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Background : Acne, one af the commonest dermatological disorders, is a disease of the pilosebaceous unit, and the primarily involved site is the face, where this structure exists in maximal density. Among the many etiologieal factors of acne, changes in the kinetics of sebum secretion in acne patients have been described, but there is no report to compare follicular density and the sebum excretion rate in different facial regions between normal and acne patients. Objectives : The purpose of this study was to compare the sebum output and follicular density in different regions of the face in women with and without acne and to evaluate the differences between the two groups. Methods : We studied 10 normal and 14 acneic women aged 19-27. Follicular density was determined by light microscopy counting pilosebaceous units on cyanoacrylate follicular biopsy specimens. The sebum excretion rate was calculated by an image analyzer with a sebum print on Sebutape Results : 1. Follicular density was not significantly different between the normal and acne group. The number of follicles decreased from the central to the lateral aspect of the face with the highest value being on the nose tip and the lowest on the lateral forehead. 2. The total sebum excretion rate and the number of actively secreting follicles showed different patterns in the two groups. There was a decreased value in the acne group in some central regions of face. In addition, central to lateral declining pattems, shown in the normd group, were not apparent in the acne group. 3. The follicular sebum excretion rate showed large variations in both groups, without apparent central to lateral declining patterns. The confluence of adjacent follicles seemed to produce falsely low or high values compared with previous studies. Conclusion : Sebum production is influenced both by the number of active follicles and their individual capacity to excrete sebum, and the total sebum excretion rate was lower than normal in low grade acne in this study. Obstruction of the outflow of sebum and regression of sebaceous glands due to comnlones may account for it.
A lipid absorbent tape(Sebutape®)is a new device for measurement of skin surface lipid I have tested the utility of lipid absorbent tape method for the measurement of sebum secretion rates of 20 healthy adult males comparing with conventional hexane extraction technique. The results are as follows : 1) The average amount of total sebum collected using lipid absorbent tape technique and hexane extraction technique were 109.20±43.89㎍/3hrs/㎠ and 113.94±47.l2㎍/3hrs/㎠ respectively. and the correlated well(r=0.93). 2) The 2 techniques were in good accord with reference to their efficacy in collection of free fatty acid(r=0.55). triglyceride(r=0.76). wax and cholesterol esters(r=0.91), and squlaene (r=0.89) from the surface of the skin, but the correlation of cholesterol(r=0.17) was poor. 3) Lipid absorbent tape furnished a good means of visualization of the droplets produced by individual follicles. Above results indicate that the lipid absorbent tape provide a new convenient technique for the measurement of sebum secretion rate and quantitation of components of skin surface lipids.
Patch tests with patients' own cosmetics, cosmetic series type 17 and 18, and Hollister-Stier antigens were performed in 246 cases of suspected cosmetic contact dermatitis. The positive rates of patch tests with patients' own cosmetics, cosmetic series and Hollister-Stier antigens were 63.5% .56.8%. and 51.8% respectively. Cinamic alcohol, benzyl salicylate, jasmin abosolute, PPDA, ammoniated mercury, balsam of Peru were the most commonly identified antigens. Among the cosmetics, skin care products were dominant causes of the cosmetic contact dermatitis. The positive rate of foreign cosmetics was more than 1.4 fold higher than the domestic ones.
We report a case of molluscum contagiosum occurring in an epidermal cyst. A-38-year old male patient had the lision which was a 1.2 x 1cm sized, elevated, round nodule on the right cheek. Histology showed true epidermal cyst containing molluscum bodies throughout the cyst wall and laminated keratotic material within the cyst itself. (Kor J Dermatd 1992; 30(6): 917-919)
Cosmetics that are moderately to strongly comedogenic in the rabbit ear model test have been found to be capable of inducing comedones in human model. In humans the test cosmetics were applied under occlusion for 4 weeks to the scapular region of young adults. The degree of follicular hyperkeratosis was assessed by a noninvasive skin surface biopsy technique, employing a fast-setting cyanoacrylate adhesive to remove the follicular content. The rabbit model was more sensitive than the human. The test materials were applied once every day for 2 weeks onto the ventral surface of ear just external to ear canal. Excised tissue was thus immeresd in water at 60℃ for 2 minutes, yielding a sheet of epidermis with microcomedones attached. The magnitude of follicular hyperkeratosis was assessed under the stereomicroscope. High correlation between assay results of comedogenicity in humans and rabbits was found. So, it was concluded that rabbit ear assay is a simple and rapid method to assess the comedogenicity of cosmetics and other contactants.
A study was made on 1,210 cases of skin tumors which were diagnosed by histopathologic examination during the periods of 14 years and 6 months from January, 1975 to June, 1989 at Department of Dermatology, Ewha Womans University Hospital in Seoul. The results were summerized as follow ; 1) The 1,210 cases of skin tumors consisted of 1,020 cases(84.3%) of benign and 190 cases(15.7%) of malignant tumors, and male to female ratio was 1: 1.4. 2) Male to female ratio for benign tumors was 1:1.6 and for malignant tumors 1.3:1. 3) Among 1,020 cases of benign tumors, 257 cases(25.2%) originated from epidermis, 213 cases(20.9%) from melanocyte, 134 cases(13.1%) from epidermal appendages, 107 cases(10.5%) from fibrous tissue, 86 cases(8.4%) from vessel, 59 cases(5.8%) from nerve, 30 cases(2.9%) from fat tissue, 10 cases(1.0%) from smooth muscle and 126 cases(12.4%) from others. 4) Among 1,020 cases of benign tumors, the most frequent tumor was syringoma(69 cases) which was followed by epidermal cyst(67 cases), epidermal nevus(58 cases). seborrheic keratosis(58 cases), urticaria pigmentosa(52 cases), neurofibromatosis(50 cases). intradermal nevus(42 cases), pyogenic granuloma(39 cases), acquired bilateral nevus of Ota-like macules(37 cases) and others(530 cases) 5) The predilection sites were face(82.6%) in syringoma, head(40.3%) in epidermal cyst, extremities(41.4%) in epidermal nevus, face(60.3%) in seborrheic keratosis, trunk(78.8%) and extremities (73.1%) in urticaria pigmentosa, trunk and extremities(100%) in neurofibromatosis, face(40.5%) in intradermal nevus, extremities(43.6%) in pyogenic granuloma. 6) Among 190 cases of malignant tumors, 57 cases(30.0%) of basal cell carcinoma, 47 cases(24.7%) of squamous cell carcinoma, 17 cases(8.9%) of malignant melanoma, 15 cases(7.9%) of Bowen's disease, 15 cases(8.9%) of Paget's disease, 11 cases(5.8%) of mycosis fungoides, 10 cases(5.3%) of metastatic cancers and 16 cases(8.4%) of others were observed. 7) The average ages of patients with malignancies were 55.6 years in basal cell carcinoma, 56.2 years in squamous cell carcinoma, 54.4 years in malignant melanoma, 58.1 years in Bowen's disease, 58.2 years in Paget's disease, 57.8 years in mycosis fungoides, 53.3 years in metastatic cancers. 8) The predilection sites were face(93.0%) in basal cell carcinoma, head(51.5%) in squamous cell carcinoma, soles(52.9%) in malignant melanoma, tnunk(33.3%) in Bowen's disease, penis(60.0%) in extramammary Paget's disease, trunk and extremities(81.8%) in mycosis fungoides, trunk(60.0%) in metastatic cancers. 9) Among 10 cases of cutaneous metastatic cancers, primary sites were stomach in 4 cases, lung in 1 cases and unknown in 5 cases.
Histamine-induced cutaneous wheal responses were measured in 24 healthy subjects. The effect of the potent H_1 blocker, hydroxyzine HCI, the H_2 blocker, cimetidine, and the two drugs in combination was determined. The H_1 blocker alone produced a mean wheal suppression of 77%(p<0.005). The H_2 blocker alone produced a mean wheal suppression of 35%(p<0.01). The H_1 plus H_2 blocker produced 79% suppression. But the augmented suppression of H_1 plus H_2 blocker vs H_1 blocker was not statistically significant (p>0.05). The result provide evidence that H_2 receptors are present in the human cutaneous blood vessel, but additional studies must be performed to determine the significance of combined H_1 and H_2 blockade over H_1 blocker alone in suppression of histamine-induced wheal formation.
Background�Porokeratosis is characterized by cornoid lamellae histologically and evolve cutaneous malignant tumors in about 7% of the patients. Actinic keratosis is the most common premalignant lesion and progressed into squamous cell carcinoma in 20% of the patients. It has been reported that the expression of p53 increased within or beneath the cornoid lamellae of porokeratosis and actinic keratosis. Objective�The purpose of this study was to understand the role of apoptosis in pathogenesis and progression into malignant tumors and to investigate whether a positive correlation occurs between apoptosis index and expression of p53, bcl-2, PCNA and iNOS in porokeratosis and actinic keratosis. Methods�TUNEL staining and immunohistochemical staining with p53, bcl-2, PCNA and iNOS antibody were done in paraffin-embedded tissue sections of 10 cases of porokeratosis and 12 cases of actinic keratosis. Results�The results are summarized as follow: 1. The mean of apoptosis index(%) was 27.3�7.82 in porokeratosis, 36.3�10.32 in cornoid lamellae of porokeratosis. 2. The mean of apoptosis index(%) of actinic keratosis was 41.5�8.98 and statistically significant higher than that of porokeratosis(p=0.002). 3. Statistically significant correlatioin between p53 expression and apoptosis index was found only in porokeratosis(sig=0.046). Conclusions : Actinic keratosis more frequently evolves into malignant tumors than porokeratosis, which is supported by more higher apoptosis index than that of porokeratosis. The apoptosis and p53, rather than proliferation, may provide the pathogenesis and progression into malignant tumor in porokeratosis, but in actinic keratosis other apoptosis-related factors may be related.
C57BL 흑색마우스에 UVB를 매일 100mJ/cm^2씩 10일간 조사하여 표피멜라닌세포를 활성화시킨 후 5% cysteine과 5% glutathione이 표피멜라닌세포의 수적 변화와 멜라닌소체 형태변화에 미치는 영향을 관찰하여 다음과 같은 결과를 얻었다. 1. Cysteine 투여군에서는 멜라닌세포의 수적변화가 없었으며 glutathione투여 5주 후에서만 멜라닌세포의 수가 감소하였다. 2. Cysteine 투여군과 glutathione 투여군은 대조군에 비해 표피멜라닌세포내 멜라닌소체의 단축 길이와 stage Ⅳ 멜라닌소체 비율에 유의한 감소를 보여 멜라닌형성 억제제로서 의의있는 효과를 나타내었다. 3. 두 실험군간의 비교에서 멜라닌소체 단축길이는 glutathione 투여군에서 투여 3주 후에 cysteine 투여군보다 의의있게 감소되었으며, stage Ⅳ 멜라닌소체의 비율은 glutathione 투여군에서는 투여 3주 후에 cysteine 투여군에서는 투여 5주 후에 각각 유의한 감소소견을 보였다. 4. Glutathione 투여군에서는 멜라닌소체 단축길이와 stage Ⅳ 멜라닌소체의 비율이 모두 투여기간에 비례하여 감소되었다. 이상과 같은 결과로 황화수소화합물인 cysteine과 glutathione은 자외선 B조사로 활성화된 표피멜라닌세포내 멜라닌소체의 단축길이와 stage Ⅳ 멜라닌소체의 비율을 감소시킴으로써 멜라닌형성을 억제하고, glutathione이 cysteine보다 멜라닌형성억제에 우수한 효과를 나타냄을 알수 있었다. The effects of sulfhydryl compounds, cysteine and glutathione, on populations of melanocytes, the sizes of melanosomes and the ratios of melanosomal stages of epidermal melanocytes in UVB-irradiated C57BL black mice were evaluated. The results were as follow: 1. Both of cysteine and glutathione showed no significant diminution in the numbers of dopa-positive melanocytes except at the end of 5 weeks' treatment with glutathione. 2. Both of cysteine and glutathione showed significant diminution in short axis of melanosomes and the percentage of stage Ⅳ melanosomes of epidermal melanocytes. 3. The lengthes of short axes of melanosomes in glutathione-treated group were smaller than those in cysteine-treated group at the end of 3rd week of intraperitoneal injection. 4. In the glutathione-treated group, the short axes of melanosomes and the percentages of stage Ⅳ melanosomes decreased in proportion to the period of intraperitoneal injection.