셀룰로오스에 브롬화비닐의 그라프트 반응과 그 방염성에 관한 연구

최금숙,조성무,채희주,유학수 연세대학교 자연과학연구소 1987 學術論文集 Vol.18 No.-

셀룰로오스에 방염성을 부여하기 위해 산화-환원 개시제인 Ce^??이온을 이용하여 브롬화비닐을 그라프시켰다. 일반적으로 그라프트율은 시간에 따라 증가하다가 정상 상태에 도달하고,단량체 농도에 비례하며 극대치를 갖는 개시제의 농도가 존재한다. 그라프트율의 증가에 따라 한계산소지수가 높아져 방염성을 보임을 알 수 있다. To impose the flame retardant properties on cellulose, vinyl bromide was grafted on cellulose by redox initiator Ce^??. Generally, graft yield increases according to graft reaction time but as time goes on it shows steady state, however, it keeps on increasing in proportion to monomer concentration and has an optimum initiator concentration. It was found that LOI was proportional to graft yield and grafted cellulose had flame retardant properties.

과민성 장 증후군의 증상 경감을 위한 비약물적 접근 고찰

최명애,김금순,안경주,채영란,최정안,홍해숙,박미정,이경숙,신기수,정재심 대한기초간호자연과학회 2005 Journal of korean biological nursing science Vol.7 No.2

There have been many trials of clinical efficacy of multicomponent and single component treatments for irritable bowel syndrome(IBS). We reviewed effects of non phamacological treatments in the IBS. Though the efficacy of multi-component approaches was unclear, several results suggest that cognitive behavioral therapy was effective in improving gastrointestinal symptoms of IBS. As a single component, cognitive therapy and relaxation with or without biofeedback could improve the symptoms and psychological health of IBS patients. Yoga, meditation, self-help information and hypnotherapy could be applicable to IBS.

Methylprednisolone pulse therapy for critically ill patients with COVID-19: a cohort study

Choi Keum-Ju,정수균,김경찬,Kim Eun Jin 대한중환자의학회 2023 Acute and Critical Care Vol.38 No.1

Background The guidelines recommend the use of dexamethasone 6 mg or an equivalent dose in patients with coronavirus disease 2019 (COVID-19) who require supplemental oxygen. Given that the severity of COVID-19 varies, we investigated the effect of a pulse dose of corticosteroids on the clinical course of critically ill patients with COVID-19. Methods This single-center, retrospective cohort study was conducted between September and December 2021, which was when the Delta variant of the COVID-19 virus was predominant. We evaluated the mortality and oxygenation of severe to critical COVID-19 cases between groups that received dexamethasone 6 mg for 10 days (control group) and methylprednisolone 250 mg/day for 3 days (pulse group). Results Among 44 patients, 14 and 30 patients were treated with control steroids and pulse steroids, respectively. There was no difference in disease severity, time from COVID-19 diagnosis to steroid administration, or use of remdesivir or antibacterial agents between the two groups. The pulse steroid group showed a significant improvement in oxygenation before and after steroid treatment (P<0.001) compared with the control steroid group (P=0.196). There was no difference in in-hospital mortality (P=0.186); however, the pulse steroid group had a lower mortality rate (23.3%) than the control steroid group (42.9%). There was a significant difference in the length of hospital stay between both two groups (P=0.039). Conclusions Pulse steroids showed no mortality benefit but were associated with oxygenation improvement and shorter hospital stay than control steroids. Hyperglycemia should be carefully monitored with pulse steroids.

The Association between Mortality and the Oxygen Saturation and Fraction of Inhaled Oxygen in Patients Requiring Oxygen Therapy due to COVID-19-Associated Pneumonia

( Keum-ju Choi ),( Hyo-lim Hong ),( Eun Jin Kim ) 대한결핵 및 호흡기학회 2021 Tuberculosis and Respiratory Diseases Vol.84 No.2

Background: The coronavirus disease (COVID-19) can manifest in a range of symptoms, including both asymptomatic systems which appear nearly non-existent to the patient, all the way to the development of acute respiratory distress syndrome (ARDS). Specifically, COVID-19-associated pneumonia develops into ARDS due to the rapid progression of hypoxia, and although arterial blood gas analysis can assist in halting this deterioration, the current environment provided by the COVID-19 pandemic, which has led to an overall lack of medical resources or equipment, has made it difficult to administer such tests in a widespread manner. As a result, this study was conducted in order to determine whether the levels of oxygen saturation (SpO₂) and the fraction of inhaled oxygen (FiO₂) (SF ratio) can also serve as predictors of ARDS and the patient’s risk of mortality. Methods: This was a retrospective cohort study conducted from February 2020 to Mary 2020, with the study’s subjects consisting of COVID-19 pneumonia patients who had reached a state of deterioration that required the use of oxygen therapy. Of the 100 COVID-19 pneumonia cases, we compared 59 pneumonia patients who required oxygen therapy, divided into ARDS and non-ARDS pneumonia patients who required oxygen, and then investigated the different factors which affected their mortality. Results: At the time of admission, the ratios of SpO₂, FiO₂, and SF for the ARDS group differed significantly from those of the non-ARDS pneumonia support group who required oxygen (p<0.001). With respect to the predicting of the occurrence of ARDS, the SF ratio on admission and the SF ratio at exacerbation had an area under the curve which measured to be around 85.7% and 88.8% (p<0.001). Multivariate Cox regression analysis identified that the SF ratio at exacerbation (hazard ratio [HR], 0.916; 95% confidence interval [CI], 0.846-0.991; p=0.029) and National Early Warning Score (NEWS) (HR, 1.277; 95% CI, 1.010-1.615; p=0.041) were significant predictors of mortality. Conclusion: The SF ratio on admission and the SF ratio at exacerbation were strong predictors of the occurrence of ARDS, and the SF ratio at exacerbation and NEWS held a significant effect on mortality.

The Korean Academy of Tuberculosis and Respiratory Diseases : Slide Session ; OS-058 : Pulmonary Vascular Diseases ; Central Emboli Rather than Saddle Emboli Predict Adverse Outcomes in Patients with Acute Pulmonary Embolism

( Keum Ju Choi ),( Seung Ick Cha ),( Seung Soo Yoo ),( Jae Hee Lee ),( Shin Yup Lee ),( Chang Ho Kim ),( Jae Yong Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: In patients with acute pulmonary embolism (PE), the prognostic implications of saddle or central emboli, as observed on computed tomography (CT), remain to be established. The aim of the present study was to assess whether the presence of saddle and central emboli could be used to predict clinical outcomes in patients with PE. Methods: The authors retrospectively reviewed 743 consecutive patients hospitalized at a tertiary referral center with a diagnosis of PE based on multi-detector row CT scan.Results: All the clinical variables did not differ between saddle emboli (5.8% [n=43]) and right or left pulmonary artery emboli (29.7% [n=221]), and the frequency of an adverse outcome was not signifi cantly different between the two groups. Saddle emboli and right or left pulmonary artery emboli were grouped into central emboli (35.5% [n=264]). Patients were allocated to an adverse outcome group (10.5% [n=78]) or acontrol group (89.5% [n=665]). Multivariate analysis demonstrated that PE severity index (PESI) score (class IV-V), N-terminal-pro-B-type natriuretic peptide level (=1,406 pg/mL), right ventricular dilation on CT (right ventricle/left ventricle diameter ratio =1), and central emboli signifi cantly predicted an adverse outcome. The addition of central emboli to other established prognostic factors such as PESI enhanced the positive predictive values and positive likelihood ratios of an adverse outcome for acute PE Conclusions: Rather than saddle emboli, central emboli could be an independent prognostic factor of adverse outcomes in patients with acute PE and provide additional prognostic value when combined with other prognostic factors

Free Paper Presentation : OS-58 ; Central Emboli Rather than Saddle Emboli Predict Adverse Outcomes in Patients with Acute Pulmonary Embolism

( Keum Ju Choi ),( Seung Ick Cha ),( Seung Soo Yoo ),( Jaehee Lee ),( Shin Yup Lee ),( Chang Ho Kim ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-

Background: In patients with acute pulmonary embolism (PE), the prognostic implications of saddle or central emboli, as observed on computed tomography (CT), remain to be established. The aim of the present study was to assess whether the presence of saddle and central emboli could be used to predict clinical outcomes in patients with PE. Methods: The authors retrospectively reviewed 743 consecutive patients hospitalized at a tertiary referral center with a diagnosis of PE based on multi-detector row CT scan. Results: All the clinical variables did not differ between saddle emboli (5.8% [n=43]) and right or left pulmonary artery emboli (29.7% [n=221]), and the frequency of an adverse outcome was not significantly different between the two groups. Saddle emboli and right or left pulmonary artery emboli were grouped into central emboli (35.5% [n=264]). Patients were allocated to an adverse outcome group (10.5% [n=78]) or a control group (89.5% [n=665]). Multivariate analysis demonstrated that PE severity index (PESI) score (class IV-V), N-terminal-pro-B-type natriuretic peptide level (=1,406 pg/mL), right ventricular dilation on CT (right ventricle/left ventricle diameter ratio =1), and central emboli significantly predicted an adverse outcome. The addition of central emboli to other established prognostic factors such as PESI enhanced the positive predictive values and positive likelihood ratios of an adverse outcome for acute PE Conclusions: Rather than saddle emboli, central emboli could be an independent prognostic factor of adverse outcomes in patients with acute PE and provide additional prognostic value when combined with other prognostic factors.

Influence of Ginsenosides on the Kainic Acid-Induced Seizure Activity in Immature Rats

Choi, Kang Ju,Baek, Nam In,Choi, Soo Young,Park, Jin Kyu,Cho, Sung Woo,Jin, Sung Ha,Choi, Keum Hee,Ko, Ji Hun,Nam, Ki Yeul 생화학분자생물학회 2000 BMB Reports Vol.32 No.4

We studied the effects of ginsenosides in immature rats based upon the previous results that ginseng has a suppressive or anticonvulsive activity. To examine the suppressive effect of ginsenosides on kainic acidinduced seizures, the severities and frequencies were observed for 4 h after injection of kainic acid (KA; i.p., 2 ㎎/㎏ b.w.) using 10-day-old male Sprague-Dawley rats (22 ±2 g). Protopanaxadiol saponins such as ginsenoside-Rb1 (Rb1), ginsenoside-Rb2 (Rb2), ginsenoside-Rc (Rc), and ginsenoside-Rd (Rd) generally reduced the seizure activities while protopanaxatriol saponins such as ginsenoside-Rg1 (Rg1) and ginsenoside-Re (Re) rather increased stereotypic $quot;paddling-like$quot; movements. When vinyl-GABA (v-G) was injected together with Rb1 or Rc, KA-induced seizure severities were additionally reduced only by the injection of Rc, but not by Rb1. The level of gamma isozyme of protein kinase C (PKC-y) in the hippocampus increased about three times as much as that of normal rats at 4 h after KA injection. The increased level of PKC-y by KA was significantly reduced to about 35% by the coinjection with v-G alone, but it was not changed by v-G together with Rb1 or Rc. The increased level of PKC-y at 4 h after injection of KA was not consistent with the reduction of seizure severities between Rb1 and Rc. These results suggest that Rc and Rb1 may reduce seizure severity independent of PKC-y levels, and Rc may additionally act with v-G regarding the GABA metabolism during the stage of KA-induced seizures in the immature rats.

N-cadherin Determines Individual Variations in the Therapeutic Efficacy of Human Umbilical Cord Blood-derived Mesenchymal Stem Cells in a Rat Model of Myocardial Infarction

Lee, Eun Ju,Choi, Eue-Keun,Kang, Soo Kyoung,Kim, Gi-Hwan,Park, Ju Young,Kang, Hyun-Jae,Lee, Sae-Won,Kim, Keum-Hyun,Kwon, Jin Sook,Lee, Ki Hong,Ahn, Youngkeun,Lee, Ho-Jae,Cho, Hyun-Jai,Choi, Soo Jin,Oh Elsevier Science B.V., Amsterdam 2012 MOLECULAR THERAPY Vol.20 No.1

Clinical Characteristics of Community-Acquired Viridans Streptococcal Pneumonia

Choi, Sun Ha,Cha, Seung-Ick,Choi, Keum-Ju,Lim, Jae-Kwang,Seo, Hyewon,Yoo, Seung-Soo,Lee, Jaehee,Lee, Shin-Yup,Kim, Chang-Ho,Park, Jae-Yong The Korean Academy of Tuberculosis and Respiratory 2015 Tuberculosis and Respiratory Diseases Vol.78 No.3

Background: Viridans streptococci (VS) are a large group of streptococcal bacteria that are causative agents of community-acquired respiratory tract infection. However, data regarding their clinical characteristics are limited. The purpose of the present study was to investigate the clinical and radiologic features of community-acquired pneumonia (CAP) with or without parapneumonic effusion caused by VS. Methods: Of 455 consecutive CAP patients with or without parapneumonic effusion, VS were isolated from the blood or pleural fluid in 27 (VS group, 5.9%) patients. Streptococcus pneumoniae was identified as a single etiologic agent in 70 (control group) patients. We compared various clinical parameters between the VS group and the control group. Results: In univariate analysis, the VS group was characterized by more frequent complicated parapneumonic effusion or empyema and bed-ridden status, lower incidences of productive cough, elevated procalcitonin (>0.5 ng/mL), lower age-adjusted Charlson comorbidity index score, and more frequent ground glass opacity (GGO) or consolidation on computed tomography (CT) scans. Multivariate analysis demonstrated that complicated parapneumonic effusion or empyema, productive cough, bed-ridden status, and GGO or consolidation on CT scans were independent predictors of community-acquired respiratory tract infection caused by VS. Conclusion: CAP caused by VS commonly presents as complicated parapneumonic effusion or empyema. It is characterized by less frequent productive cough, more frequent bed-ridden status, and less common CT pulmonary parenchymal lesions. However, its treatment outcome and clinical course are similar to those of pneumococcal pneumonia.

Complete mitochondrial genome of a Chinese scorpion Mesobuthus martensii (Chelicerata, Scorpiones, Buthidae)

Choi, Eun Hwa,Park, Shin Ju,Jang, Keum Hee,Hwang, Wook Informa Healthcare 2007 DNA sequence Vol.18 No.6

<P> The complete mitochondrial genome (15,034 bp) of a Chinese scorpion Mesobuthus martensii (Buthidae) was sequenced and characterized in detail. The genome contains 13 protein-coding genes, 21 transfer RNA genes, two ribosomal RNA genes and a large non-coding region ( = CR). Its gene arrangement pattern is identical to that of Limulus polyphemus (Chelicerata, Xiphosura), with the exceptions of the tRNAGlu-tRNAIle-tRNAMet (Q-I-M) arrangement and tRNAAsp-loss. Additional interesting features are found and discussed: high frequency of Leu(UUG) codon use, low A+T content of the genome (66.75%), and six repeat units (five 60-nt-long and one 58-nt-long repeats) in the 998-nt CR. Bayesian analysis based on amino acid sequences of the 12 proteincoding genes (excluding ATP8) reveals that the family Buthidae (Order Scorpiones) and the class Arachnida form strong monophyletic groups within Chelicerata, respectively. It indicated that the scorpions are the most ancestral arachnids.</P>