골프장 경기보조원의 근골격계 자각증상과 관련 요인

허경화,한영선,정혜선,구정완 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.1

목적: 직업관련성 근골격계질환과 관련된 여러 가지 위험요인에 노출되어 있는 경기보조원의 작업내용과 관련하여 근골격계 증상 유발 양상을 파악하고, 근골격계 증상 관련 요인을 파악하고자 하였다. 방법: 경기도 지역에 있는 6개 정규 골프장을 대상으로 경기보조원 316명에 대하여 2003년 4월 9일부터 4월 30일까지 3주간 설문지를 배부한 후 자기 기입 식으로 작성하게 하여 수거함으로써 자각증상 조사를 실시하였으며, 설문지는 미국 산업안전보건연구원이 사용하는 표준화된 설문지(NIOSH, 1993)의 국내 번역판(노상철 등, 1997)을 이용하였다. 결과: 조사대상 경기보조원의 신체 부위별 근골격계 자각증상 호소율은 다리/무릎/발목/발이 41.8%로 가장 높은 증상 호소율을 보였으며 어깨 35.8%, 등/허리 35.8%, 목 28.8%, 팔/손목/손가락 28.5% 순 이었다. 성수기의 1일 근무시간이 팔/손목/손가락 부위를 제외한 나머지 부위에 영향을 주는 것으로 나타났다. 경기보조원의 업무특성과 관련하여 골프장의 경사와 굴곡의 정도, 내장객의 폭언 및 폭행, 업무의 속도를 조절할 수 없음, 일의 육체적 부담의 강도, 고용의 불안정성, 직장을 잃을 가능성 등이 근골격계 자각증상과 유의한 연관성을 보였다. 직무스트레스 특성에서는 정신적 직무요구도가 높은 반면, 낮은 직무 재량도를 보여 근무긴장도가 높은 것으로 조사되었다. 다변량 로지스틱 회귀분석을 실시한 결과 목 부위, 어깨 부위, 등/허리 부위 및 다리/무릎/발목/발 부위의 근골결계 증상에는 성수기 12시간 이상의 근무시간이, 팔/손목/손가락 부위의 증상에는 낮은 직무 재량도에서 유의한 영향을 미치는 요인으로 관찰되었다(P<0.05). 결론: 경기보조원의 근골격계 증상은 과중한 업무시간과 높은 직무요구도에 비해 낮은 직무재량도를 보이는 고긴장 직무 등에 의해 호소율이 높게 나타남을 알 수 있다. 근골격계 질환의 호소 요인에 대한 구체적인 대안의 마련과 더불어 정부기관에서 주도적으로 검토하여 경기보조원들이 속해있는 골프장 운영업체가 근골격계질환의 예방을 위한 조치와 경기보조원의 건강과 관련한 안전보건교육 등을 시행할 수 있도록 하는 방안이 마련되어야 할 것으로 본다. Objectives: This study evaluated the complaint rates of musculoskeletal symptoms and investigated the related factors of musculoskeletal symptoms in the caddies. Methods: For 316 caddies working at 6 regular golf courses, we used the self-recording questionnaires to examine general characteristics, job stress factors, subjective musculoskeletal symptoms designed by NIOSH, working environments, and working contents. Results: The complaint rates of musculoskeletal symptoms according to the musculoskeletal criteria of NIOSH were 41.8% in leg/knee/ankle/foot, 35/8% in the upper back/lower back, 28.8% in the neck, and 28.5% in the arm/wrist/fingers. Important factors affecting musculoskeletal symptoms were daily working hours during the high-demand seasons in all anatomical sites except the arm/wrist/fingers. Other related factors were degrees of winding and inclined in the golf courses, violent language and violence of customers, inability to regulate the velocity and work load control, heavy physical burden, instability of employment, and possibility of unemployment according to the specialty of caddies. As a results of multivariate logistic regression analysis, musculoskeletal symptoms of the neck, shoulders, back/lower back and leg/knee/ankle/foot were significantly influenced by working time over 12 hours in the high-demand season, and symptoms of the arm/wrist/fingers by low decision latitude (P<0.05). Conclusions: The complaint rates of musculoskeletal symptoms in the caddies were affected by working time over 12 hours and low decision latitude against excessively high psychological job demand.

다발성 연조직 종괴를 동반한 급성 림프구성 백혈병의 증례 보고

장정용,허경회,이원진,허민석,이삼선,최순철 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.2

A 15-year-old patient, who had been diagnosed and treated as Burkitt cell type acute lymphoblastic leukemia (ALLL3) already, visited our department. He complained of gingival enlargement and loosening teeth 1 month ago. The clinical examination revealed anterior open bite, gingival enlargement, and nontender swelling particularly in molar regions of both jaws. Deep periodontal pockets and severe mobility was shown on most of the teeth. The panoramic radiographs showed severe bone destruction and extrusion of the molars. The contrast enhanced CT showed multiple enhanced mass and bone marrow obliteration in both jaws. Chemotherapy was done and the swelling was subsided at 1 month later. In conclusion, radiologic findings of leukemia with soft tissue mass, known as chloroma or granulocytic sarcoma, mimic those of lymphoma, so blood test may be needed for the final diagnosis.

PWM AC-DC 컨버터의 입력전류 직접추종제어

우정인,최선영,정영일,서정기,허태원 東亞大學校 大學院 1999 大學院論文集 Vol.24 No.-

본 논문에서는 PWM AC-DC 컨버터의 정상상태 제어오차를 제거하고, 과도 특성을 향상시키기 위한 새로운 전류제어계를 제안한다. 먼저, 일반적인 PWM 컨버터에 대한 상태공간 모델로 표현된 수학적 모델이 제시된다. 컨버터의 상태공간 모델은 제안하는 전류제어계를 포함한 PWM 컨버터의 시뮬레이션에 사용된다. 본문에서 제안하는 정현추종 제어계는 교류성분의 전류를 직접추정 제어 하기때문에 좌표변환 알고리즘을 필요로하지 않는다. 입력전류 제어계의 전달함수롤부터 정상상태 오차가 영이되는 것을 입증한다. 그리고, 시뮬레이션과 실험을 통하열 본 제어방식의 타당성을 입증하고자 한다.

정현추종 제어기를 이용한 전압형 PWM 컨버터의 입력전류제어

우정인,정기화,최선영,허태원 東亞大學校 附設 情報通信硏究所 1999 情報通信硏究所論文誌 Vol.7 No.1

This paper presents the sinusoidal tracking controllr in order to eliminate the steady state control error and to improve the transient characteristics for input current in voltage source PWN congerter. A general mathematical model with switching functions of the PWM converter that is represented as differential equation is established. The proposed model in current control system that does not require coordinate transformations is described. It is proved that the steady state deviation reduces to zero from a transfer function of input current control system. The sinusoidal tracking controller is realized by differential equations for the LC equivalent circuit. From simulations and experimental work, it is verified that the control system can eliminate the steady state error of input current and also improve the transient state characteristic.

하악 제1대구치의 치근 만곡에 영향을 주는 요인

최항문,이원진,허민석,이삼선,김정화,최순철,박태원 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.37 No.1

Purpose : To find the cause of root curvature by use of panoramic and lateral cephalometric radiograph. Materials and Methods : Twenty six 1st graders whose mandibular 1st molars just emerged into the mouth were selected. Panoramic and lateral cephalometric radiograph were taken at grade 1 and 6, longitudinally. In cephalometric radio graph, mandibular plane angle, ramus-occlusal plane angle, gonial angle, and gonion-gnathion distance (Go-Gn distance) were measured. In panoramic radio graph, elongated root length and root angle were measured by means of digital subtraction radiography. Occlusal plane-tooth axis angle was measured, too. Pearson correlations were used to evaluate the relationships between root curvature and elongated length and longitudinal variations of all variables. Multiple regression equation using related variables was computed. Results : The Pearson correlation coefficient between curved angle and longitudinal variations of occlusal plane-tooth axis angle and ramus-occlusal plane angle was 0.350 and 0.401, respectively (p<0.05). There was no significant correlation between elongated root length and longitudinal variations of all variables. The resulting regression equation was Y=10.209+0.208X_(1)+0.745X_(2) (Y: root angle, X_(1): variation of occlusal plane-tooth axis angle, X_(2): variation of ramus-occlusal plane angle). Conclusion: It was suspected that the reasons of root curvature were change of tooth axis caused by contact with 2nd deciduous tooth and amount of mesial and superior movement related to change of occlusal plane. (Korean J Oral Maxillofac Radiol 2006; 36 : 55-62)

자가 면역성 간염에서 자가항체의 발현 양상과 스테로이드 치료의 효과

박기오,채경훈,허원석,강윤세,정재훈,김연수,문희석,이엄석,김선문,이병석,김남재,이헌영 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

목적 : 최근 8년간 본원에서 경험한 자기면역성 간염의 혈액학적 특징과 스테로이드의 치료효과를 알아보고자 본 연구를 시행하였다. 방법 : 1996년 이후부터 2002년까지 충남대학교 병원에서 1999년 International Autoimmune Hepatitis Group(LAHG)에서 제시한 수정 진단 기준안에 의거하여 총 진단점수가 probable 이상에 해당하는 환자들을 대상으로 임상적 특징, 검사실 및 조직 소견과 스테로이드와 azathioprine의 치료 효과를 후향적으로 조사하였다. 결과 : 9예의 환자들은 여성이 78%, 40대가 많았고, 급성 발병이 33.3%, 피로감, 식욕부진 및 황달 등이 나타났으며, 항핵항체가 55.6%에서 그리고 항평활근 항체가 77.8%에서 양성이었고, 동반 질환은 류마치스 관절염이 2예, 특발성 혈소판 감소증 1예, Henoch-Sch nlein 자반증 및 그레브스병이 각각 1예 씩이었다. 7예에 대해서 스테로이드와 azathioprine으로 치료하여 생화학적 임상적 완해가 이루어져서 유효한 치료 결과를 얻었다. 결론 : 자가면역성 간염은 우리 나라에서 원인을 찾을 수 없는 만성 간질환의 경우, 특히 중년여성에서 다른 자가면역성 질환이 동반되었을 때 자가면역성 간염을 의심하여 자가항체 선별검사를 시행해 보아야 할 것으로 생각된다. 향후 다기관 연구를 통하여 좀 더 많은 증례를 모으고 전향적인 연구를 시행하여야 할 필요가 있다. Although autoimmune hepatitis(AIH) is common in western contries, some studties have been reported in Korea. The aim of the study was to analyze the clinical and histological features and expression pattern of the autoantibody and to examine clinical course of AIH in Korea. For 9 patients diagnosed as having AIH in our hospital since 1996, we reviewed medical records and analyzed clinical and laboratory findings retrospectively. They had a probable or definite AIH according to the revised criteria of International AIH group. The mean age was 42.7(21∼68)years and 7(77.8%) were female. Three of them(33.3%) showed acute hepatitis and five of them showed cirrhosis. Fatigue and anorexia were the most frequently complained symptoms(55.6%). Four patients(44.4%) were accompanied with other autoimmune diseases. Antinuclear antibody was detected in 5(55.6%) and anti-smooth muscle antibody was detected in 7(77.8%). Three patients showed focal picemeal necrosis and four showed periportal fibrosis. Among 7 patients who received immunosuppressive therapy, six patients(85.7%) showed initial response. and biochemical and serologic remission were achived in 5(71.4%) and 3(42.8%) patients, AIH seems to be partly responsible for chronic liver disease of unknown etiology in Korea. AIH should be suspected in female patients with unknown chronic liver disease of unknown etiolgy, especially accompanied with other autoimmune disease. The clinical characteristics of AIH may not be quite different from those of Western countries.

Production of isobutanol from crude glycerol by genetically engineered Klebsiella pneumoniae strains

Sun-Yeon HEO,Sung-Mok LEE,Baek-Rock OH,You Ree JUNG,Jang Min PARK,Won-Kyung HONG,Jung-Hoon SOHN,Dae-Hyuk KIM,Soa JUNG,Chul Ho KIM,Jeong-Woo SEO 한국생물공학회 2013 한국생물공학회 학술대회 Vol.2013 No.10

β‐catenin mediates cyclic strain‐stimulated cardiomyogenesis in mouse embryonic stem cells through ROS‐dependent and integrin‐mediated PI3K/Akt pathways

Heo, Jung Sun,Lee, Jeong‐,Chae Wiley Subscription Services, Inc., A Wiley Company 2011 Journal of cellular biochemistry Vol.112 No.7

<P><B>Abstract</B></P><P>Wnt/β‐catenin signaling regulates various cellular events involved in the proliferation and differentiation and these events are affected sensitively by applying to mechanical stimuli. However, the mechanisms by which mechanical force stimulates cardiomyogenesis are not extensively explored. In this study we investigated the cellular mechanisms by which β‐catenin signaling regulates cardiac differentiation of strain‐subjected embryonic stem (ES) cells. The application of cells to cyclic strain increased beating cardiomyocyte foci with the attendant increases of Cx 43 and Nkx 2.5 proteins. Anti‐oxidants such as vitamin C or <I>N</I>‐acetyl cysteine (NAC) blocked the strain‐mediated increases of Cx 43, Nkx 2.5, and α5/β1 integrins. These anti‐oxidants also suppressed the activation of phosphoinositide 3‐kinase (PI3K) and Akt in cyclic strain‐subjected cells. Western blot analysis revealed that PI3K is a critical downstream effector of β1 integrin signaling and mediates Cx 43 and Nkx 2.5 expression in cyclic strain‐applied ES cells. Cyclic strain increased the expression of β‐catenin and stimulated its nuclear translocation from the cytosol, which was prevented by anti‐oxidant treatment. In addition, the application to cyclic strain increased mRNA expression of β‐catenin target genes, Axin2 and c‐myc, as well as the phosphorylation of glycogen synthase kinase‐3β. Furthermore, the blockage of β‐catenin by its specific siRNA transfection diminished the cellular levels of Cx 43 and Nkx 2.5 proteins and the number of beating cardiomyocyte foci. Collectively, these results suggest that β‐catenin‐mediated signaling is required for cyclic strain‐stimulated cardiomyogenesis through ROS‐dependent and integrin‐mediated PI3K–Akt signaling cascades. J. Cell. Biochem. 112: 1880–1889, 2011. © 2011 Wiley‐Liss, Inc.</P>

Fabry disease: characterisation of the plasma proteome pre- and post-enzyme replacement therapy

Heo, Sun Hee,Kang, Eungu,Kim, Yoon-Myung,Go, Heounjeong,Kim, Kyung Yong,Jung, Jae Yong,Kang, Minji,Kim, Gu-Hwan,Kim, Jae-Min,Choi, In-Hee,Choi, Jin-Ho,Jung, Sung-Chul,Desnick, Robert J,Yoo, Han-Wook,L BMJ Publishing Group 2017 Journal of medical genetics Vol.54 No.11

<P><B>Background</B></P><P>Fabry disease is characterised by the progressive accumulation of globotriaosylceramide (Gb3) and related glycosphingolipids in vascular endothelial cells. Enzyme replacement therapy (ERT) clears this accumulation. We analysed plasma proteome profiles before and after ERT to characterise its molecular pathology.</P><P><B>Methods</B></P><P>Two-dimensional electrophoresis and matrix-assisted laser desorption/ionisation-time of flight tandem mass spectrometry (MALDI-TOF MS) and tandem mass spectrometry (MS/MS) were done using plasma samples before and after ERT in eight patients with classical Fabry disease</P><P><B>Results</B></P><P>After short-term ERT (4–12 months), the levels of 15 plasma proteins involved in inflammation, oxidative and ischaemic injury, or complement activation were reduced significantly. Among them, β-actin (ACTB), inactivated complement C3b (iC3b), and C4B were elevated significantly in pre-ERT Fabry disease plasma compared with control plasma. After longer-term ERT (46–96 months), iC3b levels gradually decreased, whereas the levels of other proteins varied. The gradual reduction of iC3b was comparable to that of Gb3 levels. In addition, iC3b increased significantly in pre-ERT Fabry disease mouse plasma, and C3 deposits were notable in renal tissues of pre-enzyme replacement therapy patients.</P><P><B>Conclusion</B></P><P>These results indicated that C3-mediated complement activation might be altered in Fabry disease and ERT might promote its stabilisation.</P>

Visualization of Embryonic Stem Cell Survival In Vivo by Adenoviral-driven Bioluminescence Reporter in Rat Corpus Cavernosum

( Jung Joon Min ),( Uyen Chi N Le ),( Ho Jae Han ),( Hyun Suk Lee ),( Sung Min Moon ),( Jung Sun Heo ),( Yun Jung Lee ),( Kyu Youn Ahn ),( Kwang Sung Park ) 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.4

The detection of implanted stem cells in vivo almost always depends on postmortem histology. In this study, we sought to demonstrate the feasibility of adenovirus-mediated transient expression of the firefly luciferase(Fluc) reporter gene and longitudinal monitoring of implanted embryonic stem(ES) cells in rat corpus cavernosum by optical bioluminescence. Mouse ES cells(ES-E14TG2a) were transiently transfected with Ad-CMVFluc( MOI=100) and implanted into the corpus cavernosum of male Sprague-Dawley rats that were derived into the following groups: sham operated controls and injection of 5 different doses of ES cells(1×103, 1×104, 1×105, 1×106 and 5×106). Cell survival was assessed histologically and by bioluminescence imaging every other day after cellular implantation. All injected rats with cell numbers over 1×104 revealed the bioluminescence in the genital area until terminating the experiment(for 2 weeks), and histology showed increased smooth muscle contents compared to control rats. The study demonstrated a feasibility of adenovirus-mediated transduction of an imaging reporter gene applied for optical imaging of ES cells. The location, magnitude and survival of ES cells in rat corpus cavernosum can be monitored noninvasively with bioluminescence imaging system.