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Lee, Jongkeun,Lee, Andy ,Jinseok,Lee, June-Koo,Park, Jongkeun,Kwon, Youngoh,Park, Seongyeol,Chun, Hyonho,Ju, Young Seok,Hong, Dongwan Oxford University Press 2018 Nucleic acids research Vol.46 No.w1
<P><B>Abstract</B></P><P>Somatic genome mutations occur due to combinations of various intrinsic/extrinsic mutational processes and DNA repair mechanisms. Different molecular processes frequently generate different signatures of somatic mutations in their own favored contexts. As a result, the regional somatic mutation rate is dependent on the local DNA sequence, the DNA replication/RNA transcription dynamics and epigenomic chromatin organization landscape in the genome. Here, we propose an online computational framework, termed Mutalisk, which correlates somatic mutations with various genomic, transcriptional and epigenomic features in order to understand mutational processes that contribute to the generation of the mutations. This user-friendly tool explores the presence of localized hypermutations (<I>kataegis</I>), dissects the spectrum of mutations into the maximum likelihood combination of known mutational signatures and associates the mutation density with numerous regulatory elements in the genome. As a result, global patterns of somatic mutations in any query sample can be efficiently screened, thus enabling a deeper understanding of various mutagenic factors. This tool will facilitate more effective downstream analyses of cancer genome sequences to elucidate the diversity of mutational processes underlying the development and clonal evolution of cancer cells. Mutalisk is freely available at http://mutalisk.org.</P>
Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma
Lee, Jake June-Koo,Park, Seongyeol,Park, Hansol,Kim, Sehui,Lee, Jongkeun,Lee, Junehawk,Youk, Jeonghwan,Yi, Kijong,An, Yohan,Park, In Kyu,Kang, Chang Hyun,Chung, Doo Hyun,Kim, Tae Min,Jeon, Yoon Kyung Elsevier 2019 Cell Vol.177 No.7
Lee, June Koo,Park, Heae Surng,Kim, Dong‐,Wan,Kulig, Kimary,Kim, Tae Min,Lee, Se‐,Hoon,Jeon, Yoon‐,Kyung,Chung, Doo Hyun,Heo, Dae Seog,Kim, Woo‐,Ho,Bang, Yung‐,Jue Wiley Subscription Services, Inc., A Wiley Company 2012 Cancer Vol.118 No.14
<P><B>Abstract</B></P><P><B>BACKGROUND:</B></P><P>The purpose of this study was to investigate the overall survival (OS) of patients with advanced <I>ALK</I>‐positive nonsmall cell lung cancer (NSCLC) who were managed in the pre‐ALK inhibitor era and to compare their survival with that of a matched case cohort of <I>ALK</I> wild‐type (WT) patients.</P><P><B>METHODS:</B></P><P>Data from 1166 patients who had stage IIIB/IV NSCLC with nonsquamous histology were collected from the NSCLC database of Seoul National University Hospital between 2003 and 2009. <I>ALK</I> fluorescence in situ hybridization (FISH) was used to analyze 262 patients who either had the WT epidermal growth factor receptor (<I>EGFR</I>) or were nonresponders to previous EGFR tyrosine kinase inhibitor (TKI) therapy. Overall survival (OS) was compared between 3 groups: 1) <I>ALK</I>‐positive patients, 2) <I>EGFR</I> mutation‐positive patients, and 3) <I>ALK</I>‐WT/<I>EGFR</I>‐WT patients. Progression‐free survival (PFS) after first‐line chemotherapy and EGFR TKIs also was analyzed.</P><P><B>RESULTS:</B></P><P>Twenty‐three patients were <I>ALK</I>‐positive according to FISH analysis and did not receive ALK inhibitors during follow‐up. The median OS for <I>ALK</I>‐positive patients, <I>EGFR</I> mutation‐positive patients, and WT/WT patients was 12.2 months, 29.6 months, and 19.3 months, respectively (vs <I>EGFR</I> mutation‐positive patients, <I>P</I> = .001; vs WT/WT, <I>P</I> = .127). The PFS after first‐line chemotherapy for the 3 groups was not different. However, the PFS for patients who received EGFR TKIs was shorter in <I>ALK</I>‐positive patients compared with the other 2 groups (vs <I>EGFR</I> mutation‐positive patients, <I>P</I> < .001; vs WT/WT, <I>P</I> < .021).</P><P><B>CONCLUSIONS:</B></P><P>In the pre‐ALK inhibitor era, <I>ALK</I>‐positive patients experienced the shortest survival, although it did not differ statistically from that of WT/WT patients. Although their responses to platinum‐based chemotherapy were not different from comparator groups, <I>ALK</I>‐positive patients were even more resistant to EGFR TKI treatment than WT/WT patients. Cancer 2012;3579–3586. © 2011 American Cancer Society.</P>
Human glioblastoma arises from subventricular zone cells with low-level driver mutations
Lee, Joo Ho,Lee, Jeong Eun,Kahng, Jee Ye,Kim, Se Hoon,Park, Jun Sung,Yoon, Seon Jin,Um, Ji-Yong,Kim, Woo Kyeong,Lee, June-Koo,Park, Junseong,Kim, Eui Hyun,Lee, Ji-Hyun,Lee, Joon-Hyuk,Chung, Won-Suk,Ju Springer Science and Business Media LLC 2018 Nature Vol.560 No.7717
초등학교에서 SNS의 교육적 활용 가능성과 효과: 교사와 학생의 인식을 중심으로
이준 ( June Lee ),구양미 ( Yang Mi Koo ),이윤옥 ( Yun Oug Lee ),김지경 ( Ji Kyoung Kim ),임진숙 ( Jin Sook Lim ) 한국교육정보미디어학회(구 한국교육정보방송학회) 2013 교육정보미디어연구 Vol.19 No.1
SNS는 인터넷상에서 친구, 동료 등 지인과의 의사소통을 강화하거나 새로운 인맥을 형성함으로써 폭넓은 인적 네트워크를 구축할 수 있게 해 주는 서비스로서 학령기 학생들의 상당수가 SNS를 이용함에 따라 최근 학교 현장에서도 활용 빈도가 증가하고 있다. 교육이 기본적으로 교사와 학생, 학생과 학생간의 의사소통을 중심으로 이루어진다고 할 때, SNS는 학생들의 눈높이에 맞는 새로운 의사소통의 도구로서 학교교육을 내실화하기 위한 방안의 하나로 검토될 수 있다. 하지만, 본래 교육 목적으로 개발되지 않은 SNS가 공교육의 질을 제고하는데 어떠한 기여를 할 수 있는지에 대한 연구는 아직 미흡하다. 본 연구는 SNS를 활용하고 있는 초등학교 교사와 학생을 대상으로 실제 학교 교육에 이용되고 있는 방법과 교육적 효과 및 역기능에 대한 인식을 조사하고 이를 토대로 공교육 내실화를 위한 시사점을 제시하였다. 본 연구의 주요 결과는 다음과 같다. SNS는 적절하게 사용될 경우 교사와 학생, 학생과 학생간의 면대면 의사소통의 장을 확장하고 상호작용의 빈도를 높일 수 있다는 장점이 있으며, 전문가나 타 학교 학생 등 외부 인적 자원과의 교류를 촉진함으로써 교육의 기회 및 다양성을 확장하는데 도움이 될 수 있다. SNS는 수업 외에도 알림장 사용과 같이 학급경영을 효율화하는 등 교과교육 외의 영역에도 활용될 수 있다. 한편, 일반적인 수준은 아니지만 SNS가 학생들의 불건전 정보접촉이나 상호비방, 교사의 업무 과다 등 역기능적 측면의 활용도 일부 드러났다. 따라서, 교사의 지도하에 교육목적에 부합하는 활동으로 활용 범위를 제한하는 노력이 필요함을 알 수 있었다. The number of people who use SNS has increased in K-12 school recently. However, because of the lack of research studies, it is not obvious whether the use of SNS contributes to improving the quality of public education. The research investigated the possibilities and limitations of using SNS in elementary school. For the purpose of the research, we conducted in-depth interviews and surveys for teachers and students who used SNS in elementary school. The main findings of this research are as follows. In terms of educational effects of SNS, students` class participation improved and their interest in learning also increased. In addition, SNS was helpful for recording learning processes, providing instant feedback, expanding the opportunity of communication, and creating an positive classroom atmosphere. During interviews, teachers acknowledged that SNS was an effective tool for reviewing teaching-learning activities. Moreover, students admitted that sharing ideas and learning material were positive sides of using SNS. However, certain adverse effects of using SNS were found such as slandering other people, accessing obscene contents, increasing teachers` burden, and disturbing students` studies.
Mun, Byung-June,Lee, Joun Ho,Kim, Byeong Koo,Choi, Hyun Chul,Kang, Bongsoon,Song, Ki Hoon,Lee, Seung Hee,Lee, Gi-Dong Institute of Electrical and Electronics Engineers 2015 IEEE transactions on electron devices Vol. No.
<P>In general, surface anchoring energy is one of the most important parameters that strongly affect electrooptical performance, especially the optical response time of liquid crystal (LC) displays. In this paper, we proposed a photoalignment method for strong surface anchoring energy by applying double ultraviolet (UV) exposure with a separated bandwidth to a photosensitive polyimide layer with embedded reactive mesogens (RMs) that can increase the anchoring energy during polymerization. We first polymerized the embedded RM molecules using long wavelength UV rays (over 340 nm), and then achieved the ordered photosensitive alignment layer using short UV rays (between 254 and 340 nm). We compared the measured surface anchoring energy and the optical response time by the proposed method with the conventional UV exposure using the in-plane switching LC mode for verification. As a result, we confirmed that the anchoring energy increased two times and the optical response time improved by 22% compared with the conventional pure UV exposure method.</P>