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심폐소생술의 순환회복 예측인자로서 호기말 이산화탄소 분압의 유용성 및 의의 : 각 심정지 원인에 따른 분석
어은경,안기옥,김정연,전영진,정구영 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3
Background: In recent years, there has been increasing interest in the use of capnometry, the noninvasive, continuous measurement of end-tidal carbon dioxide(ETCO2) in expired air during CPR. The purpose of this study is to determine the significance of ETCO2 monitoring according to immediate cause of arrest during CPR as a prognostic indicator of successful resuscitation and survival. Methods: A prospective, clinical study was performed from May 1997 to December 2000 at the Department of Emergency Medicine, Ewha Womans University Mokdong Hospital. The study included 220 patients(231cases). All patients were immediately connected to a mainstream capnometer sensor between the tube and the bag after endotracheal intubation using an infrared capnometer. Results: The 107 patients(46.3%) with return of spontaneous circulation(ROSC) had higher maximal ETCO2 during CPR than the 113 patients without ROSC(31.0±19.4 vs 11.7±9.4 mmHg, P=0.000). The ETCO2 was not significantly different in relation to age, initial rhythm, and survival time after ROSC, but there was a significant difference in the immediate cause of arrest in the ROSC group(respiratory arrest: 40.2±23.5 mmHg, P=0.000). In case of cardiac arrest due to trauma, maximal ETCO2 was not significant in the ROSC group compared with the non-ROSC group(18.2±16.6 vs 10.8±7.5 mmHg, P=0.208). When maximal ETCO2 was less than 10 mmHg, we observed a sensitivity of 94.4% and a specificity of 39.5% in predicting ROSC. There were 6 patients with ROSC even though the maximal ETCO2 was less than 10 mmHg. Conclusion: Continuous ETCO2 monitoring during CPR may be noninvasive and valuable predictor of successful resuscitation and survival from cardiac arrest. However, ETCO2 should not be used as a single indicator for either cardiac arrest due to trauma or withdrawal of CPR.
낙동강수계 댐과 다기능보의 연계운영을 통한 용수공급효율화에 관한 연구
안정민 ( Jung Min Ahn ),임태효 ( Toe Hyo Im ),이인정 ( In Jung Lee ),이경락 ( Kyung Lak Lee ),정강영 ( Kang Young Jung ),이재운 ( Jae Woon Lee ),천세억 ( Se Uk Cheon ),박인혁 ( In Hyeok Park ) 한국물환경학회 2014 한국물환경학회지 Vol.30 No.2
In order to determine the best operating rules for the Nakdong River, three cases were applied to analyze the simulated results of water supply capacity by HEC-ResSim model. This study discussed to present the best operating rules for conjunctive operating of existing the dams and new constructed the weirs through system network. The system network was constructed considering the water supply, the river environment and the operating facility. The water supply capacities are separately evaluated for each case applying the best rules. It is case1 that the dams are operated individually, case2 that the dams are operated in conjunction with the others dams, and case3 that dams and weirs are operated in conjunction with the others dams-weirs. Comparing the cases, case 3 has shown the best water supply capacity of the Nakdong River.
안정환 ( Jung Hwan Ahn ),최상천 ( Sang Cheon Choi ),윤상규 ( Sang Kyu Yoon ),정윤석 ( Yoon Seok Jung ) 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.2
Lithium is mainly prescribed for manic and depressive disorder, also frequently prescribed for the other diseases such as migraine, cluster headache, alcoholism, and obsessive-compulsive disorder. An acute lithium intoxication occurs in cases of patients ingesting large amount lithium at a time, a chronic lithium intoxication occurs in patients on chronic lithium therapy. Acute or chronic lithium poisoning occurs frequently in case of patients on chronic lithium therapy ingesting larger dose than prescribed. Manifestations of lithium poisoning are various. It is possible nervous, cardiovascular, renal, gastrointestinal and endocrine systems to be involved. Due to intracellular high concentration, mortality rate is high in acute lithium intoxication patients on chronic lithium therapy. We report a case of acutely intoxicated 40-year-old male on chronic lithium therapy. His chief complaints were deterioration and high fever. On his arrival to an emergency department, he was in cardiac arrest. He restored return of spontaneous circulation (ROSC) 5 minutes later after cardiopulmonary cerebral resuscitation (CPCR) and referred to department of internal medicine for hemodialysis. Vigorous treatment was given to the patient, but he was expired at 4th hospital day.
연구논문 : 경향성 및 패턴 분석을 이용한 낙동강 물금지역의 수질 특성
안정민 ( Jung Min Ahn ),이인정 ( In Jung Lee ),정강영 ( Kang Young Jung ),김주언 ( Ju Eon Kim ),이권철 ( Kwon Chul Lee ),천세억 ( Se Uk Cheon ),류시완 ( Si Wan Lyu ) 한국환경과학회 2016 한국환경과학회지 Vol.25 No.3
Ministry of Environment has been operating water quality monitoring network in order to obtain the basic data for the water environment policies and comprehensively understand the water quality status of public water bodies such as rivers and lakes. The observed water quality data is very important to analyze by applying statistical methods because there are seasonal fluctuations. Typically, monthly water quality data has to analyze that the transition comprise a periodicity since the change has the periodicity according to the change of seasons. In this study, trends, SOM and RDA analysis were performed at the Mulgeum station using water quality data for temperature, BOD, COD, pH, SS, T-N, T-P, Chl-a and Colon-bacterium observed from 1989 to 2013 in the Nakdong River. As a result of trends, SOM and RDA, the Mulgeum station was found that the water quality is improved, but caution is required in order to ensure safe water supply because concentrations in water quality were higher in the early spring(1~3 month) the most.
Chang, Hee Jung,Yoon, Goo,Park, Jung Sun,Kim, Mi Ha,Baek, Min Kyung,Kim, Nam Ho,Shin, Boo Ahn,Ahn, Bong Whan,Cheon, Seung Hoon,Jung, Young Do Pharmaceutical Society of Japan 2007 Biological & pharmaceutical bulletin Vol.30 No.12
<P>Licochalcones have a variety of biological properties including anti-tumor, anti-parasitic and anti-bacterial activities. Recently, a new retrochalcone (licochalcone E, Lico-E) was isolated from the roots of <I>Glycyrrhiza inflata</I> (<I>Chem. Pharm. Bull.</I>, 53, 2005, Yoon <I>et al.</I>) by cytotoxicity-guided fractionation. This study examined whether or not Lico-E-induced endothelial cell death occurs through apoptosis, and investigated molecular mechanisms involved in this process. Lico-E was found to suppress ECV304 cell growth and induce apoptosis. The induction of apoptosis by Lico-E was confirmed by the ladder-patterned DNA fragmentation, the presence of cleaved and condensed nuclear chromatin and the increased number of annexin V-positive cells. Lico-E could effectively inhibit the constitutive NF-κB activation, as revealed by the electrophoretic mobility shift assay and NF-κB-dependent luciferase reporter study. In addition, the Lico-E treatment caused a change in the Bax/Bcl-2 ratio that favored apoptosis. These results suggest that Lico-E induces endothelial cell apoptosis by modulating NF-κB and the Bcl-2 family.</P>
계절 맨-켄달 기법을 이용한 금호강 본류 BOD의 장기 경향 분석 및 탐색적 자료 분석
정강영 ( Kang Young Jung ),이인정 ( In Jung Lee ),이경락 ( Kyung Lak Lee ),천세억 ( Se Uk Cheon ),홍준영 ( Jun Young Hong ),안정민 ( Jung Min Ahn ) 한국환경과학회 2016 한국환경과학회지 Vol.25 No.2
The government has conducted a plan of total maximum daily loads(TMDL), which divides with unit watershed, for management of stable water quality target by setting the permitted total amount of the pollutant. In this study, BOD concentration trends over the last 10 years from 2005 to 2014 were analyzed in the Geumho river. Improvement effect of water quality throughout the implementation period of TMDL was evaluated using the seasonal Mann-Kendall test and a LOWESS(locally weighted scatter plot smoother) smooth. As a study result of the seasonal Mann-Kendall test and the LOWESS smooth, BOD concentration in the Geumho river appeared to have been reduced or held at a constant. As a result of quantitatively analysis for BOD concentration with exploratory data analysis(EDA), the mean and the median of BOD concentration appeared in the order of GH8 〉GH7 〉GH6 〉GH5 〉GH4 〉GH3 〉GH2 〉GH1. The monthly average concentration of BOD appeared in the order of Apr 〉Mar 〉Feb 〉May 〉Jun 〉Jul 〉Jan 〉Aug 〉Sep 〉Dec 〉Nov 〉Oct. As a result of the outlier, its value was the most frequent in February, which is estimated 1.5 times more than July, and was smallest frequent in July. The outlier in terms of water quality management is necessary in order to establish a management plan for the contaminants in watershed.
감천 유역의 TOC 농도 추정을 위한 회귀 모형 개발 및 평가
정강영 ( Kang Young Jung ),안정민 ( Jung Min Ahn ),이경락 ( Kyung Lak Lee ),김신 ( Shin Kim ),유재정 ( Jae Jeong Yu ),천세억 ( Se Uk Cheon ),이인정 ( In Jung Lee ) 한국환경과학회 2015 한국환경과학회지 Vol.24 No.6
In this study, it is an object to develop a regression model for the estimation of TOC (total organic carbon) concentration using investigated data for three years from 2010 to 2012 in the Gam Stream unit watershed, and applied in 2009 to verify the applicability of the regression model. TOC and CODMn (chemical oxygen demand) were appeared to be derived the highest correlation. TOC was significantly correlated with 5 variables including BOD (biological oxygen demand), discharge, SS (suspended solids), Chl-a (chlorophyll a) and TP (total phosphorus) of p<0.01. As a result of PCA (principal component analysis) and FA (factor analysis), COD, TOC, SS, discharge, BOD and TP have been classified as a first factor. TOCe concentration was estimated using the model developed as an independent variable BOD5 and CODMn. R squared value between TOC and measurement TOC is 0.745 and 0.822, respectively. The independent variable were added step by step while removing lower importance variable. Based on the developed optimal model, R squared value between measurement value and estimation value for TOC was 0.852. It was found that multiple independent variables might be a better the estimation of TOC concentration using the regression model equation(in a given sites).
연구논문 : 금호강 수계 난분해성 유기오염물질에 대한 시,공간적 특성 분석
정강영 ( Kang Young Jung ),안정민 ( Jung Min Ahn ),이경락 ( Kyung Lak Lee ),이인정 ( In Jung Lee ),유재정 ( Jae Jeong Yu ),천세억 ( Se Uk Cheon ),김교식 ( Kyo Sik Kim ),한건연 ( Kun Yeun Han ) 한국환경과학회 2015 한국환경과학회지 Vol.24 No.11
As a result of analysis based on the observed data for BOD, COD and TOC in order to manage non-biodegradable organics in the Geumho River, COD/BOD ratio was analyzed as the occupying predominance proportion. In this study, the classification(changes in water quality measurement : increase, equal, decrease) and measurement of BOD and COD were analyzed for trends over the past 10 years from 2005 to 2014 in the Geumho River. The Geumho River is expected to need non-biodegradable organics management because BOD was found to be reduced 61.1% and COD was found to be increased 50%. As a result of the analysis of land use, the Geumho-A is a unit watershed area of 921.13 km2, which is the most common area that is occupied by forests. The Geumho-B is a unit watershed area of 436.8 km2, which is the area that is highest occupied by agriculture and grass of 24.84%. The Geumho-C is a unit watershed area of 704.56 km2 accounted for 40.29% of the entire watershed, which is the area that is occupied by urban of 15.12%. Load of non-biodegradable organics, which is not easy biodegradable according to the discharge, appeared to be increased because flow coefficient of COD and TOC at the Geumho-B were estimated larger than 1 value. The management of non-point sources of agricultural land is required because the Geumho-B watershed area occupied by the high proportion of agriculture and field. In this segment it showed to increase the organics that biodegradation is difficult because the ratio of BOD and TOC was decreased rapidly from GR7 to GR8. Thus, countermeasures will be required for this.
독사 교상후 발생한 전신적 합병증 - 혈액학적 합병증과 신경학적 합병증을 중심으로 -
박은정,윤상규,안정환,최상천,김기운,민영기,이국종,정호성,정윤석,Park, Eun-Jung,Yoon, Sang-Kyu,Ahn, Jung-Hwan,Choi, Sang-Cheon,Kim, Gi-Woon,Min, Young-Gi,Lee, Kuk-Jong,Jung, Ho-Sung,Jung, Yoon-Seok 대한임상독성학회 2009 대한임상독성학회지 Vol.7 No.2
Purpose: This study explored and evaluated the systemic complications resulting from the bite of Korean venomous snake, focussing on hematologic and neurologic features. Methods: Medical records (demographic data, clinical measurements including laboratory results, severity score, and amount of antidote administration, and hospitalization course) of consecutive patients who presented with snakebites to two university teaching hospital during a 10-year period were retrospectively reviewed. Subgroup analysis was conducted for evaluations of anti-acetylcholine esterase administration in complicated victims. Results: The 170 patients displayed occurrence rates of hematologic and neurologic complications of 12.9% and 20.6%, respectively. Among 22 patients with hematologic complications, isolated thrombocytopenia was evident in eight patients (36.4%), prothrombin time (PT) / activated partial thromboplastin time (aPTT) prolongation in 11 patients (50.0%), and both in three patients (13.6%). The mean time to recovery was $4.5{\pm}1.8$ days for isolated thrombocytopenia, and $5.1{\pm}1.8$ days for PT and aPTT prolongation. Hematologic complications could occur suddenly 1?4 days after hospitalization. Among 35 patients with neurologic complications, dizziness was evident in 16 patients (45.7%), and diplopia / blurred vision in 19 patients (54.3%). The mean time to recovery was $3.4{\pm}0.6$ days in patients receiving anti-acetylcholine esterase and $6.9{\pm}1.8$ days in those not receiving anti-acetylcholine esterase (p=0.00). Conclusion: Occurrence rates of hematologic and neurologic complications following venomous snake bite differed as compared to other studies conducted in Korea. Onset of hematologic complications can occur rapidly days after admittance. Anti-acetylcholine esterase administration may be effective in treating neurologic complications.