신규 방사성 항암제 DW-166HC 의 소핵시험

문은이(Eun Yi Moon),이진(Jin Lee),이원용(Won Yong Lee),최청하(Chung Ha Choi),이덕근(Dug Keun Lee),유제만(Jei Man Ryu),정용호(Yong Ho Chung),윤성준(Sung June Yoon),박경배(Kyung Bae Park) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.3

DW-166HC (^(166)Holmium (^(166)Ho)-Chitosan complex) is a new radiopharmaceutic anticancer agent with a broad anti-tumorigenic spectrum, especially against human hepatic cancer. DW-166HC was evaluated for the appearance of micronucleus in polychromatic erythrocytes (PCEs) of mouse bone marrow cells after subcutaneous arid intravenous single administration. Bone marrow cells were prepared at 24 hr and 48 hr after DW-166HC-I (^(165)Ho-Chitosan complex : cold compound) administration and at 24 hr, 72 hr and 2 weeks after DW-166HC (^(166)Ho-Chitosan complex : hot compound) administration. The results showed there was no statistically significant increase of the numbers of PCEs with micronucleus in all DW-166HC-I administered groups compared with a negative control group but there was statistically significant increase of the numbers of PCEs with micronucleus at 24 hr arid 72 hr in all DW-166HC administered groups, which was recovered after 2 weeks from the drug administration. The results also showed the ratio of normochromatic erythrocytes (NCEs) to PCEs of all DW-166HC-I administered groups was not significantly different from that of a negative controi group but there was significant difference of this ratio at 24hr and 72 hr in all DW-166HC administered groups compared with that of negative group, which was also recovered after two weeks from the drug administration. These results suggested that DW-166HC-I may not cause any chromosomal damage but DW-166HC has in vivo mutagenic potential because of its radioactivity.

영역기반 피부영역검출을 위한 최소차원의 특징벡터공간 생성에 관한 연구

최종무,이준호 成均館大學校 科學技術硏究所 2001 論文集 Vol.52 No.1

본 논문에서는 효율적인 영역기반 피부 영역검출에의 적용을 위해 검출성능의 저하가 없이 최소차원의 특징벡터공간을 생성하는 방법을 제안하고 실험하였다. 제안한 방법은 입력 영상을 조각영상으로 분할하고, 각 조각영상의 Hue와 Saturation 값을 하나의 패턴으로 변환하여 고차원의 분류공간으로부터 최적으로 분류가 가능한 하위공간으로 사상하여 분류를 수행한다. 이러한 과정은 조각영상 내 화소들의 공간적 상관관계를 고려함으로써 분류 성능을 높이게 된다. 오프라인 학습단계에서는 조각영상의 패턴들에 LDA(linear discriminant analysis)를 적용하여 특징벡터들로 선형변환하고, 특징벡터의 각 원소 중에서 분별력이 가장 큰 두 개의 원소(element)만으로 2차원 LDA 인덱싱 테이블을 생성한다. 온라인 검출단계에서는 미리 생성된 2차원 LDA 인덱싱 테이블 룩업을 통하여 성능의 저하 없이 계산량을 상당히 줄일 수 있게 된다. 제안된 방법을 조명 및 손의 자세를 변화시킨 다양한 영상에 적용하여 실험한 결과 양호한 검출 결과를 얻을 수 있었다. This research presents a novel method for region based skin color segmentation. It considers spatial correlation of pixel values in a local region using a feature vector space of minimal dimensionality. We have employed a 2D feature vector space that is implemented as an indexing able. The input image is divided into patch images and each patch mage is converted to a pattern vector of which elements are hue and saturation values of the pixels in the patch. These pattern vectors are classified into skin color or non-skin color regions using 2D indexing table. We show that employing this 2D indexing table gives accurate classification of high dimensional pattern vectors. At off-line learning stage, we apply LDA(linear Discriminant Analysis) to the pattern vectors from the patch images and construct a 2D indexing table of which two axes are the most discriminant elements of feature vectors, At on-line detection stage, we can achieve fast skin color segmentation by 2D indexing table lookup. We have applied our method to various images under illumination changes and different poses. The experimental results show that the performance of our method is quite robust to illumination changes and different poses.

경주지역 여고생의 초경과 체성장간의 관계

김준섭,권오구,박진석,오종수,박정현,박제식,안세한,이용환,서정호,신태섭,최영배,김덕수,이관,박수경 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1

본 연구는 경주지역 1개 고등학교 3학년 여고생을 대상으로 초경 시작 전인 초등학교 4학년부터 고등학교 2학년까지의 키, 몸무게, 가슴둘레 수치와 초경 연령을 파악하여 여성의 초경이 빠를수록 체성장 속도의 변화가 있을 것이라는 가설을 기초로 두 요인간의 관련성을 파악하고자 시행되었다. 경주시 1개 여자고등학교 3학년생 총 317명에 대해 ㅊ경 나이, 초경시 심리 상태, 초경이 시작되었을 때의 상담 여부와 상담하였던 사람, 부모 신장과 초경전후의 식사 규칙성, 다이어트 경험, 수면시간, 스트레스, 음주/흡연 여부, 질병력 등에 대한 설문 조사를 시행하였고, 초등학교 4학년부터 고등학교 2학년까지의 키, 몸무게, 가슴둘레에 대한 정보는 건강기록부에서 확보하였다. 상기 대상자 중 건강기록부가 분실된 39명, 초경나이에 대해 응답하지 않았던 29명 및 결석 등으로 조사를 하지 못하였던 42명을 제외한 조사 대상자는 206명으로 선정하였다. 대상자들의 초경연령 평균값(Mean±SD)은 13.0±1.11이었고, 초등학교 4학년부터 고등학교 2학년까지의 초경 이후 신장 성장률은 감소하였으며, 초경연령이 빠른 군이 초등학교 때는 신장에 있어서 우위를 차지하나 고등학교에 오면서 신장은 비슷한 수준이 되었다. 초경후 1-2년 사이에 체중과 흉위의 증가율은 감소하였고, 초경연령이 빠른 군이 초등학교와 고등학교 사이에 체중과 흉위에서 모두 우위를 차지하였다. 본 연구의 결과는, 흔히 이차 성징의 시작 시점 혹은 사춘기의 시작 시점으로 보고있는 초경 연령이 청소년기의 성장과 밀접한 관련성이 있고, 특히 체중과 흉위의 성장 속도와 밀접한 관련성이 있음을 시사한다. To understand the onset of menarche in relation to changes in physical growth that take place during female adolescence, especially the changes in height and weight velocity. The 207 senior in one women high school of Kyongju were investigated in April 3 to 8, 2001. We collected the information, relation in the age at menarche, height & weight of parents, regularity of eating, and obesity diet, duration of sleeping, sickness & stress near age at menarche, by self-recording. The status of height, weight & chest circumference between the 4th grade of primary school and the junior of high school was collected by individual Health Record. The results were followed; The average age at menarche was 12.95±1.11 years old and the most frequent age of menarche is 13 years. After menarche, the velocity of height, weight and chest circumference were decreased. The most rapid group of menarche hold dominant position in height during elementary school. As time passed, they dont hold dominant position in height. The most rapid group of menarche get an advantage in the weight and the girth of chest after elementary school. The height of subjects is directly proportional to the height of their parents. These results suggest that the starting age at menestuation can be closely associated with physical growth and development.

RGB 칼라공간의 2차원 투영면을 이용한 효율적인 피부영역검출

강호진,최종무,이준호 成均館大學校 科學技術硏究所 2001 論文集 Vol.52 No.2

본 논문에서는 조명변화가 있는 영상에서 높은 피부영역의 검출 성능을 얻기 위해, RGB 칼라영상을 HSI 혹은 YIQ 칼라공간으로의 변환 없이 직접 RGB공간에서 피부영역을 검출하는 방법을 제안하고 실험하였다. RGB 칼라공간에서 피부영역이 선형적으로 분포하는 것을 이용하여 RGB 칼라영상에 주성분 분석(Principal Component Analysis)을 수행한다. 분산이 가장 큰 첫 번째 성분을 제외하고 분산이 적은 두 번째와 세 번째 축으로 이루어진 2차원 평면의 인덱싱 테이블을 만들어 피부영역 검출에 이용하였다. 조명 변화가 있는 영상에서 기존의 방법인 HSI 혹은 YIQ 칼라공간을 사용한 피부영역의 검출 성능보다 더 강인한 검출성능을 보였다. 제안한 방법의 검출성능을 평가하기 위해 Hue/Saturation 공간에서의 피부영역 검출성능을 비교 평가하였다.

위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

필러의 표면처리와 실리콘 고무의 트래킹특성

李水夫,崔鍾汶,李峻昊,池源泳 湖西大學校工業技術硏究所 1999 工業技術硏究所論文集 Vol.18 No.-

Polymer insulating materials are widely used in power distribution and transmission systems for their good dielectric properties, light weight, low cost, and good contamination performance. Tracking is one of the biggest problems to be overcome in polymer insulating materials. The alumina trihydrate(ATH) is widely used as a filler for improve the tracking performance of silicone rubber. In this paper, we have investigated the influence of surface treatment of fillers on the tracking performance of silicone insulator using the IEC 587 tracking test method.

원형 플레이트 형태에 따른 초음파 부상 장치의 진동특성에 관한 연구

정상화,최석봉,차경래,김현욱,김광호,박준호 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

In the semiconductor and optical industry the non-contact transportation is required for reducing the damages. The ultrasonic levitation is the solution of the problem. In this paper, the ultrasonic levitation system and 3 disk-type stator for levitation various object are proposed. The vibration modes of disks are analyzed with FEM and designed with the analysis results. The 3D vibration profiles of the disks are measured by Laser scanning vibrometer for verifying the vibration characteristics of the system. The amplitudes of the disks and the levitation heights of object are measured for evaluating the performance.

ICA와 LDA에 기반한 국부적 조명 변화에 강인한 얼굴인식 방법

김종선,최종무,이준호 成均館大學校 科學技術硏究所 2001 論文集 Vol.52 No.2

본 논문에서는 조명 변화, 표정 변화, 부분적인 오클루전이 있는 얼굴 영상에 대해 높은 얼굴 인식률을 얻기 위해 ICA(Independent Component Analysis)에 클래스 정보를 접목시키는 LDA(Linear Discriminant Analysis)를 결합한 얼굴인식 방법을 제안하고 실험하였다. 얼굴 영상을 구성하는 여러 개의 독립신호를 ICA를 이용하여 분리한 다음 LDA방법을 적용하였다. 기존의 ICA를 이용하는 얼굴인식 방법에 비해 LDA와 ICA를 조합하여 얼굴을 인식하는 방법은 클래스 정보를 이용하기 때문에 조명이나 표정 변화가 있는 얼굴 영상에 대해 우수한 인식 성능을 보였다. 제안된 방법의 얼굴 인식 성능을 평가하기 위하여 SKKUⅠ 과 SKKUⅡ의 얼굴 데이터베이스에 대하여 기존의 얼굴 인식 방법으로 널리 알려진 Eigenface 방법, Fisherface 방법, 그리고 ICA 방법과 함께 인식률을 비교 평가하였다.

특화거리 조성의 변천과정에서 나타난 Network의 중요성에 관한 연구

손재룡,최준호,이용준,이상호,이경회 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

Recently, the Specified streets are designated in the many cities. The specified street is formed naturally by gathering the same type of shops in the same street. The purpose of the specified street is to enhance and to make more lively the characteristics of the street. These specified street has the network consisted of elements, namely shop owner, the authorities, the consumers, etc. In the beginning, we examined how specific streets are made and composed in Seoul and Inchun: the street of the culture, the rodeo, and the furniture. As it turned out, the formation of the network organization in the specific streets showed that how much it is important that it impacted managing. The members of network work together for improvement of the street by negotiation and cooperation. In that process, the street scenery is also improved. This network promotes the spontaneous participation of the members of the affair. In the result of that, the effect of the network is a core which is one of the factors managing and improving specific street. A continuous examination of the more study would strengthen the importance of the network in changing specific street construction.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.