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- 저자 : ( Jorge Felix ) (검색결과 1 건)
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High Therapeutic Efficiency of LDV/SOF in Asian Patients with CHC Genotype 1 Infection
( Young-suk Lim ),( Henry Lik Yuen Chan ),( Yock Young Dan ),( Mei Hsuan Lee ),( Ming-lung Yu ),( Marta Silva ),( Jorge Felix ),( Zobair M. Younossi ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Current Asian treatment practices for Chronic Hepatitis C (CHC) Genotype (GT) 1 patients use regimens containing pegylated inferferon and ribavirin (PR). As interferon-free regimens become the standard of care in most Western countries, it is necessary to understand the potential impact of an all-oral, PR-free single-tablet regimen of Ledipasvir/Sofosbuvir (LDV/SOF) on Asian CHC patients. The aim of this study was to estimate long-term health outcomes of LDV/SOF therapy in 4 Asian countries: Taiwan, South Korea, Singapore, Hong Kong. Methods: A hypothetical cohort of 10,000 adult patients/country was modeled with a hybrid decision tree and Markov state-transition model capturing the natural history of CHC and treatment implications over a lifetime. Efficacy was based on randomized controlled trials; country-specific demographics, HCV-related epidemiology and treatment data were retrieved from literature. Therapeutic efficiency was defined as the number of advanced liver disease (ALD) cases averted (decompensated cirrhosis, hepatocellular carcinoma, liver transplants, HCV-related deaths) with LDV/SOF relative to PR or no treatment (NT) in treatment-naive patients. The differing immunomodulatory and anti-tumor effects of the therapies were not modeled. Results: A 12 week regimen of LDV/SOF compared to PR/NT is estimated to substantially impact CHC disease burden by reducing the incidence of ALD (Table 1): -90.6% / -94.2% vs. PR/NT (Taiwan), -92.5% / -95.7% (South Korea), -93.3% / -96.2% (Singapore), -93.4% / -96.3% (Hong Kong). Conclusions: LDV/SOF is a highly effective treatment associated with potentially more favorable health outcomes when compared with current treatment practices or no treatment for GT1 CHC Asian patients.
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