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( Howard Chu ),( Jung U Shin ),( Ji Yeon Noh ),( Seo Hyung Kim ),( Nara Lee ),( Jin Shan ),( Hemin Lee ),( Jungsoo Lee ),( Chang Ook Park ),( Ju Hee Lee ),( Kwang Hoon Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Early onset of childhood eczema, more severe eczema, and family history of atopic diseases are factors contributing to the development of allergic march. In childhood, barrier defect and immune dysregulation involving thymic stromal lymphopoietin (TSLP) are contributors in the development of allergic march. However, the characterization of allergic march patients who retain AD beyond childhood was never fully explored. Objectives: We aimed to compare the serum and T cells of AD patients who developed allergic march and who did not. Methods: 2-D Difference Gel Electrophoresis(2D-DIGE) analysis was performed for serum proteins and TMT labeled quantitative proteomics for T cell. Results: In serum proteome analysis, 11 proteins including exophilin 5 and Zinc finger protein 443 were upregulatedand 17 proteins including Zinc alpha 2-glycoprotein were downregulated in allergic march developed AD patients. Among the Gaussian fit 95% over proteins, 8 proteins were downregulated and 64 proteins were upregulated in T cell of allergic march developed AD patients. Among upregulated proteins, 12 proteins including vacuolar protein sorting associated protein 4A, Ras GTPase- activating protein 1, ADP/ATP translocase 3, protein THEM6, Alpha-2-HS-glycoprotein were increased more in allergic march developed AD patients than AD only patients. Conclusion: The biomarker to predict allergic march has not been found yet, and these proteins could be the candidates of novel allergic march biomarkers
The effect of rotating receiver hole shape on a gas turbine pre-swirl system
Jungsoo Lee,이현규,Donghwa Kim,Jinsoo Cho 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.5
The life assessment and the efficiency of turbine cooling blades and vanes are seriously affected by the cooling air delivery system of a gas turbine. The pre-swirl system in a gas turbine plays an important role between the stationary and rotating parts to supply enough cooling air at the appropriate temperature at the expense of pressure drop. In the stationary part, the pre-swirl nozzle creates the flow angle in advance of the rotating orifice, called the receiver hole, to minimize energy loss. However, because of the sudden change of direction and area of the flow path, an energy loss occurs at the inlet of the receiver holes. The circumferential velocity at the receiver hole inlet decreases even though the circumferential velocity at the pre-swirl outlet is equal to the tangential velocity of the turbine rotor system. To reduce the energy loss at the pre-swirl system, various shape parameters can be applied to the receiver hole, and the area ratio between the pre-swirl nozzle throat area and the receiver hole crosssectional area can also be varied considering the structure problem, mass flow rate, and pressure drop. In this study, the shape of the receiver holes and its effects were analyzed using a 3D CFD method that was validated by previous studies including experimental data. The edge shape, inclined angle, area ratio, and number of receiver holes were analyzed with the discharge coefficient, adiabatic effectiveness, and pressure drop. The pre-swirl system performance increased as the area ratio increased, and under fixed area ratio, a large number of smalldiameter receiver holes showed better performance. The receiver hole edge fillet was the most influential shape parameter in pre-swirl performance.
Jungsoo Lee,Yangmi Park,Hyunkee Kim,Nakhoon Kim,Wonjae Sung,Sanggon Lee,박진석 대한임상신경생리학회 2021 Annals of Clinical Neurophysiology Vol.23 No.2
Background: Nitrous oxide (N2O) is used in surgery and dentistry for its anesthetic and analgesic effects. However, neurological and psychiatric manifestations of N2O abuse have been increasingly reported among Korean adults. The aim of this study was to demonstrate laboratory findings of N2O abuse in Korean patients. Methods: Patients diagnosed with N2O-induced neuropathy or myelopathy from August 2018 to December 2019 were enrolled. Their clinical presentations and laboratory and imaging findings were analyzed. Results: Sensory changes and limb weakness were present in nine of the enrolled patients. The laboratory findings revealed that seven patients had high homocysteine levels and five had high methylmalonic acid levels in their blood. Nerve conductions studies indicated that axonal neuropathy was present in four cases and longer F-wave and Hoffman’s-reflex latencies were present in two cases. Signal changes in cervical spine imaging occurred in five patients, while two had normal results. Conclusions: Chronic N2O abuse can cause neurological damage or psychiatric problems. Because N2O is illegal for recreational use in Korea, patients tend to hide their history of use. Even though the spinal imaging results were normal, clinicians should consider the possibility of N2O use, and further electrophysiological tests should be applied for precise evaluations.
Lee, Jungsoo,Lee, Ahee,Kim, Heegoo,Shin, Mina,Yun, Sang Moon,Jung, Youngjin,Chang, Won Hyuk,Kim, Yun-Hee Hindawi 2019 Neural plasticity Vol.2019 No.-
<P>Noninvasive brain stimulation (NBS), such as repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS), has been used in stroke patients with motor impairment. NBS can help recovery from brain damage by modulating cortical excitability. However, the efficacy of NBS varies among individuals. To obtain insights of responsiveness to the efficacy of NBS, we investigated characteristic changes of the motor network in responders and nonresponders of NBS over the primary motor cortex (M1). A total of 21 patients with subacute stroke (13 males, mean age 59.6 ± 11.5 years) received NBS in the same manner: 1 Hz rTMS on the contralesional M1 and anodal tDCS on the ipsilesional M1. Participants were classified into responders and nonresponders based on the functional improvement of the affected upper extremity after applying NBS. Twelve age-matched healthy controls (8 males, mean age 56.1 ± 14.3 years) were also recruited. Motor networks were constructed using resting-state functional magnetic resonance imaging. M1 intrahemispheric connectivity, interhemispheric connectivity, and network efficiency were measured to investigate differences in network characteristics between groups. The motor network characteristics were found to differ between both groups. Specifically, M1 intrahemispheric connectivity in responders showed a noticeable imbalance between affected and unaffected hemispheres, which was markedly restored after NBS. The responders also showed greater interhemispheric connectivity and higher efficiency of the motor network than the nonresponders. These results may provide insight on patient-specific NBS treatment based on the brain network characteristics in neurorehabilitation of patients with stroke. This trial is registered with trial registration number NCT03390192.</P>
Lee, Jungsoo,Lee, Ahee,Kim, Heegoo,Chang, Won Hyuk,Kim, Yun‐,Hee WILEY-LISS, INC 2018 HUMAN BRAIN MAPPING Vol.39 No.12
<P>Most previous stroke studies have been performed in heterogeneous patient populations. Moreover, the brain network might demonstrate different recovery dynamics according to lesion location. In this study, we investigated variation in motor network alterations according to lesion location. Forty patients with subcortical ischemic stroke were enrolled. Patients were divided into two groups: 21 patients with supratentorial stroke (STS) and 19 patients with infratentorial stroke (ITS). All patients underwent resting‐state functional magnetic resonance imaging and behavioral assessment at 2 weeks and 3 months poststroke. Twenty‐four healthy subjects participated as a control group. To compare altered connectivity between groups, measures used in previous studies to evaluate interhemispheric balance and global network reorganization were investigated and the relationship between network measures and motor functions were examined. Cortico‐cerebellar connectivity was also extracted to investigate its relationship with interhemispheric connectivity. In the STS group, measures related to interhemispheric balance were disrupted compared to the control group 2 weeks poststroke, while this was not found in the ITS group. During recovery, measures related to global network reorganization in the STS group and measures related to interhemispheric balance in the ITS group demonstrated significant changes, respectively. Moreover, motor functions were correlated with altered network measures in both groups. There was an interactive relationship between cortico‐cerebellar and interhemispheric cortical connectivity only in the ITS group. Different changes in the motor network were observed depending on the location of stroke lesions. These results might originate from differences in the interactions between cortico‐cerebellar and interhemispheric connectivity.</P>