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Protective Effect of Heme Oxygenase-1 on High Glucose-Induced Pancreatic β-Cell Injury
Lee, Eun-Mi,Lee, Young-Eun,Lee, Esder,Ryu, Gyeong Ryul,Ko, Seung-Hyun,Moon, Sung-Dae,Song, Ki-Ho,Ahn, Yu-Bae Korean Diabetes Association 2011 Diabetes and Metabolism Journal Vol.35 No.5
<P><B>Background</B></P><P>Glucose toxicity that is caused by chronic exposure to a high glucose concentration leads to islet dysfunction and induces apoptosis in pancreatic β-cells. Heme oxygenase-1 (HO-1) has been identified as an anti-apoptotic and cytoprotective gene. The purpose of this study is to investigate whether HO-1 up-regulation when using metalloprotophyrin (cobalt protoporphyrin, CoPP) could protect pancreatic β-cells from high glucose-induced apoptosis.</P><P><B>Methods</B></P><P>Reverse transcription-polymerase chain reaction was performed to analyze the CoPP-induced mRNA expression of HO-1. Cell viability of INS-1 cells cultured in the presence of CoPP was examined by acridine orange/propidium iodide staining. The generation of intracellular reactive oxygen species (ROS) was measured using flow cytometry. Glucose stimulated insulin secretion (GSIS) was determined following incubation with CoPP in different glucose concentrations.</P><P><B>Results</B></P><P>CoPP increased HO-1 mRNA expression in both a dose- and time-dependent manner. Overexpression of HO-1 inhibited caspase-3, and the number of dead cells in the presence of CoPP was significantly decreased when exposed to high glucose conditions (HG). CoPP also decreased the generation of intracellular ROS by 50% during 72 hours of culture with HG. However, decreased GSIS was not recovered even in the presence of CoPP.</P><P><B>Conclusion</B></P><P>Our data suggest that CoPP-induced HO-1 up-regulation results in protection from high glucose-induced apoptosis in INS-1 cells; however, glucose stimulated insulin secretion is not restored.</P>
비강 및 비인두에 발생한 도립유두종과 편평상피암종의 p53단백 및 세포증식능에 관한 연구
한주호,윤기중,이재규,신대균,박근호,조향정,문형배 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2
The inverted papilloma and squamous cell carcinoma are common neoplasia in the sinonasal cavity and nasopharynx, but the incidence of these tumors are very low and the study on the oncogenesis or biological activity of the tumor cells are not well known. This study was designed to evaluate the oncogenic roles of the p53 gene and the proliferative activity of the tumor cells in the inflammatory polyp, inverted papilloma and squamous cell carcinoma. The experiment was carried by the immunohistochemical stains about the p53 protein, PCNA and Ki-67, histochemical stain about the AgNORs. and flow cytometric analysis about the DNA ploidy using the formalin fixed paraffin embedded tissues. The frequency of the expression of p53 protein was 0%(0/16 cases) in the inflammatory polyps, 18.8% (3/16 cases) in the inverted papillomas, and 87.5%(14/16 cases) in the squamous cell carcinomas. The labelling index(%) of the PCNA and Ki-67 was 5.3% and 3.3% in the inflammatoy polyps, 29.6% and 25.2% in the inverted papillomas, and 51.9% and 36.8% in the squamous cell carcinoma. The expression of the PCNA and Ki-67 was distributed in the periphery of the tumor islands of the inverted papilloma and was distributed in the both of center and periphery of the tumor islands of the squamous cell carcinoma. The number of nuclear AgNORs was increased in the order of inflammatory polyps (0.96), inverted papillomas(1.34) and squamous cell carcinoma(2.09). The frequency of the DNA aneuploidy was 0%(0/16 cases) in the inflammatory polyps, 18.8%(3/16 cases) in the inverted papillomas. and 12.5%(2/16 cases) in the squamous cell carcinomas. Above results indicates that the changes of the p53 gene and proliferative activity of the tumor cells are involved on the oncogenesis and the biological activity of the inverted papilloma or squamous cell carcinoma in the nasopharynx and sinonasa cavity.
배승춘,김정환,김호운,박성근,김기완 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1
PLT and PLZT feroelectric thin films were fabricated on ITO substrate by rf magnetron sputtering. Pressure was 30mTorr, rf power was 180W and substrate temperature was varied from room temperature to 500℃. In this case, PLT had the highest dielectric constant of 120 at 500 ℃, oppositly PLZT had the highest dielectric constant of 312 at room temperature. I-V characteristics of PLZT film were shown that leakage current of PLZT film deposited at room temperature was below 3μA at 100V.
배일호,이정기,박찬모,이호영,정성옥,이준 朝鮮大學校 電子情報通信硏究所 2003 電子情報通信硏究所論文誌 Vol.6 No.2
근 수 년간 클라이언트/서버 모델에서 발생하는 문제인 서버 병목 현상, DoS (Denial of Service) 공격, 그리고 시스템의 확장성에 따르는 비용 증가 등의 문제를 해결하기 위한 방법으로 P2P (Peer to Peer) 방식이 활발히 연구되고 있다. P2P 방식을 사용하는 모델은 기존의 클라이언트/서버 모델이 적용되었던 여러 분야에 이용되고 있다. 그 중 사용자간 파일 공유하는 분야에 적용된 P2P가 가장 널리 알려져 있다. P2P 파일 공유 네트워크에서 가장 중요한 이슈는 검색의 효율성이다. 검색의 효율성을 위해 제안된 가장 효과적인 접근법으로는 DHT(Distributed Hash Table)을 사용한 검색 기법이다. 이 방식에서 메시지 라우팅은 정보의 검색과 분산을 위해 사용되고, 메시지 라우팅 성능은 라우팅 Hop 수에 의해 결정된다. 그러나 기존의 접근법에서는 라우팅 Hop 수를 감소시키는 능력이 부족하다. 이를 해결하기 위해 본 연구에서는 네트워크 식별자와 노드의 그룹화에 의해 메시지 라우팅 성능을 개선하기 위한, DHT를 사용한 P2P 파일 공유 네트워크를 제안한다. 노드의 그룹화는 메시지 라우팅 Hop을 감소시키고, 한 노드 내에 많은 노드를 나타내어 확장성을 갖고 있다고 할 수 있다. 실험에는 네트워크 시뮬레이터를 사용하여 증가된 확장성과 성능의 개선을 보였다.
배영호,이현우,홍성태,서기영,차영문,권순걸 慶南大學校 附設 工業技術硏究所 1992 硏究論文集 Vol.10 No.-
이 논문은 MOSFET로 구성된 등가 Half-bridge형 고주파공진형 인버어터에 대해 기술하고 있다. 시분할 방식에 의한 게이트회로를 구성하여 구동함으로써 출력단에는 두개의 인버어터에서 동작되는 순시위상이 합성되어 있어 나타나므로 부하단 출력주파수는 소자의 수위칭주파수에 대해 두배가 되고 수위칭 손실이 경감되어 소자의 평균전류가 증가한다. This paper proposes a high frequency resonant inverter consisting of equivalent half bridge model using MOSFET. In this paper time-sharing control method is applied. as a result the output frequency is two times as high as switching frequency of device and average current of device is increased because of decreasing switching loss.
裵基瑞,宋周鎬 충남대학교 1977 工業技術開發硏究所論文集 Vol.4 No.2
This is the study of the knitting performance according to moderate yarn feeding conditions with consideration of physical property and its quality in knitting process, and the results gained from the knitting of 1×1 rib knitting fabric with 38's combed cotton yarn put in is as follows; 1) The most moderate yarn feeding speed to 38's combed cotton yarn was 56m/min. with its knitting performance tension of 50 grams. 2) The course density was indefinetly constant, regardless of any effects yarn tension increasing when yarn tension was exceeded 4 grams. 3) Formula S=Ks/l^2 could be applied to 1×1 rib knitting fabric, regardless of any conversion of yarn feeding tension. 4) Faults in knitting fabric indicated many differences according to employee's labour hours and the conditions of yarn feeding tension.