정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

원자력 발전소 근로자에서 업무상 질병으로 인정받은 급성 골수성 백혈병 1예

임현술,정해관,김수근,박병찬,이관 약업신문사 1983 의약정보 Vol.9 No.-

칡의 部位別 抗酸化 作用에 關한 硏究

林圭,朴涌基,康秉秀 대한본초학회 2001 大韓本草學會誌 Vol.16 No.2

The Parts of Pueraria thunbergiana Bentham, Puerariae Flos(PF), Puerariae Radix(PR), Puerariae Leaf(PL), Puerariae Sprout(PS) were investigated effects of for DPPH(electron donating ability) radical ability, nitrate reductase activity(NR), superoxide dismutase activity(SOD), catalase activity, lipid peroxidase(LP) and glutathione(GSH). In vitro, DPPH radical ability and nitrate reductase activity(NR) were increased according to the increasing of PF, PR, PL, PS concentrations. Among others PF, PR were significantly increased to the level of BHT. In vivo, compared with normal group, SOD(superoxide dismutase) activity and catalase activity were decreased in the acetaminophen treated group. On the other hand, PF, PR, PL, PS in the pretreated groups SOD activity and catalase activity were significantly increased. Among others PF, PR were almost increased to the level of Ascorbic acid. Compared with normal group, lipid peroxidation was increased. Among others PF, PR, PS were almost significantly decreased to the level of Ascorbic acid. In the acetaminophen treated group, GSH activity was decreased by compare with normal group. And in the PF, PR, PL, PS pretreated groups, GSH activity was increased to the control group. Among others PF, PR were almost significantly increased to the level of Asorbic acid. These results suggest that among others PF was almost increased to the level of Ascorbic acid.

모 연취급장 근로자들의 연폭로지표들과 혈압과의 관련성

임상복,김용배,이용진,리갑수,김화성,황규윤,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1998 순천향산업의학 Vol.4 No.1

In order to investigate the relationship between blood lead with other lead exposure indices and blood pressure in occupationally lead exposed male workers, 629 workers(515 lead exposed workers and 114 non lead exposed workers) in a storage battery factory were studied. Blood lead(PbB), zinc protoporphyrin(ZPP) and urinary δ-aminolevulinic acid(ALAU) were selected as an index of lead exposure. Height and weight were also meaured with calibrated automatic height-weight machine to produce fatness index directly. Personal information on smoking and drinking history were also collected. Blood pressure was mearured by trained nurses with automatic sphingomanometer. All workers took at least 30 minute rest before their measurement of blood pressure. The results obtained were as follows: 1. The prevalence rate of hypertension of lead exposed and non-exposed workers were 3.5% in both group without any difference. 2. There were no differences of systolic and diastolic pressure between groups divided by lead exposure, smoking habit, drinking habit. but the increase of age group made the difference of diastolic pressure, and only differenct of systolic pressure observed in age group of less than 20 and that of more than 40. 3. In pearson's correlation analysis, PbB was correlated with systolic pressure significantly, but not with diastolic pressure. PbB was also correlated with pressure difference(systolic pressure-diastolic pressure). 4. There were no significant increase of systolic, diastolic pressure and pressure difference by the increase of PbB and ZPP grouping. 5. Stepwise multiple regression analysis using systolic pressure as dependent variable and PbB, ZPP, ALAU, age, work duration, smoking habit, drinking habit and fatness (weight*0.9/height-100) as independent variables, revealed that PbB, age, drinking habit and fatness in order were significantly contributed to the dependent variable. 6. Stepwise multiple regression analysis using diastolic pressure as dependent variable and PbB, ZPP, ALAU, age, work duration, smoking habit, drinking habit and fatness (weight*0.9/height-100) as independent variables, revealed that ALAU, age and fatness in order were significantly contributed to the dependent variable. 7. Stepwise multiple regression analysis using pressure difference as dependent variable and PbB, ZPP, ALAU, age, work duration, smoking habit, drinking habit and fatness(weight*0.9/height-100) as independent variables, revealed that PbB, age and fatness in order were significantly contributed to the dependent variable. 8. Logistic analysis of hypertensive conditions with categorized blood lead and other selected categorized independent variables indicated that only age(40> and 40≤) and fatness(1.0> and 1.0≤) were significantly contributed to dependent variable with 95% significant odd ratio confidence interval. With above results, lead exposure in terms of blood lead seemed to be minimally contributed to the raise of blood pressure, and the effect of blood lead was found to be more prominent on the pressure difference than the systolic and diastolic pressure themselves.

四君子湯 抽出液이 家兎의 體液性 免疫反應에 미치는 影響

林圭庠,文炳淳,李起男 圓光大學校 醫科學硏究所 1987 圓光醫科學 Vol.3 No.1

The present experiment was investigated on the effects of Sagunjatang extract on the humoral immune response of rabbit. In order to understand the immune respone of the extract, one of the experimental groups was treated with the antigen, E. coli Ry 13 suspension and the extract. And the serum separated from the treated group was analyzed. The results obtained were as follows : 1. The body weight of the rabbit treated with Sagunjatang extract was increased remarkably. 2. Sagunjatang extract did not affect the number of erythrocytes, however, it increased the number of WBC in small amount. It means that the extract activates the WBC related with producing antibody. 3. The synthesis of γ-globulin was stimulated by the Sagunjatang extract in the present experiment.

畵夜間 溫度差(DIF)處理에 의한 고추 '녹광' 플러그苗의 生長反應

임기병,오중열,정재동 慶北大學校農業科學技術硏究所 1996 慶北大農學誌 Vol.14 No.-

고추 '녹광' 품종의 플러그 육묘시 주야간 온도차 처리에 따른 생육조사 결과 초장은 주간온도와 DIF에 의해 영향을 받으며 절간장도 초장과 비슷한 경향이었다. 엽전개속도는 주로 일 평균 온도에 의해 좌우되었다. 엽장, 엽폭은 일 평균 온도가 증가함에 따라 증가 하는 것으로 나타났으며 생체중은 주야간 온도가 15℃처리구에서 가장 낮았고 일평균 온도가 증가함에 따라 증가하는 경향이었다. 생체중과는 반대로 엽록소함량은 일평균 온도가 15℃처리구에서 가장 높게 나타났으며 전체적으로는 야간온도가 증가할수록 엽록소함량이 저하되었다. 줄기직경은 DT/NT=15/15처리구에서 가장 낮았고 다른 처리구는 비슷한 경향이었다. T/R율은 DT/NT=30/15℃(+15DIF)처리구에서 가장 높게 나타나 지상부가 지하부에 비해 과번무됨을 알수 있었다. 따라서 녹광 고추의 플러그 육묘시 충실한 묘를 생산하기 위해서는 주간온도가 22.5℃, 야간온도는 15-22.5℃범위의 0DIF또는 약한 +DIF조건에서 육묘하는 것이 강건한 묘생산에 유리할 것으로 판단된다. Capsicum annuum 'Nokkwang' plug seedlings were treated with 9 different day and night temperatures to investigate on growth and differentiation in controlled environment conditions. The plant height was the most affected by day temperature and DIF and stem length was the similler results as plant height. However, Leaf unfolding rate and leaf length and width increased as average daily temperature increased. and especially fresh weight was worst at ADT was 15℃ and increased as ADT increased. In contrast with fresh weight, chlorophyll content calculated highest when ADT was 15℃, and decreased as NT increased respectively. The stem lengths were not significantly different among treatments with exception of DT/NT=15/15℃ which significantly decreased. The ultimate +DIF condition, DT/NT=30/15℃, caused high T/R ratio due to abundant top growth. It is concluded that DT is 22.5℃, caused high T/R ratio due to abundant top growth. It is concluded that DT is 22.5℃, and NT is ranged from 15℃ to 22.5℃ to be produced short, healthy plug seedlings in Capsicumannuum 'Nokkwang'.

內藏山의 昆蟲相

金基卿,林京勳,金兵鎭 圓光大學校 1993 論文集 Vol.27 No.2

著者들은 內臧山의 昆蟲相을 調査하기 위하여 1990년 9월까지 이 地域의 昆蟲들을 採集하였다. 著者들의 文獻調査에 의하면 이 地域에 대한 傳門的인 昆蟲相은 지금까지 두번 수행된 적이 있다. 또한 이 地域은 觀光地 임으로 여러 文獻에서 採集地 記錄되고 있다. 採集된 모든 漂本들을 同定한 結果 12目 115科 831種이 確認, 同定되었다. 그 중에서 稀貴種으로 保護가 要求되는 種은 Parnassius bremeri(붉은 점모시나비)와 Melitaea phobe(암어리표범나비), Aporia crataegi(상제나비), Spindasis takanonis(쌍꼬리부전나비), Bibasis striata(큰수리팔랑나비), Chlorophorus diadema(범하늘소), Chrysochroa fulgidissima(비단벌레)이다. In order to study the insect fauna from Mt. Maejang authors collected insects from April, 1990 to September, 1990. Up to now the insect fauna of this area has been professionaly surveyed twice according to our references studies. After we examined all the specimens, 831 species of 115 families under 12 orders were identified in this region. Among them 7 species; parnassius bremeri, Melitaea phobe, Apocrina crataegi, Spindasis takanosis, Bibasis striata, Chlorophorus diadema and Chrysochroa fulgidissima are rare species to be protected.

母岳山의 昆蟲相

金兵珍,金基卿,林京勳,朴準庸 圓光大學校 基礎自然科學硏究所 1992 基礎科學硏究誌 Vol.11 No.1

In order to study the insect fauna from Mt.Moak, authors collected all the insects in this region from April, 1990 to September, 1990. Up to now the insect fauna from this area has not been professionally surveyd yet according to my references studies. Examining all the samples, 172 species of 29 families under 5 orders were identified in this region. Among them 4 species; Parnassius bremeri, Melotaea phoebe, Bibasis striata and Aporia crataegi are rare species to be protected.

社會體育振興을 위한 國民意識 再考方案

金柄斗,蔡鴻遠,安禹洪,李敏炯,申榮吉,金基學,鄭相澤,林銖遠 慶北大學校 體育科學硏究所 1987 체육과학연구지 Vol.3 No.-

The purpose of this paper is to investigate and analyze the nation's consciousness about the social physical education by regional groups(big cityes, middle cityes, farm village, fishing villge). And the researchers are to find a way to populize this movement. These subjects for this investigation were chosen at random among the citizens in four region. 4,450 sheets of questionnaire were given to the citizen. And 3,587(81%) sheets of them were received from male(2,582) and female(975) citizens. The results of this investigation are as follows: 1. The nation's consciousness has not been still modernized and the nation tend to depend on their doctors rather than on the new active leisure sports, which is a passive and conventional way, to keep their health. 2. Most people have spent their leisures on nonactive hobby such as reading, listening to music, and watching TV rather than sports. 3. Most residents pointed out lack of facilities, and needed professional directors and various programs they could participate. 4. The opening of citizen athletic field and the gymnasiums to citizens was needed to recruit the lack of facility, and the participation to commercial sport ws differed by economical status and leisure time, however, they usually participated such activities as table-tennis, swimning and tennis. 5. To activate social physical education, first of all, an expansion of the facilities such as athletic fields and gymnasium is needed under the active support of government. 6. The facilities for young men and the handicapped is insufficient, and to prevent juvenile delinquency and guide them into the right way, we should lead them out to participate sports activity. And the facility for the handicapped is needed too.

胎盤組織 膜結合 Adenosine Deaminase의 可溶化 및 性狀의 究明

朴基錫,林圭,黃炳斗 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1

Adenosine deaminase is solubilized with Triton X-100 from purified plasma membrane of human placenta and prtially purified 11-fold by combination of sephacryl S-300 and DEAE-sephadex A-25 column chromatography, and then its properties have been investi gated. The enzyme shows a broad pH optimum from 6 to 8, and heat labile, being completely inactivated by heat treatment at 70℃ for 10 minutes. The enzyme is inhibited to 18% by 2 mM Cu^2+ and to 50% by almost mineral ions and the inhibitory effect of Cu^2+ is recovered by 4 mM EDTA to 50%. The apparent Michaelis constant of the enzyme for adenosine is 8×10 exp(-5) M and for deoxyadenosine is 3.8×10 exp(-5) M. Kinetic analysis of the enzyme in the presence of 0.05 mM Cu^2+ shows that the nature of the inhibition is noncompetitive, considering that Km is independant while Vmax is decreased. The molecular weight of the enzyme is about 1,500,000. From the above results, the possibility that the soluble adenosine deaminase of placenta anchored to the plasma membrane through adenosine deaminase binding protein is discussed.