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( Jung Yeob Ham ),( Hoo Sang Hwang ),( Euno Kim ),( Jeong Ah Kim ),( Sung Jin Cho ),( Jae Young Ko ),( Woo Jin Lee ),( Jae Hwan Lee ),( Harish Holla ),( Joydeep Banerjee ),( Seok Ho Kim ),( Jin Ho Yan 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0
We have discovered and demonstrated the in vitro and in vivo PPARδ-selective activity of novel Y-shaped agonists. These compounds activated hPPARδ with EC(50) values between 1 and 523 nM. Surprisingly, compounds 10a, 11d, 11e and 11f were the most potent and most selective hPPARδ agonists with 10(4)-fold selectivity over the other two subtypes, namely, hPPARα and hPPARγ. The PPARδ ligands 10a, 11e and 11f showed good bioavailability and in vivo efficacy. ⓒ 2012 Elsevier Masson SAS. All rights reserved.
Min, Jung-Hong,Son, Myungwoo,Bae, Si-Young,Lee, Jun-Yeob,Yun, Joosun,Maeng, Min-Jae,Kwon, Dae-Gyeon,Park, Yongsup,Shim, Jong-In,Ham, Moon-Ho,Lee, Dong-Seon Optical Society of America 2014 Optics express Vol.22 No.suppl4
<P>Pristine graphene and a graphene interlayer inserted between indium tin oxide (ITO) and p-GaN have been analyzed and compared with ITO, which is a typical current spreading layer in lateral GaN LEDs. Beyond a certain current injection, the pristine graphene current spreading layer (CSL) malfunctioned due to Joule heat that originated from the high sheet resistance and low work function of the CSL. However, by combining the graphene and the ITO to improve the sheet resistance, it was found to be possible to solve the malfunctioning phenomenon. Moreover, the light output power of an LED with a graphene interlayer was stronger than that of an LED using ITO or graphene CSL. We were able to identify that the improvement originated from the enhanced current spreading by inspecting the contact and conducting the simulation.</P>
( Kyoung Jin Shin ),( Jung Wook Chin ),( Dong Yup Hahn ),( Jae Hwan Lee ),( Hoo Sang Hwang ),( Dong Hwan Won ),( Jung Yeob Ham ),( Hyuk Jae Choi ),( Eun Soo Kang ),( Hi Young Kim ),( Moon Kyeong Ju ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0
Three new steroids 3-oxocholest-1,22-dien-12β-ol (1), 3-oxocholest-1,4-dien-20β-ol (2), 3-oxocholest-1,4-dien-12β-ol (3), and three known steroids (20S)-20-Hydroxyergosta-1,4,24(28)-trien-3-one (4) [7a], 5α,8α-Epidioxycholesta-6,22-dien-3β-ol (5) [10] and 5-cholestene-3β,12β-diol (6) [11] were isolated from a soft coral Dendronephthya gigantea. Their chemical structures and relative stereochemistry were elucidated by the analysis of HRMS and 2-D NMR spectroscopic data. The steroids 1 and 2 showed notable inhibitory activity against farnesoid X-activated receptor (FXR) with IC(50)`s 14 and 15μM. ⓒ 2012 Elsevier Inc. All rights reserve
Lee, Jin-Wook,Choi, Yung Ji,Yang, June-Mo,Ham, Sujin,Jeon, Sang Kyu,Lee, Jun Yeob,Song, Young-Hyun,Ji, Eun Kyung,Yoon, Dae-Ho,Seo, Seongrok,Shin, Hyunjung,Han, Gil Sang,Jung, Hyun Suk,Kim, Dongho,Park American Chemical Society 2017 ACS NANO Vol.11 No.3
<P>Excellent color purity with a tunable band gap renders organic-inorganic halide perovskite highly capable of performing as light-emitting diodes (LEDs). Perovskite nanocrystals show a photoluminescence quantum yield exceeding 90%, which, however, decreases to lower than 20% upon formation of a thin film. The limited photoluminescence quantum yield of a perovskite thin film has been a formidable obstacle for development of highly efficient perovskite LEDs. Here, we report a method for highly luminescent MAPbBr(3) (MA = CH3NH3) nanocrystals formed in situ in a thin film based on nonstoichiometric adduct and solvent-vacuum drying approaches. Excess MABr with respect to PbBr2, in precursor solution plays a critical role in inhibiting crystal growth of MAPbBr(3), thereby forming nanocrystals and creating type I band alignment with core MAPbBr3 by embedding MAPbBr(3) nanocrystals in the unreacted wider band gap MABr. A solvent-vacuum drying process was developed to preserve nanocrystals in the film, which realizes a fast photoluminescence lifetime of 3.9 ns along with negligible trapping processes. Based on a highly luminescent nanocrystalline MAPbBr(3) thin film, a highly efficient green LED with a maximum external quantum efficiency of 8.21% and a current efficiency of 34.46 cd/A was demonstrated.</P>