Optimal dose of intravenous pantoprazole in patients with peptic ulcer bleeding requiring endoscopic hemostasis in Korea

Choi, Kee Don,Kim, Nayoung,Jang, In-Jin,Park, Young Soo,Cho, Joo Youn,Kim, Jung-Ryul,Shin, Jai Moo,Jung, Hyun Chae,Song, In Sung Blackwell Publishing Asia 2009 Journal of gastroenterology and hepatology Vol.24 No.10

<P>Abstract</P><P>Background and Aim: </P><P>The lowest effective dose of proton pump inhibitors (PPI) for prevention of peptic ulcer rebleeding remains unclear. The objective of the present study was to evaluate whether low-dose PPI has a similar efficacy to high-dose i.v. administration for maintaining intragastric pH above 6.</P><P>Methods: </P><P>Sixty-one patients with bleeding ulcers were randomized into one of three groups after endoscopic hemostasis: pantoprazole 80 mg bolus followed by 8 mg/h; 40 mg, 4 mg/h infusion; and bolus injection of 40 mg every 24 h. Intragastric pH values and rebleeding rates were measured. In addition, pharmacokinetic parameters and association with CYP2C19 polymorphisms and <I>H. pylori</I> infection were assessed.</P><P>Results: </P><P>Mean percentage of time with intragastric pH > 6, and the proportion of patients with pH > 6 for more than 60% of the time were significantly higher in the 40 mg, 4 mg/h infusion group compared to the 40 mg bolus injection. There was no significant difference between the 80 mg, 8 mg/h and the 40 mg, 4 mg/h groups. In the <I>H. pylori</I> (−) group, only 40% of patients that received continuous infusion reached the target pH > 6 for more than 60% of the time; this was significantly lower than the <I>H. pylori</I> (+) group, 87.5% (<I>P</I> = 0.026).</P><P>Conclusions: </P><P>A continuous infusion, regardless of high or low dose, was more effective for acid suppression than a 40 mg bolus PPI injection in Korea. <I>H. pylori</I> infection was an important factor for the maintenance of an intragastric pH > 6.</P>

Genetic Evaluation of ALADIN Gene in Early-Onset Achalasia and Alacrima Patients

( Kee Wook Jung ),( In Ja Yoon ),( Do Hoon Kim ),( Jun Won Chung ),( Kwi Sook Choi ),( Kee Don Choi ),( Ho June Song ),( Gin Hyug Lee ),( Seung Jae Myung ),( Jin Ho Kim ),( Dhiraj Maskey ),( Myeung Ju 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2011 Journal of Neurogastroenterology and Motility (JNM Vol.17 No.2

Background/Aims ALADIN gene has been known to cause achalasia, alacrima, adrenal abnormalities and a progressive neurological syndrome. A considerable proportion of achalasia patients has been known to show alacrima (decreased secretion of tear). However, the genetic mechanism between achalasia and alacrima has not been defined yet. We postulated that ALADIN gene may be involved in the occurrence of early-onset achalasia; thus, we investigated the correlation of ALADIN gene in early-onset achalasia patients. Methods From 1989 to 2007, patients who were diagnosed as primary achalasia before age 35 were enrolled. All of the enrolled patients were asked for (1) blood sampling for DNA, (2) Shirmer test and (3) dysphagia questionnaires. Results The ALADIN gene in exon 1, 2, 10, 11 and 12 from 19 patients was investigated (M:F = 12:7). The mean age of patients at diagnosis was 27 ± 5 (15-35) years old. Eight out of 19 (42%) showed alacrima by the positive Shirmer test. In spite of thorough exam in the genetic study, there was no definite abnormal genetic finding in this study. Conclusions A considerable number of achalasia patients showed alacrima. Due to the limitation of this study, it is difficult to conclude that early-onset achalasia may have significant correlations with the ALADIN gene. (J Neurogastroenterol Motil 2011;17:169-173)

New Diagnostic Criteria for Nutcracker Esophagus Using Standard Manometry

정기욱 ( Kee Wook Jung ),( Hwoon Yong Jung ),( In Ja Yoon ),( Do Hoon Kim ),( Soon Man Yoon ),( Mi Young Do ),( Jun Won Chung ),( Hyung Chul Oh ),( Kwi Sook Choi ),( Kee Don Choi ),( Ho June Song ),( Gin 대한소화기학회 2007 대한소화기학회 추계학술대회 Vol.2007 No.-

Takayasu 동맥염의 임상적 고찰

최기준(Kee Joon Choi),조주희(Joo Hee Zo),한경일(Kyung Il Han),김영권(Young Kwon Kim),조명찬(Myeong Chan Cho),손대원(Dae Won Sohn),이명묵(Myoung Mook Lee),박영배(Young Bae Park),최윤식(Yun Shik Choi),서정돈(Jung Don Seo),이영우(Young 대한내과학회 1990 대한내과학회지 Vol.39 No.5

N/A To observe the clinical features of Takayasu's arteritis and evaluate the incidence and sites of coronary arterial involvement in Takayasu's arteritis, clinical observations were made in 99 patients who were diagnosed as Takayasu's arteritis by clinical features and aortographic findings in Seoul National University Hospital from August 1971 to July 1989 Coronary arteriographies were performed prospectively in 30 patients with Takayasu's arteritis since March 1987. The results were as follows: 1) In 99 cases of Takayasu's arteritis, 15 were male and 84 were female. The male to female ratio was 1:5.7, the mean age was 29.5, and 63% of those studied were under the age of 30. 2) The following were the presenting clinical symptoms and signs in decreasing order of frequency: headache(69%), weak or nonpalpable pulse(68%), carotid or abdominal bruit(55%), Dyspnea on exertion(51%), hypertention(48%), and dizziness(43%). 3) Aorta or arterial involvement in decreasing order of frequency: left subclavian artery(62%), abdominal aorta(58%), right subclavian artery(38%), descending thoracic aorta(37%) and left renal artery(35%). 4) Using Ueno's classification, 29(29%) were Type I, 22(22g) were Type II, and 48(48%) were Type III. Type IV or pulmonary arterial involvements were seen in 11(33%) out of 33 patients. 5) In a prospective study using coronary arteriography, 8(27%) out of 30 patients of Takayasu's ateritis showed coronary involvement. Among the 13 lesions of coronary arterial narrowings in 8 patients with coronary involvements, there were 3 ostial lesions, 5 proximal and 5 middle or distal lesions. 6) Frequently there were no cardiac symptom in patients with Takayasu's arteritis who had coronary arterial lesions, and a myocadial infarction or congestive heart failure may be the first sign of the coronary arterial narrowing.

크론병에서 Infliximab 치료의 효과와 안전성 - 단일 기관에서의 경험

최기돈 ( Kee Don Choi ),송호준 ( Ho Jun Song ),김주성 ( Joo Sung Kim ),정현채 ( Hyun Chae Jung ),송인성 ( In Sung Song ) 대한소화기학회 2005 대한소화기학회지 Vol.46 No.1

종설 : 조기위암의 내시경치료

최기돈 ( Kee Don Choi ) 대한내과학회 2011 대한내과학회지 Vol.81 No.1

Endoscopic resection has become accepted as a standard treatment in selected patients with early gastric cancer (EGC) with negligible risk of lymph node metastasis. Endoscopic resection preserves the stomach and therefore improves quality of life compared with surgery. And it allows accurate histological staging of the tumor, which is critical in deciding whether additional treatment is necessary. The endoscopic submucosal dissection (ESD) method has been widely used with higher en bloc resection and complete resection rates than conventional endoscopic mucosal resection (EMR) with acceptable complication rates. Long-term clinical outcomes of these techniques are promising in terms of disease-free and overall survival. Recently, the expanded indication of endoscopic resection for early gastric cancer has been proposed because of technical advances of ESD. Long-term outcome data of the expanded indication are needed for the clinical application of the expanded criteria of ESD. (Korean J Med 2011;81:40-46)

Outcomes of endoscopic submucosal dissection for superficial esophageal neoplasms in patients with liver cirrhosis

Young Kwon Choi,Jin Hee Noh,Do Hoon Kim,Hee Kyong Na,Ji Yong Ahn,Jeong Hoon Lee,Kee Wook Jung,Kee Don Choi,Ho June Song,Gin Hyug Lee,Hwoon-Yong Jung 대한소화기내시경학회 2022 Clinical Endoscopy Vol.55 No.3

Background/Aims: The treatment of superficial esophageal neoplasms (SENs) in cirrhotic patients is challenging and rarely investigated. We evaluated the outcomes of endoscopic submucosal dissection (ESD) to determine the efficacy and safety of treating SENs in patientswith liver cirrhosis. Methods: The baseline characteristics and treatment outcomes of patients who underwent ESD for SENs between November 2005 andDecember 2017 were retrospectively reviewed. Results: ESD was performed in 437 patients with 481 SENs, including 15 cirrhotic patients with 17 SENs. En bloc resection (88.2% vs. 97.0%) and curative resection (64.7% vs. 78.9%) rates were not different between the cirrhosis and non-cirrhosis groups (p=0.105 andp=0.224, respectively). Bleeding was more common in cirrhotic patients (p=0.054), and all cases were successfully controlled endoscopically. The median procedure and hospitalization duration did not differ between the groups. Overall survival was lower in cirrhoticpatients (p=0.003), while disease-specific survival did not differ between the groups (p=0.85). Conclusions: ESD could be a safe and effective treatment option for SENs in patients with cirrhosis. Detailed preprocedural assessmentsare needed, including determination of liver function, esophageal varix status, and remaining life expectancy, to identify patientswho will obtain the greatest benefit.

The Test for Verifying a Tip-Over Analysis of a Dry Storage Cask

Don g-Hak Kim,Ki-Seog Seo,Ju-Chan Lee,Chun-Hyung Cho,Hyun-Kee Jang,Byung-Il Choi 한국방사성폐기물학회 2006 방사성폐기물학회지 Vol.4 No.3

사용후연료 건식저장용기의 전복사고조건에 대한 1/3 축소모델의 시험을 실시하여 전복해석에 대한 검증을 하였다. 전복해석은 전복각도에 따른 위치에너지와 동일한 운동에너지를 가지는 초기각속도를 이용하여 결정된 각 점에서의 속도를 충돌직전 모델에 대한 초기경계값으로 입력하여 해석하였다. 전복시험에 따른 캐니스터의 구조적 건전성을 확인하기 위하여 육안검사와 함께 액체침투법과 초음파 탐상법와 같은 비파괴검사를 실시하였다. 전복충격에 의하여 저장용기의 뚜껑 에 변형 이 발생되었지만 캐니스터의 구조적 건전성이 유지되었다. 시험에서 취득한 변형률과 가속도를 해석결과와 비교하여 해석 에 대한 검증을 실시하였다. 해석결과는 시험결과보다 대체로 두 배 정도의 큰 값을 주는 것으로 나타났다. A test of the 1/3 scale model was conducted to verify the tip-over analysis of a dry. concrete storage cask under a hypothetical accident condition. The tip-over analysis was executed using the velocity at each point as the initial conditions of the model just before the impact. The initial velocity was determined from the initial angular velocity, which would make the equivalent kinetic energy to the potential energy. To confirm the structural integrity of the canister, the visual testing and the non-detective testings such as Liquid Penetrant testing and Ultrasonic Testing were conducted. The lid of a storage cask was plastically deformed near the impact point. The structural integrity of storage cask was maintained. To verify the tip-over analysis the strains and the accelerations acquired by the tip-over test were compared with those by the analyses. The results of the analysis were larger than the test results about two times.

Heterolayered, One-Dimensional Nanobuilding Block Mat Batteries

Choi, Keun-Ho,Cho, Sung-Ju,Chun, Sang-Jin,Yoo, Jong Tae,Lee, Chang Kee,Kim, Woong,Wu, Qinglin,Park, Sang-Bum,Choi, Don-Ha,Lee, Sun-Young,Lee, Sang-Young American Chemical Society 2014 NANO LETTERS Vol.14 No.10

<P>The rapidly approaching smart/wearable energy era necessitates advanced rechargeable power sources with reliable electrochemical properties and versatile form factors. Here, as a unique and promising energy storage system to address this issue, we demonstrate a new class of heterolayered, one-dimensional (1D) nanobuilding block mat (<I>h</I>-nanomat) battery based on unitized separator/electrode assembly (SEA) architecture. The unitized SEAs consist of wood cellulose nanofibril (CNF) separator membranes and metallic current collector-/polymeric binder-free electrodes comprising solely single-walled carbon nanotube (SWNT)-netted electrode active materials (LiFePO<SUB>4</SUB> (cathode) and Li<SUB>4</SUB>Ti<SUB>5</SUB>O<SUB>12</SUB> (anode) powders are chosen as model systems to explore the proof of concept for <I>h</I>-nanomat batteries). The nanoporous CNF separator plays a critical role in securing the tightly interlocked electrode–separator interface. The SWNTs in the SEAs exhibit multifunctional roles as electron conductive additives, binders, current collectors and also non-Faradaic active materials. This structural/physicochemical uniqueness of the SEAs allows significant improvements in the mass loading of electrode active materials, electron transport pathways, electrolyte accessibility and misalignment-proof of separator/electrode interface. As a result, the <I>h</I>-nanomat batteries, which are easily fabricated by stacking anode SEA and cathode SEA, provide unprecedented advances in the electrochemical performance, shape flexibility and safety tolerance far beyond those achievable with conventional battery technologies. We anticipate that the <I>h</I>-nanomat batteries will open 1D nanobuilding block-driven new architectural design/opportunity for development of next-generation energy storage systems.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2014/nalefd.2014.14.issue-10/nl5024029/production/images/medium/nl-2014-024029_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl5024029'>ACS Electronic Supporting Info</A></P>

염화 코발트로 polycythaemia를 일으킨 흰 쥐의 혈액량

崔德瓊,南基鏞,李相敦,金昌旭 서울의대 1960 서울의대잡지 Vol.1 No.2