T1b 병기의 신세포암에서 수술 후 예후를 예측할 수 있는 임상 및 병리학적 인자에 대한 연구

오승용, 김영원, 윤형윤, 서성필, 이상근, 김원태, 윤석중, 이상철, 김원재, 김용준 충북대학교 의과대학 충북대학교 의학연구소 2014 忠北醫大學術誌 Vol.24 No.1

연구목적: T1병기의 국소신세포암(localized clear-cell renal cell carcinoma)은 근치적신적출술이 나 부분신절제술이 표준치료이며 수술 후 타 병기에 비해 양호한 예후를 보인다. 하지만, 많은 수의 환 자에서 추적관찰 중 재발 및 사망이 발생하는데, 이는 T1b 병기에서 더 높게 보고되고 있다. 본 연구 에서는 국소신세포암 중 T1b 병기의 신세포암에서 표준적 치료 후 환자의 예후에 영향을 주는 임상 및 병리학적 인자에 대하여 알아보고자 하였다. 대상 및 방법: 1999년부터 2011년 까지 5개 기관에서 근치적신적출술이나 부분신제술을 시행 받은 3567명의 국소신세포암 환자들 중 병리학적 병기가 T1b로 확진 된 702명을 대상으로 하였다. 이들 환자가 가지는 임상 및 병리학적 특성 [연령, 성별, 고혈압, 당뇨, 비만도, European Cooperative Oncology Group(ECOG) 수행도, 증상유무, 수술방법, 종양크기, 분화도, 조직학적 형태 등]을 이용 하여 환자의 예후 [무재발생존율(relapse-free survival), 암특이생존율(cancer-specific survival) 및 전체생존율(overall survival)]에 영향을 미치는 인자에 대하여 다양한 방법으로 비교분석 하였다. 결과: 추적 관찰 기간은 34.0개월 (중앙값, 0-152개월)이었으며, 이 기간 중 재발, 사망 및 암특이사 망은 각각 72례 (10.3%), 57례 (8.1%) 및 24례 (3.4%)에서 발생하였다. 단변량 및 다변량 Cox 비례위험회귀분석에서 다양한 인자들이 무재발생존율(당뇨 유무, 종양크기 및 Fuhrman등급), 암특이 생존율(나이, 체질량지수, 당뇨 유무, 종양크기) 및 전체생존율(나이, 체질량지수, ECOG 수행도, 종 양크기)에 영향을 줄 수 있는 독립적 예후인자였다. 결론: 본 연구결과 국소신세포암의 예후를 예측할 수 있는 다양한 임상 및 병리학적 인자를 확인 할 수 있었다. 이러한 위험인자를 가지고 있는 환자는 보다 적극적인 추적관찰을 통하여 재발을 조기에 발 견한다면 이들의 생존율 향상에 많은 기여를 할 수 있을 것으로 생각한다.

전북지역 블루베리에 발생하는 해충종류와 블루베리혹파리 발생양상

임주락,김은주,문형철,조종현,한수곤,김희준,송영주,Lim, Ju-Rak,Kim, Eun-Ju,Moon, Hyung-Cheol,Cho, Chong-Hyeon,Han, Soo-Gon,Kim, Hee-June,Song, Young-Ju 한국응용곤충학회 2016 한국응용곤충학회지 Vol.55 No.1

2013~2014년 동안 전북지역 블루베리에서 총 37종의 해충이 조사되었다. 주요해충은 블루베리혹파리, 목화진딧물, 갈색날개매미충, 볼록총채벌레, 미국흰불나방, 장수쐐기나방 6종이었다. 목화진딧물 피해는 5월 중순 익산과 진안에서 심하게 발생하였다. 총채벌레 피해는 모든 지역에서 개화기인 6월초에 심하였고, 어린묘에서 심하였다. 갈색날개매미충은 중산간지역인 순창과 진안지역에서 대발생하여 전 지역으로 확산되고 있었다. 미국흰불나방은 6월 익산에서 특이적으로 집중 발생하는 경향이었다. 쐐기나방은 5종이 발생하였는데 그 중 장수쐐기나방이 모든 지역에서 발생밀도가 가장 높았다. 블루베리혹파리 피해는 중산간지대인 순창과 진안지역보다 평야지대인 익산지역에서 심하였고, 3년생 이하 어린 묘에서 피해율 60~78%로 5년생 이상 피해율 30~50%에 비하여 높았다. 또한, 하우스에서 피해율은 50~80%로 노지 피해율 30~40% 보다 높게 나타났다. Thirty-seven species of insect pests were surveyed on different area blueberry farms in Jeonbuk province during 2013~2014. Six principal insect pests were found, including Dasineura oxycoccana Johnson, Aphis gossypii Glover, Scirtothrips dorsalis Hood, Ricania sp., Hyphantria cunea Drury, and Latoia consocia Walker. A. gossypii infestation was severe at Iksan and Jinan in middle May. S. dorsalis infestation was severe at all surveyed area in early June, which is the flowering season, and the degree of damage caused was higher in young plants. Ricania sp. was abundant in Jinan and Sunchang, and then appeared to spread across all areas in Jeonbuk. H. cunea had a tendency to concentrate in Iksan during June. Five species of Limacodidae was found, including L. consocia, which was dominant in all areas surveyed, with densities higher then those of the others four species. The degree of damage due to D. oxycoccana was higher in the plain areas (Iksan) than in the middle-mountain areas (Jinan, Sunchang). The rate of damage was 60~78% higher in young plant stages (i.e., those under 3 years of tree age) than in those over 5 years old (30~50%). Moreover, the rate of damage observed in greenhouses was 50~80% higher than that observed in the field (30~40%).

금속 촉매를 이용한 poly-Si의 결정화에 관한 연구

金善浩,李秀京,金泰延,康娜榮,金亨駿 弘益大學校 科學技術硏究所 2005 科學技術硏究論文集 Vol.16 No.-

Nickel induced crystallization of amorphous silicon (a-Si) has been studied by selective deposition of Ni on a-Si thin films. The kinetics of crystallization for MIC was found to be greatly enhanced than that of SPC. Ni-induced crystallization is a promising technique for low-temperature fabrication of poly-Si thin-film transistors needed for large area applications. Lateral growth of polycrystalline silicon mediated by the formation of nickel silicide, has been successfully employed for the fabrication of high-performance TFTs. A-Si thin films on which Ni films were deposited with various thickness were crystallized as a function of annealing temperatures. Throughout the thesis work, wise choice of both the thickness of Ni and the annealing temperature was found to produce poly-Si films with high quality, thus potentially resulting in the production of TFTs with high performance.

[논문]병렬 유전 알고리즘을 이용한 발전기 기동정지계획

김형수,문경준,박준호 釜山大學校生産技術硏究所 2003 生産技術硏究所論文集 Vol.62 No.-

본 논문에서는 병렬 유전 알고리즘을 이용한 발전기 기동정지계획을 제안한다. 최소 기동 및 정지 시간 등과 같은 다양한 발전기의 제약조건을 만족시키면서 발전기 기동정지계획을 수립하는 문제는 비선형적이며 많은 국부해가 존재하므로 최적해를 탐색하는데 많은 시간이 소요된다. 이러한 문제점을 해결하기 위해 16개 의 프로세서를 가진 병렬 시스템과 이를 이용한 병렬 유전 알고리즘을 제안하였으며, 제안한 방법의 효용성을 검토하기위해 10기 및 26기의 전력계통에 적용하여 시율레이션을 시행하였다. 시율레이션 결과 기존의 방법에 비해 탐색속도를 개선하였고 우수한 해를 구할 수 있었다.

NK/T 세포 림프종 환자에서 시행된 비골수제거성 조혈모세포이식

정준원,김진석,장준호,서형찬,이승태,김현옥,양우익,민유홍,한지숙,고윤웅 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.2

저자 등은 맹장, 충수돌기 및 흉막을 침범한 고위험군 NK/T 세포 림프종 환자에서 비골수제거 조혈모세포이식을 시행한 후 이식연관 합병증 없이 무병생존하였기에 보고하는 바이다. NK/T cell lymphoma is a rare type of non-Hodgkin"s lymphomas. It has the histological features of angiocentric lymphoma characterized by prominent angio-invasion by tumor cells, and commonly presents in nasal and paranasal structures. Non-nasal form of NK/T cell lymphoma involves skin, gastrointestinal tract, or liver. With conventional chemotherapy and/or radiotherapy, NK/T cell lymphoma shows poor response rate and seldom results in long term survival. Especially, non-nasal form has more aggressive clinical manifestations and grave outcome than nasal form. We report a case of NK/T cell lymphoma presenting with small bowel perforation and malignant pleural effusion due to lymphoma infiltration, transplanted with allogeneic peripheral blood stem cells from HLA identical sibling donor after fludarabine-based nonmyeloablative chemotherapy. After transplantation, the patient achieved an enduring tri-lineage hematological complete response without any evidence of relapse for 10 months.

Ⅲ-Ⅴ족 반도체의 연구 : GaAs의 합성, 단결성 및 특성 Crystal Growth and Characterization of GaAs

이형재,김영기,신영진,박해용,정양준,최춘태,김병호,김진성 全北大學校 基礎科學硏究所 1982 基礎科學 Vol.5 No.1

Temperature of 618 and 1250℃ at As and Ga sities respectively in the horizontal Bridgman furnace and growht speed of 0.7cm/h were found to be optimal for the production of single crystalline GaAs. Self-seeded and unintentionally doped GaAs crystals showd n-type characteristics with Hall mobillity of ∼0.75㎡/V-sec and carrier density of ∼10^19 m^-3 when the mesurements were made right after the growth. About three month later it was found that the same samples were converted to p-type GaAs. The analysis on the p-type sample showed that impurity scattering is dominant at around room temperature and thus the measured Hall mobility was 0.0065㎡/V-sec at 300K. 7.4±0.6 eV was obtained for acoustic deformation potential in the heavy hole band by fitting the theoretical conductivity and Hall coefficient to the corresponding experimental data. The value is very much higher than the theoretically estimated value, 3.6eV. The carrier density variation with temperature obtained from the present analysis gave 0.38 and 0.17 eV respectively for the activation energies of donor and acceptor.

FeMX(M=Mo,Ta, X=N,C)박막의 연자기특성

崔雲,金亨駿,申東勳 弘益大學校 科學技術硏究所 1995 科學技術硏究論文集 Vol.6 No.-

Magnetic properties of FeMoN, FeMoTaN and FeTaN films deposited by DC magnetron reactive sputter were investigated, and correlated with their microstructure, FeMoN films were not showen the soft magnetic properties, because of generated Fe₂Mo, Fe₃-2N and Fe₄N phases. Ta added films, however, effectivly retarted the α-Fe grain growth and suppressed the generation of Fe nitrides or carbides during heat treatment. The soft magnetic properties of Bs 15 kG, Hc : 0.25 Oe, μ´ : 4000 (at 5MHz). and Bs : 14.5 kG, Hc : 0.25 Oe, μ´ : 2700 (5MHz) were observed in Fe?Ta?N? and Fe?Ta?C? films, respectively.

Diamond-Like Carbon 코팅을 이용한 금속 장식 용구의 칼라링 및 디자인연구

변건호,김형준,최형우,권도현 한국공예학회 2001 조형디자인연구 Vol.4 No.2

The usual methods of coloring metal ornaments include surface anodizing, plating and painting. However, the anodizing method can apply to AL materials only and the plating method has been causing a severe environmental problem because of the toxicity of materials used. For these methods, surface deteriorations such as decoloration, scratch and corrosion also occur after long-time use. Therefore, a better surface treatment method is needed. This study was conducted to improve corrosion resistance and wear resistance of metal ornaments, and increase their added value by means of the DLC(Diamond-Like-Carbon) coating method, and to expand the range of its application. This study examined the characteristics of the DLC for coloring metal ornaments and the ornamental design for practical application. Coating metal ornaments could be considered as one of promising fields for application of DLC DLC film is very suitable as a coating material because it is an amorphous carbon material based on covalent bond and therefore has excellent hardness, wear resistance, lubricative property, chemical stability and light transmittance. DLC coating film was formed by the PECVD method using 13.56MHz rf plasma and CH4 gas as a material gas. At this time RF power, working pressure, transmittance according to kind and amount of auxiliary gas, and changes in optical band gap were observed. It was shown that the higher the RF power and working pressure, the lower the optical bang gap. This could be demonstrated by observing the amount of carbon-hydrogen bond by means of FT-IR. It was shown that addition of hydrogen and nitrogen would the optical band gap because they serves to break the carbon-hydrogen bond at the time of vapor deposition. The direction of design was set up in the manner that the DLC coating film could be effectively deposited on the surface of an ornament. Design was based on geometric figures and minimalism with plane elements accentuated. Accentuated, partial coating or simple, whole coating was induced by combining quadrangles, triangles and circles basically.

Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics

Kim, Eun-Ah,Kim, Ye-Hwan,Kang, Ho Won,Yoon, Hyung-Yoon,Kim, Won Tae,Kim, Yong-June,Yun, Seok-Joong,Moon, Sung-Kwon,Choi, Yung Hyun,Kim, Isaac Yi,Lee, Sang-Cheol,Kim, Wun-Jae The Korean Academy of Medical Sciences 2015 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.30 No.7

HIV Antiretroviral Resistance Mutations Among Antiretroviral Treatment-Naive and -Experienced Patients in South Korea

Kim, Min Hyung,Song, Je Eun,Ahn, Jin Young,Kim, Yong Chan,Oh, Dong Hyun,Choi, Heun,Ann, Hea Won,Kim, Jae Kyoung,Kim, Sun Bean,Jeong, Su Jin,Ku, Nam Su,Han, Sang Hoon,Song, Young Goo,Kim, June Myung,Ch Mary Ann Liebert 2013 AIDS research and human retroviruses Vol.29 No.12