한국인의 연, 망간, 알루미늄 및 실리콘의 혈중 농도

김정만,안정모,김원술,김정일,신해림,정갑열,김준연 동아대학교 산업의학연구소 2000 산업의학연구소 논총 Vol.- No.5

Blood Lead, Manganese, Aluminium and Silicon Concentrations in Korean Adults Jung Man Kim, Jung Mo Ahn, Won Sul Kim1), Jung Il Kim2), Hai Rim Shin, Kap Yeol Jung2), Joon Youn Kim Department of Preventive Medicine, College of Medicine and Industrial Medicine Research Institute. Dong-A University Department of Health Care, Handong University Sunlin Presbyterian Hotpital1) Department of Occupational Medicine, College of Medicine, Dong-A University2) 0bjectives : This study was performed to determine the reference values of blood lead, manganese, aluminium, and silicon in healthy adults. Methods : The subjects were 132 (67 male and 65 female), and classified to three age groups (≤39,40∼49, and 50≤). Hood lead, manganese and aluminium were analyzed by atomic absorption spectrophotometer, and blood silicon was analyzed by direct current plasma optical omission spectrometer. Results : Blood lead levels(geometric mean, S.D) were (3.49, 1.70) ㎍/dL in male auld (3.04, 1.65) ㎍/dL in female, but the difference is not significant, and there was no significant difference between age groups. Mean blood manganese level was 0.99±0.41㎍/dL, and there was no significant difference between sex or age groups. Mean blood aluminium level was 0.59±0.35㎍/dL and there was no significant difference between sex or age groups. Mean blood silicon level was 54.41±27.64㎍/dL in male and 43.34±23.51㎍/dL in female, and the level in male was significantly higher than that in female (p〈0.05). There was significant difference between age groups, and the oldest showed the highest level in male (p〈0.05), but no significant difference between age groups in female. Conclusions : Authors hope that this study would provide basic data for determininig reference values and evaluating health effects.

제2형 당뇨병 환자의 치료에서 복약순응도가 혈당 조절에 미치는 영향

김경선,김민정,박소현,박영주,허정순,이은경,김선영,이수형,김상수,강양호,손석만,김인주,김용기 한국병원약사회 2009 병원약사회지 Vol.26 No.2

Abstract: As known in clinical trial like DCCT, UKPDS, tight glycemic control is essential to prevent complications from diabetes mellitus(DM). In type 2 diabetes taking multiple medication, nonadherence to medications is common problem. The aim of our study is to investigate adher-ence rate of patients with type 2 DM and to evaluate association between many factors including adherence rate and HbA_(1C). 441 patients with type 2 DM who visited Busan National University Hospital endocrine internal department from Aug 13 to Sep 2, 2008(3weeks) were enrolled. We conducted a man-to-man questionnaire survey about general knowledge about diabetes mellitus, medicine and adherence, and measured HbA_(1C). Among them, 305 patients taking oral hypo-glycemic agent(OHA) were analyzed to investigate correlation between adherence rate and glycemic control. We studied 305 patients(male 126, female 179, average age 61.2±9.8 years, DM duration 8.6±6.4 years, average adherence 88.8±16.2%, average HbA_(1C) 7.03± 1.18%). HbA_(1C) showed significant relation with DM duration(r=0.137, p=0.017), number of aHA in regimen (r=0.135, p=0.018), dosage frequency(r=0.132, p=0.026), Medication Refill Adherence(MRA)(r=-0.124, p=0.030) and adherence(r=-0.168, p=0.003). Adherence had significant relation with MRA(r=0.148, p=0.010) but didn't have statical corelationship with DM duration, number of aHA and dosage frequency. Patients that their adherence rate exceed 90% took fewer OHA(p=0.011) and went on a better dietary treatment(p=0.007). In patients controlling diabetes mellitus with aHA, when adherence rate and MRA was higher, HbA_(1C) was lower. As a result, to improve adher-ence rate, it is necessary to enhance patient education, do careful consideration about prescrip-tion medicine number and dosage frequency

예비유아교사의 학업적 자기효능감과 그릿이 행복감에 미치는 영향

김정주(Jung-Ju Kim),김병만(Byung-Man Kim) 인문사회과학기술융합학회 2018 예술인문사회융합멀티미디어논문지 Vol.8 No.11

본 연구는 예비유아교사의 학업적 자기효능감과 그릿이 행복감에 어떠한 영향력을 미치는지 확인하는 데 목적이 있다. 이를 위해 부산광역시, 울산광역시, 경상남도 내에 소재하고 있는 대학교의 유아교육과에 재학 중인 예비유아교사 300명을 임의표집하여 연구대상으로 선정하였다. 예비유아교사의 학업적 자기효능감을 측정하기 위해 김아영, 박인영(2001)이 개발하고 타당화한 후 김병만, 김정주, 윤정진(2017)이 수정하여 사용한 학업적 자기효능감 검사도구를 사용하였다. 고, 그릿을 측정하기 위해 Duckworth, Peterson, Matthews와 Kelly(2007)가 개발한 Original Grit Scale(Grit-O)를 이수란(2014)이 한국실정에 맞게 번안한 척도를 사용하였으며, 행복감을 측정하기 위해 Seligman(2011)의 웰빙에 대한 PERMA 이론을 토대로 Butler와 Kern(2014)이 개발하여 김미진(2015)이 번안한 다차원적행복척도(Multidimensional Measure of Flourishing: MMF)를 사용하였다. 본 연구의 결과는 다음과 같다. 첫째, 예비유아교사의 학업적 자기효능감, 그릿, 행복감에 대한 인식에 대한 결과로 모든 변인에서 보통 이상의 긍정적인 인식 정도가 나타났다. 둘째, 예비유아교사의 학업적 자기효능감, 그릿, 행복감 간의 상관관계에는 유의미한 정적 상관관계가 있음을 알 수 있다. 셋째, 예비유아교사의 학업적 자기효능감은 예비유아교사의 행복감에 영향을 미치는 변인으로 나타났으나, 그릿은 예비유아교사의 행복감에 영향을 미치지 않는 변인으로 나타났다. The purpose of this study is to investigate the influence of pre-service early childhood teachers academic self-efficacy and grit on happiness. For this purpose, 300 Pre-service early childhood teachers in preschool education at universities located in Busan, Ulsan and Gyeongsangnam province were randomly sampled and selected. In order to measure the pre-service early childhood teachers academic self-efficacy, I used the academic self-efficacy test tool modified by Kim Byung-man, Kim Jung-ju and Youn Jung-jin (2017) after the development and validation of Kim Ae-Young and Park In-Young (2001). The original Grit Scale (Grit-O) developed by Duckworth, Peterson, Matthews and Kelly (2007) was used to measure grit. And to measure happiness, we used the multidimensional happiness scale developed by Butler and Kern (2014) and developed by Kim Mi-jin (2015) based on the PERMA theory of wellness in Seligman (2011). The results of this study are as follows. First, as a result of pre-service early childhood teachers perception of academic self-efficacy, grit, and happiness, positive perceptions were more than usual in all variables. Second, there is a significant positive correlation between the pre-service teacher s academic self-efficacy, grit, and happiness. Third, the academic self-efficacy of pre-service early childhood teachers was a factor affecting the happiness of pre-service early childhood teachers. Specifically, it was found that task difficulty preference, self-regulated efficacy, and self-confidence affect the happiness of pre-service early childhood teachers among the sub-variables of happiness. However, the sub-variables of Grit did not affect the pre-service teachers happiness.

연 착화제 효능에 관한 동물실험적 연구

김정만,김병권,김성환,서병성,김인식,김용규,정갑열,김준연 동아대학교의과대학 1997 동아의대학술지 Vol.9 No.1

연 착화제 효능에 관한 동물실험적 연구

서병성,김준연,김정만,김용규,정갑열,김성환,김인식,김병권 동아대학교 부설 산업의학연구소 1997 산업의학연구소 논총 Vol.- No.3

This experiment was carried out to compare the efficacy of 2,3-dimercaptosuccinic acid(DMSA) and calcium ethylenediamine tetraacetate(CaEDTA) as chelating agents for lead poisoning. The rats had been fed water containing 0.5% lead acetate for 3 months and randomly divided into three groups. We administered DMSA only for group I(n=5), CaEDTA only for group II(n=5), and both DMSA and CaEDTA for group III(n=10), for 4 days. We evaluated urinary lead(PbU) level, blood lead(PbB) level and blood zinc protoporphyrin(ZPP) level before and after administration of the chelating agents. The results obtained were as follows; 1. After administration of chelating agents, the mean PbU levels, which were 248.2㎍/dl, 252.6㎍/dl and 270.0㎍/dl in group I, II and III before administration, were increased to 484.6㎍/dl, 479.9㎍/dl and 1,792.1㎍/dl in group I, II and III, respectively(p<0.05). 2. After administration of chelating agents, the mean PbB levels, which were 67.4㎍/dl, 59.9㎍/dl and 62.5㎍/dl in group I, II and III before administration, were decreased to 38.1㎍/dl, 36.3㎍/dl and 31.3㎍/dl in group I, II and III, respectively(p<0.05), but there were no different changes of ZPP level among groups. 3. The blood lead clearances, which were calculated by PbB level before and after administration of chelating agents, were 49.8%, 43.5% and 39.5% in group III, I and II, respectively.

家兎及人體寄生肝吸蟲 各種抗源에 依한 皮膚反應과 沈降反應의 比較實驗

崔東翊,申大植,金正浣,金正萬 慶北大學校 醫科大學 1963 慶北醫大雜誌 Vol.4 No.1

家兎及人體寄生肝吸蟲 各種抗原에 依한 皮膚反應과 沈降反應의 比較實驗

崔東翊,申大植,金正浣,金正萬 慶北大學校 醫科大學 1963 慶北醫大誌 Vol.4 No.1

The alkali & acid soluble protein fractions and Polysaccharide fractions from the adult Clonorchis sinensis of rabbit and man were employing the identical method, and further study was carried out in the skin and precipitin reaction in order to determine the best antigen among the fraction. The results observed are summarized as follow: Ⅰ.Skin reaction 1)There is no significant difference in positive rate and reactivity between man and experimental rabbit's alkali soluble protein fraction and acid soluble protein fraction. 2)In the polysaccharide fraction, the positive rate of antigen fractionated from man's Clonorchis sinensis is higher than antigen from rabbit. 3)The positive rate of antigen fractionated from man's Clonorchis sinensis is 47.5%(38 cases among 80), whereas from antigen of rabbit, it is 6.1%(5 cases among 82) in the polysaccharide fraction remained acid media. Ⅱ.Precipitin reaction 1)No apparent differences are observed in the titres of precipitin reactons fractionated from the alkali soluble protein & polysaccharide fraction, and also from the acid soluble protein and polysaccharide fraction of man and rabbit Clonorchis sinensis. 2)The titre of precipitin reaction is higher in the polysaccharide fraction in the case of serum of human patient, while it is higher in the protein fraction in the cases of rabbit serum.

Palmes Tube를 이용한 실내외 NO₂농도 측정

정갑열,김정만,김용규,김준연 동아대학교 의과대학 부설 산업의학연구소 1992 산업의학연구소 논총 Vol.- No.1

실내 공기오염의 주요인자의 하나인 NO₂에 대하여 부산의 도심지역(중구의 남포동, 광복동, 창선동)과 외곽지역(서구, 사하구)의 사무실, 식당, 다방(150개소)을 대상으로 하여 NO₂에 의한 실내외 공기오염의 정도를 파악하고 NO₂에 농도에 영향을 미칠 가능성이 있는 몇가지 인자에 대하여 조사함으로써 NO₂에 의한 인체장해의 예방대책을 수립하기 위한 기초 자료를 얻고자 본 연구를 실시하였다. 조사기간은 1988년 12월부터 1989년 2월까지 동계 3개월간이었고 NO₂에측정은 Palmes method 에 의하였으며 그 결과는 다음과 같다. 1. 도심지역의 NO₂평균농도; 1) 사무실의 홀 : 0.045±0.032 ppm, 2) 식당의 주방 : 0.106±0.049 ppm, 홀 : 0.076±0.030 ppm, 3) 다방의 주방 : 0.082±0.033 ppm, 홀 : 0.077±0.041 ppm 및 4) 옥외 : 0.031±0.009 ppm이었다. 2. 외곽지역의 NO₂평균농도; 1) 사무실의 홀 : 0.036±0.019 ppm, 2) 식당의 주방 : 0.079±0.045 ppm, 홀 : 0.056±0.034 ppm, 3) 다방의 주방 : 0.054±0.024 ppm, 홀 : 0.042±0.024 ppm 및 4) 옥외 : 0.021±0.007 ppm이었다. 3.1일 연료 소비량별 홀의 NO₂농도는 5L 미만 0.037±0.017 ppm, 5∼ 10L 미만 0.047±0.027 ppm, 10∼ 20 L 미만 0.065±0.042 ppm으로 연료 소비량이 증가할수록 홀의 NO₂농도는 유의하게 증가하였다. (p<0.01). 4. 환기를 실시하지 않는 홀의 NO₂농도는가 환기를 실시하는 홀의 NO₂농도 및 옥의 NO₂농도보다 유의하게 높았고(p<0.001), 환기를 실시하는 홀의 NO₂농도는 옥외 농도와 유사하여 인공환기시 홀의 NO₂농도는 상당히 감소하였다. Recently nitrogen dioxide(NO₂) has been regarded as one of the main elements among indoor air pollutants. For the purpose of preparing the fundamental data for evaluation and control on the health effect relevant to NO₂levels, the authors measured the indoor and outdoor NO₂levels by the type of subject(office, restaurant, coffee shop) with some factors related to the indoor NO₂levels. The level of NO₂was measured by Palmes method, and this survey was carried out to 150 subjects in the Pusan area from December, 1988 to Feburary, 1989. The obtained results were as follows; 1. The mean indoor and outdoor NO₂levels at down-town 1) Hall of office : 0.045±0.032 ppm, 2) Hall of restaurant : 0.076±0.030 ppm, Kitchen of restaurant : 0.106±0.049 ppm, 3) Hall of coffee shop : 0.077±0.041 ppm, Kitchen of coffee shop : 0.082±0.033 ppm, and 4) Outdoor : 0.031±0.009 ppm 2. The mean indoor and outdoor NO₂levels at outskirt 1) Hall of office : 0.036±0.019 ppm, 2) Hall of restaurant : 0.056±0.034 ppm, Kitchen of restaurant : 0.079±0.045 ppm, 3) Hall of coffee shop : 0.042±0.024 ppm, Kitchen of coffee sho : 0.054±0.024 ppm, and 4) Outdoor : 0.021±0.007 ppm 3. The NO₂levels of Hall by daily fuel consumption were; 1) ∼5L: 0.037±0.017 ppm, 2) 5 ∼ 10L : 0.047±0.027 ppm, and 3) 10 ∼ 20L : 0.065±0.042 ppm The NO₂levels of Hall were significantly increased with the daily fuel consumption amount. 4. The NO₂levels of vented Hall was significantly lower than the NO₂levels of unvented Hall, which decreased when artificial ventilation was conducted, and the NO₂levels of vented Hall was similar to the outdoor NO₂level.

부산지역 무균성 뇌막염 원인 바이러스의 분리 및 동정 : 1998년을 중심으로

김영희,정영기,김기순,지영미,윤재득,김병준,구평태,민상기,정구영,김만수,조경순 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

The incidence of aseptic meningitis infection is ensuing and threatening the health of children. Enteroviruses are the major agents of aseptic meningitis and identification of virus has been a clue to diagnosis and epidemiology. The outbreak of aseptic meningitis occurred in Pusan, 1998. Patients were concentrated from April through November. Children were more susceptible than adults. Among 306 cases of specimens from stool, throat swab tested, only 7.2% were positive on virus isolation, 12 cases from stool and 10 from throat, respectively. All isolated 7 serotypes of viruses represented cytopathic effect on cultured cells. Three types of echovirus 6, 25, 30 and coxsackievirus B2, B3, B4, B6 were identified by neutralizing anti body test. Isolated coxsackievirus and echovirus were observed by an electron microscope with negative staining.

Diffusion of Choline Chloride in Aqueous Solutions of Chondroitin Sulfate

Jung, Ok-Sun,Kim, Si-Joong,Kim, Hyoung-Man Korean Chemical Society 1984 Bulletin of the Korean Chemical Society Vol.5 No.6

Mutual diffusion coefficients of choline chloride were determined by using the diaphragm cell method in aqueous solutions of chondroitin sulfate A at $25^{\circ}C$. The diffusion coefficients of choline chloride in 0.1g/100ml, 0.5g/100ml and 1g/100ml respectively of chondroitin sulfate solutions were compared with those of binary systems of water-choline chloride. At low concentrations, the diffusion coefficients of the choline chloride in the presence of chondroitin sulfate were significantly smaller than the values obtained in the absence of chondroitin sulfate, indicating a strong interaction between these solutes. The effect of this interaction on the diffusion of choline ion is largest at higher chondroitin sulfate concentrations and at lower choline chloride concentrations. The influence of chondroitin sulfate is overcome at higher choline chloride concentrations. Self-diffusion coefficients of choline ion in the presence of chondroitin sulfate are also obtained. Excellent agreements were obtained between the experimental data and the calculated values obtained by using the Manning's equations. These observations suggest that the interaction between choline chloride and chondroitin sulfate involves primarily a long range electrostatic effect and there is no appreciable "condensation" or binding of choline ion to the chondroitin sulfate.