일부농촌지역의 농약사용실태 및 농약중독 요인 조사

이경민,송주희,장재혁,심수정,강양화,안재경,이숭호,박미영,정문호 대한보건협회 2002 대한보건연구 Vol.28 No.4

Object The usage of agricultural chemical is on the increasing. Use of pesticides has increased agricultural production. However, negative externalities from such use have increased too. Pesticide poisoning is a major public problem. The purpose if this study is to find out the relationship between keeping the safety rules or protective equipments or attending safety education or dose of pesticides use , and poisoning experience. Methods For Gu, H.M. and Pack, S.G. study , we obtained questionnaire data concerning pesticides poisoming. A person interviews on 203 were conducted in two villages in Sinmeari and woulbonri Chunchun , Kangwon province, July 2002. Result 1. 144 people(70.9%) have sprayed pesticides and the rata of experiences of pesticide poisoning was 26% among 144. Spraying time of pesticides was 1-2 hours in 63.9% of farmers. Rate of using the protective equipment was 25.7% (protective clothes), 49.3% (Mask), 48.6 (Gloves), 7.0 (Protective glasses), 64.6% (boots) respectively. 2. Chi-square and multiple logistic regression analysis showed that Duration of spraying per day (<2hr) and using of mask(protective equipment)are significantly association with poisoning experience.(x^2=5.2684 p=0.0217, CI=0.140-0.5853 OR=0.346 p=0.0211 respectively). But no association between poisoning experience and keeping safety rule, attending of safety education. 3. Spraying pesticides. Duration of spraying pesticides, reading manuals and no spraying at fatigue (keeping safety rule) are significantly association with symptom experience(x^2=14.0621 p=0.0002, x^2=7.0639 p=0.0079, CI01.395-10.950 OR=3.908 p=0.0095, CI=0.101-0.726 OR=0.271 0.0094 respectively). But no association between symptom experience and protective equipments, attending of safety education.

강교량의 수요·공급 변동률과 낙찰율 변동 관계 추정모델

이정훈,김경주 중앙대학교 기술과학연구소 2003 기술과학연구소 논문집 Vol.33 No.-

1997년 외환위기(IMF)이후 강교량 발주물량은 감소하였으며, 반면 강교량 관련 제작업체의 수는 증가하였다. 이는 강교량의 수요와 공급의 불균형으로 이어져 강교량 하도급단가 하락에 영향을 미치게 되었다. 이러한 요인을 수요와 공급 측면에서 조사 분석하였으며 이를 위해 연도별 하도급단가 변화추이와 공급측면에서의 철강재설치공사업체의 등록추이, 수요측면에서의 교량용 강재소비량, 물가지수와의 관계를 각각 비교하여 이러한 요인들이 강교량 하도급 단가에 미치는 영향과 이들의 상관관계를 조사 및 분석하였다. 그 결과 강교량의 수요와 공급의 불균형은 강교량 하도급단가의 변화에 영향을 미치는 것으로 나타났다. After the Korean economic crisis in 1997, steel bridge contract quality was reduced while the number of factories related to the steel bridge production was increased. It led to the imbalance of the steel bridge supply &emand and affected to the steel bridge subcontract price. This study investigated the dffect contract price in aspect of supply &emand. For this purpose, annual subcontract price change, steel bridge production factory’ number, quantity of steel bridge construction, and the price index were compared respectively and the effect of these components to the subcontract price of steel bridge was analyzed. Analysis shows, the imbalance on supply &emand the steel bridge affects to the subcontract price change.

변위매복된 상악전치의 자가이식을 통한 자발적 맹출 유도

김재곤,이두철,오경선,백병주 대한소아치과학회 2001 大韓小兒齒科學會誌 Vol.28 No.2

매복치아의 치료는 단순한 관찰에서 외과적 노출후 교정적 견인까지 매우 다양하며, 매복치의 위치 이상이 심한 경우에는 자가이식을 고려한다. 치아의 자가이식술은 맹출되었거나, 매복치아, 변위맹출된 치아 혹은 기능을 못하는 치아를 동일한 개체의 구강내에서 기존의 발치와나 외과적으로 형성한 수용부에 재위치시키는 술식을 의미한다. 자가이식할 치아는 치근장의 ½∼¾ 정도의 치근 발육시기가 치아가 쉽게 발거되고, 합병증이 적게 생기며, 치근의 최종길이가 충분하게 발육한다. 치근 미완성 치아 이식은 무조건 근관치료 하지 않고, 대부분 치수치유를 목표로 하게 된다. 본 증례는 구순열 부위의 과잉치와 함께 상악 우측 중절치의 맹출지연을 주소로 본원에 내원한 환아로, 방사선사진상 상악 우측 중절치와 측절치의 변위매복을 발견하였으며, 치은내 자가이식술을 시행하여 자발적 맹출을 유도, 정상적 치근발육 및 맹출 후 치열의 양호한 배열을 얻을 수 있었다. The treatment method of impacted tooth is various from simple observation to surgical exposure and orthodontic methods, autotransplantation is concerned to severe malposed impacted tooth Autotransplantation is the transplantation of embedded, impacted, of unerupted tooth, into extraction socket of surgically prepared in the safe individual Autotransplantation of tooth with ½∼¾ root development provldes a good chance of easily extracted, a littte complication, pulp survival, and complete root formation. Transplantation of uncompleted root apex tooth is aim to pulpal healing, not endodontic treatment. The case which were treated with autotransplantation is reported, and induced normal physiologic eruption and good dental alignment.

뇌수술 시 과호흡과 만니톨의 투여가 뇌혈류와 뇌산소대사에 미치는 영향

김지헌,김경식,문봉기,조경기,신용삼,이영주,김진수 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

Background: There are therapies to lower intracranial pressure (ICP) including head elevation, hyperventilation, diuretics injection, intravenous mannitol, hypothermia, cerebrospinal fluid drainage, and cerebral resection in neurosurgical patients. However in recent reports, hyperventilation followed by mannitol administration may lead to cerebral ischemia. Therefore, we investigated the effect of 0.5-1.0 g/kg mannitol administration on jugular venous oxygen saturation (SjVO_2) and cerebral arterial-jugular venous oxygen content difference (AVDO_2) at PaCO_2 25-30 mmHg and 35-40 mmHg in patients undergoing neurosurgery. Methods: we studied 17 patients undergoing neurosurgery in the Ajou University Hospital. Anesthesia was induced with fentanyl, midazolam, thiopental, and vecuronium, and maintained with )_2-Air-Isoflorane, a continuous infusion of fentanyl, and vecuronium. Patients were divided into two groups. Group 1 (n = 10) which is PaCO_2 25-30 mmHg and Group 2 (n = 7) which is PaCO_2 35-40 mmHg by controlling ventilator. Measurements of SjVO_2 and AVDO_2 in following time intervals: Ⅰ = preinjection of mannitol, Ⅱ = postinjection 20 minutes of mannitol, Ⅲ = postinjection 40 minutes of mannitol were obtainde for each group. 0.5-1.0 g/kg mannitol was administered intravenously just at duramater opening. Results: Hemodynamics and hematologics were not significantly different among the two groups. SjVO_2 of each group are as follows; Group 1; Ⅰ (70.3 ± 8.1%), Ⅱ (66.3 ± 6.9%), Ⅲ (69.1 ± 7.9%) and Group 2; Ⅰ (78.6 ± 7.4%), Ⅱ (75.1 ± 8.1%), Ⅲ (76.0 ± 11.2%), Hyperventilation significantly decreased SjVO_2- AVDO_2 was not significantly different but SjVO_2 in Ⅱ was significantly decreased compared with Ⅰ and Ⅲ in Group 1 (20% patients). Conclusions: Mannitol produced a change of SjVO_2 during hyterventilation. Therefore, intravenous mannitol during hyperventilation should be given cautiously according to the patients status because it may cause cerebral ischemia in critical patients. (Korean J Anesthediol 2002; 43: 462~467)

피조개, Scapharca broughtonii의 대사에 미치는 부니의 영향

정의영,신윤경,이주하 한국패류학회 1994 The Korean Journal of Malacology Vol.10 No.1

Genetic Mapping with Recombinant Inbreds in Maize Using CACTA-TD and SSR Markers

Ju Kyong Lee,Jong Yeol Park,Jin Hong Kim,Soon Jae Kwon,Ji Hyeon Shin,Young Boum Shin,Jae Keun Choi,Hwang Kee Min,Nam Soo Kim 한국육종학회 2005 한국육종학회 학술발표회 발표요지 Vol.37 No.1

Synthesis and Evaluation of a Novel Deguelin Derivative, L80, which Disrupts ATP Binding to the C-terminal Domain of Heat Shock Protein 90

Lee, Su-Chan,Min, Hye-Young,Choi, Hoon,Kim, Ho Shin,Kim, Kyong-Cheol,Park, So-Jung,Seong, Myeong A,Seo, Ji Hae,Park, Hyun-Ju,Suh, Young-Ger,Kim, Kyu-Won,Hong, Hyun-Seok,Kim, Hee,Lee, Min-Young,Lee, Je American Society for Pharmacology and Experimental 2015 Molecular pharmacology Vol.88 No.2

<P>The clinical benefit of current anticancer regimens for lung cancer therapy is still limited due to moderate efficacy, drug resistance, and recurrence. Therefore, the development of effective anticancer drugs for first-line therapy and for optimal second-line treatment is necessary. Because the 90-kDa molecular chaperone heat shock protein (Hsp90) contributes to the maturation of numerous mutated or overexpressed oncogenic proteins, targeting Hsp90 may offer an effective anticancer therapy. Here, we investigated antitumor activities and toxicity of a novel deguelin-derived C-terminal Hsp90 inhibitor, designated L80. L80 displayed significant inhibitory effects on the viability, colony formation, angiogenesis-stimulating activity, migration, and invasion of a panel of non–small cell lung cancer cell lines and their sublines with acquired resistance to paclitaxel with minimal toxicity to normal lung epithelial cells, hippocampal cells, vascular endothelial cells, and ocular cells. Biochemical analyses and molecular docking simulation revealed that L80 disrupted Hsp90 function by binding to the C-terminal ATP-binding pocket of Hsp90, leading to the disruption of the interaction between hypoxia-inducible factor (HIF)-1<I>α</I> and Hsp90, downregulation of HIF-1<I>α</I> and its target genes, including vascular endothelial growth factor (VEGF) and insulin-like growth factor 2 (IGF2), and decreased the expression of various Hsp90 client proteins. Consistent with these in vitro findings, L80 exhibited significant antitumor and antiangiogenic activities in H1299 xenograft tumors. These results suggest that L80 represents a novel C-terminal Hsp90 inhibitor with effective anticancer activities with minimal toxicities.</P>

<i>Isaac</i>-CACTA transposons: new genetic markers in maize and sorghum

Lee, Ju Kyong,Kwon, Soon-Jae,Park, Kyong-Cheul,Kim, Nam-Soo Canadian Science Publishing 2005 Genome Vol.48 No.3

<P> CACTA is an En/Spm transposon superfamily present in high copy number in plant genomes, and Isaac is a subfamily of the CACTA superfamily. The TIR sequence of the Isaac subfamily was used for the purpose of transposon display (TD) in maize and sorghum. The Isaac TD produced 50–80 amplified fragments, depending on the primer combination, and the amplification profile was highly polymorphic among maize inbred lines. Isaac TD-based phylogenetic clustering distinguished the maize inbred lines according to their lineages and was consistent with the results of phylogenetic reports derived from other marker techniques by others researchers. The Isaac TD profile proved to be highly reproducible with different brands of Taq DNA polymerases and thermocyclers. The Isaac TD was also applied to recombinant inbred lines to assess genetic segregation; we observed 40–50 recordable segregation markers, depending on the primer combination. These Isaac TD markers segregated mostly as dominant markers, although, in a few cases, non-parental bands were observed in the segregating populations. In addition, the Isaac TD was very successful in the amplification of sorghum accessions. Therefore, the Isaac TD may provide another useful protocol for genetic analysis in maize and sorghum.Key words: CACTA, Isaac, transposon display, maize, sorghum. </P>

Regioselective Addition Reactions of the Organoindium Reagents onto α,β-Unsaturated Ketones

Lee, Phil-Ho,Kim, Hyun,Lee, Koo-Yeon,Seomoon, Dong,Kim, Sun-Dae,Kim, Hee-Chul,Kim, Hyun-Seok,Lee, Mi-Ae,Shim, Eun-Kyong,Lee, Seok-Ju,Kim, Mi-Sook,Han, Mi-Jeong,Noh, Kwang-Hyun,Sridhar, Madabhushi Korean Chemical Society 2004 Bulletin of the Korean Chemical Society Vol.25 No.11

Regioselectivity on the reactions of ${\alpha},{\beta}$--enones with organoindium such as in situ generated allylindium and allenylindium was systematically studied in the presence of TMSCl as an additive. Treatment of 2-cyclohexen-1-one, carvone, 2-cyclohepten-1-one, and chalcone with allylindium reagent produced 1,4-addition products in good yields, while 2-cyclopenten-1-one, 2-methyl-2-cyclopenten-1-one, 4,4-dimethylcyclohexen-1-one, 3-nonen-2-one, 4-hexen-3-one, and 4-phenyl-3-buten-2-one afforded 1,2-addition products. Indium reagent derived from indium and propargyl bromide in Grignard type gave addition products in good yields, under which the successive addition of ${\alpha},{\beta}$-enone and TMSCl were necessary. Although organoindium reagent derived from propargyl bromide produced propargylated compound in Grignard type except 2-cyclohepten-1-one, indium reagent obtained from 1-bromo-2-butyne having ${\gamma}$-methyl group gave allenylated product inBarbier type.

Effects of Low Temperature Interlayer Dielectric Films on the Oxide Reliability and Hot Carrier Immunity of Deep Submicron MOSFET`s

Lee,Sang Gi,Lee,Hi Deok,Lee,Young Jong,Jeong,Ju Young,Kwon,Oh Kyong,Lee,Chang Hyo 대한전자공학회 1997 ICVC : International Conference on VLSI and CAD Vol.5 No.1

We investigate the effects of various ILD structures on device performance. The ILD films' property of electron trap generation rate and mobile ion were measured by constant current FN stress method and BTS(Bias Temperature Stress). The electron trap generation rate analysis shows that the HLD/BPSG and PETEOS/BPSG structure have more negative trap charges inside the gate oxide than the PETEOS/USG structure. The BTS results for the metal gate structure shows that PETEOS/USG results more mobile ions in the oxide than the HLD/BPSG. Also, the PETEOS/USG structure shows better gate oxide lifetime but more device degradation.