교잡종 찰옥수수에 대한 연구 : Ⅱ. 새로 육성된 찰옥수수 교잡종 "대덕찰"에 대한 농업적 특성 Ⅱ. Agronomic Characteristics of the New Waxy Hybrids "Daedukchals"

이희봉,김효기,김동욱,김준표,정재영,최현구,강윤규 충남대학교 농업과학연구소 2002 농업과학연구 Vol.29 No.2

1. 새로 육성된 4개의 대덕찰 찰옥수수 교잡종에 대한 간장은 대조구인 찰옥 1호보다 큰 반면에 개화기는 약 4∼7일 늦었으며, 모든 공시 교잡종의 주당 분얼수는 한 개이하의 무효분얼로 나타났다. 2. 새로 육성된 대덕찰옥수수의 이삭길이와 직경은 대조구인 찰옥 1호보다 크게 나타났으며, 특히 대덕찰옥수수 1호와 2호의 과피두께는 대구조보다 얇았고, 당도 역시 높게 나타나 우수 교잡종으로 평가되었다. Stem height of the new developed "Daedekchals" waxy hybrids were higher than check hybrid. Chalok #1, while days to tasseling were delayed about four to seven days. Number of tillers per plant of the these new hybrids including check were appeared to be one less as non-effective tiller. Ear length and diameter of the new waxy hybrids were longer and thicker than check, respectively. In addition pericarp thickness of the Daedekchal #1 and #2 among new developed waxy hybrids were thinner and sugar content were higher than check.

사료용 교잡종 옥수수 연구 : Ⅲ. CNU와 SK계통을 이용한 교잡종 옥수수의 건물중 및 종실 수량

이희봉,김동욱,김준표,김용일,정재영,최현구,문현귀,이충열 충남대학교 농업과학연구소 2003 농업과학연구 Vol.30 No.2

공시 교잡종에 대한 각 지역에서 선발된 우수 교잡종의 간장 및 착수고는 대조구와 비슷한 경향이었으며, 생체 및 건물수량은 분얼수 및 간장과 관련이 큰 것으로 나타났으나 재식 밀도와 기상상태와도 밀접한 관계로 나타났다. 따라서 생체중은 대전지역에서 재배된 교잡종 H67이 대조구인 광안옥에 비해 53.2%로 높았고, 수원에서 역시 41.8%으로 높았으며, 종실수량은 H15과 H67에서 대조구보다 11.7%와 9.7%로 각각 높게 나타났다. 대전에서 분얼성인 H42와 무얼성인 H65에서 대조구보다 9.1%, 5.2%증가하였고, 수원에서는 분얼성이 H42와 무얼성인 H65에서 대조구보다 9.1%, 8.5% 증가하여 교잡종간, 지역간에 큰 차이를 보였다. 한편 후기 녹체성은 무얼형보다 분얼형에서 낮은 경향을 보였는데 SK계통과 교배된 조합에서 우수한 편으로 나타나 우수 교잡종 육성시 중요 고려사항으로 지적되었다. In order to develop the crude forage maize hybrids with high dry matter and grain yield, several hybrids evaluated as superior hybrids at three regions in 2001. They were planted and surveyed again for the second selection in 2002. The selected hybrids showed large difference in some major characteristics according to planting areas and dates(Suwon : April 25. Daejeon : May 15 and Milyang : May 25), but insect and disease injury were similar to check. Fresh and dry weight of the H67 hybrid at Suwon and Daejeon was the highest among hybrids including check, but low in Milyang due to raining after flowering. Grain yield was higher than check in H15 at Suwon H45 and H37 at Daejeon and H67 at Milyang.

유색미에 관한 연구 : Ⅰ. 감마선 처리에 의해 유래된 Dohoku 유색미 돌연변이체의 주요 특성 Ⅰ. Characteristics of Dohoku color rice mutants derived by Gamma-ray Mutagenesis

이희봉,최현구,김동욱,김준표,정재영,정종태 충남대학교 농업과학연구소 2002 농업과학연구 Vol.29 No.2

1. 돌연변이체 DM-1과 DM-2의 간장은 양친인 Dohoku나 대구조인 흑진주벼보다 짧은 반면에 출수기는 7일내지 20일가량 늦어졌다. 2. 이들 DM-1과 DM-2의 수장은 대조구와 비슷하였으나 주당 이삭수는 대조구와 같이 DM-2에서 매우 많았다. 3. 선발된 계통들에 대한 주당 영화수는 대조구보다 적었으나 영색은 갈색내지 짙은 자주색으로 다양한 변이를 보였고 까락길이 역시 변이가 컸다. 4. 안토치안 색소에 대한 공시계통간 차이를 optical density(OD_(530))값으로 나타낸 결과 DM-2 변이계통에서 2.23, DM-3 변이계통에서 2.26으로 나타나 대조구인 흑진주벼의 2.59보다 크게 낮았다. Culm length of Dohoku mutant 1(DM 1) and mutant 2(DM 2) were shorter than Dohuko parent and Heukjinjubyo check, while days to heading were delayed seven to 20 days Panicle length of these were similar to check and number of panicle per plant of DM 2 was highly appeared than check. Spikelets per plant of the selected lines were lower than check, and glume color of these were varied from brown to dark purple and awn length was also varied according to line used. Anthocyanin content of each mutant line as measured by 530㎚ were lower than that of check in that OD 2.23 and OD 2.26 for DM 1 and DM 2, respectively, and 2.59 for check.

한국어 판 구조화 임상면담도구 개발 : 신뢰도 연구

한오수,안준호,송선희,조맹제,김장규,배재남,조성진,정범수,서동우,함봉진,이동우,박종익,홍진표 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

연구목적: 정신장애의 정확한 진단과 평가는 임상에서뿐만 아니라 신뢰성 있는 연구를 위해서도 매우 중요하다. Structured Clinical Interview for DSM-IV(SCID)는 임상전문가들이 사용하는 진단도구로서, 비교적 짧은 시간에 정확한 진단을 내릴 수 있다. 본 연구는 한국어판SCID를 개발하고 그 신뢰도를 평가하기 위해 수행되었다. 방법: 국문학자가 포함된 번역위원회를 통하여 연구용판 SCID를 번역한 후, 정신과 의사 2인과 임상심리학자 1인에게 한국어판SCID 실시방법을 교육시킨 뒤 한국어판SCID를 이용한 면담의 평가자간 신뢰도 (interrater reliability)를 검증하였다. 면담 대상은 1999년 2월에서 3월까지 2개 병원 정신과에 치료중인 환자 90명(남:41명, 여:29명)이었다. 결과: 현재 장애(current disorder) 평가에서 주요 우울장애, 기분부전장애, 정신분열병, 알코올 남용 및 의존, 기타 물질 남용 또는 의존, 여러 불안장애들 및 섭식장애 등과 같은 대부분 장애의 kappa값은 .70이상으로 매우 높았다. 그 이외의 양극성 장애, 망상장애, 광장공포증, 감별 불능 신체화 장애 및 건강염려증의 kappa값도 .69에서 .40사이로 수용할 수 있는 정도였다. 평생 장애(lifetime disorder)에서는 양극성 장애(k=.69)와 감별 불능 신체화장애(k=.59)를 제외한 다른 모든 장애의 kappa값이 .70이상이었다. K-SCID 면담시 Ⅰ축 질환에 대하여 흔하게 다중 진단이 내려졌으며, 평균 진단 수는 1.5∼1.7개로 나타났다. 결론: 한국어판 SCID는 신뢰도가 높은 진단도구로 생각되며, 향후 정신질환의 정확한 진단과 임상연구에 유용하게 사용될 수 있다. Objectives: Accurate diagnosis and assessment for psychiatric disorders is crucial for research, as well as for clinical practice. Structured Clinical Interview for DSM-Ⅳ(SCID-RV) is a less time-consumimg and more accurate structured diagnostic interview form. It can be used by clinical professions and is known for a reliable diagnostic tool. Present study was conducted to develop Korean version of SCID-RV and to test the inter-rater reliability. Methods: The authors have translated original SCID-RV into Korean, and revised in parallel with sociocultural background of Korea. Ninety patients from two psychiatric hospitals, both outpatient and inpatient, were interviewed and rated independently by three raters. Results: The kappa coefficients for most of illnesses, such as major depressive disorder, dysthymia, schizophrenia, alcohol abuse and dependency, anxiety disorder and eating disorder were excellent(>0.70) in the evaluation of current disorders. And the kappa coefficients for bipolar disorder, delusional disorder, agoraphobia, undifferentiated somatoform disorder, and hypochondriasis were acceptable(>0.40) in the evaluation of current disorders. In the evalua-tion of lifetime disorders, the concordant rates of all the diagnoses except bipolar disorder and undifferentiated somatoform disorder were excellent. Lack of hierarchy in DSM-Ⅳ allows for multiple Axis I diagnoses. Mean numbers of Axis I diagnoses per subject assigned by the three raters were 1.5-1.7. Conclusions: Our findings confirm that SCID-RV yields highly reliable diagnoses. SCID-RV is recommended for accurate diagnosis in clinical practice and research on psychiatric disorders.

계지의 항염 효과에 관한 연구

박히준,이지숙,이재동,김남재,표지희,강전모,최일환,김수영,심범상,이제헌,임사비나 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : Cinnamomi Ramulus (CR), the young twing of Cinnamomi loureirii nees, has been used for treating symptoms related to pain. rheumatic arthritis and inflammation in Korean herb medicine. This study was carried out to investigate the anti-inflammatory effect of CR in vivo and in vitro. Methods : Extracts of CR were prepared and the chemical components of the extracts were examined by gas chromatography-mass spectrometry (GC-MS). The extracts were administrated to the rat paw edema model induced by carrageenan to evaluate the anti-inflammatory effect of CR. The expressions of nitric oxide (NO). prostaglandin E2(PGE2), inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 were also quantified in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages to survey the effect of CR in vitro. The main components were cinnamaldechyde and coumarin. Results : We examined the anti-inflammatory activity of the 80% ethanol extract of Cinnamomi Ramulus in vivo by using carrageenan-induced rat paw edema model. Maximum inhibition of 54.9% was noted at the dose of 1000㎎/㎏ after 2 hours of drug administration in carrageenan-induced rat paw edema and this showed a potent anti-inflammatory effect. Conclusions : The results showed that Cinnamomi Ramulus suppressed dose-dependently LPS-induced NO production in RAW 264.7 macrophages and also decreased iNOS protein expression. Cinnamomi Ramulus also showed a significant inhibitory effect in LPS-induced PGE2 production and COX-2 expression.

한국 주요정신장애의 유병률 및 관련요인 : 2006 전국정신질환역학조사

조맹제,장성만,함봉진,정인원,배안,이영문,안준호,원승희,손정우,홍진표,배재남,이동우,조성진,박종익,이준영,김진영,전홍진,이해우 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.3

Objectives The aims of this study are to estimate the prevalence of the DSM-IV psychiatric disorders in the Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI), and to compare those with previous studies. Methods The Korean Epidemiologic Catchment Area study Replication (KECA-R) was Conducted between August 2006 and April 2007. The sampling of the subjects was carried out across 12 catchment areas. A multistage, cluster sampling design was adopted. The target Population included all eligible residents aged 181o 64 years. Face-to-face interviews were conducted with the Korean version of Composite International Diagnostic Interview (K-CIDI) based on the DSM-IV (N=6,510, response rate=81.7%). Results A total of 6,510 participants completed the interview. The lifetime and 12-month prevalence rates for all types of DSM-IV disorders were 30.0% and 17.3%, respectively. Those of Specific disorders were as follows : 1) alcohol use disorder, 16.2% and 5.6% ; 2) nicotine use disorder, 9.0% and 6.0% ; 3) specific phobia, 3.8% and 3.4% ; 4) major depressive disorder, 5.6% and 2.5% ; and 5) generalized anxiety disorder, 1.6% and 0.8%. Data relating to nicotine and alcohol use disorder revealed a very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among females than males. Conclusion The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in the distribution of psychiatric disorders across the country and times were observed.

Development of SPICA FPC

Dae-Hee Lee,Woong-Seob Jeong,Toshio Matsumoto,Hyung Mok Lee,Young Sik Park,Chang Hee Rhee,Bong Gon Moon,Jeong Hyun Pyo,Sung Jun Park,Wonyong Han,Geon Hee Kim,Norihide Takeyama 한국천문학회 2010 天文學會報 Vol.35 No.2

공정 압력과 산소 가스비가 투명 플라스틱 기판에 성장시킨 AZO 박막에 미치는 영향

이준표(Jun Pyo Lee),강서운(Seong Jun Kang),정양희(Yang Hee Joung),윤영섭(Yung Sup Yoon) 대한전자공학회 2010 電子工學會論文誌-SD (Semiconductor and devices) Vol.47 No.2

본 연구에서는 RF magnetron sputtering 법으로 기판온도 200 ℃ 에서 공정 압력 (5∼20 mTorr)과 산소 가스비 (0∼3 %) 를 변화시켜가며 PES 플라스틱 기판 위에 AZO (Al : 3 wt%) 박막을 제작하여 광학적 및 전기적 특성을 조사하였다. XRD 측정을 통해 공정 조건에 관계없이 모든 AZO 박막이 c 축으로 우선 성장함을 확인할 수 있었다. 박막의 표면을 AFM 으로 조사한 결과, 표면 거칠기 값은 공정압력 5 mTorr, 산소 가스비 3 % 에서 제작한 박막에서 가장 낮은 값 (3.49 ㎚) 을 나타내었다. 모든 AZO 박막이 가시광 영역에서 80 % 정도의 투과율을 보였으며, 공정 압력과 산소 가스비가 감소할수록 에너지 밴드갭이 증가하는 Burstein-Moss 효과를 관찰할 수 있었다. Hall 측정 결과, 공정 압력 5 mTorr와 산소 가스비 0 %에서 제작한 AZO 박막에서 가장 높은 캐리어 농도 2.63 × 10<SUP>20</SUP> ㎝<SUP>-3</SUP> 값과 가장 낮은 비저항 4.35 × 10<SUP>-3</SUP> Ω㎝ 값을 나타내었다. In this study, AZO (Al : 3 wt%) thin films have been prepared on PES Plastic substrates at various working pressure (5∼20 mTorr), O2 gas flow rate (0∼3 %) and the fixed substrate temperature of 200 ℃ by using the RF magnetron sputtering and their optical and electrical properties have been studied. The XRD measurement shows that AZO thin films exhibit c-axis preferred orientation. From the results of AFM measurements, it is known that the lowest surface roughness (3.49 ㎚) is obtained for the AZO thin film fabricated at 5 mTorr of working pressure and 3 % of O₂ gas flow rate. The optical transmittance of AZO thin films is measured as 80 % in the visible region. We observe that the energy band gap of AZO thin films increases with decreasing the working pressure and the O₂ gas flow rate. This phenomenon is due to the Burstein-Moss effect. Hall measurement shows that the maximum carrier concentration (2.63 × 10<SUP>20</SUP> ㎝<SUP>-3</SUP>) and the minimum resistivity (4.35 × 10<SUP>-3</SUP> Ω㎝) are obtained for the AZO thin film fabricated at 5 mTorr of working pressure and 0 % of O2 gas flow rate.

Apoptotic Effect of Tolfenamic Acid in KB Human Oral Cancer Cells: Possible Involvement of the p38 MAPK Pathway

Kim, Jun-Hee,Jung, Ji-Youn,Shim, Jung-Hyun,Kim, Jin,Choi, Kyeong-Hee,Shin, Ji-Ae,Choi, Eun-Sun,Lee, Syng-Ook,Chintharlapalli, Sudhakar,Kwon, Ki Han,Leem, Dae-Ho,Cho, Nam-Pyo,Cho, Sung-Dae the Society for Free Radical Research Japan 2010 Journal of clinical biochemistry and nutrition Vol.47 No.1

<P>Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to inhibit cancer growth by inhibiting the activity of cyclooxygenase (COX). However, there is increasing evidence that the COX-independent pathway may be also involved in the inhibitory effect of NSAIDs against tumor progression. Tolfenamic acid is a NSAID that exhibits anticancer activity in pancreatic and colorectal cancer models. In the present study, the anti-tumor effect of tolfenamic acid in KB human oral cancer cells is investigated. The results showed that tolfenamic acid does not alter the expression of the COX proteins, but it inhibits cell growth and induces apoptosis as evidenced by the annexin V positivity, sub-G<SUB>1</SUB> population, nuclear fragmentation and the cleavage of poly ADP-ribose polymerase. In addition, tolfenamic acid also leads to a loss of the mitochondrial membrane potential in KB cells. These effects are related to the activation of p38 mitogen-activated protein kinase (MAPK) pathway. These results suggest that tolfenamic acid-induced apoptotic cell death inhibits cancer growth by activating the p38 MAPK pathway for cancer prevention.</P>

고육근충 위암의 예후와 예후에 영향을 미치는 인자

윤희정 ( Hee Jung Yoon ),정준표 ( Jun Pyo Chung ),최승호 ( Seung Ho Choi ),김철식 ( Chul Sik Kim ),강병승 ( Byung Seung Kang ),이태희 ( Tae Hee Lee ),지상원 ( Sang Won Chi ),조준식 ( Jun Sik Cho ),문범수 ( Byoung Soo Moon ),이관식 대한소화기학회 2003 대한소화기학회지 Vol.41 No.2

Background/Aims: The purpose of this study was to evaluate the prognosis of gastric proper muscle (pm) cancer and its prognostic factors to identify a high risk group of patients with recurrence. Methods: Consecutive 154 patients (mean age, 57.6 years; M;