristics. As a part of such efforts, this study conducted a simulated CFD analysis on Wanju Hwaamsa Temple in each wind direction in order to induce changes in temperature and humidity according to increase of wind velocity due to micro climate characteristics. The results showed that wind velocity affects humidity. Air flow analysis results can be utilized as fundamental data to present the method of building preservation through control of wind velocity.