Two cases of childhood granulomatous periorificial dermatitis

( Jung Yoon Ohn ),( Eun Jung Hwang ),( Kwang Hyun Cho ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Childhood granulomatous periorificial dermatitis is acneiform facial papular eruption, characteristically, around mouse, nose, and eyes. In histopathological examination of the papules, multinucleated giant cells are forming granulomas without central caseous necrosis. Its etiology is not yet known. But it is more common in dark-skinned prepubescent children. Herein, we reports two cases of childhood Granulomatous periorificial dermatitis in 11-year-old and 9-year-old male patient. One case responded to topical tacrolimus in combination with the oral medication, roxithromycin. But we cannot evaluate the effect of treatments in the other one, because of follow-up loss.

A case of Acquired idiopathic generalized anhidrosis (AIGA) in Korean

( Jung Tae Park ),( Jung Yoon Ohn ),( Yun Seon Choi ),( Kyu Han Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

A-23 year-old male visited our clinic with generalized anhidrosis which was suddenly started 1 year ago. He also presented cholinergic urticaria, but did not sweat. We did laboratory test, histologic examination and Iodine starch test. We also referred him to Neurology department and he received neurological examination, function test including Nerve conduction study (NCS), Quantitative sudomoter axon reflex test (QSART), Autonomic nervous system (ANS) function test, and was also checked Brain and Spine MRI. All test results was nonspecific and showed normal features except Iodine starch test. We diagnosed him as Acquired generalized idiopathic anhidrosis (AGIA) and tried cyclosporine 300mg for 2 weeks and 200mg for another 1 month. But there was no effect and we recommended him high dose steroid pulse therapy but he didn’t’ visit our clinic again. Anhidrosis is a kind of sweat gland disorder which is characterized by a decrease or cessation of sweat in response to appropriate stimulus. Acquired idiopathic generalized anhidrosis is subtype that there was no evidence of any neurologic disorder and histological sweat gland abnormality. We tried cyclosporine as immunomodulator, but there was no effect unfortunately. However this case is meaningful in reporting cyclosporine is not effective for AIGA, when the estimated successful rate of cyclosporine is unclear. Therefore, we need to accumulate the data for treatment using cyclosporine.

여행사의 외환위험관리기법에 관한 연구

윤대순,온정희 관광경영학회 2002 관광경영연구 Vol.15 No.-

This study intends to protect travel agencies from their exposure to foreign exchange risk and fluctuation of foreign exchange rate by proposing the method for such travel agencies to be able to simply use in order to minimize such risk through developing the method of managing foreign exchange risk. In this research, the method of managing foreign exchange risk are generally reviewed and established. Thereafter empirical research is performed by questionnaires. Risk management of foreign exchange of travel agencies could be explained in two ways Transactional foreign exchange risk is an embedded foreign exchange risk caused by a travel package to be paid in foreign currency in performance of obligation under such contract. For a travel agencies, economic foreign exchange risk is a transaction exposure, which is possibility for national currency to be influenced by fluctuation of foreign exchange rate when making payment in foreign currency such as settlement of landing fee, etc. An external management method of economic foreign exchange risk is not effective for a travel agencies. Accordingly, in the future, various studies regarding risk management method of foreign exchange in a travel industry should be continued.

프레넬 간츠펠드 자극기의 임상적 유용성

한정우(Jung Woo Han),공윤진(Yoon Jin Kong),박태관(Tae Kwann Park),온영훈(Young Hoon Ohn) 대한안과학회 2015 대한안과학회지 Vol.56 No.12

목적: 기존의 Ganzfeld 반구를 이용한 자극기와 Fresnel ganzfeld 자극기를 비교하였으며 Fresnel ganzfeld 자극기의 임상성 유용성을 확인하고자 하였다. 대상과 방법: 안과적 과거력이 없는 25명 50안을 대상으로 기존의 ganzfeld 자극기와 Fresnel ganzfeld 자극기를 이용하여 양안의 망막전위도를 측정하였다. 망막전위도의 진폭 및 반응도달 시간을 두 자극기 간에 비교하였다. 또한 Fresnel ganzfeld를 이용하여 얻은 망막전위도를 양안 간에, 그리고 앉은 자세와 누운 자세에서 측정하여 비교하였다. 결과: 기존의 ganzfeld 반구를 이용한 자극기와 Fresnel ganzfeld 자극기를 이용하여 얻은 Dark adapted 0.01, 3.0 electroretinogram(ERG), Photopic 3.0 ERG, Photopic 3.0 flicker의 a 및 b파의 진폭과 반응도달 시간은 통계학적으로 의미 있는 차이가 없었다. Fresnel ganzfeld 자극기로 측정된 대상군의 망막전위도의 진폭과 반응도달 시간의 양안차이는 없었다. 또한 앉아서 측정한 망막전위도와 누운 자세로 측정한 망막전위도 수치 역시 의미 있는 차이가 없었다 결론: Fresnel 렌즈가 몰딩된 ganzfeld 자극기는 기존의 돔형 ganzfeld를 대체할 수 있으며 거동이 불편한 환자나 협조가 어려운 소아에서도 유용하게 사용될 수 있을 것으로 사료된다. Purpose: To compare electroretinogram (ERG) waveforms acquired using a ganzfeld stimulator and a Fresnel ganzfeld stimulator. Methods: ERGs were recorded with a ganzfeld stimulator and a Fresnel ganzfeld stimulator from both eyes of 25 volunteers. Peak-to-trough amplitudes and peak implicit times were compared between both eyes and between a ganzfeld stimulator and a Fresnel ganzfeld stimulator. ERGs taken from the sitting and supine positions were also compared using the Fresnel ganzfeld stimulator. Results: There was no statistically significant difference between the Fresnel ganzfeld stimulator and dome-shaped ganzfeld stimulator in amplitude and implicit time of dark adapted 0.01, 3.0 ERG, photopic 3.0 ERG, photopic 3.0 flicker. The differences in amplitude and implicit time between the right and left eyes were not influenced by the Fresnel ganzfeld stimulator. Additionally, no differences were observed in ERGs obtained from the sitting and supine positions using the Fresnel ganzfeld stimulator. Conclusions: The newly developed ganzfeld stimulator with a sealed Fresnel lens can be considered as a reliable alternative method for measuring ERGs. Fresnel ganzfeld stimulator is useful for patients having problems with mobility or uncooperative children.

교과 역량 함양을 위한 교과서 단원 설계 방안 탐색

온정덕(Jung duk Ohn),윤지영(Ji young Yoon) 연세대학교 교육연구소 2017 미래교육학연구 Vol.30 No.1

최근 고시된 2015 개정 교육과정에서는 학생의 역량 계발을 개정의 비전으로 설정하였고, 이는 교수･학습 및 평가에 변화를 요구한다. 우리나라에서 교과서는 교육과정의 비전과 목적을 구현하는 수단이며 교실 수업에 직접적인 영향을 행사한다. 이에 본 연구에서는 역량 교육에서 보는 학습의 의미와 역량의 특징을 고찰하여 교육과정, 교수･학습, 평가에의 함의점을 도출하고, 이를 구현하기 위한 교육과정 설계모형으로 백워드 설계의 가능성을 논의한 후 교과서 단원 설계 및 구성 방식을 제안하였다. 교과서 단원 설계는 심층 학습 및 학생 맞춤형 수업, 실생활 맥락 속에서 지식의 습득과 적용, 학생 학습의 과정을 중시하는 평가에 초점을 두었다. 전체 구성은 학생들에게 학습의 방향과 결과를 안내하는 도입부, 학습 내용의 의미를 탐색하고 적용하며 더 나아가 새로운 상황에서 배운 내용을 적용하도록 하는 수행부, 스스로 자신의 학습을 돌아보고 성찰하도록 하는 정리부로 체계화하였다. The key competencies are embedded as the vision of the 2015 revised national curriculum and it requires changes in teaching and learning as well as assessment. Textbook is a fundamental material for teaching and learning and is supposed to embody the vision and goals of national education. Therefore, in this study, we examined the meaning of learning in the historical context of competency-based education and reviewed three characteristics of competency to look for implications for curriculum design, instruction, assessment. In addition, we examined the relationship between implications drawn from the characteristics of competency and backward design, and proposed a direction of unit design based on the backward design.

A case of congenital neurofollicular hamartoma

( Yun Seon Choe ),( Jung Yoon Ohn ),( Kyu Han Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

A 7-month old male presented with well-demarcated, irregularly grouped, pinkish to skin colored papules on upper back since birth. There was no symptom like itching or tenderness, and the size of lesion has changed little over the seven months. He had no perinatal problem,and has shown normal development well. Punch biopsy was performed, and hyperplastic folliculo-sebaceous units surrounded by bland-looking spindle cell proliferation were observed. Immunohistochemical studies showed positivity for S-100 among the spindle cells, otherwise negativity for Melan A(MART-1) and CD34. By clinic-pathologic findings, it was diagnosed as neurofollicular hamartoma, which is characterized by a stroma composed of spindle cells proliferation and hyperplastic pilosebaceous units. Neurofollicular hamartoma is an unusual dermal neoplasm, and diagnosed by histopathological findings with immunohistochemical features consistent with neuroid differentiation showing positive S-100 antigen. Clinically it is usually appeared on nose or nasolabial fold of middle aged male as tiny solitary skin colored papule. However, our case was congenital lesion and showed bigger and grouped feature on the back, not on the face. Herein, we report a rare case of congenital neurofollicular harmatoma with review of literature.

P089 : Toll-like receptor 2 mediates a cutaneous reaction induced by repetitive ultraviolet b irradiation in c57/bl6 mice in vivo

( Jin Yong Kim ),( Jung Yoon Ohn ),( Hyun Sun Park ),( Seon Pil Jin ),( Youn Gae Lee ),( In Gyung Oh ),( Serah Lee ),( Jung Ho Kim ),( Kwang Hyun Cho ),( Jin Ho Chung ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Toll like receptors (TLR) are a family of pattern recognition receptors that play an essential role in the induction of the immune response. Objectives: Previous studies suggested that single ultraviolet (UV) exposure may initiate a TLR-mediated sterile inflammation in vitro. This study was conducted to verify whether TLR2 mediates sterile inflammation, which is induced by repetitive to UVB exposure in vivo. Methods: Inflammatory responses to repetitive UVB irradiation were compared between wild-type (WT) and TLR2 knock-out (KO) mice. Results: After 6 weeks of repetitive UVB irradiation, inflammatory response of the TLR2 KO group was less severe than that of the TLR2 WT group. Compared to the group of TLR2 WT mice, the group of TLR2 KO mice displayed less prominent erythema and scaling; and histopathologically fewer inflammatory cells and significantly thinner skin. UVB-induced expression of the heat shock protein 70, an endogenous ligand of TLR2, was lower in the TLR2 KO group. Quantitative RT-PCR was used to measure the gene expression levels of interleukin (IL)-1β, IL-6, and matrix metalloproteinase (MMP)-13, all of which were lower in the TLR2 KO group, compared to the WT group. This finding was further corroborated with ELISA and western blot, each of which showed lower protein expression level of IL-1β, and MMP-13, respectively. Conclusion: This study demonstrated that TLR2 is involved in cutaneous inflammatory reaction to repetitive UV irradiation in C57/B16 mice.

역량의 총체성에 따른 교육과정 설계 방향 탐색

윤지영 ( Ji-young Yoon ),온정덕 ( Jung-duk Ohn ) 한국교육과정학회 2016 교육과정연구 Vol.34 No.2

본 연구는 역량의 특성인 총체성을 듀이의 경험 개념에 비추어 고찰하고, 이를 반영한 교육과정 설계 방향을 제시하는 것을 목적으로 한다. 이를 위해 역량 기반 교육에 제기되는 비판점을 살펴보고, 이러한 비판에 대해 역량의 총체성을 중심으로 듀이의 경험 개념에 비추어 논의하였다. 그리고 역량의 총체성 실현을 위해 학습자 경험에 반영되어야 할 내용을 지식의 성격, 사고기능 및 과정, 가치 및 태도의 측면에서 탐구하고, 구체적인 교육과정 설계의 사례로 싱가포르 과학과 교육과정을 살펴보았으며, 2015 개정 교과 교육과정의 구성방식을 논의하였다. 본 연구의 시사점은 다음과 같다. 첫째, 역량 기반 교육은 역량의 총체적 특성을 중심으로 이해되어야 한다. 경험의 원리에 따르면 계속되는 학습 경험의 상호작용에 참여하는 과정은 내적 특성이 총체적으로 발휘되는 역량 발현의 과정이고, 경험을 통해 얻은 총체적 형태의 결과는 학습자의 역량이다. 역량 기반 교육에서 학습 경험은 다음 경험의 상호작용에서 이전 경험이 전이될 수 있도록 구성되어야 하며, 다음 경험에 영향을 주는 가치와 태도를 습득할 수 있게 해야 한다. 둘째, 교과 교육과정에서 학습 내용은 전이 가능한 지식, 사고기능과 사고과정, 가치 및 태도를 포함하며 이는 서로 통합적으로 다루어져야 한다. 셋째, 지식, 사고기능과 사고과정, 가치 및 태도 측면에서의 학습내용을 통합적으로 적용한 학습의 결과는 성취기준에 반영하여 제시할 수도 있으며, 교수ㆍ학습의 과정에서 구현될 수도 있다. The purpose of the study is to present a direction for competency-based curriculum design by focusing on the holistic nature of competency. To accomplish this goal, we have examined major criticism regarding competency-based education and discussed the holistic nature of competency in light of Dewey’s concept of experience. In addition, we explore the type of knowledge, thinking skills and processes, and attitudes and values required in the growth of students’ experiences to embody the holistic nature of competence. We then consider the case of the Singapore science curriculum document as an example of the direction of competency-based curriculum design and critically examine the Korean 2015 revised science curriculum document. This study provides the following implications: First, according to Dewey’s concept of experience, both interaction and continuity enable the growth of experiences. In competency-based education, all competencies are involved in the process of interaction, and the result of experience remains a holistic construct or whole knowledge as competency; here, whole knowledge as competency is used when students make sense of new experience. Second, for the development of students’ competency, the curriculum should contain transferable knowledge, thinking skills and processes, and values and attitudes; these should be taught in an integration way each other. Third, in terms of the integration of knowledge, skills and processes, values and attitudes, the learning outcome can be reflected in achievement standards or embodied in the process of teaching and learning in the classroom.

형광직접접합법에 의한 인간정자의 연령별 염색체이상에 관한 연구

이숙환(Sook Hwan Lee),윤태기(Tae Ki Yoon),차광열(Kwang Yul Cha),곽인평(In Pyung Kwak),이재호(Jae Ho Lee),엄기봉(Ki Boong Oum),손지은(Jie Ohn Shon),고정재(Jung Jae Ko) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.2

N/A Determmation of the chomosomal constitution of human spermatozoa has been camed out though the human-hamster interspecific in vitro fertilization(IVF) system. In recent years, the introduction of fluorescence in-situ hybridization(FISH) technique has provided an alternative approach to evaluate the cbmmosomal constitution of human spermatozoa. The nuclei of mature spermatozoa are highly condensed with interpmtamine disulphide bridges, therefore the success of FISH on interphase human spermatozoa relies on partial decondensation of the sperm chromatin. In early studies, dithioothreitol(DTT) has been known as an efficient decondensation agent. Since then, several different decondensation methods using D1T have been establisdhed, and in terms of decondensation, we were tried to fix the optimal decondensation protocol using DlT. In our study, the optimal concentration and treatment time were 1-mM and 30 min, respectively. We examined chromosome complements of human sperm to investigate the effect of paternal age on the hequency of nondisjunction in human sperm. We investgated sperm karyotypes ftom two diffaent age groups)28+-0.5, 46+-6), A minimum of 1000 spermatozoa for one patient were analyzed. The mean frequencies of YY, XX, XY, 21-disamy spermatozoa ware 0.04%, 0.45%, 0.40%, 0.45% respectively in young age group and 1.06%, 0.62%, 1.06%, 0.76% in old ages. The mean frequency of disomy spermatozoa was higher in old age poup compare with those of young age group.

뇌졸중 및 뇌손상 환자의 경관 유동식이에섬유소 첨가시 설사에 대한 효과

전세일,김동아,온석훈,조성래,서정훈,윤태준,유성,전중선,김정남,윤지영 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.5