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Lee, Yongseok,Yoo, Jung-Keun,Oh, Youngseok,Park, Hyunyoung,Go, Wonseok,Myung, Seung-Taek,Kim, Jongsoon The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.36
<P>We report a monoclinic Na2.4V2(PO4)3/poly(3,4-ethylenedioxythiophene) (M-NVP/PEDOT) composite as a novel cathode material for sodium-ion batteries. The active materials were homogenously encapsulated by thin layers of the electro-conductive polymer PEDOT, and X-ray diffraction analysis indicated that the final products were crystallized into a monoclinic structure. The composite exhibited much more outstanding power capability and cyclability than pristine M-NVP. The discharge capacity of the M-NVP/PEDOT electrode was maintained up to ∼109.8 mA h g<SUP>−1</SUP> at 10C (1C = ∼178 mA g<SUP>−1</SUP>), which was ∼9 times higher than that of pristine M-NVP under the same conditions. Moreover, whereas severe capacity degradation was observed for pristine M-NVP, the M-NVP/PEDOT composite delivered ∼81% capacity retention compared with the initial capacity over ∼500 cycles at 1C. In particular, the available capacity of M-NVP/PEDOT was ∼143.3 mA h g<SUP>−1</SUP>, corresponding to ∼2.4 mol Na<SUP>+</SUP> (de)intercalation, which is larger than the reversible capacity of rhombohedral Na3V2(PO4)3, at which only 2 mol Na<SUP>+</SUP> can be (de)intercalated. This unexpectedly high capacity of the M-NVP/PEDOT composite was clearly confirmed through combined studies using several experiments and first-principles calculation.</P>
Go, Misun,Choi, Heekyoung,Moon, Cheol Joo,Park, Jaehyeon,Choi, Yeonweon,Lee, Shim Sung,Choi, Myong Yong,Jung, Jong Hwa American Chemical Society 2018 Inorganic Chemistry Vol.57 No.1
<P>We demonstrate the different origins of helical directions in polymeric gels derived from a hydrazone reaction in the absence and presence of Ni<SUP>2+</SUP>. The right-handed helicity of polymeric gels without Ni<SUP>2+</SUP> originates from the enantiomeric <SMALL>d</SMALL>-form alanine moiety embedded in the building block. However, the right-handed helicity is inverted to a left-handed helicity upon the addition of Ni<SUP>2+</SUP>, indicating that added Ni<SUP>2+</SUP> greatly affects the conformation of the polymeric gel by overcoming the influence of the enantiomer embedded in the building block on the helicity at the supramolecular level. More interestingly, the ratio of the right-toleft-handed helical fibers varies with the concentration of Ni<SUP>2+</SUP>, which converts from 100% right-handed helical fiber to 90% left-handed helical fiber. In the presence of Ni<SUP>2+</SUP>, both right- and left-handed helical fibers coexist at the supramolecular level. Some fibers also exhibit both right- and left-handed helicities in a single fiber.</P><P>We demonstrate the different origins of both right and left-handed helicities in polymeric gels prepared with and without Ni<SUP>2+</SUP>. The right-handed helicity of gels without Ni<SUP>2+</SUP> arises from the <SMALL>d</SMALL>-form alanine moiety in the building block. In the presence of Ni<SUP>2+</SUP>, however, a left-handed helicity occurs, indicating that added Ni<SUP>2+</SUP> greatly affects the conformation of the polymeric gel by overcoming the influence of the enantiomer in the building block on the helicity at the supramolecular level.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/inocaj/2018/inocaj.2018.57.issue-1/acs.inorgchem.7b02588/production/images/medium/ic-2017-02588q_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ic7b02588'>ACS Electronic Supporting Info</A></P>
Jung, Yeoun Joong,Park, Young Cheol,Lee, Ka Jeong,Kim, Min Seon,Go, Kyeong Ri,Park, Sang Gi,Kwon, Soon Jae,Yang, Ji Hye,Mok, Jong Soo Elsevier 2017 MARINE POLLUTION BULLETIN Vol.115 No.1
<P><B>Abstract</B></P> <P>We aimed to compare the spatial and seasonal distributions of fecal coliforms (FCs) and other physiochemical factors in the drainage basin of the Jaranman-Saryangdo area. Among the pollution sources, the mean daily loads and half-circle radii of FCs were the highest in June. However, the pollutants did not reach the boundary line of the designated area due to an existing buffer zone. The value of the FC geometric mean at station 1 was highest in August during periods of heavy rainfall; however, this value was lower than the regulation limit. The highest daily loads of chemical oxygen demand (COD) and chlorophyll-<I>a</I> (Chl-<I>a</I>) in seawater were in the surface layer in August; however, dissolved oxygen (DO) in the bottom water layer was at its lowest in August. This study demonstrated that season and rainfall have significant effects on the FC, COD, DO, and Chl-<I>a</I> concentrations in seawater.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The Jaranman-Saryangdo area can be easily contaminated by various drainage sources. </LI> <LI> The geometric mean for FCs was at its maximum in August periods of heavy rainfall in Korea. </LI> <LI> Season and rainfall have significant effects on the FC and physiochemical factors. </LI> </UL> </P>
Go, Misun,Choi, Heekyoung,Kim, Ka Young,Moon, Cheol Joo,Choi, Yeonweon,Miyake, Hiroyuki,Lee, Shim Sung,Jung, Sung Ho,Choi, Myong Yong,Jung, Jong Hwa The Royal Society of Chemistry 2019 Organic chemistry frontiers Vol.6 No.8
<P>This study describes the temperature-controlled helicity inversion of supramolecular polymers based on <I>N</I>-triphenylamines (TPAs) bearing different numbers of d-alanine and/or glycine moieties. Despite chiral branching differences, the three investigated TPAs form helical supramolecular polymers <I>via</I> a typical nucleation-elongation model, characteristic of a cooperative assembly. The supramolecular polymer TPA-3, composed of symmetric tri-alanine segments, was more thermodynamically stable compared with TPA-1 and TPA-2, which had one or two alanine segments. More interestingly, at the microscopic level, temperature-dependent circular dichroism (CD) measurements revealed that the left-handed (<I>M</I>-type) helicity of supramolecular polymers TPA-1 and TPA-2 was inverted to the right-handed (<I>P</I>-type) helicity during heating. The (+/−) pattern of the vibrational circular dichroism (VCD) signal in the region of amide groups of self-assembled TPA-1 was also converted to the (−/+) pattern of the VCD signal. This indicates that the conformation of achiral gycine groups with the left-handed orientation was changed to the conformation of the glycine groups with the right-handed orientation. However, at the macroscopic level, the left- and the right-handed helical fibers were observed to coexist in self-assembled TPA-1 and TPA-2 at lower and higher temperatures. In contrast, no helicity conversion with the increase in temperature was observed for self-assembled TPA-3, which exhibited an ambiguous left-handed helical structure with a long helical pitch. Furthermore, the origin of the helical inversion at the microscopic level was supported <I>via</I> computational simulations. The helical inversion was possibly due to a molecular conformational change of flexible glycine moieties during the formation of supramolecular polymers. Based on AFM observations and DFT calculations, we conclude that even though either the positive or the negative signal of supramolecular polymers TPAs was obtained in CD spectra, the right- and the left-handed supramolecular polymer TPAs co-existed at the microscopic and macroscopic levels. Thus, the handedness of supramolecular polymers TPAs was determined by relative distribution of the right- and left-handed helical fibers.</P>
Uterine metastatic rhabdomyosarcoma in a scimitar-horned oryx ( <i>Oryx dammah</i> )
GO, Du-Min,WOO, Sang-Ho,LEE, Su-Hyung,KWON, Soo-Whan,CHUNG, Dong-Hee,YOUN, Soong-Hee,JUNG, Eun,KIM, Dae-Yong The Japanese Society of Veterinary Science 2018 The Journal of veterinary medical science Vol.80 No.10
<P>A 13-year-old female scimitar-horned oryx (<I>Oryx dammah</I>) died after progressive anorexia, weight loss, and depression. The necropsy showed that the retroperitoneum was compressed by a large white-to-tan uterine mass and on several sections of the mass, the uterine wall was markedly thickened because of ill-defined transmural tumor tissue. Metastatic nodules were detected in the omentum, mesentery, diaphragm, and lung. The genital tract and pulmonary and abdominal nodules exhibited highly pleomorphic sarcoma. The primary and metastatic neoplastic cells showed positive results for vimentin, desmin, and sarcomeric actin, and negative results for smooth muscle actin. Uterine metastatic rhabdomyosarcoma was diagnosed on the basis of the gross, histopathology and immunohistochemistry results.</P>
Jung, Eunhye,Lee, Joo-Youn,Kim, Ho Jeong,Ryu, Chung-Kyu,Lee, Kee-In,Kim, Meehyein,Lee, Chong-Kyo,Go, Yun Young Elsevier 2018 Bioorganic & medicinal chemistry letters Vol.28 No.14
<P><B>Abstract</B></P> <P>Picornaviruses are non-enveloped viruses that represent a large family of positive-sense single-stranded RNA viruses including a number of causative agents of many human and animal diseases such as coxsackievirus B3 (CVB3) and rhinoviruses (HRV). In this study, we performed a high-throughput screening of a compound library composed of ∼6000 small molecules in search of potential picornavirus 3C protease (3C<SUP>pro</SUP>) inhibitors. As results, we identified quinone analogues that effectively inhibited both CVB3 3C<SUP>pro</SUP> and HRV 3C<SUP>pro</SUP> with IC<SUB>50</SUB> values in low micromolar range. Together with predicted binding modes of these compounds to the active site of the viral protease, it is implied that structural features of these non-peptidic inhibitors may act as useful scaffold for further anti-picornavirus drug design and development.</P> <P><B>Highlights</B></P> <P> <UL> <LI> High-throughput screening assay of CVB3 3C<SUP>pro</SUP> inhibitors using FRET assay. </LI> <LI> Quinone analogues inhibited picornavirus 3C<SUP>pro</SUP> activity with nanomolar IC<SUB>50</SUB> values. </LI> <LI> Molecular docking predicted that 77035 and 169999 covalently bound in the active site of picornavirus 3C<SUP>pro</SUP>. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Go, Da-Hyeon,Jeon, Hee-Jeong,Kim, Tae-Hwan,Kim, Geun-Seok,Choi, Jin-Hee,Lee, Jae-Yeol,Kim, Jung-Ahn,Yoo, Hyun-Oh,Bae, You-Han The Polymer Society of Korea 2008 Macromolecular Research Vol.16 No.7
A new and useful poly(ethylene oxide)-based pH-sensitive block copolymer is introduced. Poly(ethylene oxide-b-N-phenylmaleimide) was first synthesized by anionic polymerization of N-phenylmaleimide (N-PMI) using mixed alkali metal polymeric alkoxide by sequential monomer addition method in the mixture of benzene/THF/DMSO (10/5/3, v/v/v) at room temperature. Reductive deimidation of the resulting block copolymer was performed using hydrazine monohydrate leading to the formation of the corresponding pH-sensitive poly(ethylene oxide-b-maleic acid).
Jung, Gyung-Ah,Shin, Bong-Shik,Jang, Yeon-Sue,Sohn, Jae-Bum,Woo, Seon-Rang,Kim, Jung-Eun,Choi, Go,Lee, Kyung-Mi,Min, Bon-Hong,Lee, Kee-Ho,Park, Gil-Hong Korean Society for Biochemistry and Molecular Bion 2011 Experimental and molecular medicine Vol.43 No.10
Protein arginine methylation is important for a variety of cellular processes including transcriptional regulation, mRNA splicing, DNA repair, nuclear/cytoplasmic shuttling and various signal transduction pathways. However, the role of arginine methylation in protein biosynthesis and the extracellular signals that control arginine methylation are not fully understood. Basic fibroblast growth factor (bFGF) has been identified as a potent stimulator of myofibroblast dedifferentiation into fibroblasts. We demonstrated that symmetric arginine dimethylation of eukaryotic elongation factor 2 (eEF2) is induced by bFGF without the change in the expression level of eEF2 in mouse embryo fibroblast NIH3T3 cells. The eEF2 methylation is preceded by ras-raf-mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK1/2)-$p21^{Cip/WAF1}$ activation, and suppressed by the mitogen-activated protein kinase (MAPK) inhibitor PD98059 and $p21^{Cip/WAF1}$ short interfering RNA (siRNA). We determined that protein arginine methyltransferase 7 (PRMT7) is responsible for the methylation, and that PRMT5 acts as a coordinator. Collectively, we demonstrated that eEF2, a key factor involved in protein translational elongation is symmetrically arginine-methylated in a reversible manner, being regulated by bFGF through MAPK signaling pathway.