Effects of <i>Ginkgo biloba</i> Extract on Promotion of Neurogenesis in the Hippocampal Dentate Gyrus in C57BL/6 Mice

YOO, Dae Young,NAM, YoonYi,KIM, Woosuk,YOO, Ki-Yeon,PARK, Jaeil,LEE, Choong Hyun,CHOI, Jung Hoon,YOON, Yeo Sung,KIM, Dong-Woo,WON, Moo-Ho,HWANG, In Koo Japanese Society of Veterinary Science 2011 The Journal of veterinary medical science Vol.73 No.1

<P><I>Ginkgo biloba </I>leaf extract (Gb) has been known to improve blood flow and preclude the tissue from free radical damage. Effects of Gb were examined by using Ki67, a specific proliferative marker for cellular proliferation, and doublecortin (DCX), a marker for immature neurons, indicating degree of neuroblast differentiation in the hippocampal dentate gyrus (DG) of adult C57BL/6 mice. The mice were fed with Gb at 40 and 100 mg/kg once daily for 28 days. The increase of Ki67- and DCX-immunoreactive cells in the DG was increased in a dose-dependent manner. Especially, the group having 100 mg/kg Gb showed a significant increase of DCX-immunoreactive neuroblasts with well-developed tertiary dendrites. Expression of DCX protein in the Gb groups was also significantly increased upon compared with the vehicle group. The results suggested that repeated intake of Gb would enhance cell proliferation and neuroblast differentiation in the mouse DG.</P>

지중내 공동 탐지를 위한 비파괴 검사 기법에 대한 실험적 연구

유정동(Jund Dong?Yoo),양학모(Hak Mo?Yang),장기창(Ki Chang?Jang),강승민(Seung Min?Kang),조소현(So Hyun?Cho),김현기(Hyun-Ki?Kim),Seung Soo?Kim,Da Bin?Jin 대한토목학회 2018 대한토목학회 학술대회 Vol.2018 No.10

조혈모세포이식 환자에서 침습성 진균 감염에 대한 이트라코나졸 액과 플루코나졸 시럽의 예방 효과 : 전향적, 무작위, 비교 임상시험

최수미,이동건,최정현,박선희,엄기성,김유진,김희제,민창기,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2005 감염과 화학요법 Vol.37 No.2

목적 : 조혈모세포이식 환자에서 호중구 감소 기간 동안 이트라코나졸 액(ITZS)과 플루코나졸 시럽(FCZS)의 진균 감염에 대한 예방 효과를 전향적으로 비교해 보고자 하였다. 재료 및 방법 : 2001년 8월부터 2002년 6월까지 가톨릭 조혈모세포이식센터에 입원하여 동종 조혈모세포이식을 받은 만 18세 이상의 환자들을 각각 ITZS와 FCZS군으로 무작위 배정하여 침습성 진균 감염 발생과 약제 관련 부작용을 전향적으로 조사하였다. 결과 : ITZS군에 40명, FCZS군에 38명이 배정되었고, FCZS군 환자의 평균 나이가 더 많았다. 시험 약제 평균투여기간은 ITZS군 16.4일, FCZS군 21.9일로 ITZS군이 더 짧았다. 이는 ITZS군에서 소화기 부작용으로 인한 약제 중단이 더 많았기 때문으로 보인다. 시험 약제 투여 후 총 빌리루빈 수치의 유의한 증가가 관찰되었으나, 약제 관련 부작용은 모든 환자에서 가역적이었다. 호중구감소 기간동안 표재성 진균 감염은 두 군에서 모두 발생하지 않았고, 침습성 진균 감염은 ITZS군 5명(12.5%), FCZS군 8명(21.1%)으로 FCZS군에서 많았으나, 통계학적으로 유의하지 않았고, 사망률에도 유의한 차이는 없었다. 결론 : 침습성 진균 감염에 대한 이트라코나졸 액과플루코라졸 시럽의 예방 효과에 유의한 차이는 없었으나, 앞으로 더 많은 환자를 대상으로 잘 짝지어진 대조군 연구가 필요할 것으로 보인다. 부작용 중 간독성과 관련하여 이식시 투여되는 여러 약제들과의 상호작용에 대한 연구도 필요할 것이다. Background : Though fluconazole is widely used for antifungal prophylaxis, it is ineffective against mould infections including Aspergillus species. Itraconazole has a broader spectrum than fluconazole but the capsule form shows erratic bioavailability in neutropenic patients. In this study, we compared itraconazole oral solution (ITZS) with fluconazole syrup (FCZS) for the prevention of invasive fungal infection (IFI) in allogeneic hematopoietic stem cell transplant recipients. Materials and Methods : Adults receiving allogeneic hematopoietic stem cell transplantation (HSCT) from september 2001 to June 2002, were randomly allocated to either the ITZS group or the FCZS group. We prospectively evaluated the safety and efficacy of each drug. Results : Out of 78 patients (40 patients in the ITZS group and 38 patients in the FCZS group) who were eligible for this study, 37 patients completed the course of prophylaxis without any evidence of IFI. The mean duration of prophylaxis was 16.4 days for the ITZS group and 21.9 days for the FCZS group (P<0.006). Drug-related adverse events occurred in 28 patients (70.0%) and 19 patients (50.0%) in the ITZS group and the FCZS group, respectively. Common adverse events of ITZS were nausea, vomiting, and diarrhea. Drug-related reversible hepatotoxicity occurred in 4 patients in the ITZS group. There was a significant elevation of total bilirubin level in the ITZS group. The incidence of suspected IFI occurred in 5 patients (12.5%) who received ITZS, compared with 8 (21.1%) who received FCZS (P=0.372). There were no proven IFIs or superficial (oral/vaginal) fungal infections in both groups. Overall mortality was not different between the two groups (2.5% in the ITZS group versus 5.3% in the FCZS group, P=0.610). Conclusion : ITZS and FCZS showed similar protection against IFI during pre-engraftment period. Poor tolerability due to gastrointestinal troubles of ITZS might limit its success as prophylactic therapy. Well matched controlled study with large number of patients will be required in the future.

경기 일부지역 육용 양돈작업장의 분진 및 내독소 농도

유동호,김형아,허용,성재혁,이한기,박용규 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1

The aim of this study was to evaluate exposure to dust and endotoxin produced while working at swine confinement buildings. The dusts and endotoxin may cause adverse health effects on humans. Fourteen swine farms located at Yong-In, I-Cheon and Yeo-Ju of onggi-do were investigated. Husbandry workers form the farms were requested to wear personal sampler to measure respirable dust levels. Area samplings for total and respirable dust were also conducted at swine confinements buildings by season (summer under window open, winter under window close.) Gravimetric analyses and Limulus Amebocyte Lysate assay for measu- rement of dust level and endotoxin, respectively. The highest geometric mean (GM) concentration of airbome dusts was 7.47mg/㎡ for area respirable dust. and 10.35mg/㎡ for personal respirable dust. For respirable dust levels, seven farmers exceeded level of ACGIH, 3mg/㎥. The highest GM of endo- toxin was 5745.40 EU/㎥ for personal respirable dust. Significantly increased level of total dust (p〈0.001) and endotoxin in area total dust was observe with winter samples compared with those of summer. Area total dust and area respirable dust (r-0.622, p〈0.0001) was very significantly correlated in winter. Swine husbandry worker may have a considerable risk of ill health whenexposed to level of dust or endotoxin demonstrated at this study.

日本地域의 韓國學 및 數學의 硏究動向

柳基龍,李基東,李仁錫,李尙憲 慶北大學校 東洋文化硏究所 1982 東洋文化硏究 Vol.9 No.-

해안서식 어패류 중 유해중금속 함량에 관한 연구 (Ⅰ)

유영찬,정진일,박유신,이종숙,인상환,최동기,김동우 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

일부 도시지역 성인들의 혈중지질치의 참고치 및 저콜레스테롤혈증에 미치는 요인 분석

유기하,이동배,이태용,조영채,김수영 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1

Data from 3.982 adults participating in a health examination in a university hospital were analysed to determine the reference values of hyperlipidemia and hypolipidemia, and those were compared with American data. Also health related behaviors affecting hypocholesterolemia were investigated. 29.3% of the males diseased subjects, and as were 25.6% of the females in their twenties, 69.5% of the males in their 60s and 78.6% of the females in their 50s. The rate of diseased subjects tended increase with increasing age. The rates of the diseased were 60.1% for males and 55.2% for females. Among cardiovascular risk factors, the proportion of hyperlipidemia was 46.6%, fat liver 42.2%, hypertension 21.8%, glucose intolerance 13.7%, abnormal EKG 11. 0%, obesity 2.9% and anemia 1.7% for male subjects and hyperlipidemia was 31.2%, fat liver 29. 5%, anemia 27.5%, hypertension 21.1%, abnormal EKG 15.7%, obesity 7.3% for females in that order. The rates of cardiovascular risk factors were higher in males than in females except for anemia, abnormal EKG and obesity. The total cholesterol levels of 95 percentile for males and females were 227.0 mgldl, 226.0 mg/dl and the 5 percentile levels for males and females were 134.0 rag/dl, 131.0 mgldl, respectively. The LDL cholesterol level of 95 percentile for males and females were 150.0 mg/dl, 147.0 mgldl, and the 5 percentile were 53.0 mgldl, 51.0 mg/dl, respectively. The HDL cholesterol 95 percentile levels for males and females were 82.0 mg/dl, 83. 0 mg/dl, and those of 5 percentile were 36.0 mg/dl and 39.0 mg/dl, respectively. These data show that the mean levels of total cholesterol, triglyceride, LDL cholesterol were related to increased age in both sexes, and were slightly higher in the females than in the males over all ages, but those of HDL cholesterol decreased. The high cholesterol level group was associated with age, the amount of alcohol consumption, smoking and body mass index. But that was not associated with meat intake and regular exercise. No significant difference were found among the rates of all diseases except for diseases and anemia up to 160 mg/dl of cholesterol level in both sexes. Sex, regular exercise and glucose intolerance were revealed as influencing factors in the low serum cholesterol levels, but disease and abnormal EKG had a lowing effect for the low cholesterol risks. In conclusion, the reference values of Korean serum lipids were 5-25 mg/dl lower than Americans. The cut-off value to diagnosis hypolipidemia for the Korean is recommended as below 140 mg/dl of serum total cholesterol. The hyperlipidemia cut-off value should above 220 mg/dl of serum total cholesterol.

四君子湯 및 四物湯이 人體波動과 活性酸素에 미치는 影響에 關한 實驗的 硏究

조기용,柳同烈 대전대학교 한의학연구소 2000 한의학연구소 논문집 Vol.9 No.1

To prove the effect of Sagunjantang(SGJT) and Samultang(SMT) extract on the wave of Human Body and Active Oxygen experimentally, QRS & Free Radical of extract and precipitate of SGJT and SMT was measured. The results were summarized as follows; 1.SGJT extract and precipitate, as a result of measuring QRS and Free Radical, had a considerable effect on the function of immunity & pituitary gland. 2.BaekBokRung of SGJT, as a result of measuring QRS and Free Radical, had a considerable effect on the function of heart & spleen. 3.BaekChul and Gamcho of SGJT, as a result of measuring QRS and Free Radical, had a considerable effect on the function of stomach & duodenum. 4.YinSam of SGJT, as a result of measuring QRS and Free Radical, had a considerable effect on the function of immunity & spleen. 5.SMT extract and precipitate, as a result of measuring QRS and Free radical, had a considerable effect on the function of immunity & uterus. 6.SukJiHwang of SMT, as a result of measuring QRS and Free Radical, had a considerable effect on the function of immunity & liver. 7.DangGui of SMT, as a result of measuring QRS and Free Radical, had a considerbale effect on the function of heart & spleen. 8.ChunGung of SMT, as a result of measuring QRS and Free Radical, had a considerbale effect on the function of spleen & pituitary gland. 9.BaekJakYak of SMT, as a result of measuring QRS and Free Radical, had a considerbale effect on the function of stomach & duodenum. 10.SMT extract had an effect on the function of female Urogenital system,SGJT extract had an effect on the function of male Urogenital system. These results suggested that SGJT and SMT extract might be usefully applied for suppresing of Active Oxygen formation, preventing the aging, curing all the disease resulted from Active Oxygen.

컴퓨터 프로그램을 이용한 질적자료의 분석-NUDㆍIST와 The Ethnograph을 중심으로-

전기홍,이해종,이영재,김정은,서현정,유동현,이희경 대한의료정보학회 1996 Healthcare Informatics Research Vol.2 No.1

방사성 페기물 처리장의 지하수 온도 측정을 위한 광섬유 센서의 제작 및 특성 분석

서정기,유욱재,장경원,조동현,신상훈,이봉수 제주대학교 방사선응용과학연구소 2008 방사선응용과학연구소논문집 Vol.22 No.-

Fiber-optic temperature sensing technology can alternative to classical measurement techniques in nuclear environment, Its advantages allow low cost, a long distance measurement and real-time, In this study, we have measured the optical power of power meter and the output voltage of photodiode according to change temperature of water.